A systematic review of opioid overdose interventions delivered within emergency departments

Journal article


Chen, Yanjin, Wang, Yanbin, Nielsen, Suzanne, Kuhn, Lisa and Lam, Tina. (2020). A systematic review of opioid overdose interventions delivered within emergency departments. Drug and Alcohol Dependence. 213, p. Article 108009. https://doi.org/10.1016/j.drugalcdep.2020.108009
AuthorsChen, Yanjin, Wang, Yanbin, Nielsen, Suzanne, Kuhn, Lisa and Lam, Tina
Abstract

Background
People with opioid use disorders are at higher risk of fatal opioid overdose and attend emergency departments (ED) more frequently compared to the general population. This review aimed to synthesise evidence on the ED-based delivery of opioid overdose prevention interventions.

Methods
Using the PRISMA guidelines, four databases (Medline; Embase; Scopus; PsycINFO) were searched for peer-reviewed articles on ED based interventions to prevent opioid overdose, published January 1998 to October 2018.

Results
The 13 identified studies were grouped into four main intervention types. Seven focused on provision of take-home naloxone (THN) and overdose education. These described the successful delivery of THN by ED staff; in collaboration with community partners; and barriers to delivery. Three studies examined medication safety interventions. These generally delivered positive outcomes on overdose-risk knowledge, but not consistently on behaviour change. One study examined buprenorphine-naloxone treatment initiation within the ED, finding positive outcomes on reported illicit drug use and treatment engagement compared to those randomised to brief intervention and referral, or referral only. Two studies explored psychosocial interventions, including motivational interviewing, which demonstrated lower non-medical prescription opioid use at follow up compared to control.

Conclusions
ED provision of a range of opioid overdose prevention interventions is feasible, acceptable to patients and ED personnel. Interventions require adequate staffing/role responsibility for sustainable implementation. Most evidence was for THN, with an emerging evidence base for other intervention types reducing opioid-overdose risks in ED settings. Further research on implementation and sustainability may assist in translation of effective interventions into the ED setting.

Keywordsopioid overdose; overdose prevention; emergency department; naloxone; emergency department delivered interventions
Year2020
JournalDrug and Alcohol Dependence
Journal citation213, p. Article 108009
PublisherElsevier B.V.
ISSN0376-8716
Digital Object Identifier (DOI)https://doi.org/10.1016/j.drugalcdep.2020.108009
PubMed ID32580113
Scopus EID2-s2.0-85086572896
Page range1-13
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online23 May 2020
Publication process dates
Accepted10 Apr 2020
Deposited04 Jul 2023
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