Upper limb Onabotulinumtoxin A injections in children under 2 years with cerebral palsy : A retrospective chart review

Journal article


Centorame, Danni, Rawicki, Barry, Hennel, Sabine and Hoare, Brian. (2022). Upper limb Onabotulinumtoxin A injections in children under 2 years with cerebral palsy : A retrospective chart review. Journal of Child Neurology. 37(12-14), pp. 949-955. https://doi.org/10.1177/08830738221124365
AuthorsCentorame, Danni, Rawicki, Barry, Hennel, Sabine and Hoare, Brian
Abstract

Aim: To report on the safety of using Onabotulinumtoxin A (OnaA) in the upper limb(s) of children <2 years of age with cerebral palsy and to describe a proactive clinical model of care in the management of upper limb impairment in children with cerebral palsy. Methods and procedures: Retrospective chart audit of 65 infants aged 13-23 months (mean 18.69) who received upper limb OnaA injections. Administration procedures, trends in muscle selection, and adverse events were examined. Results: Adverse events were reported in 6 (4%) of the 65 children. Across the study period, muscles that control thumb and forearm movements were most commonly injected. The number of OnaA injections to subscapularis and flexor digitorum profundus increased over this period. Conclusions and implications: OnaA is a safe treatment option for the short-term management of focal upper limb muscle overactivity in children under 2 years of age with cerebral palsy. In line with existing evidence, OnaA should always be considered as an adjunct to evidence-based therapy.

KeywordsOnabotulinumtoxin A; cerebral palsy; spasticity; upper limb; child
Year2022
JournalJournal of Child Neurology
Journal citation37 (12-14), pp. 949-955
PublisherSAGE Publications
ISSN0883-0738
Digital Object Identifier (DOI)https://doi.org/10.1177/08830738221124365
PubMed ID36113444
Scopus EID2-s2.0-85138288723
Page range949-955
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online15 Sep 2022
Publication process dates
Accepted03 Aug 2022
Deposited12 Jul 2023
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