Upper limb Onabotulinumtoxin A injections in children under 2 years with cerebral palsy : A retrospective chart review
Journal article
Centorame, Danni, Rawicki, Barry, Hennel, Sabine and Hoare, Brian. (2022). Upper limb Onabotulinumtoxin A injections in children under 2 years with cerebral palsy : A retrospective chart review. Journal of Child Neurology. 37(12-14), pp. 949-955. https://doi.org/10.1177/08830738221124365
Authors | Centorame, Danni, Rawicki, Barry, Hennel, Sabine and Hoare, Brian |
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Abstract | Aim: To report on the safety of using Onabotulinumtoxin A (OnaA) in the upper limb(s) of children <2 years of age with cerebral palsy and to describe a proactive clinical model of care in the management of upper limb impairment in children with cerebral palsy. Methods and procedures: Retrospective chart audit of 65 infants aged 13-23 months (mean 18.69) who received upper limb OnaA injections. Administration procedures, trends in muscle selection, and adverse events were examined. Results: Adverse events were reported in 6 (4%) of the 65 children. Across the study period, muscles that control thumb and forearm movements were most commonly injected. The number of OnaA injections to subscapularis and flexor digitorum profundus increased over this period. Conclusions and implications: OnaA is a safe treatment option for the short-term management of focal upper limb muscle overactivity in children under 2 years of age with cerebral palsy. In line with existing evidence, OnaA should always be considered as an adjunct to evidence-based therapy. |
Keywords | Onabotulinumtoxin A; cerebral palsy; spasticity; upper limb; child |
Year | 2022 |
Journal | Journal of Child Neurology |
Journal citation | 37 (12-14), pp. 949-955 |
Publisher | SAGE Publications |
ISSN | 0883-0738 |
Digital Object Identifier (DOI) | https://doi.org/10.1177/08830738221124365 |
PubMed ID | 36113444 |
Scopus EID | 2-s2.0-85138288723 |
Page range | 949-955 |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 15 Sep 2022 |
Publication process dates | |
Accepted | 03 Aug 2022 |
Deposited | 12 Jul 2023 |
https://acuresearchbank.acu.edu.au/item/8z48z/upper-limb-onabotulinumtoxin-a-injections-in-children-under-2-years-with-cerebral-palsy-a-retrospective-chart-review
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