Health related quality of life and associated factors with medication adherence among tuberculosis patients in selected districts of Gandaki Province of Nepal

Journal article

Yadav, Rajesh Kumar, Kaphle, Hari Prasad, Yadav, Dipendra Kumar, Marahatta, Sujan Babu, Shah, Naveen Prakash, Baral, Sushila, Khatri, Elina and Ojha, Renuka. (2021). Health related quality of life and associated factors with medication adherence among tuberculosis patients in selected districts of Gandaki Province of Nepal. Journal of Clinical Tuberculosis and Other Mycobacterial Diseases. 23, p. Article 100235. https://doi.org/10.1016/j.jctube.2021.100235
AuthorsYadav, Rajesh Kumar, Kaphle, Hari Prasad, Yadav, Dipendra Kumar, Marahatta, Sujan Babu, Shah, Naveen Prakash, Baral, Sushila, Khatri, Elina and Ojha, Renuka
Abstract

Background
Tuberculosis is one of the significant public health problems of Nepal. Adherence to medication is very important for improving quality of life and preventing complication. Adherence to tuberculosis medications has significant economic and therapeutic consequences as non-adherence patients are at greater risk of developing complications which affect their health status and overall quality of life. The study aims to determine the factors associated with medication adherence and its effect on health related quality of life among tuberculosis patients in selected districts of Gandaki Province.

Methods
A health facility based cross-sectional study was carried out among 180 tuberculosis patients registered under DOTS and receiving treatment more than or equal to 60 days. WHOQOL-BREF tools to assess quality of life and Morisky medication adherence scale (MMAS-8) was adopt to assess medication adherence. Data was entered in Epi-data and analysis was performed with the help of the Statistical Package for Social Science (SPSS). The odds ratio with a 95% CI was calculated and p-value of <0.05 was considered as cutoff for statistical significance.

Results
A total 180 TB patients were participated in this study. Overall quality of life ranges from 10.75 to 89.25 with Mean ± SD as 55.96 ± 14.65. More than three-fourth (79.4%) respondents were adhere to medication. Medication adherence and health related quality of life was found statistically significant with relationship with health workers, favourable time at DOTS centre, absence of co-infection. Participants who were highly adhered to medication had good quality of life.

Conclusion
Majority of tuberculosis patients adhering to medication had good quality of life. Especial emphasis should be given to tuberculosis patients with co-infection, health workers should behave friendly and provide appropriate counselling in order to maintain the medication adherence and quality of life.

Keywordsmedication adherence; tuberculosis; Gandaki Province; Nepal
Year2021
JournalJournal of Clinical Tuberculosis and Other Mycobacterial Diseases
Journal citation23, p. Article 100235
PublisherElsevier Ltd
ISSN2405-5794
Digital Object Identifier (DOI)https://doi.org/10.1016/j.jctube.2021.100235
PubMed ID33997309
Scopus EID2-s2.0-85104650752
PubMed Central IDPMC8095181
Open accessPublished as ‘gold’ (paid) open access
Page range1-9
FunderNepal Health Research Council (NHRC)
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online15 Apr 2021
Publication process dates
Deposited24 Nov 2022
Grant ID1585
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