Marital status and prostate cancer incidence : A pooled analysis of 12 case–control studies from the PRACTICAL consortium
Journal article
Salmon, Charlotte, Song, Lixin, Muir, Kenneth, UKGPCS Collaborators, Pashayan, Nora, Dunning, Alison M., Batra, Jyotsna, Chambers, Suzanne, Stanford, Janet L., Ostrander, Elaine A., Park, Jong Y., Lin, Hui-Yi, Cussenot, Olivier, Cancel-Tassin, Géraldine, Menegaux, Florence, Cordina-Duverger, Emilie, Kogevinas, Manolis, Llorca, Javier, Kaneva, Radka, ... Parent, Marie-Élise. (2021). Marital status and prostate cancer incidence : A pooled analysis of 12 case–control studies from the PRACTICAL consortium. European Journal of Epidemiology. 36(9), pp. 913-925. https://doi.org/10.1007/s10654-021-00781-1
Authors | Salmon, Charlotte, Song, Lixin, Muir, Kenneth, UKGPCS Collaborators, Pashayan, Nora, Dunning, Alison M., Batra, Jyotsna, Chambers, Suzanne, Stanford, Janet L., Ostrander, Elaine A., Park, Jong Y., Lin, Hui-Yi, Cussenot, Olivier, Cancel-Tassin, Géraldine, Menegaux, Florence, Cordina-Duverger, Emilie, Kogevinas, Manolis, Llorca, Javier, Kaneva, Radka, Slavov, Chavdar, Razack, Azad, Lim, Jasmine, Gago-Dominguez, Manuela, Castelao, Jose Esteban, Kote-Jarai, Zsofia, Eeles, Rosalind A. and Parent, Marie-Élise |
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Abstract | While being in a committed relationship is associated with a better prostate cancer prognosis, little is known about how marital status relates to its incidence. Social support provided by marriage/relationship could promote a healthy lifestyle and an increased healthcare seeking behavior. We investigated the association between marital status and prostate cancer risk using data from the PRACTICAL Consortium. Pooled analyses were conducted combining 12 case–control studies based on histologically-confirmed incident prostate cancers and controls with information on marital status prior to diagnosis/interview. Marital status was categorized as married/partner, separated/divorced, single, or widowed. Tumours with Gleason scores ≥ 8 defined high-grade cancers, and low-grade otherwise. NCI-SEER’s summary stages (local, regional, distant) indicated the extent of the cancer. Logistic regression was used to derive odds ratios (ORs) and 95% confidence intervals (CI) for the association between marital status and prostate cancer risk, adjusting for potential confounders. Overall, 14,760 cases and 12,019 controls contributed to analyses. Compared to men who were married/with a partner, widowed men had an OR of 1.19 (95% CI 1.03–1.35) of prostate cancer, with little difference between low- and high-grade tumours. Risk estimates among widowers were 1.14 (95% CI 0.97–1.34) for local, 1.53 (95% CI 1.22–1.92) for regional, and 1.56 (95% CI 1.05–2.32) for distant stage tumours. Single men had elevated risks of high-grade cancers. Our findings highlight elevated risks of incident prostate cancer among widowers, more often characterized by tumours that had spread beyond the prostate at the time of diagnosis. Social support interventions and closer medical follow-up in this sub-population are warranted. |
Keywords | marital status; prostate cancer; consortium; pooled analysis; meta-analysis |
Year | 2021 |
Journal | European Journal of Epidemiology |
Journal citation | 36 (9), pp. 913-925 |
Publisher | Springer |
ISSN | 0393-2990 |
Digital Object Identifier (DOI) | https://doi.org/10.1007/s10654-021-00781-1 |
Scopus EID | 2-s2.0-85117169193 |
Page range | 913-925 |
Funder | Canadian Institutes of Health Research |
European Commission | |
Cancer Research UK | |
National Institutes of Health (NIH), United States of America | |
Institute of Cancer Research | |
Prostate Cancer Research Foundation | |
Orchid Cancer Appeal | |
Rosetrees Trust | |
National Cancer Research Network UK | |
National Cancer Research Institute (NCRI) UK | |
National Institute for Health Research (NIHR) | |
Cancer Council Victoria | |
National Health and Medical Research Council (NHMRC) | |
VicHealth | |
Prostate Cancer Foundation of Australia | |
Whitten Foundation | |
PricewaterhouseCoopers (PwC) | |
Tattersall's | |
National Human Genome Research Institute (NHGRI), National Institutes of Health | |
Fonds de Recherche sur la Société et la Culture (FRQSC) | |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 18 Jul 2021 |
Publication process dates | |
Accepted | 23 Jun 2021 |
Deposited | 28 Nov 2022 |
Grant ID | HEALTH-F2-2009-223175 |
C5047/A7357 | |
C1287/A10118 | |
C1287/A16563 | |
C5047/A3354 | |
C5047/ A10692 | |
C16913/A6135 | |
U19 CA 148537-01 | |
126402 | |
209057 | |
251533 | |
396414 | |
450104 | |
504700 | |
504702 | |
504715 | |
623204 | |
940394 | |
614296 |
https://acuresearchbank.acu.edu.au/item/8y7v4/marital-status-and-prostate-cancer-incidence-a-pooled-analysis-of-12-case-control-studies-from-the-practical-consortium
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