Motivational and myopic mechanisms underlying dopamine medication-induced impulsive-compulsive behaviors in Parkinson's disease
Dawson, Andrew, Ortelli, Paola, Carter, Adrian, Ferrazzoli, Davide, Dissanayaka, Nadeeka N., Evans, Andrew, Chye, Yann, Lorenzetti, Valentina, Frazzitta, Giuseppe and Yucel, Murat. (2023). Motivational and myopic mechanisms underlying dopamine medication-induced impulsive-compulsive behaviors in Parkinson's disease. Frontiers in Behavioral Neuroscience. 16, p. Article 949406. https://doi.org/10.3389/fnbeh.2022.949406
|Authors||Dawson, Andrew, Ortelli, Paola, Carter, Adrian, Ferrazzoli, Davide, Dissanayaka, Nadeeka N., Evans, Andrew, Chye, Yann, Lorenzetti, Valentina, Frazzitta, Giuseppe and Yucel, Murat|
Introduction: Dopaminergic medications can trigger impulsive-compulsive behaviors (ICBs) in pre-disposed patients with Parkinson's disease (PD), but what this implies on a neurocognitive level is unclear. Previous findings highlighted potentially exacerbated incentive motivation (willingness to work for rewards) and choice impulsivity (preferring smaller, immediate rewards over larger, delayed rewards) in PD patients with ICBs (PD + ICBs).
Methods: To deeply understand this evidence, we studied 24 PD + ICBs and 28 PD patients without ICBs (PD-ICBs). First of all, patients underwent the assessment of impulsivity traits, mood, anxiety, and addiction condition. We further administered robust objective and subjective measures of specific aspects of motivation. Finally, we explored whether these processes might link to any heightened antisocial behavior (aggression and risky driving) in PD + ICBs.
Results: High levels of positive urgency trait characterized PD + ICBs. They choose to exert more effort for rewards under the conditions of low and medium reward probability and as reward magnitude increases. Findings on choice impulsivity show a great tendency to delay discounting in PD + ICBs, other than a high correlation between delay and probability discounting. In addition, we found what appears to be the first evidence of heightened reactive aggression in PD patients with ICBs. Exacerbated incentive motivation and delay discounting trended toward positively predicting reactive aggression in PD + ICBs.
Discussion: Our promising results suggest that there might be immense value in future large-scale studies adopting a transdiagnostic neurocognitive endophenotype approach to understanding and predicting the addictive and aggressive behaviors that can arise from dopaminergic medication in PD.
|Keywords||Parkinson’s disease; dopamine replacement therapy; addiction; motivation; impulsivity; aggression|
|Journal||Frontiers in Behavioral Neuroscience|
|Journal citation||16, p. Article 949406|
|Publisher||Frontiers Research Foundation|
|Digital Object Identifier (DOI)||https://doi.org/10.3389/fnbeh.2022.949406|
|PubMed Central ID||PMC9889554|
|Open access||Published as ‘gold’ (paid) open access|
|Funder||Research Training Program Scholarship (RTP), Australian Government|
File Access Level
|Online||18 Jan 2023|
|Publication process dates|
|Accepted||27 Dec 2022|
|Deposited||19 Jun 2023|
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