Updated trabecular bone score accounting for the soft tissue thickness (TBSTT) demonstrated significantly improved bone microstructure with denosumab in the FREEDOM TBS post hoc analysis
Journal article
Hans, Didier, Shevroja, Enisa, McDermott, Michele, Huang, Shuang, Kim, Min and McClung, Michael Roy. (2022). Updated trabecular bone score accounting for the soft tissue thickness (TBSTT) demonstrated significantly improved bone microstructure with denosumab in the FREEDOM TBS post hoc analysis. Osteoporosis International. 33(12), pp. 2517-2525. https://doi.org/10.1007/s00198-022-06549-x
Authors | Hans, Didier, Shevroja, Enisa, McDermott, Michele, Huang, Shuang, Kim, Min and McClung, Michael Roy |
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Abstract | TBS algorithm has been updated to account for regional soft tissue noise. In postmenopausal women with osteoporosis, denosumab improved tissue thickness-adjusted TBS vs placebo independently of bone mineral density over 3 years, with the magnitude of changes from baseline or placebo numerically greater than body mass index-adjusted TBS. Introduction: To evaluate the effect of denosumab on bone microarchitecture assessed by trabecular bone score (TBS) in the FREEDOM study using the updated algorithm that accounts for regional soft tissue thickness (TBSTT) in dual-energy X-ray absorptiometry (DXA) images and to compare percent changes from baseline and placebo with classical body mass index (BMI)-adjusted TBS (TBSBMI). Methods: Postmenopausal women with lumbar spine or total hip bone mineral density (BMD) T score < - 2.5 and ≥ - 4.0 received placebo or denosumab 60 mg subcutaneously every 6 months. TBSBMI and TBSTT were assessed on lumbar spine DXA scans at baseline and months 1, 12, 24, and 36 in a subset of 279 women (129 placebo, 150 denosumab) who completed the 3-year FREEDOM DXA substudy and rolled over to open-label extension study. Results: Baseline characteristics were similar between groups. TBSTT in the denosumab group showed numerically greater changes from both baseline and placebo than TBSBMI at months 12, 24, and 36. Denosumab led to progressive increases in BMD (1.2, 5.6, 8.1, and 10.5%) and TBSTT (0.4, 2.3, 2.6, and 3.3%) from baseline to months 1, 12, 24, and 36, respectively. Both TBS changes were significant vs baseline and placebo from months 12 to 36 (p < 0.0001). As expected, BMD and TBSTT were poorly correlated both at baseline and for changes during treatment. Conclusion: In postmenopausal women with osteoporosis, denosumab significantly improved bone microstructure assessed by TBSTT over 3 years. TBSTT seemed more responsive to denosumab treatment than TBSBMI and was independent of BMD. |
Keywords | Bone mineral density (BMD); Denosumab; Osteoporosis ; Postmenopausal women; Soft tissue thickness; Trabecular bone score (TBS) |
Year | 01 Jan 2022 |
Journal | Osteoporosis International |
Journal citation | 33 (12), pp. 2517-2525 |
Publisher | Springer UK |
ISSN | 0937-941X |
Digital Object Identifier (DOI) | https://doi.org/10.1007/s00198-022-06549-x |
PubMed ID | 36115888 |
PubMed Central ID | PMC9652244 |
Web address (URL) | https://link.springer.com/article/10.1007/s00198-022-06549-x |
Open access | Published as ‘gold’ (paid) open access |
Research or scholarly | Research |
Page range | 2517-2525 |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 17 Sep 2022 |
Publication process dates | |
Accepted | 01 Sep 2022 |
Deposited | 13 Jan 2023 |
Supplemental file | License File Access Level Open |
Additional information | © The Author(s) 2022. |
Open access funding provided by University of Lausanne This study was funded by Amgen Inc., Thousand Oaks, CA, USA. | |
Place of publication | United Kingdom |
https://acuresearchbank.acu.edu.au/item/8y93v/updated-trabecular-bone-score-accounting-for-the-soft-tissue-thickness-tbstt-demonstrated-significantly-improved-bone-microstructure-with-denosumab-in-the-freedom-tbs-post-hoc-analysis
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Publisher's version
OA_McClung_2022_Updated_trabecular_bone_score_accounting_for.pdf | |
License: CC BY-NC 4.0 | |
File access level: Open |
Supplemental file
OA_McClung_2022_Updated_trabecular_bone_score_SupplementaryMaterial.pdf | |
License: CC BY-NC 4.0 | |
File access level: Open |
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