Role of vitamin D supplementation in the management of musculoskeletal diseases : update from an European Society of Clinical and Economical Aspects of Osteoporosis, Osteoarhtitis and Musculoskeletal Diseases (ESCEO) working group
Journal article
Chevalley, Thierry, Brandi, Maria, Cashman, Kevin, Cavalier, Etienne, Harvey, Nicholas, Maggi, Stefania, Cooper, Cyrus, Al-Daghri, Nasser, Bock, Oliver, Bruyère, Olivier, Rosa, Mario, Cortet, Bernard, Cruz-Jentoft, Alfonso, Cherubini, Antonio, Dawson-Hughes, Bess, Fielding, Roger, Fuggle, Nicholas, Halbout, Philippe, Kanis, John Anthony, ... Rizzoli, Rene. (2022). Role of vitamin D supplementation in the management of musculoskeletal diseases : update from an European Society of Clinical and Economical Aspects of Osteoporosis, Osteoarhtitis and Musculoskeletal Diseases (ESCEO) working group. Aging Clinical and Experimental Research. 34(11), pp. 2603-2623. https://doi.org/10.1007/s40520-022-02279-6
Authors | Chevalley, Thierry, Brandi, Maria, Cashman, Kevin, Cavalier, Etienne, Harvey, Nicholas, Maggi, Stefania, Cooper, Cyrus, Al-Daghri, Nasser, Bock, Oliver, Bruyère, Olivier, Rosa, Mario, Cortet, Bernard, Cruz-Jentoft, Alfonso, Cherubini, Antonio, Dawson-Hughes, Bess, Fielding, Roger, Fuggle, Nicholas, Halbout, Philippe, Kanis, John Anthony, Kaufman, Jean-Marc, Lamy, Olivier, Laslop, Andrea, Yerro, Maria, Radermecker, Regis, Thiyagarajan, Jotheeswaran, Thomas, Thierry, Veronese, Nicola, de Wit, Marten, Reginster, Jean-Yves and Rizzoli, Rene |
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Abstract | Vitamin D is a key component for optimal growth and for calcium–phosphate homeostasis. Skin photosynthesis is the main source of vitamin D. Limited sun exposure and insufficient dietary vitamin D supply justify vitamin D supplementation in certain age groups. In older adults, recommended doses for vitamin D supplementation vary between 200 and 2000 IU/day, to achieve a goal of circulating 25-hydroxyvitamin D (calcifediol) of at least 50 nmol/L. The target level depends on the population being supplemented, the assessed system, and the outcome. Several recent large randomized trials with oral vitamin D regimens varying between 2000 and 100,000 IU/month and mostly conducted in vitamin D-replete and healthy individuals have failed to detect any efficacy of these approaches for the prevention of fracture and falls. Considering the well-recognized major musculoskeletal disorders associated with severe vitamin D deficiency and taking into account a possible biphasic effects of vitamin D on fracture and fall risks, an European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group convened, carefully reviewed, and analyzed the meta-analyses of randomized controlled trials on the effects of vitamin D on fracture risk, falls or osteoarthritis, and came to the conclusion that 1000 IU daily should be recommended in patients at increased risk of vitamin D deficiency. The group also addressed the identification of patients possibly benefitting from a vitamin D loading dose to achieve early 25-hydroxyvitamin D therapeutic level or from calcifediol administration. |
Keywords | Vitamin D; Fragility fracture; Falls; Osteoarthritis |
Year | 01 Jan 2022 |
Journal | Aging Clinical and Experimental Research |
Journal citation | 34 (11), pp. 2603-2623 |
Publisher | Springer Nature Switzerland AG |
ISSN | 1594-0667 |
Digital Object Identifier (DOI) | https://doi.org/10.1007/s40520-022-02279-6 |
Web address (URL) | https://link.springer.com/article/10.1007/s40520-022-02279-6 |
Open access | Open access |
Research or scholarly | Research |
Page range | 2603-2623 |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 26 Oct 2022 |
Publication process dates | |
Accepted | 10 Oct 2022 |
Deposited | 07 Sep 2023 |
Additional information | © The Author(s) 2022. |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ | |
Place of publication | Switzerland |
https://acuresearchbank.acu.edu.au/item/8z9q7/role-of-vitamin-d-supplementation-in-the-management-of-musculoskeletal-diseases-update-from-an-european-society-of-clinical-and-economical-aspects-of-osteoporosis-osteoarhtitis-and-musculoskeletal
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Kanis_2022_Role_of_vitamin_D_supplementation_in.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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