Investigating longitudinal changes to frontal cortico-striatal tracts in Huntington’s disease : The IMAGE-HD study
Journal article
Tan, Brendan, Shishegar, Rosita, Oldham, Stuart, Fornito, Alex, Poudel, Govinda and Georgiou-Karistianis, Nellie. (2022). Investigating longitudinal changes to frontal cortico-striatal tracts in Huntington’s disease : The IMAGE-HD study. Brain Imaging and Behavior. 16, pp. 2457-2466. https://doi.org/10.1007/s11682-022-00699-6
Authors | Tan, Brendan, Shishegar, Rosita, Oldham, Stuart, Fornito, Alex, Poudel, Govinda and Georgiou-Karistianis, Nellie |
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Abstract | The striatum is the principal site of disease pathology in Huntington’s disease and contains neural connections to numerous cortical brain regions. Studies examining abnormalities to neural connections find that white matter integrity is compromised in HD; however, further regional, and longitudinal investigation is required. This paper is the first longitudinal investigation into region-based white-matter integrity changes in Huntington’s Disease. The aim of this study was to better understand how disease progression impacts white matter tracts connecting the striatum to the prefrontal and motor cortical regions in HD. We used existing neuroimaging data from IMAGE-HD, comprised of 25 pre-symptomatic, 27 symptomatic, and 25 healthy controls at three separate time points (baseline, 18-months, 30-months). Fractional anisotropy, axial diffusivity and radial diffusivity were derived as measures of white matter microstructure. The anatomical regions of interest were identified using the Desikan-Killiany brain atlas. A Group by Time repeated measures ANCOVA was conducted for each tract of interest and for each measure. We found significantly lower fractional anisotropy and significantly higher radial diffusivity in the symptomatic group, compared to both the pre-symptomatic group and controls (the latter two groups did not differ from each other), in the rostral middle frontal and superior frontal tracts; as well as significantly higher axial diffusivity in the rostral middle tracts only. We did not find a Group by Time interaction for any of the white matter integrity measures. These findings demonstrate that whilst the microstructure of white matter tracts, extending from the striatum to these regions of interest, are compromised during the symptomatic stages of Huntington’s disease, 36-month follow-up did not show progressive changes in these measures. Additionally, no correlations were found between clinical measures and tractography changes, indicating further investigations into the relationship between tractography changes and clinical symptoms in Huntington’s disease are required. |
Keywords | Huntington’s disease; white matter; tractography; diffusion tensor imaging |
Year | 2022 |
Journal | Brain Imaging and Behavior |
Journal citation | 16, pp. 2457-2466 |
Publisher | Springer |
ISSN | 1931-7557 |
Digital Object Identifier (DOI) | https://doi.org/10.1007/s11682-022-00699-6 |
PubMed ID | 35768755 |
Scopus EID | 2-s2.0-85133208751 |
PubMed Central ID | PMC9712302 |
Open access | Published as ‘gold’ (paid) open access |
Page range | 2457-2466 |
Funder | CHDI Foundation |
National Health and Medical Research Council (NHMRC) | |
Sylvia and Charles Viertel Charitable Foundation | |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 29 Jun 2022 |
Publication process dates | |
Accepted | 06 Jun 2022 |
Deposited | 05 Dec 2022 |
Grant ID | A: 3433 |
606650 |
https://acuresearchbank.acu.edu.au/item/8y84z/investigating-longitudinal-changes-to-frontal-cortico-striatal-tracts-in-huntington-s-disease-the-image-hd-study
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Publisher's version
OA_Tan_2022_Investigating_longitudinal_changes_to_frontal_cortico.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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