Falls, fractures, and areal bone mineral density in older adults with sarcopenic obesity : A systematic review and meta-analysis

Journal article


Gandham, Anoohya, Mesinovic, Jakub, Jansons, Paul, Zengin, Ayse, Bonham, Maxine, Ebeling, Peter and Scott, David. (2021). Falls, fractures, and areal bone mineral density in older adults with sarcopenic obesity : A systematic review and meta-analysis. Obesity Reviews. 22(5), pp. 1-13. https://doi.org/10.1111/obr.13187
AuthorsGandham, Anoohya, Mesinovic, Jakub, Jansons, Paul, Zengin, Ayse, Bonham, Maxine, Ebeling, Peter and Scott, David
Abstract

Sarcopenia and obesity are common conditions in older adults that may have differing effects on falls and fracture risk. This systematic review and meta-analysis aimed to determine whether older adults with sarcopenic obesity have increased risk of falls and fractures or lower bone mass compared with older adults with sarcopenia, obesity, or neither condition. Twenty-six studies (n = 37,124) were included in the systematic review and 17 (n = 31,540) were included in the meta-analysis. Older adults with sarcopenic obesity had lower femoral neck areal bone mineral density (aBMD) compared with those with obesity alone but had higher femoral neck aBMD compared with counterparts with sarcopenia alone (both P < 0.05). Older adults with sarcopenic obesity had higher nonvertebral fracture rates (incidence rate ratio: 1.88; 95% confidence intervals: 1.09, 3.23; based on two studies), compared with those with sarcopenia alone, and also had higher falls risk compared with controls (risk ratio: 1.30; 95% confidence intervals: 1.10, 1.54) and obesity alone (risk ratio: 1.17; 95% confidence intervals: 1.01, 1.36). In conclusion, this systematic review and meta-analysis has demonstrated that older adults with sarcopenic obesity are at increased risk of adverse musculoskeletal outcomes compared with individuals with obesity, sarcopenia, or neither condition. These data support the need for developing interventions to improve bone health and physical function in this population.

Keywordsfalls; fracture; obesity; sarcopenia
Year01 Jan 2021
JournalObesity Reviews
Journal citation22 (5), pp. 1-13
PublisherWiley-Blackwell Publishing Ltd.
ISSN1467-7881
Digital Object Identifier (DOI)https://doi.org/10.1111/obr.13187
PubMed ID33491333
Web address (URL)https://onlinelibrary.wiley.com/doi/10.1111/obr.13187
Open accessPublished as non-open access
Research or scholarlyResearch
Page range1-13
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online06 Apr 2021
Publication process dates
Accepted15 Nov 2020
Deposited05 Jan 2023
Additional information

© 2020 World Obesity Federation.

Place of publicationUnited Kingdom
Permalink -

https://acuresearchbank.acu.edu.au/item/8y908/falls-fractures-and-areal-bone-mineral-density-in-older-adults-with-sarcopenic-obesity-a-systematic-review-and-meta-analysis

Restricted files

Publisher's version

  • 39
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Sarcopenia definitions and their association with fracture risk in older Swedish women
Gandham, Anoohya, Gregori, Giulia, Johansson, Lisa, Johansson, Helena, Harvey, Nicholas, Vandenput, Liesbeth, McCloskey, Eugene, Kanis, John Anthony, Litsne, Henrik, Axelsson, Kristian and Lorentzon, Karl Mattias. (2024). Sarcopenia definitions and their association with fracture risk in older Swedish women. JBMR Plus. 39(4), pp. 453-461. https://doi.org/10.1093/jbmr/zjae026
Effects of Moderate- to High-Impact Exercise Training on Bone Structure Across the Lifespan: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Ng, Carrie-Anne, Gandham, Anoohya, Mesinovic, Jakub, Owen, Patrick J., Ebeling, Peter and Scott, David. (2023). Effects of Moderate- to High-Impact Exercise Training on Bone Structure Across the Lifespan: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of Bone and Mineral Research. 38(11), pp. 1612-1634. https://doi.org/10.1002/jbmr.4899
Vitamin D supplementation and exercise for improving physical function, body composition and metabolic health in overweight or obese older adults with vitamin D deficiency : A pilot randomized, double-blind, placebo-controlled trial
Mesinovic, Jakub, Rodriguez, Alexander J., Cervo, Mavil May, Gandham, Anoohya, Xu, Cecilia L. H., Glavas, Costas, de Courten, Barbora, Zengin, Ayse, Ebeling, Peter R. and Scott, David. (2023). Vitamin D supplementation and exercise for improving physical function, body composition and metabolic health in overweight or obese older adults with vitamin D deficiency : A pilot randomized, double-blind, placebo-controlled trial. European Journal of Nutrition. 62(2), pp. 951-964. https://doi.org/10.1007/s00394-022-03038-z
Sex Differences in Bone Health Among Indian Older Adults with Obesity, Sarcopenia, and Sarcopenic Obesity
Gandham, Anoohya, Scott, David, Bonham, Maxine, Kulkarni, Bharati, Kinra, Sanjay, Ebeling, Peter and Zengin, Ayse. (2022). Sex Differences in Bone Health Among Indian Older Adults with Obesity, Sarcopenia, and Sarcopenic Obesity. Calcified Tissue International. 111(2), pp. 152-161. https://doi.org/10.1007/s00223-022-00981-1
Associations of accelerometer-determined physical activity and sedentary behavior with sarcopenia and incident falls over 12 months in community-dwelling Swedish older adults
Scott, David, Johansson, Jonas, Gandham, Anoohya, Ebeling, Peter, Nordström, Peter and Nordström, Anna. (2021). Associations of accelerometer-determined physical activity and sedentary behavior with sarcopenia and incident falls over 12 months in community-dwelling Swedish older adults. Journal of Sport and Health Science. 10(5), pp. 577-584. https://doi.org/10.1016/j.jshs.2020.01.006
Associations between socioeconomic status and obesity, sarcopenia, and sarcopenic obesity in community-dwelling older adults : The Tasmanian Older Adult Cohort Study
Gandham, Anoohya, Zengin, Ayse, Bonham, Maxine, Brennan-Olsen, Sharon, Aitken, Dawn, Winzenberg, Tania, Ebeling, Peter, Jones, Graeme and Scott, David. (2021). Associations between socioeconomic status and obesity, sarcopenia, and sarcopenic obesity in community-dwelling older adults : The Tasmanian Older Adult Cohort Study. Experimental Gerontology. 156, pp. 1-7. https://doi.org/10.1016/j.exger.2021.111627
Impact of protein intake in older adults with sarcopenia and obesity : A gut microbiota perspective
Prokopidis, Konstantinos, Cervo, Mavil May, Gandham, Anoohya and Scott, David. (2020). Impact of protein intake in older adults with sarcopenia and obesity : A gut microbiota perspective. Nutrients. 12(8), p. Article 2285. https://doi.org/10.3390/nu12082285
Incidence and predictors of fractures in older adults with and without obesity defined by body mass index versus body fat percentage
Gandham, Anoohya, Zengin, Ayse, Bonham, Maxine P., Winzenberg, Tania, Balogun, Saliu, Wu, Feitong, Aitken, Dawn, Cicuttini, Flavia, Ebeling, Peter R., Jones, Graeme and Scott, David. (2020). Incidence and predictors of fractures in older adults with and without obesity defined by body mass index versus body fat percentage. Bone. 140, p. Article 115546. https://doi.org/10.1016/j.bone.2020.115546
Associations of health-related quality of life, fear of falling and objective measures of physical function with bone health in postmenopausal women with low bone mass
Gandham, Anoohya, McMillan, Lachlan B., Ng, Carrie-Anne, Humbert, Ludovic, Bonham, Maxine P., Zengin, Ayse, Ebeling, Peter R. and Scott, David. (2019). Associations of health-related quality of life, fear of falling and objective measures of physical function with bone health in postmenopausal women with low bone mass. Journal of Clinical Medicine. 8(9), p. Article 1370. https://doi.org/10.3390/jcm8091370