Intrauterine exposure to preeclampsia does not impair vascular health in children

Journal article


Varley, Benjamin, Henry, Amanda, Roberts, Lynne, Davis, Gregory, Skilton, Michael, Craig, Maria and Gow, Megan. (2022). Intrauterine exposure to preeclampsia does not impair vascular health in children. Frontiers in Public Health. 10, p. Article 1071304. https://doi.org/10.3389/fpubh.2022.1071304
AuthorsVarley, Benjamin, Henry, Amanda, Roberts, Lynne, Davis, Gregory, Skilton, Michael, Craig, Maria and Gow, Megan
Abstract

Background and objectives: Preeclampsia is a serious multisystem blood pressure disorder during pregnancy that is associated with increased long-term risk of cardiovascular disease to the mother and offspring. We investigated the vascular health of children exposed to intrauterine preeclampsia.

Materials and methods: This was a cross-sectional study of offspring in a prospective cohort of women with complications during pregnancy. Children aged between 2 and 5 years [median age 4.7 (2.8, 5.1) years] exposed to intrauterine preeclampsia (n = 26) or normotensive controls (n = 34), were recruited between July 2020 and April 2021. Vascular health was assessed by measuring aortic intima-media thickness and pulse wave velocity. Univariate generalized linear regression models were used to explore associations between vascular measurements and explanatory variables.

Results: Children exposed to preeclampsia had a lower body mass index at assessment (15.5 vs. 16.2 kg/m2, p = 0.04), birth weight (2.90 vs. 3.34 kg, p = 0.004), gestational age at birth (37.5 vs. 39.4 weeks, p < 0.001) and higher frequency of preterm birth (27% vs. 6%, p = 0.02). There were no differences in vascular health between children exposed to preeclampsia vs. controls (mean aortic intima-media thickness 0.575 mm vs. 0.563 mm, p = 0.51, pulse wave velocity 4.09 vs. 4.18 m/s, p = 0.54) and there were no significant associations in univariate analyses.

Conclusions: There were no major adverse differences in vascular health which contrasts with existing studies. This suggests exposure to intrauterine preeclampsia may result in a less severe cardiovascular phenotype in young children. While reassuring, longitudinal studies are required to determine if and when exposure to intrauterine preeclampsia affects vascular health in children.

Keywordspreeclampsia; aortic intima-media thickness; pulse wave velocity; children; early arterial injury
Year2022
JournalFrontiers in Public Health
Journal citation10, p. Article 1071304
PublisherFrontiers Media S.A.
ISSN2296-2565
Digital Object Identifier (DOI)https://doi.org/10.3389/fpubh.2022.1071304
PubMed ID36620255
Scopus EID2-s2.0-85145694133
PubMed Central IDPMC9814159
Open accessPublished as ‘gold’ (paid) open access
Page range1-10
FunderResearch Training Program Scholarship (RTP), Australian Government
National Health and Medical Research Council (NHMRC)
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online22 Dec 2022
Publication process dates
Accepted05 Dec 2022
Deposited21 Jul 2023
Grant ID1158876
1136735
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