Falls, fractures, and areal bone mineral density in older adults with sarcopenic obesity : A systematic review and meta-analysis

Journal article

Gandham, Anoohya, Mesinovic, Jakub, Jansons, Paul, Zengin, Ayse, Bonham, Maxine, Ebeling, Peter and Scott, David. (2021). Falls, fractures, and areal bone mineral density in older adults with sarcopenic obesity : A systematic review and meta-analysis. Obesity Reviews. 22(5), pp. 1-13. https://doi.org/10.1111/obr.13187
AuthorsGandham, Anoohya, Mesinovic, Jakub, Jansons, Paul, Zengin, Ayse, Bonham, Maxine, Ebeling, Peter and Scott, David
Abstract

Sarcopenia and obesity are common conditions in older adults that may have differing effects on falls and fracture risk. This systematic review and meta-analysis aimed to determine whether older adults with sarcopenic obesity have increased risk of falls and fractures or lower bone mass compared with older adults with sarcopenia, obesity, or neither condition. Twenty-six studies (n = 37,124) were included in the systematic review and 17 (n = 31,540) were included in the meta-analysis. Older adults with sarcopenic obesity had lower femoral neck areal bone mineral density (aBMD) compared with those with obesity alone but had higher femoral neck aBMD compared with counterparts with sarcopenia alone (both P < 0.05). Older adults with sarcopenic obesity had higher nonvertebral fracture rates (incidence rate ratio: 1.88; 95% confidence intervals: 1.09, 3.23; based on two studies), compared with those with sarcopenia alone, and also had higher falls risk compared with controls (risk ratio: 1.30; 95% confidence intervals: 1.10, 1.54) and obesity alone (risk ratio: 1.17; 95% confidence intervals: 1.01, 1.36). In conclusion, this systematic review and meta-analysis has demonstrated that older adults with sarcopenic obesity are at increased risk of adverse musculoskeletal outcomes compared with individuals with obesity, sarcopenia, or neither condition. These data support the need for developing interventions to improve bone health and physical function in this population.

Keywordsfalls; fracture; obesity; sarcopenia
Year01 Jan 2021
JournalObesity Reviews
Journal citation22 (5), pp. 1-13
PublisherWiley-Blackwell Publishing Ltd.
ISSN1467-7881
Digital Object Identifier (DOI)https://doi.org/10.1111/obr.13187
PubMed ID33491333
Web address (URL)https://onlinelibrary.wiley.com/doi/10.1111/obr.13187
Open accessPublished as non-open access
Research or scholarlyResearch
Page range1-13
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online06 Apr 2021
Publication process dates
Accepted15 Nov 2020
Deposited05 Jan 2023
Additional information

© 2020 World Obesity Federation.

Place of publicationUnited Kingdom
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