Different frequency of Heschl’s gyrus duplication patterns in neuropsychiatric disorders : An MRI study in bipolar and major depressive disorders
Journal article
Takahashi, Tsutomu, Sasabayashi, Daiki, Yücel, Murat, Whittle, Sarah, Lorenzetti, Valentina, Walterfang, Mark, Suzuki, Michio, Pantelis, Christos, Malhi, Gin S. and Allen, Nicholas B.. (2022). Different frequency of Heschl’s gyrus duplication patterns in neuropsychiatric disorders : An MRI study in bipolar and major depressive disorders. Frontiers in Human Neuroscience. 16, p. Article 917270. https://doi.org/10.3389/fnhum.2022.917270
Authors | Takahashi, Tsutomu, Sasabayashi, Daiki, Yücel, Murat, Whittle, Sarah, Lorenzetti, Valentina, Walterfang, Mark, Suzuki, Michio, Pantelis, Christos, Malhi, Gin S. and Allen, Nicholas B. |
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Abstract | An increased prevalence of duplicated Heschl’s gyrus (HG) has been repeatedly demonstrated in various stages of schizophrenia as a potential neurodevelopmental marker, but it remains unknown whether other neuropsychiatric disorders also exhibit this macroscopic brain feature. The present magnetic resonance imaging study aimed to examine the disease specificity of the established finding of altered HG patterns in schizophrenia by examining independent cohorts of bipolar disorder (BD) and major depressive disorder (MDD). Twenty-six BD patients had a significantly higher prevalence of HG duplication bilaterally compared to 24 age- and sex-matched controls, while their clinical characteristics (e.g., onset age, number of episodes, and medication) did not relate to HG patterns. No significant difference was found for the HG patterns between 56 MDD patients and 33 age- and sex-matched controls, but the patients with a single HG were characterized by more severe depressive/anxiety symptoms compared to those with a duplicated HG. Thus, in keeping with previous findings, the present study suggests that neurodevelopmental pathology associated with gyral formation of the HG during the late gestation period partly overlaps between schizophrenia and BD, but that HG patterns may make a somewhat distinct contribution to the phenomenology of MDD. |
Keywords | superior temporal gyrus; Heschl’s gyrus; gyrification; major depressive disorder; bipolar disorder |
Year | 2022 |
Journal | Frontiers in Human Neuroscience |
Journal citation | 16, p. Article 917270 |
Publisher | Frontiers Media S.A. |
ISSN | 1662-5161 |
Digital Object Identifier (DOI) | https://doi.org/10.3389/fnhum.2022.917270 |
PubMed ID | 35769254 |
Scopus EID | 2-s2.0-85133546103 |
PubMed Central ID | PMC9234751 |
Open access | Published as ‘gold’ (paid) open access |
Page range | 1-10 |
Funder | Japan Society for the Promotion of Science (JSPS) |
Japan Agency for Medical Research and Development (AMED) | |
National Health and Medical Research Council (NHMRC) | |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 13 Jun 2022 |
Publication process dates | |
Accepted | 26 May 2022 |
Deposited | 15 Aug 2023 |
Grant ID | JP18K07550 |
JP18K15509 | |
JP20H03598 | |
JP19DK0307029 | |
1196508 | |
1150083 |
https://acuresearchbank.acu.edu.au/item/8z86x/different-frequency-of-heschl-s-gyrus-duplication-patterns-in-neuropsychiatric-disorders-an-mri-study-in-bipolar-and-major-depressive-disorders
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Publisher's version
OA_Takahashi_2022_Different_frequency_of_Heschls_gyrus_duplication.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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