Scaffolds for dermal tissue engineering

Book chapter


Debels, Heidi and Morrison, Wayne. (2019). Scaffolds for dermal tissue engineering. In Handbook of tissue engineering scaffolds : Volume two pp. 147-172 Elsevier Ltd. https://doi.org/10.1016/B978-0-08-102561-1.00006-3
AuthorsDebels, Heidi and Morrison, Wayne
Abstract

Skin grafts are often used to restore skin defects after trauma and cancer. Scarcity of skin and donor site morbidity have led to the development of various bioengineered and synthetic alternatives to promote healing in superficial and deep skin wounds. This chapter gives an updated overview of the different bioengineered and synthetic products that are currently available for treatment of dermal skin defects. An overview is given of scaffolds that substitute the dermal layer or both the epidermal and dermal layer. Results of relevant clinical studies using these products are given. A variety of skin substitutes are on the market today. Some show to be excellent alternatives for autologous skin grafts. Despite this, current challenges still to be addressed are the high cost, the variable graft take in the wound, the altering pigmentation of the newly formed skin, and the often reduced skin mobility and elasticity in the treated area. Using skin scaffolds shows promising clinical results. Future developments in this field are, however, necessary to overcome current disadvantages such as high cost, variable take, uneven pigmentation, or reduced skin mobility and elasticity.

Keywordsdermal matrices; dermal scaffolds; scaffolds; skin substitutes; tissue engineering
Page range147-172
Year2019
Book titleHandbook of tissue engineering scaffolds : Volume two
PublisherElsevier Ltd
Place of publicationCambridge, United Kingdom
Cambridge, Massachusetts
Oxford, United Kingdom
ISBN9780081025628
9780081025611
Digital Object Identifier (DOI)https://doi.org/10.1016/B978-0-08-102561-1.00006-3
Scopus EID2-s2.0-85080813227
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All rights reserved
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Controlled
Output statusPublished
Publication dates
Online21 Jun 2019
Print2019
Publication process dates
Deposited22 Sep 2023
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