For flux sake : Isotopic tracer methods of monitoring human carbohydrate metabolism during exercise

Journal article


Gonzalez, Javier T. and King, Andy J.. (2023). For flux sake : Isotopic tracer methods of monitoring human carbohydrate metabolism during exercise. International Journal of Sport Nutrition and Exercise Metabolism. 33(1), pp. 60-70. https://doi.org/10.1123/ijsnem.2022-0170
AuthorsGonzalez, Javier T. and King, Andy J.
Abstract

Isotopic tracers can reveal insights into the temporal nature of metabolism and track the fate of ingested substrates. A common use of tracers is to assess aspects of human carbohydrate metabolism during exercise under various established models. The dilution model is used alongside intravenous infusion of tracers to assess carbohydrate appearance and disappearance rates in the circulation, which can be further delineated into exogenous and endogenous sources. The incorporation model can be used to estimate exogenous carbohydrate oxidation rates. Combining methods can provide insight into key factors regulating health and performance, such as muscle and liver glycogen utilization, and the underlying regulation of blood glucose homeostasis before, during, and after exercise. Obtaining accurate, quantifiable data from tracers, however, requires careful consideration of key methodological principles. These include appropriate standardization of pretrial diet, specific tracer choice, whether a background trial is necessary to correct expired breath CO2 enrichments, and if so, what the appropriate background trial should consist of. Researchers must also consider the intensity and pattern of exercise, and the type, amount, and frequency of feeding (if any). The rationale for these considerations is discussed, along with an experimental design checklist and equation list which aims to assist researchers in performing high-quality research on carbohydrate metabolism during exercise using isotopic tracer methods.

Keywordsstable isotopes; glucose; kinetics; physical activity; nutrition
Year2023
JournalInternational Journal of Sport Nutrition and Exercise Metabolism
Journal citation33 (1), pp. 60-70
PublisherHuman Kinetics, Inc.
ISSN1526-484X
Digital Object Identifier (DOI)https://doi.org/10.1123/ijsnem.2022-0170
Scopus EID2-s2.0-85144598955
Page range60-70
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online29 Nov 2022
Publication process dates
Deposited18 Jan 2023
Permalink -

https://acuresearchbank.acu.edu.au/item/8y9v5/for-flux-sake-isotopic-tracer-methods-of-monitoring-human-carbohydrate-metabolism-during-exercise

Restricted files

Publisher's version

  • 32
    total views
  • 0
    total downloads
  • 2
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Short severe energy restriction with refueling reduces body mass without altering training-associated performance improvement
Burke, Louise M., Whitfield, Jamie, Ross, Megan L., Tee, Nicolin, Sharma, Avish P., King, Andy K., Heikura, Ida A., Morabito, Aimee and McKay, Alannah K. A.. (2023). Short severe energy restriction with refueling reduces body mass without altering training-associated performance improvement. Medicine and Science in Sports and Exercise. 55(8), pp. 1487-1498. https://doi.org/10.1249/MSS.0000000000003169
Eating disorders are associated with increased risk of fall injury and fracture in Swedish men and women
Axelsson, K. F., Woessner, M. N., Litsne, H., Wheeler, M., Flehr, A., King, A. J., Kalén, M., Vandenput, L. and Lorentzon, M.. (2022). Eating disorders are associated with increased risk of fall injury and fracture in Swedish men and women. Osteoporosis International. 33(6), pp. 1347-1355. https://doi.org/10.1007/s00198-022-06312-2
Glucose and fructose hydrogel enhances running performance, exogenous carbohydrate oxidation, and gastrointestinal tolerance
Rowe, Joshua T., King, Roderick F. G. J., King, Andy J., Morrison, Douglas J., Preston, Thomas, Wilson, Oliver J. and O'Hara, John P.. (2022). Glucose and fructose hydrogel enhances running performance, exogenous carbohydrate oxidation, and gastrointestinal tolerance. Medicine and Science in Sports and Exercise. 54(1), pp. 129-140. https://doi.org/10.1249/MSS.0000000000002764
Nutrition and indoor cycling : A cross-sectional analysis of carbohydrate intake for online racing and training
King, Andrew J. and Hall, Rebecca C.. (2022). Nutrition and indoor cycling : A cross-sectional analysis of carbohydrate intake for online racing and training. British Journal of Nutrition. 127(8), pp. 1204-1213. https://doi.org/10.1017/S0007114521001860
Short-term very high carbohydrate diet and gut-training have minor effects on gastrointestinal status and performance in highly trained endurance athletes
King, Andrew J., Etxebarria, Naroa, Ross, Megan L., Garvican-Lewis, Laura, Heikura, Ida A., McKay, Alannah K. A., Tee, Nicolin, Forbes, Sara F., Beard, Nicole A., Saunders, Philo U., Sharma, Avish P., Gaskell, Stephanie K., Costa, Ricardo J. S. and Burke, Louise M.. (2022). Short-term very high carbohydrate diet and gut-training have minor effects on gastrointestinal status and performance in highly trained endurance athletes. Nutrients. 14(9), p. Article 1929. https://doi.org/10.3390/nu14091929
A 150-mile ultra-endurance type 1 diabetes cycling event : Qualitative analysis of knowledge, preparation and management strategies
King, Andrew, Pickering, Katie, Pringle, Andy and Kime, Nicky. (2022). A 150-mile ultra-endurance type 1 diabetes cycling event : Qualitative analysis of knowledge, preparation and management strategies. Practical Diabetes. 39(2), pp. 16-23. https://doi.org/10.1002/pdi.2384
The Challenge of Maintaining Metabolic Health During a Global Pandemic
Andy J. King, Louise M. Burke, Shona L. Halson and John A. Hawley. (2020). The Challenge of Maintaining Metabolic Health During a Global Pandemic. Sports Medicine. 50(7), pp. 1233-1241. https://doi.org/10.1007/s40279-020-01295-8
Carbohydrate hydrogel products do not improve performance or gastrointestinal distress during moderate-intensity endurance exercise
King, Andy J., Rowe, Joshua T. and Burke, Louise M.. (2020). Carbohydrate hydrogel products do not improve performance or gastrointestinal distress during moderate-intensity endurance exercise. International Journal of Sport Nutrition and Exercise Metabolism. 30(5), pp. 305-314. https://doi.org/10.1123/ijsnem.2020-0102
Military combat movements and exercises : Is there a role for adopting sports nutrition carbohydrate recommendations during exercise?
King, A. J., Mellor, A. and O’Hara, J. P.. (2019). Military combat movements and exercises : Is there a role for adopting sports nutrition carbohydrate recommendations during exercise? Royal Naval Medical Service Journal. 105(1), pp. 34-39. https://doi.org/10.1136/jrnms-105-34
The virtual runner learning game
Behringer, Reinhold, King, Roderick, Smith, Abraham, Matu, Jamie, King, Andrew, Taylor, Bengamin and Parivesh, Parichay. (2013). The virtual runner learning game. Interaction Design and Architecture(s) Journal.
Oxygen saturation and outcomes in preterm infants
Stenson, Ben J., Tarnow-Mordi, William, Darlow, Brian A., Simes, John, Juszczak, Edmund, Askie, Lisa, Battin, Malcolm, Bowler, Ursula, Broadbent, Roland, Cairns, Pamela, Davis, Peter, Deshpande, Sanjeev, Donoghoe, Mark, Doyle, Lex, Fleck, Brian W., Ghadge, Alpana, Hague, Wendy, Halliday, Henry L., Hewson, Michael, ... Brocklehurst, Peter. (2013). Oxygen saturation and outcomes in preterm infants. New England Journal of Medicine. 368(22), pp. 2094 - 2104. https://doi.org/10.1056/NEJMoa1302298
Treatment of neonatal sepsis with intravenous immune globulin
Brocklehurst, Peter, Farrell, Barbara, King, Andrew, Juszczak, Edmund, Darlow, Brian A., Haque, Khalid, Salt, Alison, Stenson, Ben J. and Tarnow-Mordi, William. (2012). Treatment of neonatal sepsis with intravenous immune globulin. New England Journal of Medicine. 365(13), pp. 1201 - 1211. https://doi.org/10.1056/NEJMoa1100441