Global, regional, and national burden of epilepsy, 1990–2016 : A systematic analysis for the Global Burden of Disease Study 2016

Journal article


Beghi, Ettore, Giussani, Giorgia, Nichols, Emma, Abd-Allah, Foad, Abdela, Jemal, Abdelalim, Ahmed, Abraha, Haftom Niguse, Adib, Mina G., Agrawal, Sutapa, Alahdab, Fares, Awasthi, Ashish, Ayele, Yohanes, Barboza, Miguel A., Belachew, Abate Bekele, Biadgo, Belete, Bijani, Ali, Bitew, Helen, Carvalho, Félix, Chaiah, Yazan, ... Murray, Christopher J. L.. (2019). Global, regional, and national burden of epilepsy, 1990–2016 : A systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology. 18(4), pp. 357-375. https://doi.org/10.1016/S1474-4422(18)30454-X
AuthorsBeghi, Ettore, Giussani, Giorgia, Nichols, Emma, Abd-Allah, Foad, Abdela, Jemal, Abdelalim, Ahmed, Abraha, Haftom Niguse, Adib, Mina G., Agrawal, Sutapa, Alahdab, Fares, Awasthi, Ashish, Ayele, Yohanes, Barboza, Miguel A., Belachew, Abate Bekele, Biadgo, Belete, Bijani, Ali, Bitew, Helen, Carvalho, Félix, Chaiah, Yazan, Daryani, Ahmad, Do, Huyen Phuc, Dubey, Manisha, Endries, Aman Yesuf Yesuf, Eskandarieh, Sharareh, Faro, Andre, Farzadfar, Farshad, Fereshtehnejad, Seyed-Mohammad, Fernandes, Eduarda, Fijabi, Daniel Obadare, Filip, Irina, Fischer, Florian, Gebre, Abadi Kahsu, Tsadik, Afewerki Gebremeskel, Gebremichael, Teklu Gebrehiwo, Gezae, Kebede Embaye, Ghasemi-Kasman, Maryam, Weldegwergs, Kidu Gidey, Degefa, Meaza Girma, Gnedovskaya, Elena V., Hagos, Tekleberhan B., Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hassen, Hamid Yimam, Hay, Simon I., Jakovljevic, Mihajlo, Kasaeian, Amir, Kassa, Tesfaye Dessale, Khader, Yousef Saleh, Khalil, Ibrahim, Khan, Ejaz Ahmad, Khubchandani, Jagdish, Kisa, Adnan, Krohn, Kristopher J., Kulkarni, Chanda, Nirayo, Yirga Legesse, Mackay, Mark T., Majdan, Marek, Majeed, Azeem, Manhertz, Treh, Mehndiratta, Man Mohan, Mekonen, Tesfa, Meles, Hagazi Gebre, Mengistu, Getnet, Mohammed, Shafiu, Naghavi, Mohsen, Mokdad, Ali H., Mustafa, Ghulam, Irvani, Seyed Sina Naghibi, Nguyen, Long Hoang, Nixon, Molly R., Ogbo, Felix Akpojene, Olagunju, Andrew T., Olagunju, Tinuke O., Owolabi, Mayowa Ojo, Phillips, Michael R., Pinilla-Monsalve, Gabriel David, Qorbani, Mostafa, Radfar, Amir, Rafay, Anwar, Rahimi-Movaghar, Vafa, Reinig, Nickolas, Sachdev, Perminder S., Safari, Hosein, Safari, Saeed, Safiri, Saeid, Sahraian, Mohammad Ali, Samy, Abdallah M., Sarvi, Shahabeddin, Sawhney, Monika, Shaikh, Masood A., Sharif, Mehdi, Singh, Gagandeep, Smith, Mari, Szoeke, Cassandra E. I., Tabarés-Seisdedos, Rafael, Temsah, Mohamad-Hani, Temsah, Omar, Tortajada-Girbés, Miguel, Tran, Bach Xuan, Tsegay, Amanuel Amanuel Tesfay, Ullah, Irfan, Venketasubramanian, Narayanaswamy, Westerman, Ronny, Winkler, Andrea Sylvia, Yimer, Ebrahim M., Yonemoto, Naohiro, Feigin, Valery L., Vos, Theo and Murray, Christopher J. L.
Abstract

Background
Seizures and their consequences contribute to the burden of epilepsy because they can cause health loss (premature mortality and residual disability). Data on the burden of epilepsy are needed for health-care planning and resource allocation. The aim of this study was to quantify health loss due to epilepsy by age, sex, year, and location using data from the Global Burden of Diseases, Injuries, and Risk Factors Study.

Methods
We assessed the burden of epilepsy in 195 countries and territories from 1990 to 2016. Burden was measured as deaths, prevalence, and disability-adjusted life-years (DALYs; a summary measure of health loss defined by the sum of years of life lost [YLLs] for premature mortality and years lived with disability), by age, sex, year, location, and Socio-demographic Index (SDI; a compound measure of income per capita, education, and fertility). Vital registrations and verbal autopsies provided information about deaths, and data on the prevalence and severity of epilepsy largely came from population representative surveys. All estimates were calculated with 95% uncertainty intervals (UIs).

Findings
In 2016, there were 45·9 million (95% UI 39·9–54·6) patients with all-active epilepsy (both idiopathic and secondary epilepsy globally; age-standardised prevalence 621·5 per 100 000 population; 540·1–737·0). Of these patients, 24·0 million (20·4–27·7) had active idiopathic epilepsy (prevalence 326·7 per 100 000 population; 278·4–378·1). Prevalence of active epilepsy increased with age, with peaks at 5–9 years (374·8 [280·1–490·0]) and at older than 80 years of age (545·1 [444·2–652·0]). Age-standardised prevalence of active idiopathic epilepsy was 329·3 per 100 000 population (280·3–381·2) in men and 318·9 per 100 000 population (271·1–369·4) in women, and was similar among SDI quintiles. Global age-standardised mortality rates of idiopathic epilepsy were 1·74 per 100 000 population (1·64–1·87; 1·40 per 100 000 population [1·23–1·54] for women and 2·09 per 100 000 population [1·96–2·25] for men). Age-standardised DALYs were 182·6 per 100 000 population (149·0–223·5; 163·6 per 100 000 population [130·6–204·3] for women and 201·2 per 100 000 population [166·9–241·4] for men). The higher DALY rates in men were due to higher YLL rates compared with women. Between 1990 and 2016, there was a non-significant 6·0% (−4·0 to 16·7) change in the age-standardised prevalence of idiopathic epilepsy, but a significant decrease in age-standardised mortality rates (24·5% [10·8 to 31·8]) and age-standardised DALY rates (19·4% [9·0 to 27·6]). A third of the difference in age-standardised DALY rates between low and high SDI quintile countries was due to the greater severity of epilepsy in low-income settings, and two-thirds were due to a higher YLL rate in low SDI countries.

Interpretation
Despite the decrease in the disease burden from 1990 to 2016, epilepsy is still an important cause of disability and mortality. Standardised collection of data on epilepsy in population representative surveys will strengthen the estimates, particularly in countries for which we currently have no or sparse data and if additional data is collected on severity, causes, and treatment. Sizeable gains in reducing the burden of epilepsy might be expected from improved access to existing treatments in low-income countries and from the development of new effective drugs worldwide.

Year2019
JournalThe Lancet Neurology
Journal citation18 (4), pp. 357-375
PublisherElsevier Ltd
ISSN1474-4465
1474-4422
Digital Object Identifier (DOI)https://doi.org/10.1016/S1474-4422(18)30454-X
PubMed ID30773428
Scopus EID2-s2.0-85062711685
PubMed Central IDPMC6416168
Open accessPublished as ‘gold’ (paid) open access
Page range357-375
FunderBill & Melinda Gates Foundation
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online14 Feb 2019
Publication process dates
Deposited21 Mar 2023
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A comparison of Geriatric Depression Scale scores in older Australian and Japanese women
Campbell, Katherine E., Dennerstein, Lorraine, Tacey, Mark, Fujise, Noboru, Ikeda, Manabu and Szoeke, Cassandra. (2017). A comparison of Geriatric Depression Scale scores in older Australian and Japanese women. Epidemiology and Psychiatric Sciences. https://doi.org/10.1017/S2045796015001110
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: A systematic analysis for the Global Burden of Disease Study 2015
Forouzanfar, Mohammad H., Afshin, Ashkan, Alexander, Lily T., Anderson, H. Ross, Bhutta, Zulfiqar A., Biryukov, Stan, Brauer, Michael, Burnett, Richard, Cercy, Kelly, Charlson, Fiona J., Cohen, Aaron J., Dandona, Lalit, Estep, Kara, Ferrari, Alize J., Frostad, Joseph J., Fullman, Nancy, Gething, Peter W., Godwin, William W., Griswold, Max, ... GBD 2015 Risk Factors Collaborators. (2016). Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: A systematic analysis for the Global Burden of Disease Study 2015. The Lancet. 388(10053), pp. 1659 - 1724. https://doi.org/10.1016/S0140-6736(16)31679-8
Measuring the health-related sustainable development goals in 188 countries: A baseline analysis from the Global Burden of Disease Study 2015
Lim, Stephen S., Allen, Kate, Bhutta, Zulfiqar A., Dandona, Lalit, Forouzanfar, Mohammad H., Fullman, Nancy, Gething, Peter W., Goldberg, Ellen M., Hay, Simon I., Holmberg, Mollie, Kinfu, Yohannes, Kutz, Michael J., Larson, Heidi J., Liang, Xiaofeng, Lopez, Alan D., Lozano, Rafael, McNellan, Claire R., Mokdad, Ali H., Mooney, Meghan D., ... GBD 2015 SDG Collaborators. (2016). Measuring the health-related sustainable development goals in 188 countries: A baseline analysis from the Global Burden of Disease Study 2015. The Lancet. 388(10053), pp. 1813 - 1850. https://doi.org/10.1016/S0140-6736(16)31467-2
Patterns of social engagement in the transition to later life
Burn, Katherine F., Dennerstein, Lorraine, Browning, Colette and Szoeke, Cassandra. (2016). Patterns of social engagement in the transition to later life. Maturitas. 88(June), pp. 90 - 95. https://doi.org/10.1016/j.maturitas.2016.03.016
Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: A systematic analysis for the Global Burden of Disease Study 2015
Kassebaum, Nicholas J., Arora, Megha, Barber, Ryan M., Bhutta, Zulfiqar A., Brown, Jonathan, Carter, Austin, Casey, Daniel C., Charlson, Fiona J., Coates, Matthew M., Coggeshall, Megan, Cornaby, Leslie, Dandona, Lalit, Dicker, Daniel J., Erskine, Holly E., Ferrari, Alize J., Fitzmaurice, Christina, Foreman, Kyle, Forouzanfar, Mohammad H., Fullman, Nancy, ... HALE Collaborators. (2016). Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: A systematic analysis for the Global Burden of Disease Study 2015. The Lancet. 388(10053), pp. 1603 - 1658. https://doi.org/10.1016/S0140-6736(16)31460-X
Boomerang families and failure-to-launch: Commentary On adult children living at home
Burn, Katherine F. and Szoeke, Cassandra. (2016). Boomerang families and failure-to-launch: Commentary On adult children living at home. Maturitas. 83, pp. 9 - 12. https://doi.org/10.1016/j.maturitas.2015.09.004
Predictive Factors for Verbal Memory Performance Over Decades of Aging: Data from the Women's Healthy Ageing Project
Szoeke, Cassandra, Lehert, Philippe, Henderson, Victor W., Dennerstein, Lorraine, Desmond, Patricia and Campbell, Stephen. (2016). Predictive Factors for Verbal Memory Performance Over Decades of Aging: Data from the Women's Healthy Ageing Project. American Journal of Geriatric Psychiatry. https://doi.org/10.1016/j.jagp.2016.05.008
High content, multi-parameter analyses in buccal cells to identify Alzheimer's Disease
François, Maxime, Fenech, Michael F., Thomas, Philip, Hor, Maryam, Savage, Greg, Martins, Ralph N., Rainey-Smith, Stephanie R., Masters, Colin L., Ames, David, Rowe, Christopher C., Macaulay, Stuart Lance, Hill, Andrew F., Leifert, Wayne R., Appannah, Arti, Barnes, Margaret, Barnham, K. J., Bedo, Justin, Bellingham, Shayne, Bon, Lynette, ... Szoeke, Cassandra. (2016). High content, multi-parameter analyses in buccal cells to identify Alzheimer's Disease. Current Alzheimer Research. 13(7), pp. 787 - 799.
Global, regional, and national levels of maternal mortality, 1990-2015: A systematic analysis for the Global Burden of Disease Study 2015
Kassebaum, Nicholas J., Barber, Ryan M., Bhutta, Zulfiqar A., Dandona, Lalit, Gething, Peter W., Hay, Simon I., Kinfu, Yohannes, Larson, Heidi J., Liang, Xiaofeng, Lim, Stephen S., Lopez, Alan D., Lozano, Rafael, Mensah, George A., Mokdad, Ali H., Naghavi, Mohsen, Pinho, Christine, Salomon, Joshua A., Steiner, Caitlyn, Vos, Theo, ... GBD 2015 Maternal Mortality Collaborators. (2016). Global, regional, and national levels of maternal mortality, 1990-2015: A systematic analysis for the Global Burden of Disease Study 2015. The Lancet. 388(10053), pp. 1775 - 1812. https://doi.org/10.1016/S0140-6736(16)31470-2
Patterns of social engagement in the transition to later life
Burn, Katherine F., Dennerstein, Lorraine, Browning, Colette and Szoeke, Cassandra. (2016). Patterns of social engagement in the transition to later life. Maturitas. https://doi.org/10.1016/j.maturitas.2016.03.016
Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980-2015: A systematic analysis for the Global Burden of Disease Study 2015
Wang, Haidong, Bhutta, Zulfiqar A., Coates, Matthew M., Coggeshall, Megan, Dandona, Lalit, Diallo, Khassoum, Franca, Elisabeth Barboza, Fraser, Maya, Fullman, Nancy, Gething, Peter W., Hay, Simon I., Kinfu, Yohannes, Kita, Maaya, Kulikoff, Xie Rachel, Larson, Heidi J., Liang, Juan, Lim, Stephen S., Lind, Margaret, Lopez, Alan D., ... GBD 2015 Child Mortality Collaborators. (2016). Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980-2015: A systematic analysis for the Global Burden of Disease Study 2015. The Lancet. 388(10053), pp. 1725 - 1774. https://doi.org/10.1016/S0140-6736(16)31575-6
The impact of red and processed meat consumption on cardiovascular disease risk in women
Bovalino, Stephen, Charleson, Georgia and Szoeke, Cassandra. (2016). The impact of red and processed meat consumption on cardiovascular disease risk in women. Nutrition. 32(3), pp. 349 - 354. https://doi.org/10.1016/j.nut.2015.09.015
Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: A systematic analysis for the Global Burden of Disease Study 2015
Wang, Haidong, Naghavi, Mohsen, Allen, Christine, Barber, Ryan M., Bhutta, Zulfiqar A., Carter, Austin, Casey, Daniel C., Charlson, Fiona J., Chen, Alan Zian, Coates, Matthew M., Coggeshall, Megan, Dandona, Lalit, Dicker, Daniel J., Erskine, Holly E., Ferrari, Alize J., Fitzmaurice, Christina, Foreman, Kyle, Forouzanfar, Mohammad H., Fraser, Maya S., ... GBD 2015 Mortality and Causes of Death Collaborators. (2016). Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: A systematic analysis for the Global Burden of Disease Study 2015. The Lancet. 388(10053), pp. 1459 - 1544. https://doi.org/10.1016/S0140-6736(16)31012-1
Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990--2015: a systematic analysis for the Global Burden of Disease Study 2015
Vos, Theo, Allen, Christine, Arora, Megha, Barber, Ryan M., Bhutta, Zulfiqar A., Brown, Alexandria, Carter, Austin, Casey, Daniel C., Charlson, Fiona J., Chen, Alan Z., Coggeshall, Megan, Cornaby, Leslie, Dandona, Lalit, Dicker, Daniel J., Dilegge, Tina, Erskine, Holly E., Ferrari, Alize J., Fitzmaurice, Christina, Fleming, Tom, ... Murray, Christopher J. L.. (2016). Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990--2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet. 388(10053), pp. 1545 - 1602. https://doi.org/10.1016/S0140-6736(16)31678-6
Phenomenological characterization of memory complaints in preclinical and prodromal Alzheimer's disease
Buckley, Rachel F., Ellis, Kathryn A., Ames, David, Rowe, Christopher C., Lautenschlager, Nicola T., Maruff, Paul Thomas, Villemagne, Victor L., Macaulay, S. Lance, Szoeke, Cassandra, Martins, Ralph N., Masters, Colin L., Savage, Greg, Rainey-Smith, Stephanie R., Rembach, Alan R. and Saling, Michael M.. (2015). Phenomenological characterization of memory complaints in preclinical and prodromal Alzheimer's disease. Neuropsychology. https://doi.org/10.1037/neu0000156
Grandparenting predicts late-life cognition: Results from the Women's Healthy Ageing Project
Burn, Katherine F. and Szoeke, Cassandra. (2015). Grandparenting predicts late-life cognition: Results from the Women's Healthy Ageing Project. Maturitas. https://doi.org/10.1016/j.maturitas.2015.03.013
Longitudinal cognitive decline in the AIBL cohort: The role of APOE E4 status
Albrecht, Matthew A., Szoeke, Cassandra, Maruff, Paul Thomas, Savage, Greg, Lautenschlager, Nicola T., Ellis, Kathryn A., Taddei, Kevin, Martins, Ralph N., Masters, Colin L., Ames, David and Foster, Jonathan K.. (2015). Longitudinal cognitive decline in the AIBL cohort: The role of APOE E4 status. Neuropsychologia. https://doi.org/10.1016/j.jalz.2014.04.303
Evaluating the effects of increasing physical activity to optimize rehabilitation outcomes in hospitalized older adults (MOVE Trial): Study protocol for a randomized controlled trial
Said, Catherine M., Morris, Meg E., McGinley, Jennifer L., Szoeke, Cassandra, Workman, Barbara, Liew, Danny, Hill, Keith David, Woodward, Michael Clifford, Wittwer, Joanne E., Churilov, Leonid, Ventura, Cameron and Bernhardt, Julie. (2015). Evaluating the effects of increasing physical activity to optimize rehabilitation outcomes in hospitalized older adults (MOVE Trial): Study protocol for a randomized controlled trial. Trials. 16(1), pp. 1 - 9. https://doi.org/10.1186/s13063-014-0531-y
Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease
Kerestes, Rebecca, Phal, Pramit M., Steward, Chris, Moffat, Bradford A., Salinas, Simon, Cox, Kay L., Ellis, Kathryn A., Cyarto, Elizabeth V., Ames, David, Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Sharman, Matthew J., Salvado, Oliver, Szoeke, Cassandra, Lai, Michelle, Lautenschlager, Nicola T. and Desmond, Patricia M.. (2015). Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease. BJPsych Open. 1(2), pp. 139 - 148. https://doi.org/10.1192/bjpo.bp.115.001339
Is grandparenting a form of social engagement that benefits cognition in ageing?
Burn, Katherine F. and Szoeke, Cassandra. (2015). Is grandparenting a form of social engagement that benefits cognition in ageing? Maturitas. 80(2), pp. 122 - 125. https://doi.org/10.1016/j.maturitas.2014.10.017
Semi-automated hippocampal segmentation in people with cognitive impairment using an age appropriate template for registration
Merkel, Bernd, Steward, Christopher, Vivash, Lucy, Malpas, Charles B., Phal, Pramit, Moffat, Bradford A., Cox, Kay L., Ellis, Kathryn A., Ames, David J., Cyarto, Elizabeth V., Lai, Michelle M. Y., Sharman, Matthew J., Szoeke, Cassandra, Masters, Colin L., Lautenschlager, Nicola T. and Desmond, Patricia. (2015). Semi-automated hippocampal segmentation in people with cognitive impairment using an age appropriate template for registration. Journal of Magnetic Resonance Imaging. https://doi.org/10.1002/jmri.24966
Dietary patterns and cognitive decline in an Australian study of ageing
Gardener, S. L., Rainey-Smith, Stephanie R., Barnes, Margaret, Sohrabi, H. R., Weinborn, M., Lim, Yen Ying, Harrington, Karra D., Taddei, Kevin, Gu, Yian, Rembach, Alan R., Szoeke, Cassandra, Ellis, Kathryn A., Masters, C. L., Macaulay, Stuart Lance, Rowe, Christopher C., Ames, David, Keogh, Jennifer B., Scarmeas, Nikolaos and Martins, Ralph N.. (2015). Dietary patterns and cognitive decline in an Australian study of ageing. Molecular Psychiatry. https://doi.org/10.1038/mp.2014.79
Prehypertension in midlife is associated with worse cognition a decade later in middle-aged and older women
Chen, Karen, Henderson, Victor, Stolwyk, Rene, Dennerstein, Lorraine and Szoeke, Cassandra. (2015). Prehypertension in midlife is associated with worse cognition a decade later in middle-aged and older women. Age and Ageing. https://doi.org/10.1093/ageing/afv026
Anxiety symptoms, cerebral amyloid burden and memory decline in healthy older adults without dementia: 3-year prospective cohort study
Pietrzak, Robert H., Scott, James, Neumeister, Alexander, Lim, Yen Ying, Ames, David, Ellis, Kathryn A., Harrington, Karra D., Lautenschlager, Nicola T., Szoeke, Cassandra, Martins, Ralph N., Masters, Colin L., Villemagne, Victor L., Rowe, Christopher C. and Maruff, Paul Thomas. (2014). Anxiety symptoms, cerebral amyloid burden and memory decline in healthy older adults without dementia: 3-year prospective cohort study. British Journal of Psychiatry. https://doi.org/10.1192/bjp.bp.113.134239
Rates of diagnostic transition and cognitive change at 18-month follow-up among 1,112 participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL)
Ellis, Kathryn A., Szoeke, Cassandra, Bush, Ashley I., Darby, David, Graham, Petra, Lautenschlager, Nicola T., Macaulay, S Lance, Martins, Ralph N., Maruff, Paul Thomas, Masters, Colin L., McBride, Simon J., Pike, Kerryn E., Rainey-Smith, Stephanie R., Rembach, Alan R., Robertson, Joanne, Rowe, Christopher C., Savage, Greg, Villemagne, Victor L., Woodward, Michael Clifford, ... Ames, David. (2014). Rates of diagnostic transition and cognitive change at 18-month follow-up among 1,112 participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL). International Psychogeriatrics. https://doi.org/10.1017/S1041610213001956
Aß and cognitive change: Examining the preclinical and prodromal stages of Alzheimer's disease
Lim, Yen Ying, Maruff, Paul Thomas, Pietrzak, Robert H., Ellis, Kathryn A., Darby, David, -, David Ames, Harrington, Karra J., Martins, Ralph N., Masters, Colin L., Szoeke, Cassandra, Savage, Greg, Villemagne, Victor L. and Rowe, Christopher C.. (2014). Aß and cognitive change: Examining the preclinical and prodromal stages of Alzheimer's disease. Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2013.11.005
Incidence of cerebral microbleeds in preclinical Alzheimer disease
Yates, Paul A., Desmond, Patricia M., Phal, Pramit M., Steward, Christopher, Szoeke, Cassandra, Salvado, Olivier, Ellis, Kathryn A., Martins, Ralph N., Masters, Colin L., Ames, David, Villemagne, Victor L. and Rowe, Christopher C.. (2014). Incidence of cerebral microbleeds in preclinical Alzheimer disease. Neurology. https://doi.org/10.1212/WNL.0000000000000285
Among vitamin B12 deficient older people, high folate levels are associated with worse cognitive function: Combined data from three cohorts
Moore, Eileen, Ames, David, Mander, Alastair, Carne, Ross, Brodaty, Henry, Woodward, Michael Clifford, Boundy, Karen, Ellis, Kathryn A., Bush, Ashley I., Faux, Noel G., Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Szoeke, Cassandra and Watters, David. (2014). Among vitamin B12 deficient older people, high folate levels are associated with worse cognitive function: Combined data from three cohorts. Journal of Alzheimer's Disease. https://doi.org/10.3233/JAD-131265
Associations between gonadotropins, testosterone and ß amyloid in men at risk of Alzheimer's disease
Verdile, G., Laws, S. M., Henley, D., Ames, David, Bush, A. I., Ellis, Kathryn A., Faux, N. G., Gupta, V. B., Li, Q., Masters, C L., Pike, K E., Rowe, C. C., Szoeke, Cassandra, Taddei, K., Villemagne, V. L. and Martins, R. N.. (2014). Associations between gonadotropins, testosterone and ß amyloid in men at risk of Alzheimer's disease. Molecular Psychiatry. https://doi.org/10.1038/mp.2012.147
Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer's disease
Lim, Yen Ying, Maruff, Paul Thomas, Pietrzak, Robert H., Ames, David, Ellis, Kathryn A., Harrington, Karra J., Lautenschlager, Nicola T., Szoeke, Cassandra, Martins, Ralph N., Masters, Colin L., Villemagne, Victor L. and Rowe, Christopher C.. (2014). Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer's disease. Brain. 137(1), pp. 221 - 231. https://doi.org/10.1093/brain/awt286
Autobiographical narratives relate to Alzheimer's disease biomarkers in older adults
Buckley, Rachel F., Saling, Michael M., Irish, Muireann, Ames, David, Rowe, Christopher C., Villemagne, Victor L., Lautenschlager, Nicola T., Maruff, Paul Thomas, Macaulay, S Lance, Martins, Ralph N., Szoeke, Cassandra, Masters, Colin L., Rainey-Smith, Stephanie R., Rembach, Alan R., Savage, Greg and Ellis, Kathryn A.. (2014). Autobiographical narratives relate to Alzheimer's disease biomarkers in older adults. International Psychogeriatrics. https://doi.org/10.1017/S1041610214001136
Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease
Rembach, Alan R., Gaux, Noel G., Watt, Andrew D., Pertile, Kelly Kathleen, Rumble, Rebecca L., Trounson, Brett O., Fowler, Christopher J., Roberts, Blaine R., Perez, Keyla A., Li, Qiaoxin, Laws, Simon M., Taddei, Kevin, Rainey-Smith, Stephanie R., Robertson, Joanne, Vandijck, Manu LJ, Vanderstichele, Hugo M. J., Barnham, Kevin Jeffrey, Ellis, Kathryn A., Szoeke, Cassandra, ... Masters, Colin L.. (2014). Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease. Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2012.12.006
Genetic algorithm with logistic regression for prediction of progression to Alzheimer's disease
Johnson, Piers, Vandewater, Luke, Wilson, William, Maruff, Paul Thomas, Savage, Greg, Graham, Petra, Macaulay, Lance S., Ellis, Kathryn A., Szoeke, Cassandra, Martins, Ralph N., Rowe, Christopher C., Masters, Colin L., Ames, David and Zhang, Ping. (2014). Genetic algorithm with logistic regression for prediction of progression to Alzheimer's disease. BMC Bioinformatics. 15(S11), pp. 1 - 14. https://doi.org/10.1186/1471-2105-15-S16-S11
Dehydroepiandrosterone sulfate and cognition in midlife, post-menopausal women
Chua, Catherine K.Z., Henderson, Victor W., Dennerstein, Lorraine, Ames, David and Szoeke, Cassandra. (2014). Dehydroepiandrosterone sulfate and cognition in midlife, post-menopausal women. Neurobiology of Aging. 35(7), pp. 1654 - 1655. https://doi.org/10.1016/j.neurobiolaging.2014.01.140
The Women's Healthy Ageing Project: Fertile ground for investigation of healthy participants 'at risk' for dementia
Szoeke, Cassandra, Robertson, Joanne, Rowe, Christopher C., Yates, Paul A., Campbell, Katherine, Masters, C. L., Ames, David, Dennerstein, L. and Desmond, P.. (2013). The Women's Healthy Ageing Project: Fertile ground for investigation of healthy participants 'at risk' for dementia. International Review of Psychiatry. https://doi.org/10.3109/09540261.2013.873394
Lack of reliable evidence for a distinctive e4-related cognitive phenotype that is independent from clinical diagnostic status: Findings from the Australian Imaging, Biomarkers and Lifestyle Study
Foster, Jonathan, Albrecht, Matthew A., Savage, Greg, Lautenschlager, Nicola T., Ellis, Kathryn A., Maruff, Paul Thomas, Szoeke, Cassandra, Taddei, Kevin, Martins, Ralph N., Masters, Colin L. and Ames, David. (2013). Lack of reliable evidence for a distinctive e4-related cognitive phenotype that is independent from clinical diagnostic status: Findings from the Australian Imaging, Biomarkers and Lifestyle Study. Brain. https://doi.org/10.1093/brain/awt127
Aß amyloid, cognition, and APOE genotype in healthy older adults
Lim, Yen Ying, Ellis, Kathryn A., Ames, David, Darby, David, Harrington, Karra J., Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Savage, Greg, Szoeke, Cassandra, Villemagne, Victor L. and Maruff, Paul Thomas. (2013). Aß amyloid, cognition, and APOE genotype in healthy older adults. Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2012.07.004
Physical activity and amyloid-Beta plasma and brain levels: Results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing
Brown, Belinda M., Peiffer, J. J., Taddei, Kevin, Lui, J. K., Laws, Simon M., Gupta, V. B., Taddei, Tania, Ward, Vanessa K., Rodrigues, Mark A., Burnham, Samantha, Rainey-Smith, Stephanie R., Villemagne, Victor L., Bush, Ashley I., Ellis, Kathryn A., Masters, Colin L., Ames, David, Macaulay, S. Lance, Szoeke, Cassandra, Rowe, Christopher C. and Martins, Ralph N.. (2013). Physical activity and amyloid-Beta plasma and brain levels: Results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Molecular Psychiatry. https://doi.org/10.1038/mp.2012.107
Retinal vascular biomarkers for early detection and monitoring of Alzheimer's disease
Frost, Shaun M., Kanagasinam, Yogesan, Sohrabi, Hamid R., Vignarajan, Janardhan, Bourgeat, Pierrick T., Salvado, Oliver, Villemagne, Victor Luis, Rowe, Christopher C., Macaulay, S. Lance, Szoeke, Cassandra, Ellis, Kathryn A., Ames, David, Masters, Colin L., Rainey-Smith, Stephanie R. and Martins, Ralph N.. (2013). Retinal vascular biomarkers for early detection and monitoring of Alzheimer's disease. Translational Psychiatry. https://doi.org/10.1038/tp.2012.150
Normative Data for the Tower Of London Performance in Australian Midlife Women
Lee, Young Eun C., Anderson, Jacqueline F., Dennerstein, Lorraine, Henderson, Victor W. and Szoeke, Cassandra. (2013). Normative Data for the Tower Of London Performance in Australian Midlife Women. Australian Psychologist. https://doi.org/10.1111/ap.12033
Factors affecting subjective memory complaints in the AIBL aging study: Biomarkers, memory, affect, and age
Buckley, Rachel F., Saling, Michael M., Ames, David, Rowe, Christopher C., Lautenschlager, Nicola T., Macaulay, S. Lance, Martins, Ralph N., Masters, Colin L., O'Meara, T., Savage, Greg, Szoeke, Cassandra, Villemagne, Victor L. and Ellis, Kathryn A.. (2013). Factors affecting subjective memory complaints in the AIBL aging study: Biomarkers, memory, affect, and age. International Psychogeriatrics. https://doi.org/10.1017/S1041610213000665
Predicting Alzheimer disease with beta-amyloid imaging: Results from the Australian imaging, biomarkers, and lifestyle study of ageing
Rowe, Christopher C., Bourgeat, Pierrick, Ellis, Kathryn A., Brown, Belinda M., Lim, Yen Ying, Mulligan, Rachel, Jones, Gareth, Maruff, Paul Thomas, Woodward, Michael Clifford, Price, Roger Ian, Robins, Peter, Tochon-Danguy, Henri, O'Keefe, Graeme, Pike, Kerryn E., Yates, Patsy, Szoeke, Cassandra, Salvado, Olivier, Macaulay, S. Lance, O'Meara, Timothy, ... Villemagne, Victor L.. (2013). Predicting Alzheimer disease with beta-amyloid imaging: Results from the Australian imaging, biomarkers, and lifestyle study of ageing. Annals of Neurology. https://doi.org/10.1002/ana.24040
Cognitive consequences of high Aß amyloid in mild cognitive impairment and healthy older adults: Implications for early detection of alzheimer's disease
Lim, Yen Ying, Ellis, Kathryn A., Harrington, Karra J., Kamer, Adrian, Pietrzak, Robert H., Bush, Ashley I., Darby, David G., Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Savage, Greg R., Szoeke, Cassandra, Villemagne, Victor L., Ames, David and Maruff, Paul Thomas. (2013). Cognitive consequences of high Aß amyloid in mild cognitive impairment and healthy older adults: Implications for early detection of alzheimer's disease. Neuropsychology. https://doi.org/10.1037/a0032321
Research and standardization in Alzheimer's trials: Reaching international consensus
Carillo, Maria C., Rowe, Christopher C., Szoeke, Cassandra, Masters, Colin L., Ames, David, O'Meara, Timothy, Macaulay, S Lance, Milner, Andrew, Ellis, Kathryn A., Maruff, Paul Thomas, Rainey-Smith, Stephanie R., Martins, Ralph N., Bain, Lisa J. and Head, Richard. (2013). Research and standardization in Alzheimer's trials: Reaching international consensus. Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2012.10.006
Cognitive decline in adults with amnestic mild cognitive impairment and high amyloid-: Prodromal Alzheimer's disease?
Lim, Yen Ying, Ellis, Kathryn A., Harrington, Karra J., Pietrzak, Robert H., Gale, Joanne, Ames, David, Bush, Ashley I., -, David Darby, Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Savage, Greg, Szoeke, Cassandra, Villemagne, Victor L. and Maruff, Paul Thomas. (2013). Cognitive decline in adults with amnestic mild cognitive impairment and high amyloid-: Prodromal Alzheimer's disease? Journal of Alzheimer's Disease. https://doi.org/10.3233/JAD-121771
Three-month stability of the cogstate brief battery in healthy older adults, mild cognitive impairment, and alzheimer's disease: Results from the Australian imaging, biomarkers, and lifestyle-rate of change substudy (AIBL-ROCS)
Lim, Yen Ying, Jaeger, Judith, Harrington, Karra J., Ashwood, Tim J., Ellis, Kathryn A., Stoffler, Albrecht, Szoeke, Cassandra, -, Rebecca Lachovitzki, Martins, Ralph N., Villemagne, Victor L., Bush, Ashley I., Masters, Colin L., Rowe, Christopher C., Ames, David, Darby, David and Maruff, Paul Thomas. (2013). Three-month stability of the cogstate brief battery in healthy older adults, mild cognitive impairment, and alzheimer's disease: Results from the Australian imaging, biomarkers, and lifestyle-rate of change substudy (AIBL-ROCS). Archives of Clinical Neuropsychology. https://doi.org/10.1093/arclin/act021
Amyloid ß deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: A prospective cohort study
Villemagne, Victor L., Burnham, Samantha, Bourgeat, Pierrick, Brown, Belinda M., Ellis, Kathryn A., Salvado, Olivier, Szoeke, Cassandra, Macaulay, S. Lance, Martins, Ralph N., Maruff, Paul Thomas, Ames, David, Rowe, Christopher C. and Masters, Colin L.. (2013). Amyloid ß deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: A prospective cohort study. The Lancet Neurology. https://doi.org/10.1016/S1474-4422(13)70044-9
The association of ABeta amyloid and composite cognitive measures in healthy older adults and MCI
Harrington, Karra J., Lim, Yen Ying, Ellis, Kathryn A., Copolov, Carly, Darby, D, Weinborn, M., Ames, David, Martins, R. N., Savage, G., Szoeke, Cassandra, Rowe, C. C., Villemagne, V. L., Masters, C. L. and Maruff, Paul Thomas. (2013). The association of ABeta amyloid and composite cognitive measures in healthy older adults and MCI. International Psychogeriatrics. https://doi.org/10.1017/S1041610213001087
Increased risk of cognitive impairment in patients with diabetes is associated with metformin
Moore, Eileen, Mander, Alastair, Ames, David, Kotowicz, Mark A., Carne, Ross, Brodaty, Henry, Woodward, Michael Clifford, Boundy, Karen, Ellis, Kathryn A., Bush, Ashley I., Faux, Noel G., Martins, Ralph N., Szoeke, Cassandra, Rowe, Christopher C. and Watters, David. (2013). Increased risk of cognitive impairment in patients with diabetes is associated with metformin. Diabetes Care. https://doi.org/10.2337/dc13-0229
Decline in cognitive function over 18 months in healthy older adults with high amyloid-beta
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Predictors of rapid cognitive decline in Alzheimer's disease: Results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of ageing
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Hormone levels and cognitive function in postmenopausal midlife women
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Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults
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Use of the CogState Brief Battery in the assessment of Alzheimer's disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study
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Adherence to a Mediterranean diet and Alzheimer's disease risk in an Australian population
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Cognition and beta-amyloid in preclinical Alzheimer's disease: Data from the AIBL study
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Advances in structural and molecular neuroimaging in Alzheimer's disease
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Effects of anticholinergic drugs on cognitive function in older Australians: Results from the AIBL study
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Plasma apolipoprotein E and Alzheimer disease risk: The AIBL study of aging
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Association of plasma Aß peptides with blood pressure in the elderly
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Executive functions in recently postmenopausal women: Absence of strong association with serum gonadal steroids
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Homocysteine, vitamin B12, and folic acid levels in Alzheimer's disease, mild cognitive impairment, and healthy elderly: Baseline characteristics in subjects of the Australian imaging biomarker lifestyle study
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A web-based normative data tool for assessing cognitive performance in healthy older Australians
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Independent contribution of temporal beta-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer's disease
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