Ingestion of an ample amount of meat substitute based on a lysine-enriched,plant-based protein blend stimulates postprandial muscle proteinsynthesis to a similar extent as an isonitrogenous amount of chickenin healthy, young men
Journal article
Kouw, Imre W. K., Pinckaers, Philippe J. M., Le Bourgot, Cindy, van Kranenburg, Janneau M. X., Zorenc, Antoine H., de Groot, Lisette C. P. G. M., Verdijk, Lex, Snijders, Tim and van Loon, Luc J. C.. (2022). Ingestion of an ample amount of meat substitute based on a lysine-enriched,plant-based protein blend stimulates postprandial muscle proteinsynthesis to a similar extent as an isonitrogenous amount of chickenin healthy, young men. British Journal of Nutrition. 128, pp. 1955-1965. https://doi.org/10.1017/S0007114521004906
Authors | Kouw, Imre W. K., Pinckaers, Philippe J. M., Le Bourgot, Cindy, van Kranenburg, Janneau M. X., Zorenc, Antoine H., de Groot, Lisette C. P. G. M., Verdijk, Lex, Snijders, Tim and van Loon, Luc J. C. |
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Abstract | Plant-based proteins are considered to be less effective in their capacity to stimulate muscle protein synthesis when compared with animal-based protein sources, likely due to differences in amino acid contents. We compared the postprandial muscle protein synthetic response following the ingestion of a lysine-enriched plant-based protein product with an isonitrogenous amount of chicken. Twenty-four men (age 24 ± 5 years; BMI 22·9 ± 2·6 kg·m−2) participated in this parallel, double-blind, randomised controlled trial and consumed 40 g of protein as a lysine-enriched wheat and chickpea protein product (Plant, n 12) or chicken breast fillet (Chicken, n 12). Primed, continuous intravenous L-(ring-13C6)-phenylalanine infusions were applied while repeated blood and muscle samples were collected over a 5-h postprandial period to assess plasma amino acid responses, muscle protein synthesis rates and muscle anabolic signalling responses. Postprandial plasma leucine and essential amino acid concentrations were higher following Chicken (P < 0·001), while plasma lysine concentrations were higher throughout in Plant (P < 0·001). Total plasma amino acid concentrations did not differ between interventions (P = 0·181). Ingestion of both Plant and Chicken increased muscle protein synthesis rates from post-absorptive: 0·031 ± 0·011 and 0·031 ± 0·013 to postprandial: 0·046 ± 0·010 and 0·055 ± 0·015 % h−1, respectively (P-time < 0·001), with no differences between Plant and Chicken (time x treatment P = 0·068). Ingestion of 40 g of protein in the form of a lysine-enriched plant-based protein product increases muscle protein synthesis rates to a similar extent as an isonitrogenous amount of chicken in healthy, young men. Plant-based protein products sold as meat replacers may be as effective as animal-based protein sources to stimulate postprandial muscle protein synthesis rates in healthy, young individuals. |
Keywords | muscle protein synthesis; plant-based proteins; chicken; meat substitute; protein blends |
Year | 2022 |
Journal | British Journal of Nutrition |
Journal citation | 128, pp. 1955-1965 |
Publisher | Cambridge University Press |
ISSN | 0007-1145 |
Digital Object Identifier (DOI) | https://doi.org/10.1017/S0007114521004906 |
Scopus EID | 2-s2.0-85121207749 |
Open access | Published as ‘gold’ (paid) open access |
Page range | 1955-1965 |
Funder | Tereos |
TiFN | |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 09 Dec 2021 |
Publication process dates | |
Accepted | 24 Nov 2021 |
Deposited | 01 Dec 2022 |
https://acuresearchbank.acu.edu.au/item/8y7y8/ingestion-of-an-ample-amount-of-meat-substitute-based-on-a-lysine-enriched-plant-based-protein-blend-stimulates-postprandial-muscle-proteinsynthesis-to-a-similar-extent-as-an-isonitrogenous-amount-of
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OA_Kouw_2021_Ingestion_of_an_ample_amount_of.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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