Is resting-state functional connectivity altered in regular cannabis users? A systematic review of the literature

Journal article


Thomson, Hannah, Labuschagne, Izelle, Greenwood, Lisa-Marie, Robinson, Emily, Sehl, Hannah, Suo, Chao and Lorenzetti, Valentina. (2022). Is resting-state functional connectivity altered in regular cannabis users? A systematic review of the literature. Psychopharmacology. 239, pp. 1191-1209. https://doi.org/10.1007/s00213-021-05938-0
AuthorsThomson, Hannah, Labuschagne, Izelle, Greenwood, Lisa-Marie, Robinson, Emily, Sehl, Hannah, Suo, Chao and Lorenzetti, Valentina
Abstract

Rationale
Regular cannabis use has been associated with brain functional alterations within frontal, temporal, and striatal pathways assessed during various cognitive tasks. Whether such alterations are consistently reported in the absence of overt task performance needs to be elucidated to uncover the core neurobiological mechanisms of regular cannabis use.

Objectives
We aim to systematically review findings from studies that examine spontaneous fluctuations of brain function using functional Magnetic Resonance Imaging (fMRI) resting-state functional connectivity (rsFC) in cannabis users versus controls, and the association between rsFC and cannabis use chronicity, mental health symptoms, and cognitive performance.

Methods
We conducted a PROSPERO registered systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and searched eight databases.

Results
Twenty-one studies were included for review. Samples comprised 1396 participants aged 16 to 42 years, of which 737 were cannabis users and 659 were controls. Most studies found greater positive rsFC in cannabis users compared to controls between frontal-frontal, fronto-striatal, and fronto-temporal region pairings. The same region pairings were found to be preliminarily associated with varying measures of cannabis exposure.

Conclusions
The evidence to date shows that regular cannabis exposure is consistently associated with alteration of spontaneous changes in Blood Oxygenation Level-Dependent signal without any explicit cognitive input or output. These findings have implications for interpreting results from task-based fMRI studies of cannabis users, which may additionally tax overlapping networks. Future longitudinal rsFC fMRI studies are required to determine the clinical relevance of the findings and their link to the chronicity of use, mental health, and cognitive performance.

Keywordsfunctional magnetic resonance imaging; fMRI; brain; cannabis; resting-state functional connectivity; rsFC; connectivity; seed-based connectivity; systematic review
Year2022
JournalPsychopharmacology
Journal citation239, pp. 1191-1209
PublisherSpringer
ISSN1432-2072
Digital Object Identifier (DOI)https://doi.org/10.1007/s00213-021-05938-0
Scopus EID2-s2.0-85113146858
Page range1191-1209
FunderResearch Training Program Scholarship (RTP), Australian Government
Australian National University
Publisher's version
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All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online20 Aug 2021
Publication process dates
Accepted13 Jul 2021
Deposited21 Nov 2022
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Chye, Yann, Suo, Chao, Lorenzetti, Valentina, Batalla, Albert, Cousijn, Janna, Goudriaan, Anna E., Martin-Santos, Rocio, Whittle, Sarah, Solowij, Nadia and Yücel, Murat. (2019). Cortical surface morphology in long-term cannabis users: A multi-site MRI study. European Neuropsychopharmacology. 29(2), pp. 257 - 265. https://doi.org/10.1016/j.euroneuro.2018.11.1110
Brain regions showing white matter loss in Huntington's Disease are enriched for synaptic and metabolic genes
McColgan, Peter, Gregory, Sarah, Seunarine, Kiran K., Razi, Adeel, Papoutsi, Marina, Johnson, Eileanoir B., Dürr, Alexandra, Roos, Raymund, Leavitt, Blair R., Holmans, Peter, Scahill, Rachael I., Clark, Chris A., Rees, Geraint, Tabrizi, Sarah J., Coleman, A., Decolongon, J., Fan, M., Petkau, T., Jauffret, C., ... Crawfurd, D.. (2018). Brain regions showing white matter loss in Huntington's Disease are enriched for synaptic and metabolic genes. Biological Psychiatry. 83(5), pp. 456-465. https://doi.org/10.1016/j.biopsych.2017.10.019
Testing a longitudinal compensation model in premanifest Huntington's disease
Gregory, Sarah, Long, Jeffrey D., Klöppel, Stefan, Razi, Adeel, Scheller, Elisa, Minkova, Lora, Johnson, Eileanoir B., Durr, Alexandra, Roos, Raymund A. C., Leavitt, Blair R., Mills, James A., Stout, Julie C., Scahill, Rachael I., Tabrizi, Sarah J., Rees, Geraint, the Track-On investigators and Labuschagne, Izelle*. (2018). Testing a longitudinal compensation model in premanifest Huntington's disease. Brain. 141(7), pp. 2156-2166. https://doi.org/10.1093/brain/awy122
Working memory-related effective connectivity in Huntington's disease patients
Lahr, Jacob, Minkova, Lora, Tabrizi, Sarah J., Stout, Julie C., Klöppel, Stefan, Scheller, Elisa, the TrackOn-HD Investigators and Labuschagne, I.. (2018). Working memory-related effective connectivity in Huntington's disease patients. Frontiers in Neurology. 9, p. Article 370. https://doi.org/10.3389/fneur.2018.00370
The relationship between body dysmorphic disorder and obsessive-compulsive disorder: A systematic review of direct comparative studies
Malcolm, Amy, Labuschagne, Izelle, Castle, David J, Terrett, Gill, Rendell, Peter and Rossell, Susan. (2018). The relationship between body dysmorphic disorder and obsessive-compulsive disorder: A systematic review of direct comparative studies. Australian and New Zealand Journal of Psychiatry. 52(11), pp. 1030-1049. https://doi.org/10.1177/0004867418799925
Visual scanning of the eye region of human faces predicts emotion recognition performance in Huntington's disease
Catarina C. Kordsachia, Izelle Labuschagne and Julie C Stout. (2018). Visual scanning of the eye region of human faces predicts emotion recognition performance in Huntington's disease. Neuropsychology. 32(3), pp. 356-365. https://doi.org/10.1037/neu0000424
Oxytocin selectively modulates brain processing of disgust in Huntington's disease gene carriers
Izelle Labuschagne, Govinda Poudel, Catarina C. Kordsachia, Qizhu Wu, Hannah Thomson, Nellie Georgiou-Karistianis and Julie C Stout. (2018). Oxytocin selectively modulates brain processing of disgust in Huntington's disease gene carriers. Progress in Neuropsychopharmacology and Biological Psychiatry. 81, pp. 11-16. https://doi.org/10.1016/j.pnpbp.2017.09.023
Oxytocin and brain activity in humans: A systematic review and coordinate-based meta-analysis of functional MRI studies
Sally A. Grace, Susan Rossell, Markus Heinrichs, Catarina C. Kordsachia and Izelle Labuschagne. (2018). Oxytocin and brain activity in humans: A systematic review and coordinate-based meta-analysis of functional MRI studies. Psychoneuroendocrinology. 96, pp. 6-24. https://doi.org/10.1016/j.psyneuen.2018.05.031
Intranasal oxytocin does not reduce age-related difficulties in social cognition
Sarah A. Grainger, Julie Henry, Henriette R. Steinvik, Eric J Vanman, Peter Rendell and Izelle Labuschagne. (2018). Intranasal oxytocin does not reduce age-related difficulties in social cognition. Hormones and Behaviour. 99, pp. 25-34. https://doi.org/10.1016/j.yhbeh.2018.01.009
Diminished facial EMG responses to disgusting scenes and happy and fearful faces in Huntington's disease
Catarina C. Kordsachia, Izelle Labuschagne, Sophie C. Andrews and Julie C. Stout. (2018). Diminished facial EMG responses to disgusting scenes and happy and fearful faces in Huntington's disease. Cortex. 106, pp. 185-199. https://doi.org/10.1016/j.cortex.2018.05.019
Decision-making, somatic markers and emotion processing in opiate users
Kathryn Biernacki, Gill Terrett, Skye McLennan, Izelle Labuschagne, Phoebe Morton and Peter Rendell. (2018). Decision-making, somatic markers and emotion processing in opiate users. Psychopharmacology. 235(1), pp. 223-232. https://doi.org/10.1007/s00213-017-4760-0
Brief Report: The Impact of Sensory Hypersensitivity and Intolerance of Uncertainty on Anxiety in Williams Syndrome
Mirko Uljarević, Izelle Labuschagne, Rebecca Bobin, Anna Atkinson and Darren R. Hocking. (2018). Brief Report: The Impact of Sensory Hypersensitivity and Intolerance of Uncertainty on Anxiety in Williams Syndrome. Journal of Autism and Developmental Disorders. 48(11), pp. 3958-3964. https://doi.org/10.1007/s10803-018-3631-9
Reduced amygdala volumes are related to motor and cognitive signs in Huntington's disease: The IMAGE-HD study
Ahveninen, Lotta M., Stout, Julie C., Georgiou-Karistianis, Nellie, Lorenzetti, Valentina and Glikmann-Johnston, Yifat. (2018). Reduced amygdala volumes are related to motor and cognitive signs in Huntington's disease: The IMAGE-HD study. NeuroImage: Clinical. 18, pp. 881 - 887. https://doi.org/10.1016/j.nicl.2018.03.027
The anticipation and outcome phases of reward and loss processing: A neuroimaging meta-analysis of the monetary incentive delay task
Oldham, Stuart, Murawski, Carsten, Fornito, Alex, Youssef, George J., Yücel, Murat and Lorenzetti, Valentina. (2018). The anticipation and outcome phases of reward and loss processing: A neuroimaging meta-analysis of the monetary incentive delay task. Human Brain Mapping. 39(8), pp. 3398 - 3418. https://doi.org/10.1002/hbm.24184
Exploring the association of legalisation status of cannabis with problematic cannabis use and impulsivity in the USA
Destrée, Louise, Amiet, Danielle, Carter, Adrian, Lee, Rico, Lorenzetti, Valentina, Segrave, Rebecca, Youssef, George, Solowij, Nadia and Yücel, Murat. (2018). Exploring the association of legalisation status of cannabis with problematic cannabis use and impulsivity in the USA. Drugs in Context. 7, pp. 1 - 5. https://doi.org/10.7573/dic.212541
Intranasal oxytocin reduces heart rate variability during a mental arithmetic task: A randomised, double-blind, placebo-controlled cross-over study
Tracy, Lincoln M., Gibson, Stephen J., Labuschagne, Izelle, Georgiou-Karistianis, Nellie and Giummarra, Melita J.. (2018). Intranasal oxytocin reduces heart rate variability during a mental arithmetic task: A randomised, double-blind, placebo-controlled cross-over study. Progress in Neuropsychopharmacology and Biological Psychiatry. 81, pp. 408 - 415. https://doi.org/10.1016/j.pnpbp.2017.08.016
Emotion regulation using virtual environments and real-time fMRI neurofeedback
Lorenzetti, Valentina, Melo, Bruno, Basílio, Rodrigo, Suo, Chao, Yücel, Murat, Tierra-Criollo, Carlos J. and Moll, Jorge. (2018). Emotion regulation using virtual environments and real-time fMRI neurofeedback. Frontiers in Neurology. 9, pp. 1 - 15. https://doi.org/10.3389/fneur.2018.00390
Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA consortium
Kong, Xiang-Zhen, Mathias, Samuel R., Guadalupe, Tulio, ENIGMA Laterality Working Group, , Glahn, David C., Franke, Barbara, Crivello, Fabrice, Tzourio-Mazoyer, Nathalie, Fisher, Simon E., Thompson, Paul M., Francks, Clyde, Lorenzetti, Valentina and ENIGMA Laterality Working Group. (2018). Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA consortium. Proceedings of the National Academy of Sciences of USA. 115(22), pp. E5154 - E5163. https://doi.org/10.1073/pnas.1718418115
A systematic review and meta-analysis of the neural correlates of psychological therapies in major depression
Sankar, Anjali, Melin, Alice, Lorenzetti, Valentina, Horton, Paul, Costafreda, Sergi G. and Fu, Cynthia H. Y.. (2018). A systematic review and meta-analysis of the neural correlates of psychological therapies in major depression. Psychiatry Research: Neuroimaging. 279, pp. 31 - 39. https://doi.org/10.1016/j.pscychresns.2018.07.002
A transdiagnostic dimensional approach towards a neuropsychological assessment for addiction: an international Delphi consensus study
Yucel, Murat, Oldenhof, Erin, Ahmed, Serge H., Belin, David, Billieux, Joel, Bowden-Jones, Henrietta, Carter, Adrian, Chamberlain, Samuel R., Clark, Luke, Connor, Jason P., Daglish, Mark, Dom, Geert, Dannon, Pinhas, Duka, Theodora, Fernandez-Serrano, Maria Jose, Field, Matt, Franken, Ingmar, Goldstein, Rita Z., Gonzalez, Raul, ... Verdejo-Garcia, Antonio. (2018). A transdiagnostic dimensional approach towards a neuropsychological assessment for addiction: an international Delphi consensus study. Addiction. 114(6), pp. 1095 - 1109. https://doi.org/10.1111/add.14424
Unpacking the role of self-reported compulsivity and impulsivity in obsessive-compulsive disorder
Prochazkova, Luisa, Parkes, Linden, Dawson, Andrew, Youssef, George J., Ferreira, Gabriela M., Lorenzetti, Valentina, Segrave, Rebecca A., Fontenelle, Leonardo F. and Yücel, Murat. (2018). Unpacking the role of self-reported compulsivity and impulsivity in obsessive-compulsive disorder. CNS Spectrums. 23(1), pp. 51 - 58. https://doi.org/10.1017/S1092852917000244
Families affected by Huntington's Disease report difficulties in communication, emotional involvement, and problem solving
Jona, Celine M. H., Labuschagne, Izelle, Mercieca, Emily-Clare, Fisher, Fiona, Gluyas, Cathy, Stout, Julie C. and Andrews, Sophie C.. (2017). Families affected by Huntington's Disease report difficulties in communication, emotional involvement, and problem solving. Journal of Huntington's Disease. 6(3), pp. 169-177. https://doi.org/10.3233/JHD-170250
Neuroscience in gambling policy and treatment: an interdisciplinary perspective
Murat Yucel, Adrian Carter, Amy R Allen, Bernard Balleine, Luke Clark, Nicki A Dowling, Sally M Gainsbury, Anna E Goudriaan, Jon Grant, Alan Hayes, David Hodgins, Ruth van Holst, Ralph Lattimore, Charles Livingstone, Valentina Lorenzetti, Dan Lubman, Carsten Murawski, Linden Parkes, Nancy Petry, ... Wayne Hall. (2017). Neuroscience in gambling policy and treatment: an interdisciplinary perspective. The Lancet Psychiatry. 4(6), pp. 501-506. https://doi.org/10.1016/S2215-0366(16)30369-8
Sex-specific effects of intranasal oxytocin on thermal pain perception: A randomised, double-blind, placebo-controlled cross-over study
Tracy, Lincoln M., Labuschagne, Izelle, Georgiou-Karistianis, Nellie, Gibson, Stephen J. and Giummarra, Melita J.. (2017). Sex-specific effects of intranasal oxytocin on thermal pain perception: A randomised, double-blind, placebo-controlled cross-over study. Psychoneuroendocrinology. 83, pp. 101 - 110. https://doi.org/10.1016/j.psyneuen.2017.05.028
Orbitofrontal and caudate volumes in cannabis users: A multi-site mega-analysis comparing dependent versus non-dependent users
Chye, Yann, Solowij, Nadia, Suo, Chao, Batalla, Albert, Cousijn, Janna, Goudriaan, Anna E., Martin-Santos, Rocio, Whittle, Sarah, Lorenzetti, Valentina and Yücel, Murat. (2017). Orbitofrontal and caudate volumes in cannabis users: A multi-site mega-analysis comparing dependent versus non-dependent users. Psychopharmacology. 234(13), pp. 1985 - 1995. https://doi.org/10.1007/s00213-017-4606-9
Beyond emotion recognition deficits: A theory guided analysis of emotion processing in Huntington's disease
Kordsachia, Catarina C., Labuschagne, Izelle and Stout, Julie C.. (2017). Beyond emotion recognition deficits: A theory guided analysis of emotion processing in Huntington's disease. Neuroscience and Biobehavioral Reviews. 73, pp. 276 - 292. https://doi.org/10.1016/j.neubiorev.2016.11.020
Cannabis-related hippocampal volumetric abnormalities specific to subregions in dependent users
Chye, Yann, Suo, Chao, Yücel, Murat, den Ouden, Lauren, Solowij, Nadia and Lorenzetti, Valentina. (2017). Cannabis-related hippocampal volumetric abnormalities specific to subregions in dependent users. Psychopharmacology. 234(14), pp. 2149 - 2157. https://doi.org/10.1007/s00213-017-4620-y
Impairments in spatiotemporal gait adaptation during obstacle navigation in Huntington’s disease
Anwar, Naznine, Labuschagne, Izelle, Simpson, Katrina, Smith, Luke and Georgiou-Karistianis, Nellie. (2017). Impairments in spatiotemporal gait adaptation during obstacle navigation in Huntington’s disease. Neurorehabilitation and Neural Repair. 31(10-11), pp. 934 - 943. https://doi.org/10.1177/1545968317736818
Abnormal visual scanning of emotionally evocative natural scenes in Huntington's disease
Kordsachia, Catarina C., Labuschagne, Izelle and Stout, Julie C.. (2017). Abnormal visual scanning of emotionally evocative natural scenes in Huntington's disease. Frontiers in Psychology. 8(March), pp. 1 - 10. https://doi.org/10.3389/fpsyg.2017.00405
White matter predicts functional connectivity in premanifest Huntington's disease
McColgan, Peter, Gregory, Sarah, Razi, Adeel, Seunarine, Kiran K., Gargouri, Fatma, Durr, Alexandra, Roos, Raymund A. C., Leavitt, Blair R., Scahill, Rachael I., Clark, Chris A., Tabrizi, Sarah J., Rees, Geraint, Coleman, Allison J., Decolongon, J., Fan, M., Petkau, T., Jauffret, Céline, Justo, Damian, Lehericy, S., ... Johnson, H.. (2017). White matter predicts functional connectivity in premanifest Huntington's disease. Annals of Clinical and Translational Neurology. 4(2), pp. 106 - 118. https://doi.org/10.1002/acn3.384
The neurobiology of body dysmorphic disorder: A systematic review and theoretical model
Grace, Sally A., Labuschagne, Izelle, Kaplan, Ryan A. and Rossell, Susan L.. (2017). The neurobiology of body dysmorphic disorder: A systematic review and theoretical model. Neuroscience and Biobehavioral Reviews. 83, pp. 83 - 96. https://doi.org/10.1016/j.neubiorev.2017.10.003
A psychometric validation study of the Impulsive-Compulsive Behaviours Checklist: A transdiagnostic tool for addictive and compulsive behaviours
Guo, Karen, Youssef, George J., Dawson, Andrew, Parkes, Linden, Oostermeijer, Sanne, López-Solà, Clara, Lorenzetti, Valentina, Greenwood, Christopher, Fontenelle, Leonardo F. and Yücel, Murat. (2017). A psychometric validation study of the Impulsive-Compulsive Behaviours Checklist: A transdiagnostic tool for addictive and compulsive behaviours. Addictive Behaviors. 67, pp. 26 - 33. https://doi.org/10.1016/j.addbeh.2016.11.021
Longitudinal study of hippocampal volumes in heavy cannabis users
Koenders, L., Lorenzetti, Valentina, de Haan, L., Suo, C., Vingerhoets, W. A. M., van den Brink, W., Wiers, R. W., Meijer, C. J., MacHielsen, M. W. J., Goudriaan, Anna E., Veltman, D. J., Yücel, Murat and Cousijn, Janna. (2017). Longitudinal study of hippocampal volumes in heavy cannabis users. Journal of Psychopharmacology. 31(8), pp. 1027 - 1034. https://doi.org/10.1177/0269881117718380
Emotion processing in persons who respond vicariously towards others in pain: Disinhibited left-lateralized neural activity for threatening expressions
Giummarra, Melita J., Poudel, Govinda, Niu, P. Amanda, Nicholls, Michael E. R., Fielding, Joanne, Verdejo-Garcia, Antonio and Labuschagne, Izelle. (2017). Emotion processing in persons who respond vicariously towards others in pain: Disinhibited left-lateralized neural activity for threatening expressions. Laterality: Assymetries of body, brain and cognition. 23(2), pp. 184 - 208. https://doi.org/10.1080/1357650X.2017.1349781
Identification of genetic variants associated with Huntington's disease progression: A genome-wide association study
Hensman Moss, Davina J., Pardiñas, Antonio F., Langbehn, Douglas, Lo, Kitty, Leavitt, Blair R., Roos, Raymund, Durr, Alexandra, Mead, Simon, TRACK-HD investigators, , REGISTRY investigators, , Labuschagne, Izelle, TRACK-HD investigators and REGISTRY investigators. (2017). Identification of genetic variants associated with Huntington's disease progression: A genome-wide association study. The Lancet Neurology. 16(9), pp. 701 - 711. https://doi.org/10.1016/S1474-4422(17)30161-8
Role of orbitofrontal sulcogyral pattern on lifetime cannabis use and depressive symptoms
Chye, Yann, Solowij, Nadia, Ganella, Eleni P., Suo, Chao, Yücel, Murat, Batalla, Albert, Cousijn, Janna, Goudriaan, Anna E., Martin-Santos, Rocio, Whittle, Sarah, Bartholomeusz, Cali F. and Lorenzetti, Valentina. (2017). Role of orbitofrontal sulcogyral pattern on lifetime cannabis use and depressive symptoms. Progress in Neuropsychopharmacology and Biological Psychiatry. 79, pp. 392 - 400. https://doi.org/10.1016/j.pnpbp.2017.07.017
Investigating the role of anticipatory reward and habit strength in obsessive-compulsive disorder
Ferreira, Gabriela M., Yücel, Murat, Dawson, Andrew, Lorenzetti, Valentina and Fontenelle, Leonardo F.. (2017). Investigating the role of anticipatory reward and habit strength in obsessive-compulsive disorder. CNS Spectrums. 22(3), pp. 295 - 304. https://doi.org/10.1017/S1092852916000535
The neurobiology of cannabis use disorders: A call for evidence
Valentina Lorenzetti, Janna Cousijn, Nadia Solowij, Hugh Garavan, Chao Suo, Murat Yucel and Antonio Verdejo-Garcia. (2016). The neurobiology of cannabis use disorders: A call for evidence. Frontiers in Behavioral Neuroscience. 10, pp. 1-3. https://doi.org/10.3389/fnbeh.2016.00086
Olfactory sulcus morphology in patients with current and past major depression
Takahashi, Tsutomu, Nishikawa, Yumiko, Yücel, Murat, Whittle, Sarah, Lorenzetti, Valentina, Walterfang, Mark, Sasabayashi, Daiki, Suzuki, Michio, Pantelis, Christos and Allen, Nicholas B.. (2016). Olfactory sulcus morphology in patients with current and past major depression. Psychiatry Research: Neuroimaging. 255, pp. 60 - 65. https://doi.org/10.1016/j.pscychresns.2016.07.008
The wisdom to know the difference : Strategy-situation fit in emotion regulation in daily life is associated with well-being
Haines, Simon J., Gleeson, John, Kuppens, Peter, Hollenstein, Tom, Ciarrochi, Joseph, Labuschagne, Izelle, Grace, Caitlin and Koval, Peter. (2016). The wisdom to know the difference : Strategy-situation fit in emotion regulation in daily life is associated with well-being. Psychological Science. 27(12), pp. 1651-1659. https://doi.org/10.1177/0956797616669086
Genetic imaging consortium for addiction medicine: From neuroimaging to genes
Mackey, Scott, Kan, Kees-Jan, Chaarani, Bader, Alia-Klein, Nelly, Batalla, Albert, Brooks, Samantha, Cousijn, Janna, Dagher, Alain, de Ruiter, Michiel, Desrivieres, Sylvane, Feldstein Ewing, Sarah W., Goldstein, Rita Z., Goudriaan, Anna E., Heitzeg, Mary M., Hutchison, Kent, Li, Chiang-Shan R., London, Edythe D., Lorenzetti, Valentina, Luijten, Maartje, ... Conrod, Patricia. (2016). Genetic imaging consortium for addiction medicine: From neuroimaging to genes. In Neuroscience for addiction medicine: From prevention to rehabilitation - methods and interventions pp. 203 - 223 Elsevier. https://doi.org/10.1016/bs.pbr.2015.07.026
Adolescent cannabis use: What is the evidence for functional brain alteration?
Lorenzetti, Valentina, Alonso-Lana, Silvia, Youssef, G. J., Verdejo-Garcia, Antonio, Suo, Chao, Cousijn, Janna, Takagi, Michael, Yucel, Murat and Solowij, Nadia. (2016). Adolescent cannabis use: What is the evidence for functional brain alteration? Current Pharmaceutical Design. 22(42), pp. 6353 - 6365. https://doi.org/10.2174/1381612822666160805155922
The role of cannabinoids in neuroanatomic alterations in cannabis users
Lorenzetti, Valentina, Solowij, Nadia and Yücel, Murat. (2016). The role of cannabinoids in neuroanatomic alterations in cannabis users. Biological Psychiatry. 79(7), pp. e17 - e31. https://doi.org/10.1016/j.biopsych.2015.11.013
Improving research standards to restore trust in intranasal oxytocin
Carson, Dean S., Yuan, Hsiangkuo and Labuschagne, Izelle. (2016). Improving research standards to restore trust in intranasal oxytocin. Biological Psychiatry. 79(8), pp. e53 - e54. https://doi.org/10.1016/j.biopsych.2015.08.031
Hippocampal harms, protection and recovery following regular cannabis use
Yücel, Murat, Lorenzetti, Valentina, Suo, C., Zalesky, Andrew, Fornito, Alex, Takagi, Michael J., Lubman, Dan I. and Solowij, Nadia. (2016). Hippocampal harms, protection and recovery following regular cannabis use. Translational Psychiatry. 6(1), pp. 1 - 7. https://doi.org/10.1038/tp.2015.201
An MRI study of white matter tract integrity in regular cannabis users: Effects of cannabis use and age
Jakabek, David, Yucel, Murat, Lorenzetti, Valentina and Solowij, Nadia. (2016). An MRI study of white matter tract integrity in regular cannabis users: Effects of cannabis use and age. Psychopharmacology. 233(19-20), pp. 3627 - 3637. https://doi.org/10.1007/s00213-016-4398-3
Effects of oxytocin and genetic variants on brain and behaviour : Implications for treatment in schizophrenia
Bartholomeusz, Cali, Ganella, Eleni, Labuschagne, Izelle, Bousman, Chad and Pantelis, Christos. (2015). Effects of oxytocin and genetic variants on brain and behaviour : Implications for treatment in schizophrenia. Schizophrenia Research. 168(3), pp. 614 - 627. https://doi.org/10.1016/j.schres.2015.06.007
Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder
Gorka, Stephanie M., Fitzgerald, Daniel A., Labuschagne, Izelle, Hosanagar, Avinash, Wood, Amanda G., Nathan, Pradeep J. and Phan, K. Luan. (2015). Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder. Neuropsychopharmacology. 40(2), pp. 278 - 286. https://doi.org/10.1038/npp.2014.168
Detection of motor changes in huntington's disease using dynamic causal modeling
Minkova, Lora, Scheller, Elisa, Peter, Jessica, Abdulkadir, Ahmed, Kaller, Christoph P., Roos, Raymund A. C., Dürr, Alexandra, Leavitt, Blair R., Tabrizi, Sarah J., Kloppel, Stefan, Coleman, Allison J., Decolongon, J., Fan, M., Koren, T., Jauffret, Céline, Justo, Damian, Lehericy, Stephane, Nigaud, Kevin, Valabrègue, Romain, ... Mills, J.. (2015). Detection of motor changes in huntington's disease using dynamic causal modeling. Frontiers in Human Neuroscience. 9, pp. 1 - 13. https://doi.org/10.3389/fnhum.2015.00634
Gross morphological brain changes with chronic, heavy cannabis use
Lorenzetti, Valentina, Solowij, Nadia, Whittle, Sarah, Fornito, Alex, Lubman, Dan I., Pantelis, Christos and Yücel, Murat. (2015). Gross morphological brain changes with chronic, heavy cannabis use. British Journal of Psychiatry. 206(1), pp. 77 - 78. https://doi.org/10.1192/bjp.bp.114.151407
Compensation in preclinical Huntington's disease: Evidence from the track-on hd study
Kloppel, Stefan, Gregory, Sarah, Scheller, Elisa, Minkova, Lora, Razi, Adeel, Durr, Alexandra, Roos, Raymund A. C., Leavitt, Blair R., Papoutsi, Marina, Landwehrmeyer, G. Bernhard, Reilmann, Ralf, Borowsky, Beth, Johnson, Hans, Mills, James A., Owen, Gail N., Stout, Julie C., Scahill, Rachael I., Long, Jeffrey D., Rees, Geraint, ... Orth, M.. (2015). Compensation in preclinical Huntington's disease: Evidence from the track-on hd study. EBioMedicine. 2(10), pp. 1420 - 1429. https://doi.org/10.1016/j.ebiom.2015.08.002
Neuropsychiatry and white matter microstructure in Huntington's Disease
Gregory, Sarah L., Scahill, Rachael I., Seunarine, Kiran K., Stopford, Cheryl, Zhang, Hui, Zhang, Jiaying, Orth, Michael, Dürr, Alexandra, Roos, Raymund A. C., Langbehn, Douglas R., Long, Jeffrey D., Johnson, Hans, Rees, Geraint, Tabrizi, Sarah J., Craufurd, David I. O., Campbell, C., Campbell, Melissa, Labuschagne, Izelle, Milchman, C., ... Campbell, Colin. (2015). Neuropsychiatry and white matter microstructure in Huntington's Disease. Journal of Huntington's Disease. 4(3), pp. 239 - 249. https://doi.org/10.3233/JHD-150160
Cortico-limbic network abnormalities in individuals with current and past major depressive disorder
Klauser, Paul, Fornito, Alex, Lorenzetti, Valentina, Davey, Christopher G., Dwyer, Dominic B., Allen, Nicholas B. and Yücel, Murat. (2015). Cortico-limbic network abnormalities in individuals with current and past major depressive disorder. Journal of Affective Disorders. 173, pp. 45 - 52. https://doi.org/10.1016/j.jad.2014.10.041
Differential effects of social stress on laboratory-based decision-making are related to both impulsive personality traits and gender
Wise, Richard J., Phung, Alissa L., Labuschagne, Izelle and Stout, Julie C.. (2015). Differential effects of social stress on laboratory-based decision-making are related to both impulsive personality traits and gender. Cognition and Emotion. 29, pp. 1475 - 1485. https://doi.org/10.1080/02699931.2014.989815
Safety, tolerability, and efficacy of PBT2 in Huntington's disease: A phase 2, randomised, double-blind, placebo-controlled trial
Angus, D., Herd, C., Stone, C., Stout, Julie, Wieler, Marguerite, Reilmann, Ralf, Ritchie, C. W., Dorsey, Earl Ray, Helles, K., Kayson, Elise, Oakes, David, Rosas, Herminia Diana, Vaughan, Carr J., Panegyres, Peter K., Ames, David J., Goh, Anita, Agarwal, Pinky, Churchyard, Andrew, Murathodizic, M., ... Targum, S.. (2015). Safety, tolerability, and efficacy of PBT2 in Huntington's disease: A phase 2, randomised, double-blind, placebo-controlled trial. Lancet Neurology. 14(1), pp. 39 - 47. https://doi.org/10.1016/S1474-4422(14)70262-5
The impact of occipital lobe cortical thickness on cognitive task performance : An investigation in Huntington's Disease
Johnson, Eileanoir, Rees, Elin, Labuschagne, Izelle, Durr, Alexandra, Leavitt, Blair, Roos, Raymund, Reilmann, Ralf, Johnson, Hans, Hobbs, Nicola, Langbehn, Douglas, Stout, Julie, Tabrizi, Sarah and Scahill, Rachael. (2015). The impact of occipital lobe cortical thickness on cognitive task performance : An investigation in Huntington's Disease. Neuropsychologia. 79, pp. 138 - 146. https://doi.org/10.1016/j.neuropsychologia.2015.10.033
The association between regular cannabis exposure and alterations of human brain morphology: An updated review of the literature
Lorenzetti, Valentina, Solowij, Nadia, Fornito, Alex, Lubman, Dan Ian and Yücel, Murat. (2014). The association between regular cannabis exposure and alterations of human brain morphology: An updated review of the literature. Current Pharmaceutical Design. 20(13), pp. 2138 - 2167. https://doi.org/10.2174/13816128113199990435
Modulation of resting-state amygdala-frontal functional connectivity by oxytocin in generalized social anxiety disorder
Dodhia, Sonam, Hosanagar, Avinash, Fitzgerald, Daniel A., Labuschagne, Izelle, Wood, Amanda G., Nathan, Pradeep J. and Phan, Kinhluan Luan. (2014). Modulation of resting-state amygdala-frontal functional connectivity by oxytocin in generalized social anxiety disorder. Neuropsychopharmacology. 39(9), pp. 2061 - 2069. https://doi.org/10.1038/npp.2014.53
Using theories of delusion formation to explain abnormal beliefs in Body Dysmorphic Disorder (BDD)
Rossell, Susan L., Labuschagne, Izelle, Dunai, Judith, Kyrios, Michael and Castle, David. (2014). Using theories of delusion formation to explain abnormal beliefs in Body Dysmorphic Disorder (BDD). Psychiatry Research. 215(3), pp. 599 - 605. https://doi.org/10.1016/j.psychres.2013.12.030
The neural cascade of olfactory processing: A combined fMRI-EEG study
Masaoka, Yuri, Harding, Ian H., Koiwa, Nobuyoshi, Yoshida, Masaki, Harrison, Ben J., Lorenzetti, Valentina, Ida, Masahiro, Izumizaki, Masahiko, Pantelis, Christos and Homma, Ikuo. (2014). The neural cascade of olfactory processing: A combined fMRI-EEG study. Respiratory Physiology & Neurobiology. 204, pp. 71 - 77. https://doi.org/10.1016/j.resp.2014.06.008
The potential of composite cognitive scores for tracking progression in Huntington's disease.
Jones, Rebecca D., Stout, Julie C., Labuschagne, Izelle, Say, Miranda Julia, Justo, Damian, Coleman, Allison J., Dumas, Eve M., Hart, Ellen P., Owen, Gail N., Durr, Alexandra, Leavitt, Blair R., Roos, Raymund A. C., O'Regan, Alison M., Langbehn, Doug R., Tabrizi, Sarah J. and Frost, Chris D.. (2014). The potential of composite cognitive scores for tracking progression in Huntington's disease. Journal of Huntington's Disease. 3(2), pp. 197 - 207. https://doi.org/10.3233/JHD-140101
The cognitive burden in Huntington's disease: Pathology, phenotype and mechanisms of compensation
Papoutsi, Marina, Labuschagne, Izelle, Tabrizi, Sarah J. and Stout, Julie C.. (2014). The cognitive burden in Huntington's disease: Pathology, phenotype and mechanisms of compensation. Movement Disorders Society. 29(5), pp. 673 - 683. https://doi.org/10.1002/mds.25864
A comparison of executive function in Body Dysmorphic Disorder (BDD) and Obsessive-Compulsive Disorder (OCD)
Labuschagne, Izelle, Rossell, Susan, Dunai, Judith, Castle, David and Kyrios, Michael. (2013). A comparison of executive function in Body Dysmorphic Disorder (BDD) and Obsessive-Compulsive Disorder (OCD). Journal of Obsessive-Compulsive and Related Disorders. 2(3), pp. 257 - 262. https://doi.org/10.1016/j.jocrd.2013.05.003
Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex
Sripada, Chandra, Phan, Kinhluan, Labuschagne, Izelle, Welsh, Robert, Nathan, Pradeep and Wood, Amanda. (2013). Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex. International Journal of Neuropsychopharmacology (print). 16(2), pp. 255 - 260. https://doi.org/10.1017/S1461145712000533
Emotional face recognition deficits and medication effects in pre-manifest through stage-II Huntington's disease
Labuschagne, Izelle, Jones, Rebecca, Callaghan, Jenny, Whitehead, Daisy, Dumas, Eve, Say, Miranda, Hart, Ellen, Justo, Damian, Coleman, Allison, Dar Santos, Rachelle, Frost, Chris, Craufurd, David, Trabrizi, Sarah and Stout, Julie. (2013). Emotional face recognition deficits and medication effects in pre-manifest through stage-II Huntington's disease. Psychiatry Research. 207(1-2), pp. 118 - 126. https://doi.org/10.1016/j.psychres.2012.09.022
Human amygdala volume is predicted by common DNA variation in the stathmin and serotonin transporter genes
Stjepanović, D., Lorenzetti, Valentina, Yücel, Murat, Hawi, Z. and Bellgrove, M. A.. (2013). Human amygdala volume is predicted by common DNA variation in the stathmin and serotonin transporter genes. Translational Psychiatry. 3(7), pp. 1 - 7. https://doi.org/10.1038/tp.2013.41
Emotional face recognition deficits and medication effects in pre-manifest through stage-II Huntington's disease
Labuschagne, Izelle, Jones, Rebecca, Callaghan, Jenny, Whitehead, Daisy, Dumas, Eve, Say, Miranda, Hart, Ellen, Justo, Damian, Coleman, Allison, Dar Santos, Rachelle, Frost, Chris, Craufurd, David, Tabrizi, Sarah and Stout, Julie. (2013). Emotional face recognition deficits and medication effects in pre-manifest through stage-II Huntington's disease. Psychiatry Research. 207(1-2), pp. 118 - 126. https://doi.org/10.1016/j.psychres.2012.09.022
Alteration to hippocampal shape in cannabis users with and without schizophrenia
Solowij, Nadia, Walterfang, Mark, Lubman, Dan I., Whittle, Sarah, Lorenzetti, Valentina, Styner, Martin, Velakoulis, Dennis, Pantelis, Christos and Yucel, Murat. (2013). Alteration to hippocampal shape in cannabis users with and without schizophrenia. Schizophrenia Research. 143(1), pp. 179 - 184. https://doi.org/10.1016/j.schres.2012.10.040
Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex
Sripada, Chandra, Phan, Kinhluan, Labuschagne, Izelle, Welsh, Robert, Nathan, Pradeep and Wood, Amanda. (2013). Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex. International Journal of Neuropsychopharmacology. 16(2), pp. 255 - 260. https://doi.org/10.1017/S1461145712000533
Visual working memory impairment in premanifest gene-carriers and early Huntington's Disease
Dumas, Eve M., Say, Miranda Julia, Jones, Rebecca D., Labuschagne, Izelle, O'Regan, Alison M., Hart, Ellen P., van den Bogaard, Simon J. A., Queller, Sarah, Justo, Damian, Coleman, Allison J., dar Santos, Rachelle C., Durr, Alexandra, Leavitt, Blair R., Tabrizi, Sarah J., Roos, Raymund A. C. and Stout, Julie C.. (2012). Visual working memory impairment in premanifest gene-carriers and early Huntington's Disease. Journal of Huntington's Disease. 1(1), pp. 97 - 106. https://doi.org/10.3233/JHD-2012-120010
Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease
Stout, Julie, Jones, Rebecca, Labuschagne, Izelle, O'Regan, Alison, Say, Miranda, Dumas, Eve, Queller, Sarah, Justo, Damian, Dar Santos, Rachelle, Coleman, Allison, Hart, Ellen, Durr, Alexandra, Leavitt, Blair, Roos, Raymund, Langbehn, Doug, Tabrizi, Sarah J. and Frost, Chris. (2012). Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease. Journal of Neurology, Neurosurgery and Psychiatry. 83(7), pp. 687 - 694. https://doi.org/10.1136/jnnp-2011-301940
Medial frontal hyperactivity to sad faces in generalized social anxiety disorder and modulation by oxytocin
Labuschagne, Izelle, Phan, K. Luan, Wood, Amanda, Angstadt, Mike, Chua, Phyllis, Heinrichs, Markus, Stout, Julie C., Nathan, Pradeep J. and Pradeep, . (2012). Medial frontal hyperactivity to sad faces in generalized social anxiety disorder and modulation by oxytocin. International Journal of Neuropsychopharmacology (print). 15(7), pp. 883 - 896. https://doi.org/10.1017/S1461145711001489
Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease
Stout, Julie, Jones, Rebecca, Labuschagne, Izelle, O'Regan, Alison, Say, Miranda, Dumas, Eve, Queller, Sarah, Justo, Damian, Dar Santos, Rachelle, Coleman, Allison, Hart, Ellen, Durr, Alexandra, Leavitt, Blair, Roos, Raymund, Langbehn, Douglas, Tabrizi, Sarah J. and Frost, Chris. (2012). Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease. Journal of Neurology, Neurosurgery and Psychiatry. 83(7), pp. 687 - 694. https://doi.org/10.1136/jnnp-2011-301940
What the cognitive deficits in body dysmorphic disorder tell us about the underlying neurobiology: An investigation of three cases
Labuschagne, Izelle, Castle, David and Rossell, Susan L.. (2011). What the cognitive deficits in body dysmorphic disorder tell us about the underlying neurobiology: An investigation of three cases. International Journal of Cognitive Therapy. 4(1), pp. 21 - 33. https://doi.org/10.1521/ijct.2011.4.1.21
Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder
Labuschagne, Izelle, Phan, K. Luan, Wood, Amanda G., Angstadt, Mike, Chua, Phyllis, Heinrichs, Markus, Stout, Julie C. and Nathan, Pradeep. (2010). Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder. Neuropsychopharmacology. 35(12), pp. 2403 - 2413. https://doi.org/10.1038/npp.2010.123
Augmenting serotonin neurotransmission with citalopram modulates emotional expression decoding but not structural encoding of moderate intensity sad facial emotional stimuli: An event-related potential (ERP) investigation
Labuschagne, Izelle, Croft, Rodney, Phan, K. Luan and Nathan, Pradeep. (2010). Augmenting serotonin neurotransmission with citalopram modulates emotional expression decoding but not structural encoding of moderate intensity sad facial emotional stimuli: An event-related potential (ERP) investigation. Journal of Psychopharmacology. 24(8), pp. 1153 - 1164. https://doi.org/10.1177/0269881108097878
Executive function in body dysmorphic disorder
Dunai, Judith, Labuschagne, Izelle, Castle, David J., Kyrios, Michael and Rossell, Susan. (2010). Executive function in body dysmorphic disorder. Psychological Medicine. 40(9), pp. 1541 - 1548. https://doi.org/10.1017/S003329170999198X
An examination of delusional thinking and cognitive styles in body dysmorphic disorder
Labuschagne, Izelle, Castle, David J., Dunai, Judith, Kyrios, Michael and Rossell, Susan. (2010). An examination of delusional thinking and cognitive styles in body dysmorphic disorder. Australian and New Zealand Journal of Psychiatry. 44(8), pp. 706 - 712. https://doi.org/10.3109/00048671003671007
Evidence for modulation of facial emotional processing bias during emotional expression decoding by serotonergic and noradrenergic antidepressants: An event-related potential (ERP) study
Kerestes, Rebecca, Labuschagne, Izelle, Croft, Rodney, O'Neill, Barry, Bhagwagar, Zubin M., Phan, K Luan and Nathan, Pradeep. (2009). Evidence for modulation of facial emotional processing bias during emotional expression decoding by serotonergic and noradrenergic antidepressants: An event-related potential (ERP) study. Psychopharmacology. 202(4), pp. 621 - 634. https://doi.org/10.1007/s00213-008-1340-3