L-arabinose co-ingestion delays glucose absorption derived from sucrose in healthy men and women : A double-blind, randomized crossover trial
Journal article
Pasmans, Kenneth, Meex, Ruth C. R., Trommelen, Jorn, Senden, Joan M. G., Vaughan, Elaine E., van Loon, Luc J. C. and Blaak, Ellen E.. (2021). L-arabinose co-ingestion delays glucose absorption derived from sucrose in healthy men and women : A double-blind, randomized crossover trial. British Journal of Nutrition. 128(6), pp. 1072-1081. https://doi.org/10.1017/S0007114521004153
Authors | Pasmans, Kenneth, Meex, Ruth C. R., Trommelen, Jorn, Senden, Joan M. G., Vaughan, Elaine E., van Loon, Luc J. C. and Blaak, Ellen E. |
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Abstract | Dietary interventions to delay carbohydrate digestion or absorption can effectively prevent hyperglycaemia in the early postprandial phase. L-arabinose can specifically inhibit sucrase. It remains to be assessed whether co-ingestion of L-arabinose with sucrose delays sucrose digestion, attenuates subsequent glucose absorption and impacts hepatic glucose output. In this double-blind, randomised crossover study, we assessed blood glucose kinetics following ingestion of a 200-ml drink containing 50 g of sucrose with 7·5 g of L-arabinose (L-ARA) or without L-arabinose (CONT) in twelve young, healthy participants (24 ± 1 years; BMI: 22·2 ± 0·5 kg/m2). Plasma glucose kinetics were determined by a dual stable isotope methodology involving ingestion of (U-13C6)-glucose-enriched sucrose, and continuous intravenous infusion of (6,6–2H2)-glucose. Peak glucose concentrations reached 8·18 ± 0·29 mmol/l for CONT 30 min after ingestion. In contrast, the postprandial rise in plasma glucose was attenuated for L-ARA, because peak glucose concentrations reached 6·62 ± 0·18 mmol/l only 60 min after ingestion. The rate of exogenous glucose appearance for L-ARA was 67 and 57 % lower compared with CONT at t = 15 min and 30 min, respectively, whereas it was 214 % higher at t = 150 min, indicating a more stable absorption of exogenous glucose for L-ARA compared with CONT. Total glucose disappearance during the first hour was lower for L-ARA compared with CONT (11 ± 1 v. 17 ± 1 g, P < 0·0001). Endogenous glucose production was not differentially affected at any time point (P = 0·27). Co-ingestion of L-arabinose with sucrose delays sucrose digestion, resulting in a slower absorption of sucrose-derived glucose without causing adverse effects in young, healthy adults. |
Keywords | healthy adults; sugar; sweetener; sugar-sweetened beverage; glucose metabolism; insulin; indirect calorimetry; steady energy |
Year | 2021 |
Journal | British Journal of Nutrition |
Journal citation | 128 (6), pp. 1072-1081 |
Publisher | Cambridge University Press |
ISSN | 0007-1145 |
Digital Object Identifier (DOI) | https://doi.org/10.1017/S0007114521004153 |
PubMed ID | 34657640 |
Scopus EID | 2-s2.0-85121026520 |
PubMed Central ID | PMC9381304 |
Open access | Published as ‘gold’ (paid) open access |
Page range | 1072-1081 |
Funder | Sensus B.V. |
Knowledge Center Sugar and Nutrition (KSV) | |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 28 Sep 2022 |
Publication process dates | |
Accepted | 13 Oct 2021 |
Deposited | 21 Nov 2022 |
https://acuresearchbank.acu.edu.au/item/8y70y/l-arabinose-co-ingestion-delays-glucose-absorption-derived-from-sucrose-in-healthy-men-and-women-a-double-blind-randomized-crossover-trial
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Publisher's version
OA_Pasmans_2021_L-arabinose_co-ingestion_delays_glucose.pdf | |
License: CC BY-NC-ND 4.0 | |
File access level: Open |
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