Sulfation pathways during neurodevelopment
Journal article
Clarke, Taylor, Fernandez, Francesca E. and Dawson, Paul A.. (2022). Sulfation pathways during neurodevelopment. Frontiers in Molecular Biosciences. 9, p. Article 866196. https://doi.org/10.3389/fmolb.2022.866196
Authors | Clarke, Taylor, Fernandez, Francesca E. and Dawson, Paul A. |
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Abstract | Sulfate is an important nutrient that modulates a diverse range of molecular and cellular functions in mammalian physiology. Over the past 2 decades, animal studies have linked numerous sulfate maintenance genes with neurological phenotypes, including seizures, impaired neurodevelopment, and behavioral abnormalities. Despite sulfation pathways being highly conserved between humans and animals, less than one third of all known sulfate maintenance genes are clinically reportable. In this review, we curated the temporal and spatial expression of 91 sulfate maintenance genes in human fetal brain from 4 to 17 weeks post conception using the online Human Developmental Biology Resource Expression. In addition, we performed a systematic search of PubMed and Embase, identifying those sulfate maintenance genes linked to atypical neurological phenotypes in humans and animals. Those findings, together with a search of the Online Mendelian Inheritance in Man database, identified a total of 18 candidate neurological dysfunction genes that are not yet considered in clinical settings. Collectively, this article provides an overview of sulfate biology genes to inform future investigations of perturbed sulfate homeostasis associated with neurological conditions. |
Keywords | sulfate; brain; embryological; fetal; gene expression; neurological dysfunction |
Year | 2022 |
Journal | Frontiers in Molecular Biosciences |
Journal citation | 9, p. Article 866196 |
Publisher | Frontiers Research Foundation |
ISSN | 2296-889X |
Digital Object Identifier (DOI) | https://doi.org/10.3389/fmolb.2022.866196 |
Scopus EID | 2-s2.0-85128932766 |
Open access | Published as ‘gold’ (paid) open access |
Page range | 1-10 |
Funder | Mater Foundation |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 14 Apr 2022 |
Publication process dates | |
Accepted | 24 Mar 2022 |
Deposited | 21 Oct 2022 |
https://acuresearchbank.acu.edu.au/item/8y5y0/sulfation-pathways-during-neurodevelopment
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Publisher's version
OA_Clarke_2022_Sulfation_pathways_during_neurodevelopment.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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