For flux sake : Isotopic tracer methods of monitoring human carbohydrate metabolism during exercise

Journal article


Gonzalez, Javier T. and King, Andy J.. (2023). For flux sake : Isotopic tracer methods of monitoring human carbohydrate metabolism during exercise. International Journal of Sport Nutrition and Exercise Metabolism. 33(1), pp. 60-70. https://doi.org/10.1123/ijsnem.2022-0170
AuthorsGonzalez, Javier T. and King, Andy J.
Abstract

Isotopic tracers can reveal insights into the temporal nature of metabolism and track the fate of ingested substrates. A common use of tracers is to assess aspects of human carbohydrate metabolism during exercise under various established models. The dilution model is used alongside intravenous infusion of tracers to assess carbohydrate appearance and disappearance rates in the circulation, which can be further delineated into exogenous and endogenous sources. The incorporation model can be used to estimate exogenous carbohydrate oxidation rates. Combining methods can provide insight into key factors regulating health and performance, such as muscle and liver glycogen utilization, and the underlying regulation of blood glucose homeostasis before, during, and after exercise. Obtaining accurate, quantifiable data from tracers, however, requires careful consideration of key methodological principles. These include appropriate standardization of pretrial diet, specific tracer choice, whether a background trial is necessary to correct expired breath CO2 enrichments, and if so, what the appropriate background trial should consist of. Researchers must also consider the intensity and pattern of exercise, and the type, amount, and frequency of feeding (if any). The rationale for these considerations is discussed, along with an experimental design checklist and equation list which aims to assist researchers in performing high-quality research on carbohydrate metabolism during exercise using isotopic tracer methods.

Keywordsstable isotopes; glucose; kinetics; physical activity; nutrition
Year2023
JournalInternational Journal of Sport Nutrition and Exercise Metabolism
Journal citation33 (1), pp. 60-70
PublisherHuman Kinetics, Inc.
ISSN1526-484X
Digital Object Identifier (DOI)https://doi.org/10.1123/ijsnem.2022-0170
Scopus EID2-s2.0-85144598955
Page range60-70
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online29 Nov 2022
Publication process dates
Deposited18 Jan 2023
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