Falls, fractures, and areal bone mineral density in older adults with sarcopenic obesity : A systematic review and meta-analysis
Journal article
Gandham, Anoohya, Mesinovic, Jakub, Jansons, Paul, Zengin, Ayse, Bonham, Maxine, Ebeling, Peter and Scott, David. (2021). Falls, fractures, and areal bone mineral density in older adults with sarcopenic obesity : A systematic review and meta-analysis. Obesity Reviews. 22(5), pp. 1-13. https://doi.org/10.1111/obr.13187
Authors | Gandham, Anoohya, Mesinovic, Jakub, Jansons, Paul, Zengin, Ayse, Bonham, Maxine, Ebeling, Peter and Scott, David |
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Abstract | Sarcopenia and obesity are common conditions in older adults that may have differing effects on falls and fracture risk. This systematic review and meta-analysis aimed to determine whether older adults with sarcopenic obesity have increased risk of falls and fractures or lower bone mass compared with older adults with sarcopenia, obesity, or neither condition. Twenty-six studies (n = 37,124) were included in the systematic review and 17 (n = 31,540) were included in the meta-analysis. Older adults with sarcopenic obesity had lower femoral neck areal bone mineral density (aBMD) compared with those with obesity alone but had higher femoral neck aBMD compared with counterparts with sarcopenia alone (both P < 0.05). Older adults with sarcopenic obesity had higher nonvertebral fracture rates (incidence rate ratio: 1.88; 95% confidence intervals: 1.09, 3.23; based on two studies), compared with those with sarcopenia alone, and also had higher falls risk compared with controls (risk ratio: 1.30; 95% confidence intervals: 1.10, 1.54) and obesity alone (risk ratio: 1.17; 95% confidence intervals: 1.01, 1.36). In conclusion, this systematic review and meta-analysis has demonstrated that older adults with sarcopenic obesity are at increased risk of adverse musculoskeletal outcomes compared with individuals with obesity, sarcopenia, or neither condition. These data support the need for developing interventions to improve bone health and physical function in this population. |
Keywords | falls; fracture; obesity; sarcopenia |
Year | 01 Jan 2021 |
Journal | Obesity Reviews |
Journal citation | 22 (5), pp. 1-13 |
Publisher | Wiley-Blackwell Publishing Ltd. |
ISSN | 1467-7881 |
Digital Object Identifier (DOI) | https://doi.org/10.1111/obr.13187 |
PubMed ID | 33491333 |
Web address (URL) | https://onlinelibrary.wiley.com/doi/10.1111/obr.13187 |
Open access | Published as non-open access |
Research or scholarly | Research |
Page range | 1-13 |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 06 Apr 2021 |
Publication process dates | |
Accepted | 15 Nov 2020 |
Deposited | 05 Jan 2023 |
Additional information | © 2020 World Obesity Federation. |
Place of publication | United Kingdom |
https://acuresearchbank.acu.edu.au/item/8y908/falls-fractures-and-areal-bone-mineral-density-in-older-adults-with-sarcopenic-obesity-a-systematic-review-and-meta-analysis
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