Regulation of pancreatic β-cell function by the NPY system
Journal article
Yang, Chieh-Hsin, Onda, Danise-Ann, Oakhill, Jonathan S., Scott, John W., Galic, Sandra and Loh, Kim. (2021). Regulation of pancreatic β-cell function by the NPY system. Endocrinology. 162(8), pp. 1-8. https://doi.org/10.1210/endocr/bqab070
Authors | Yang, Chieh-Hsin, Onda, Danise-Ann, Oakhill, Jonathan S., Scott, John W., Galic, Sandra and Loh, Kim |
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Abstract | The neuropeptide Y (NPY) system has been recognized as one of the most critical molecules in the regulation of energy homeostasis and glucose metabolism. Abnormal levels of NPY have been shown to contribute to the development of metabolic disorders including obesity, cardiovascular diseases, and diabetes. NPY centrally promotes feeding and reduces energy expenditure, while the other family members, peptide YY (PYY) and pancreatic polypeptide (PP), mediate satiety. New evidence has uncovered additional functions for these peptides that go beyond energy expenditure and appetite regulation, indicating a more extensive function in controlling other physiological functions. In this review, we will discuss the role of the NPY system in the regulation of pancreatic β-cell function and its therapeutic implications for diabetes. |
Keywords | neuropeptide Y; peptide YY; pancreatic polypeptide; pancreatic β-cell; insulin secretion; type 2 diabetes |
Year | 2021 |
Journal | Endocrinology |
Journal citation | 162 (8), pp. 1-8 |
Publisher | Oxford University Press |
ISSN | 0013-7227 |
Digital Object Identifier (DOI) | https://doi.org/10.1210/endocr/bqab070 |
PubMed ID | 33824978 |
Scopus EID | 2-s2.0-85108397896 |
Page range | 1-8 |
Funder | National Health and Medical Research Council (NHMRC) |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 26 Jun 2021 |
Publication process dates | |
Accepted | 30 Mar 2021 |
Deposited | 05 Sep 2023 |
Grant ID | 1156634 |
1158242 |
https://acuresearchbank.acu.edu.au/item/8z961/regulation-of-pancreatic-cell-function-by-the-npy-system
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