Brain volumes in alcohol use disorder : Do females and males differ? A whole-brain magnetic resonance imaging mega-analysis
Journal article
Maggioni, Eleonora, Rossetti, Maria G., Allen, Nicholas B., Batalla, Albert, Bellani, Marcella, Chye, Yann, Cousijn, Janna, Goudriaan, Anna E., Hester, Robert, Hutchison, Kent, Li, Chiang-Shan R., Martin-Santos, Rocio, Momenan, Reza, Sinha, Rajita, Schmaal, Lianne, Solowij, Nadia, Suo, Chao, van Holst, Ruth J., Veltman, Dick J., ... Lorenzetti, Valentina. (2023). Brain volumes in alcohol use disorder : Do females and males differ? A whole-brain magnetic resonance imaging mega-analysis. Human Brain Mapping. 44, p. 4652–4666. https://doi.org/10.1002/hbm.26404
Authors | Maggioni, Eleonora, Rossetti, Maria G., Allen, Nicholas B., Batalla, Albert, Bellani, Marcella, Chye, Yann, Cousijn, Janna, Goudriaan, Anna E., Hester, Robert, Hutchison, Kent, Li, Chiang-Shan R., Martin-Santos, Rocio, Momenan, Reza, Sinha, Rajita, Schmaal, Lianne, Solowij, Nadia, Suo, Chao, van Holst, Ruth J., Veltman, Dick J., Yücel, Murat, Thompson, Paul M., Conrod, Patricia, Mackey, Scott, Garavan, Hugh, Brambilla, Paolo and Lorenzetti, Valentina |
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Abstract | Emerging evidence suggests distinct neurobiological correlates of alcohol use disorder (AUD) between sexes, which however remain largely unexplored. This work from ENIGMA Addiction Working Group aimed to characterize the sex differences in gray matter (GM) and white matter (WM) correlates of AUD using a whole-brain, voxelbased, multi-tissue mega-analytic approach, thereby extending our recent surfacebased region of interest findings on a nearly matching sample using a complementary methodological approach. T1-weighted magnetic resonance imaging (MRI) data from 653 people with AUD and 326 controls was analyzed using voxel-based morphometry. The effects of group, sex, group-by-sex, and substance use severity in AUD on brain volumes were assessed using General Linear Models. Individuals with AUD relative to controls had lower GM volume in striatal, thalamic, cerebellar, and widespread cortical clusters. Group-by-sex effects were found in cerebellar GM and WM volumes, which were more affected by AUD in females than males. Smaller groupby- sex effects were also found in frontotemporal WM tracts, which were more affected in AUD females, and in temporo-occipital and midcingulate GM volumes, which were more affected in AUD males. AUD females but not males showed a negative association between monthly drinks and precentral GM volume. Our results suggest that AUD is associated with both shared and distinct widespread effects on GM and WM volumes in females and males. This evidence advances our previous region of interest knowledge, supporting the usefulness of adopting an exploratory perspective and the need to include sex as a relevant moderator variable in AUD. |
Keywords | alcohol dependence; alcohol use disorders; MRI; sex; voxel-based morphometry |
Year | 2023 |
Journal | Human Brain Mapping |
Journal citation | 44, p. 4652–4666 |
Publisher | Wiley Periodicals |
ISSN | 1065-9471 |
Digital Object Identifier (DOI) | https://doi.org/10.1002/hbm.26404 |
Web address (URL) | https://onlinelibrary.wiley.com/doi/10.1002/hbm.26404 |
Open access | Published as ‘gold’ (paid) open access |
Research or scholarly | Research |
Page range | 4652–4666 |
Funder | Australian Catholic University (ACU) |
Australian Research Council (ARC) | |
David Winston Turner Endowment Fund | |
Fundação Bial | |
Ministero della Salute | |
National Health and Medical Research Council (NHMRC) | |
National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health | |
National Institute on Drug Abuse (NIDA), National Institutes of Health | |
National Institutes of Health (NIH), United States of America | |
Ramaciotti Foundations | |
ZonMw | |
University of Vermont | |
Italian Ministry of Health | |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 2023 |
Publication process dates | |
Accepted | 09 Jun 2023 |
Deposited | 12 Jul 2023 |
ARC Funded Research | This output has been funded, wholly or partially, under the Australian Research Council Act 2001 |
Grant ID | FT110100752 |
288/2020 | |
GR-2019-12370616 | |
1117188 | |
R01-AA013892 | |
PL30-1DA024859-01 | |
UL1-RR24925-01 | |
459111 | |
31160004 | |
31180002 | |
91676084 | |
NIH/NIDAR01DA047119 | |
RicercaCorrente2023 | |
Additional information | © 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. |
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
https://acuresearchbank.acu.edu.au/item/8z4qx/brain-volumes-in-alcohol-use-disorder-do-females-and-males-differ-a-whole-brain-magnetic-resonance-imaging-mega-analysis
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Publisher's version
OA_Maggioni_2023_Brain_volumes_in_alcohol_use_disorder.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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