How prospective trial registration can prevent selective outcome reporting and salami slicing?

Journal article


Gray, Richard, Waters, Amanda and Mackay, Bridgina. (2022). How prospective trial registration can prevent selective outcome reporting and salami slicing? Women and Birth. 35(2), pp. 105-107. https://doi.org/10.1016/j.wombi.2021.07.007
AuthorsGray, Richard, Waters, Amanda and Mackay, Bridgina
Abstract

Background: Pre-registration of a clinical trial before the first participant is recruited can help to prevent selective outcome reporting and salami-slicing that can distort the evidence base for an intervention and result in people being offered care or treatment that is not effective. Rates of clinical trial registration in nursing and midwifery are low.

Aim: To use a hypothetical example from midwifery practice to illustrate how selective outcome reporting and salami-slicing can distort the evidence base.

Findings: A trial of immersion in water during labour and birth is used to consider issues in outcome selection and how researchers may be drawn to switch primary outcomes or report different outcomes across multiple papers.

Discussion: In nursing and midwifery science, selective outcome and salami reporting are seemingly common. Prospective trial registration is intended to prevent these practices, enhancing the quality and integrity of the work.

Conclusion: Clinical trials are a robust form of primary research evidence and directly impact clinical practice. Researchers must ensure their trials are correctly registered and editors need to reconcile submitted papers and registration entries as part of the review process.

Keywordsselective outcome reporting; salami slicing; trial registration; midwifery
Year2022
JournalWomen and Birth
Journal citation35 (2), pp. 105-107
PublisherElsevier Ltd
ISSN1871-5192
Digital Object Identifier (DOI)https://doi.org/10.1016/j.wombi.2021.07.007
PubMed ID34344635
Scopus EID2-s2.0-85111557985
Page range105-107
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online14 Mar 2022
Publication process dates
Accepted25 Jul 2021
Deposited07 Sep 2023
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https://acuresearchbank.acu.edu.au/item/8z988/how-prospective-trial-registration-can-prevent-selective-outcome-reporting-and-salami-slicing

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