Eight-hour time-restricted eating does not lower daily myofibrillar protein synthesis rates : A randomized control trial

Journal article

Parr, Evelyn B., Kouw, Imre W. K., Wheeler, Michael J., Radford, Bridget E., Hall, Rebecca C., Senden, Joan M., Goessens, Joy P. B., Van Loon, Luc J. C. and Hawley, John A.. (2023). Eight-hour time-restricted eating does not lower daily myofibrillar protein synthesis rates : A randomized control trial. Obesity. 31(S1), pp. 116-126. https://doi.org/10.1002/oby.23637
AuthorsParr, Evelyn B., Kouw, Imre W. K., Wheeler, Michael J., Radford, Bridget E., Hall, Rebecca C., Senden, Joan M., Goessens, Joy P. B., Van Loon, Luc J. C. and Hawley, John A.
Abstract

Objective
This study aimed to assess the impact of time-restricted eating (TRE) on integrated skeletal muscle myofibrillar protein synthesis (MyoPS) rates in males with overweight/obesity.

Methods
A total of 18 healthy males (age 46 ±  5 years; BMI: 30 ± 2 kg/m2) completed this exploratory, parallel, randomized dietary intervention after a 3-day lead-in diet. Participants then consumed an isoenergetic diet (protein: ~1.0 g/kg body mass per day) following either TRE (10:00 a.m. to 6:00 p.m.) or an extended eating control (CON; 8:00 a.m. to 8:00 p.m.) protocol for 10 days. Integrated MyoPS rates were measured using deuterated water administration with repeated saliva, blood, and muscle sampling. Secondary measures included continuous glucose monitoring and body composition (dual-energy x-ray absorptiometry).

Results
There were no differences in daily integrated MyoPS rates (TRE: 1.28% ± 0.18% per day, CON: 1.26% ± 0.22% per day; p = 0.82) between groups. From continuous glucose monitoring, 24-hour total area under the curve was reduced following TRE (−578 ± 271 vs. CON: 12 ± 272 mmol/L × 24 hours; p = 0.001). Total body mass declined (TRE: −1.6 ± 0.9 and CON: −1.1 ± 0.7 kg; p < 0.001) with no differences between groups (p = 0.22). Lean mass loss was greater following TRE compared with CON (−1.0 ± 0.7 vs. −0.2 ± 0.5 kg, respectively; p = 0.01).

Conclusion
Consuming food within an 8-hour time-restricted period does not lower daily MyoPS rates when compared with an isoenergetic diet consumed over 12 hours. Future research should investigate whether these results translate to free-living TRE.

Year2023
JournalObesity
Journal citation31 (S1), pp. 116-126
PublisherWiley Periodicals LLC
ISSN1930-7381
Digital Object Identifier (DOI)https://doi.org/10.1002/oby.23637
PubMed ID36546330
Scopus EID2-s2.0-85144856560
PubMed Central IDPMC10107304
Open accessPublished as ‘gold’ (paid) open access
Page range116-126
FunderEuropean Society for Clinical Nutrition and Metabolism (ESPEN)
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online22 Dec 2022
Publication process dates
Accepted22 Oct 2022
Deposited15 Oct 2023
Permalink -

https://acuresearchbank.acu.edu.au/item/8zvxx/eight-hour-time-restricted-eating-does-not-lower-daily-myofibrillar-protein-synthesis-rates-a-randomized-control-trial

Log in to edit

Download files

Publisher's version
OA_Parr_2023_Eight_hour_time_restricted_eating_does.pdf
License: CC BY-NC-ND 4.0
File access level: Open

  • 108
    total views
  • 29
    total downloads
  • 5
    views this month
  • 2
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Exercise-regulated mitochondrial and nuclear signalling networks in skeletal muscle
Reisman, Elizabeth G., Hawley, John A. and Hoffman, Nolan J.. (2024). Exercise-regulated mitochondrial and nuclear signalling networks in skeletal muscle. Sports Medicine. 54, pp. 1097-1119. https://doi.org/10.1007/s40279-024-02007-2
Exploring Australian Dietitians' knowledge, experience and perspectives of time-restricted eating in private practice : A qualitative study
Pye, Caitlin, Parr, Evelyn Bridget, Flint, Steve and Devlin, Brooke Lea. (2024). Exploring Australian Dietitians' knowledge, experience and perspectives of time-restricted eating in private practice : A qualitative study. Clinical Obesity. pp. 1-11. https://doi.org/10.1111/cob.12671
Carbohydrate Ingestion before Exercise for Individuals with McArdle Disease : Survey Evidence of Implementation and Perception in Real-World Settings
Torrens, Sam L., Parr, Evelyn Bridget, McNulty, Craig, Ross, Lynda, MacLaughlin, Helen and Robergs, Robert A.. (2024). Carbohydrate Ingestion before Exercise for Individuals with McArdle Disease : Survey Evidence of Implementation and Perception in Real-World Settings. Nutrients. 16(10), pp. 1-12. https://doi.org/10.3390/nu16101423
“It gave me a sense of achievement and a sense of purpose” - a qualitative study of patient experiences of a virtually supervised exercise program for adults with advanced cancer and cachexia
Bland, K., France-Ratcliffe, Madeleine, Krishnasamy, Meinir, Nandi, Amruta, Parr, E., Martin, Peter, Cormie, P., Van Loon, Luc J. C. and Zopf, E.. (2024). “It gave me a sense of achievement and a sense of purpose” - a qualitative study of patient experiences of a virtually supervised exercise program for adults with advanced cancer and cachexia. Supportive Care in Cancer. 32(5), pp. 1-11. https://doi.org/10.1007/s00520-024-08526-y
Type 2 Diabetes Mellitus and Sarcopenia as Comorbid Chronic Diseases in Older Adults : Established and Emerging Treatments and Therapies
Mesinovic, Jakub, Fyfe, Jackson, Talevski, Jason, Wheeler, Michael, Leung, Gloria K W, George, Elena S., Hunegnaw, Melkamu T., Glavas, Costas, Jansons, Paul, Daly, Rob and Scott, David. (2023). Type 2 Diabetes Mellitus and Sarcopenia as Comorbid Chronic Diseases in Older Adults : Established and Emerging Treatments and Therapies. Diabetes and Metabolism Journal. 47(6), pp. 719-742. https://doi.org/10.4093/dmj.2023.0112
Discordant skeletal muscle gene and protein responses to exercise
Bishop, David J., Hoffman, Nolan J., Taylor, Dale F., Saner, Nicholas J., Lee, Matthew J.-C. and Hawley, John A.. (2023). Discordant skeletal muscle gene and protein responses to exercise. Trends in Biochemical Sciences. 48(11), pp. 927-936. https://doi.org/10.1016/j.tibs.2023.08.005
Approaches to addressing the rise in obesity levels
Apovian, Caroline M., Guo, Xi-Rong, Hawley, John A., Karmali, Shahzeer, Loos, Ruth J. F. and Waterlander, Wilma E.. (2023). Approaches to addressing the rise in obesity levels. Nature Reviews Endocrinology. 19, pp. 76-81. https://doi.org/10.1038/s41574-022-00777-1
Interrelated but not time-aligned response in myogenic regulatory factors demethylation and mRNA expression after divergent exercise bouts
Telles, Guilherme Defante, Libardi, Cleiton Augusto, Conceição, Miguel Soares, Vechin, Felipe Cassaro, Lixandrão, Manoel Emílio, Mangone, Flavia Regina Rotea, Pavanelli, Ana Carolina, Nagai, Maria Aparecida, Camera, Donny Michael, Hawley, John A. and Ugrinowitsch, Carlos. (2023). Interrelated but not time-aligned response in myogenic regulatory factors demethylation and mRNA expression after divergent exercise bouts. Medicine and Science in Sports and Exercise. 55(2), pp. 199-208. https://doi.org/10.1249/MSS.0000000000003049
Intradialytic protein ingestion and exercise do not compromise uremic toxin removal throughout hemodialysis
Hendriks, Floris K., Kuijpers, Jeffrey H. W., van Kranenburg, Janneau M. X., Senden, Joan M. G., van der Sande, Frank M., Kooman, Jeroen P., Meex, Steven J. R. and van Loon, Luc J. C.. (2023). Intradialytic protein ingestion and exercise do not compromise uremic toxin removal throughout hemodialysis. Journal of Renal Nutrition. 33(2), pp. 376-385. https://doi.org/10.1053/j.jrn.2022.07.006
Restricting sugar or carbohydrate intake does not impact physical activity level or energy intake over 24 h despite changes in substrate use : A randomised crossover study in healthy men and women
Hengist, Aaron, Davies, Russell G., Rogers, Peter J., Brunstrom, Jeff M., van Loon, Luc J. C., Walhin, Jean-Philippe, Thompson, Dylan, Koumanov, Françoise, Betts, James A. and Gonzales, Javier T.. (2023). Restricting sugar or carbohydrate intake does not impact physical activity level or energy intake over 24 h despite changes in substrate use : A randomised crossover study in healthy men and women. European Journal of Nutrition. 62(2), pp. 921-940. https://doi.org/10.1007/s00394-022-03048-x
Perspective : Vegan Diets for Older Adults? A Perspective On the Potential Impact On Muscle Mass and Strength
Domic, Jacinta, Grootswagers, Pol, Van Loon, Lucas and de Groot, Lisette. (2022). Perspective : Vegan Diets for Older Adults? A Perspective On the Potential Impact On Muscle Mass and Strength. Advances in Nutrition. 13(3), pp. 712-725. https://doi.org/10.1093/advances/nmac009
Eating disorders are associated with increased risk of fall injury and fracture in Swedish men and women
Axelsson, K. F., Woessner, M. N., Litsne, H., Wheeler, M., Flehr, A., King, A. J., Kalén, M., Vandenput, L. and Lorentzon, M.. (2022). Eating disorders are associated with increased risk of fall injury and fracture in Swedish men and women. Osteoporosis International. 33(6), pp. 1347-1355. https://doi.org/10.1007/s00198-022-06312-2
Cheese ingestion increases muscle protein synthesis rates both at rest and during recovery from exercise in healthy, young males : A randomized parallel-group trial
Hermans, Wesley J. H., Fuchs, Cas J., Hendriks, Floris K., Houben, Lisanne H. P., Senden, Joan M., Verdijk, Lex B. and Van Loon, Luc. (2022). Cheese ingestion increases muscle protein synthesis rates both at rest and during recovery from exercise in healthy, young males : A randomized parallel-group trial. The Journal of Nutrition. 152(4), pp. 1022-1030. https://doi.org/10.1093/jn/nxac007
High-intensity interval training in polycystic ovary syndrome : A two-center, three-armed randomized
Kiel, Ida A., Lionett, Sofie, Parr, Evelyn B., Jones, Helen, Røset, Maria A. H., Salvesen, Øyvind, Hawley, John A., Vanky, Eszter and Moholdt, Trine. (2022). High-intensity interval training in polycystic ovary syndrome : A two-center, three-armed randomized. Medicine and Science in Sports and Exercise. 54(5), pp. 717-727. https://doi.org/10.1249/MSS.0000000000002849
Perspective : Time-restricted eating—integrating the what with the when
Parr, Evelyn B., Devlin, Brooke L. and Hawley, John A.. (2022). Perspective : Time-restricted eating—integrating the what with the when. Advances in Nutrition. 13(3), pp. 699-711. https://doi.org/10.1093/advances/nmac015
Reassessing the relationship between mRNA levels and protein abundance in exercised skeletal muscles
Bishop, David J. and Hawley, John A.. (2022). Reassessing the relationship between mRNA levels and protein abundance in exercised skeletal muscles. Nature Reviews Molecular Cell Biology. 23(12), pp. 773-774. https://doi.org/10.1038/s41580-022-00541-3
Muscle protein synthesis after protein administration in critical illness
Chapple, Lee-anne S., Kouw, Imre W. K., Summers, Matthew J., Weinel, Luke M., Gluck, Samuel, Raith, Eamon, Slobodian, Peter, Soenen, Stijn, Deane, Adam M., Van Loon, Luc J. C. and Chapman, Marianne J.. (2022). Muscle protein synthesis after protein administration in critical illness. American Journal of Respiratory and Critical Care Medicine. 206(6), pp. 740-749. https://doi.org/10.1164/rccm.202112-2780OC
Methodological considerations for investigating iron status and regulation in exercise and sport science studies
McKay, Alannah K. A., Sim, Marc, Moretti, Diego, Hall, Rebecca, Stellingwerff, Trent, Burden, Richard J. and Peeling, Peter. (2022). Methodological considerations for investigating iron status and regulation in exercise and sport science studies. International Journal of Sport Nutrition and Exercise Metabolism. 32(8), pp. 359-370. https://doi.org/10.1123/ijsnem.2021-0343
Resistance exercise training increases muscle mass and strength in prostate cancer patients on androgen deprivation therapy
Houben, Lisanne H. P., Overkamp, Maarten, van Kraaij, Puck, Trommelen, Jorn, van Roermund, Joep G. H., de Vries, Peter, de Laet, Kevin, van der Meer, Saskia, Mikkelsen, Ulla R., Verdijk, Lex B., van Loon, Luc J. C., Beijer, Sandra and Beelen, Milou. (2022). Resistance exercise training increases muscle mass and strength in prostate cancer patients on androgen deprivation therapy. Medicine and Science in Sports and Exercise. 55(4), pp. 614-624. https://doi.org/10.1249/MSS.0000000000003095
"I want to get myself as fit as I can and not die just yet" - Perceptions of exercise in people with advanced cancer and cachexia : A qualitative study
Bland, Kelcey A., Krishnasamy, Meinir, Parr, Evelyn B., Mulder, Stella, Martin, Peter, van Loon, Luc, Cormie, Prue, Michael, Natasha and Zopf, Eva M.. (2022). "I want to get myself as fit as I can and not die just yet" - Perceptions of exercise in people with advanced cancer and cachexia : A qualitative study. BMC Palliative Care. 21(1), p. Article 75. https://doi.org/10.1186/s12904-022-00948-x
Myofibrillar protein synthesis rate are increased in chronically exercised skeletal muscle despite decreased anabolic signaling
Langer, Henning T., West, Daniel, Senden, Joan, Spuler, Simone, van Loon, Luc J. C. and Baar, Keith. (2022). Myofibrillar protein synthesis rate are increased in chronically exercised skeletal muscle despite decreased anabolic signaling. Scientific Reports. 12(1), p. Article 7553. https://doi.org/10.1038/s41598-022-11621-x
The muscle protein synthetic response to the ingestion of a plant-derived protein blend does not differ from an equivalent amount of milk protein in healthy, young males
Pinckaers, Philippe J. M., Kouw, Imre W. K., Gorissen, Stefan H. M., Houben, Lisanne H. P., Senden, Joan M., Wodzig, Will K. H. W., de Groot, Lisette C. P. G. M., Verdijk, Lex B., Snijders, Tim and van Loon, Luc J. C.. (2022). The muscle protein synthetic response to the ingestion of a plant-derived protein blend does not differ from an equivalent amount of milk protein in healthy, young males. The Journal of Nutrition. 152(12), pp. 2734-2743. https://doi.org/10.1093/jn/nxac222
Relative validity and reliability of isometric lower extremity strength assessment in older adults by using a handheld dynamometer
Grootswagers, Pol, Vaes, Anouk M. M., Hangelbroek, Roland, Tieland, Michael, Van Loon, Lucas J. C. and de Groot, Lisette C. P. G. M.. (2022). Relative validity and reliability of isometric lower extremity strength assessment in older adults by using a handheld dynamometer. Sports Health. 14(6), pp. 899-905. https://doi.org/10.1177/19417381211063847
Development of a novel method to measure bone marrow fat fraction in older women using high-resolution peripheral quantitative computed tomography
Flehr, Alison, Källgård, Julius, Alvén, Jennifer, Lagerstrand, Kerstin, Papalini, Evin, Wheeler, Michael, Vandenput, Liesbeth, Kahl, Fredrik, Axelsson, Kristian F., Sundh, Daniel, Mysore, Raghunath Shirish and Lorentzon, Mattias. (2022). Development of a novel method to measure bone marrow fat fraction in older women using high-resolution peripheral quantitative computed tomography. Osteoporosis International. 33(7), pp. 1545-1556. https://doi.org/10.1007/s00198-021-06224-7
Ingestion of free amino acids compared with an equivalent amount of intact protein results in more rapid amino acid absorption and greater postprandial plasma amino acid availability without affecting muscle protein synthesis rates in young adults in a double-blind randomized trial
Weijzen, Michelle E. G., van Gassel, Rob J. J., Kouw, Imre W. K., Trommelen, Jorn, Gorissen, Stefan H. M., van Kranenburg, Janneau, Goessens, Joy P. B., van de Poll, Marcel C. G., Verdijk, Lex B. and van Loon, Luc J. C.. (2022). Ingestion of free amino acids compared with an equivalent amount of intact protein results in more rapid amino acid absorption and greater postprandial plasma amino acid availability without affecting muscle protein synthesis rates in young adults in a double-blind randomized trial. The Journal of Nutrition. 152(1), pp. 59-67. https://doi.org/10.1093/jn/nxab305
Nutrition and indoor cycling : A cross-sectional analysis of carbohydrate intake for online racing and training
King, Andrew J. and Hall, Rebecca C.. (2022). Nutrition and indoor cycling : A cross-sectional analysis of carbohydrate intake for online racing and training. British Journal of Nutrition. 127(8), pp. 1204-1213. https://doi.org/10.1017/S0007114521001860
Potato protein ingestion increases muscle protein synthesis rates at rest and during recovery from exercise in humans
Pinckaers, Philippe J. M., Hendriks, Floris K., Hermans, Wesley J. H., Goessens, Joy J. B., Senden, Joan M., Van Kranenburg, Janneau M. X., Wodzig, Will K. H. W., Snijders, Tim and van Loon, Luc J. C.. (2022). Potato protein ingestion increases muscle protein synthesis rates at rest and during recovery from exercise in humans. Medicine and Science in Sports and Exercise. 54(9), pp. 1572-1581. https://doi.org/10.1249/MSS.0000000000002937
Disrupting AMPK-glycogen binding in mice increases carbohydrate utilization and reduces exercise capacity
Janzen, Natalie R., Whitfield, Jamie, Murray-Segal, Lisa, Kemp, Bruce E., Hawley, John A. and Hoffman, Nolan J.. (2022). Disrupting AMPK-glycogen binding in mice increases carbohydrate utilization and reduces exercise capacity. Frontiers in Physiology. 13, p. 859246. https://doi.org/10.3389/fphys.2022.859246
Twist2-expressing cells reside in human skeletal muscle and are responsive to aging and resistance exercise training
Gaulton, Nick, Wakelin, Griffen, Young, Laura V., Wotherspoon, Scott, Kamal, Michael, Parise, Gianni, Nederveen, Joshua P., Holwerda, Andy, Verdijk, Lex B., van Loon, Luc J. C., Snijders, Tim and Johnston, Adam P.. (2022). Twist2-expressing cells reside in human skeletal muscle and are responsive to aging and resistance exercise training. The FASEB Journal. 36(12), p. Article e22642. https://doi.org/10.1096/fj.202201349RR
Skeletal Muscle Fibre Characteristics of the Lumbar Multifidus Muscle in Patients Undergoing Microdiscectomy for Unilateral Lumbar Disc Herniation
Stevens, S, Agten, A, Snijders, T, Plazier, M, Bamps, S, Assieker, T, Betz, M, Timmermans, A, Van Loon, Lucas and Vandenabeele, F. (2022). Skeletal Muscle Fibre Characteristics of the Lumbar Multifidus Muscle in Patients Undergoing Microdiscectomy for Unilateral Lumbar Disc Herniation. Muscle, Ligaments and Tendons Journal (MLTJ). 12(3), pp. 432-443. https://doi.org/10.32098/mltj.03.2022.19
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity : A randomized controlled trial
Haganes, Kamilla, Silva, Catalina, Eyjolfsdottir, Svala, Steen, Sandra, Grindberg, Martine, Lydersen, Stian, Hawley, John Alan and Moholdt, Trine. (2022). Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity : A randomized controlled trial. Cell Metabolism. 34(10), pp. 1457-1471. https://doi.org/10.1016/j.cmet.2022.09.003
Metabolomics reveals mouse plasma metabolite responses to acute exercise and effects of disrupting AMPK-glycogen interactions
Belhaj, Mehdi, Lawler, Nathan, Hawley, John Alan, Broadhurst, David, Hoffman, Nolan John and Reinke, Stacey. (2022). Metabolomics reveals mouse plasma metabolite responses to acute exercise and effects of disrupting AMPK-glycogen interactions. Frontiers in Molecular Biosciences. pp. 1-16. https://doi.org/10.3389/fmolb.2022.957549
Dietary nitrate increases submaximal SERCA activity and ADP-transfer to mitochondria in slow-twitch muscle of female mice
Petrick, Heather, Brownell, Stuart, Vachon, Bayley, Brunetta, Henver, Handy, Rachel, Van Loon, Lucas, Murrant, Coral and Holloway, Graham. (2022). Dietary nitrate increases submaximal SERCA activity and ADP-transfer to mitochondria in slow-twitch muscle of female mice. American Journal of Physiology: Endocrinology and Metabolism. 323(2), pp. 1-14. https://doi.org/10.1152/ajpendo.00371.2021
Raw eggs to support post-exercise recovery in healthy young men : Did Rocky get it right or wrong?
Fuchs, Cas J., Hermans, Wesley J. H., Smeets, Joey S. J., Senden, Joan M., van Kranenburg, Janneau, Gorissen, Stefan H. M., Burd, Nicholas A., Verdijk, Lex B. and van Loon, Luc J. C.. (2022). Raw eggs to support post-exercise recovery in healthy young men : Did Rocky get it right or wrong? The Journal of Nutrition. 152, pp. 2376-2386. https://doi.org/10.1093/jn/nxac174
Skeletal muscles of patients infected with SARS-CoV-2 develop severe myofiber damage upon one week of admission on the intensive care unit
Stevens, Sjoerd, Hendrickx, Paul, Snijders, Tim, Lambrichts, Ivo, Stessel, Björn, Dubois, Jasperina, van Loon, Lucas J. C., Vandenabeele, Frank and Agten, Anouk. (2022). Skeletal muscles of patients infected with SARS-CoV-2 develop severe myofiber damage upon one week of admission on the intensive care unit. Applied Sciences. 12(14), p. Article 7310. https://doi.org/10.3390/app12147310
Ingestion of an ample amount of meat substitute based on a lysine-enriched,plant-based protein blend stimulates postprandial muscle proteinsynthesis to a similar extent as an isonitrogenous amount of chickenin healthy, young men
Kouw, Imre W. K., Pinckaers, Philippe J. M., Le Bourgot, Cindy, van Kranenburg, Janneau M. X., Zorenc, Antoine H., de Groot, Lisette C. P. G. M., Verdijk, Lex, Snijders, Tim and van Loon, Luc J. C.. (2022). Ingestion of an ample amount of meat substitute based on a lysine-enriched,plant-based protein blend stimulates postprandial muscle proteinsynthesis to a similar extent as an isonitrogenous amount of chickenin healthy, young men. British Journal of Nutrition. 128, pp. 1955-1965. https://doi.org/10.1017/S0007114521004906
Sleep, circadian biology and skeletal muscle interactions : Implications for metabolic health
Morrison, Matthew, Halson, Shona L., Weakley, Jonathon and Hawley, John A.. (2022). Sleep, circadian biology and skeletal muscle interactions : Implications for metabolic health. Sleep Medicine Reviews. 66, p. Article 101700. https://doi.org/10.1016/j.smrv.2022.101700
Cardiometabolic health impacts of time-restricted eating : Implications for type 2 diabetes, cancer and cardiovascular diseases
Kirkham, Amy A., Parr, Evelyn B. and Kleckner, Amber S.. (2022). Cardiometabolic health impacts of time-restricted eating : Implications for type 2 diabetes, cancer and cardiovascular diseases. Current Opinion in Clinical Nutrition and Metabolic Care. 25(6), pp. 378-387. https://doi.org/10.1097/MCO.0000000000000867
Nutritional strategies to attenuate postprandial glycemic response
Pasmans, Kenneth, Meex, Ruth C. R., van Loon, Luc J. C. and Blaak, Ellen E.. (2022). Nutritional strategies to attenuate postprandial glycemic response. Obesity Reviews. 23(9), p. e13486. https://doi.org/10.1111/obr.13486
Exercise-based interventions to counteract skeletal muscle mass loss in people with cancer : Can we overcome the odds?
Bland, Kelcey A., Kouw, Imre W. K., van Loon, Luc J. C., Zopf, Eva M. and Fairman, Ciaran M.. (2022). Exercise-based interventions to counteract skeletal muscle mass loss in people with cancer : Can we overcome the odds? Sports Medicine. 52(5), pp. 1009-1027. https://doi.org/10.1007/s40279-021-01638-z
The impact of collagen protein ingestion on musculoskeletal connective tissue remodeling : A narrative review
Holwerda, Andrew M. and van Loon, Luc J. C.. (2022). The impact of collagen protein ingestion on musculoskeletal connective tissue remodeling : A narrative review. Nutrition Reviews. 80(6), pp. 1497-1514. https://doi.org/10.1093/nutrit/nuab083
Impact of magnesium on bone health in older adults : A systematic review and meta-analysis
Groenendijk, Inge, van Delft, Marieke, Versloot, Pieter, van Loon, Luc J. C. and de Groot, Lisette C. P. G. M.. (2022). Impact of magnesium on bone health in older adults : A systematic review and meta-analysis. Bone. 154, p. Article 116233. https://doi.org/10.1016/j.bone.2021.116233
L-arabinose co-ingestion delays glucose absorption derived from sucrose in healthy men and women : A double-blind, randomized crossover trial
Pasmans, Kenneth, Meex, Ruth C. R., Trommelen, Jorn, Senden, Joan M. G., Vaughan, Elaine E., van Loon, Luc J. C. and Blaak, Ellen E.. (2021). L-arabinose co-ingestion delays glucose absorption derived from sucrose in healthy men and women : A double-blind, randomized crossover trial. British Journal of Nutrition. 128(6), pp. 1072-1081. https://doi.org/10.1017/S0007114521004153
Amino acid removal during hemodialysis can be compensated for by protein ingestion and is not compromised by intradialytic exercise : A randomized controlled crossover trial
Hendriks, Floris K., Smeets, Joey S. J., van Kranenburg, Janneau M. X., Broers, Natascha J. H., van der Sande, Frank M., Verdijk, Lex B., Kooman, Jeroen P. and van Loon, Luc J. C.. (2021). Amino acid removal during hemodialysis can be compensated for by protein ingestion and is not compromised by intradialytic exercise : A randomized controlled crossover trial. American Journal of Clinical Nutrition. 114(6), pp. 2074-2083. https://doi.org/10.1093/ajcn/nqab274
Fragile bones of elite cyclists : To treat or not to treat?
Hilkens, Luuk, Knuiman, Pim, Heijboer, Mathieu, Kempers, Robert, Jeukendrup, Asker E., van Loon, Luc J. C. and van Dijk, Jan-Willem. (2021). Fragile bones of elite cyclists : To treat or not to treat? Journal of Applied Physiology. 131, pp. 26-28. https://doi.org/10.1152/japplphysiol.01034.2020
Gut amino acid absorption in humans : Concepts and relevance for postprandial metabolism
Trommelen, Jorn, Tomé, Daniel and van Loon, Luc J. C.. (2021). Gut amino acid absorption in humans : Concepts and relevance for postprandial metabolism. Clinical Nutrition Open Science. 36, pp. 43-55. https://doi.org/10.1016/j.nutos.2020.12.006
Isolated and combined effects of highintensity interval training and timerestricted eating on glycaemic control in reproductive-aged women with overweight or obesity : Study protocol for a four-armed randomised controlled trial
Moholdt, Trine, Silva, Catalina P., Lydersen, Stian and Hawley, John A.. (2021). Isolated and combined effects of highintensity interval training and timerestricted eating on glycaemic control in reproductive-aged women with overweight or obesity : Study protocol for a four-armed randomised controlled trial. BMJ Open. 11(2), p. Article e040020. https://doi.org/10.1136/bmjopen-2020-040020
Comprehensive assessment of post-prandial protein handling by the application of intrinsically labelled protein in vivo in human subjects
Trommelen, Jorn, Holwerda, Andrew M., Pinckaers, Philippe J. M. and van Loon, Lucas J. C.. (2021). Comprehensive assessment of post-prandial protein handling by the application of intrinsically labelled protein in vivo in human subjects. Proceedings of the Nutrition Society. 80(2), pp. 221-229. https://doi.org/10.1017/S0029665120008034
Mimicking exercise : What matters most and where to next?
Hawley, John A., Joyner, Michael J. and Green, Daniel J.. (2021). Mimicking exercise : What matters most and where to next? The Journal of Physiology. 599(3), pp. 791-802. https://doi.org/10.1113/JP278761
Dietary protein interventions to improve nutritional status in end-stage renal disease patients undergoing hemodialysis
Hendriks, Floris K., Kooman, Jeroen P. and van Loon, Luc J. C.. (2021). Dietary protein interventions to improve nutritional status in end-stage renal disease patients undergoing hemodialysis. Current Opinion in Clinical Nutrition and Metabolic Care. 24(1), pp. 79-87. https://doi.org/10.1097/MCO.0000000000000703
A white paper on collagen hydrolyzates and ultrahydrolyzates : Potential supplements to support joint health in osteoarthritis?
Mobasheri, Ali, Mahmoudian, Armaghan, Kalvaityte, Ursule, Uzieliene, Ilona, Larder, Christina E., Iskandar, Michèle M., Kubow, Stan, Hamdan, Paulo Cesar, de Almeida Jr, Cyro Scala, Favazzo, Lacey J., van Loon, Luc J. C., Emans, Pieter J., Plapler, Pérola G. and Zuscik, Michael J.. (2021). A white paper on collagen hydrolyzates and ultrahydrolyzates : Potential supplements to support joint health in osteoarthritis? Current Rheumatology Reports. 23(11), p. Article 78. https://doi.org/10.1007/s11926-021-01042-6
The anabolic response to plant-based protein ingestion
Pinckaers, Philippe J. M., Trommelen, Jorn, Snijders, Tim and van Loon, Luc J. C.. (2021). The anabolic response to plant-based protein ingestion. Sports Medicine. 51(Supplement 1), pp. 59-74. https://doi.org/10.1007/s40279-021-01540-8
Hepatic steatosis contributes to the development of muscle atrophy via inter-organ crosstalk
Pasmans, Kenneth, Adriaens, Michiel E., Olinga, Peter, Langen, Ramon, Rensen, Sander S., Schaap, Frank G., Damink, Steven W. M. Olde, Caiment, Florian, van Loon, Luc J. C., Blaak, Ellen E. and Meex, Ruth C. R.. (2021). Hepatic steatosis contributes to the development of muscle atrophy via inter-organ crosstalk. Frontiers in Endocrinology. 12, p. Article 733625. https://doi.org/10.3389/fendo.2021.733625
Different frequencies of active interruptions to sitting have distinct effects on 22 h glycemic control in type 2 diabetes
Homer, Ashleigh R., Taylor, Frances C., Dempsey, Paddy C., Wheeler, Michael J., Sethi, Parneet, Grace, Megan S., Green, Daniel J., Cohen, Neale D., Larsen, Robyn N., Kingwell, Bronwyn A., Owen, Neville and Dunstan, David W.. (2021). Different frequencies of active interruptions to sitting have distinct effects on 22 h glycemic control in type 2 diabetes. Nutrition Metabolism and Cardiovascular Diseases. 31(10), pp. 2969-2978. https://doi.org/10.1016/j.numecd.2021.07.001
The effect of morning vs evening exercise training on glycaemic control and serum metabolites in overweight/obese men : A randomised trial
Moholdt, Trine, Parr, Evelyn B., Devlin, Brooke L., Debik, Julia, Giskeødegård, Guro and Hawley, John A.. (2021). The effect of morning vs evening exercise training on glycaemic control and serum metabolites in overweight/obese men : A randomised trial. Diabetologia. 64(9), pp. 2061-2076. https://doi.org/10.1007/s00125-021-05477-5
Acute effects of dietary nitrate on exercise tolerance, muscle oxygenation, and cardiovascular function in patients with peripheral arterial disease
van der Avoort, Cindy M.T., Van Loon, Luc J.C., Verdijk, Lex B., Poyck, Paul P.C., Thijssen, Dick T.J. and Hopman, Maria T.E.. (2021). Acute effects of dietary nitrate on exercise tolerance, muscle oxygenation, and cardiovascular function in patients with peripheral arterial disease. International Journal of Sport Nutrition and Exercise Metabolism. 31(5), pp. 385-396. https://doi.org/10.1123/ijsnem.2021-0054
Mice with whole-body disruption of AMPK-glycogen binding have increased adiposity, reduced fat oxidation and altered tissue glycogen dynamics
Janzen, Natalie, Whitfield, Jamie, Murray-Segal, Lisa, Kemp, Bruce E., Hawley, John A. and Hoffman, Nolan J.. (2021). Mice with whole-body disruption of AMPK-glycogen binding have increased adiposity, reduced fat oxidation and altered tissue glycogen dynamics. International Journal of Molecular Sciences. 22(17), p. Article: 9616. https://doi.org/10.3390/ijms22179616
Mass spectrometry imaging of L-[ring-13 C6]- labeled phenylalanine and tyrosine kinetics in non-small cell lung carcinoma 
Cao, Jianhua, Balluff, Benjamin, Arts, Martijn, Dubois, Ludwig J., van Loon, Luc J. C., Hackeng, Tilman M., van Eijk, Hans M. H., Eijkel, Gert, Heij, Lara R., Soons, Zita, Olde Damink, Steven W. M. and Heeren, Ron M. A.. (2021). Mass spectrometry imaging of L-[ring-13 C6]- labeled phenylalanine and tyrosine kinetics in non-small cell lung carcinoma . Cancer & Metabolism. 9, p. Article 26. https://doi.org/10.1186/s40170-021-00262-9
Insects are a viable protein source for human consumption : From insect protein digestion to postprandial muscle protein synthesis in vivo in humans : A double-blind randomized trial
Hermans, Wesley J. H., Senden, Joan M., Churchward-Venne, Tyler A., Paulussen, Kevin J. M., Fuchs, Cas J., Smeets, Joey S. J., van Loon, Joop J. A., Verdijk, Lex B. and van Loon, Luc J. C.. (2021). Insects are a viable protein source for human consumption : From insect protein digestion to postprandial muscle protein synthesis in vivo in humans : A double-blind randomized trial. American Journal of Clinical Nutrition. 114(3), pp. 934-944. https://doi.org/10.1093/ajcn/nqab115
Increasing nitrate-rich vegetable intake lowers ambulatory blood pressure in (pre)hypertensive middle-aged and older adults : A 12-wk randomized controlled trial
van der Avoort, Cindy M. T., ten Haaf, Dominique S. M., Bongers, Coen C. W. G., van Oorschot, Frederieke, Verdijk, Lex B., van Loon, Luc J. C. and Hopman, Maria T. E.. (2021). Increasing nitrate-rich vegetable intake lowers ambulatory blood pressure in (pre)hypertensive middle-aged and older adults : A 12-wk randomized controlled trial. The Journal of Nutrition. 151(9), pp. 2667-2679. https://doi.org/10.1093/jn/nxab157
Neither beetroot juice supplementation nor increased carbohydrate oxidation enhance economy of prolonged exercise in elite race walkers
Burke, Louise M., Hall, Rebecca, Heikura, Ida A., Ross, Megan L., Tee, Nicolin, Kent, Georgina L., Whitfield, Jamie, Forbes, Sara F., Sharma, Avish P., Jones, Andrew M., Peeling, Peter, Blackwell, Jamie R., Mujika, Iñigo, Mackay, Karen, Kozior, Marta, Vallance, Brent and McKay, Alannah K. A.. (2021). Neither beetroot juice supplementation nor increased carbohydrate oxidation enhance economy of prolonged exercise in elite race walkers. Nutrients. 13(8), p. Article 2767. https://doi.org/10.3390/nu13082767
Eat like an athlete : Insights of sports nutrition science to support active aging in healthy older adults
Oikawa, Sara Y., Brisbois, Tristin D., van Loon, Luc J. C. and Rollo, Ian. (2021). Eat like an athlete : Insights of sports nutrition science to support active aging in healthy older adults. GeroScience. 43(5), pp. 2485-2495. https://doi.org/10.1007/s11357-021-00419-w
Undeclared doping substances are highly prevalent in commercial sports nutrition supplements
Duiven, Erik, Luc J.C. van Loon, Spruijt, Laila, Koert, Willem and de Hon, Olivier M.. (2021). Undeclared doping substances are highly prevalent in commercial sports nutrition supplements. Journal of Sports Science and Medicine. 20, pp. 328-338. https://doi.org/10.52082/jssm.2021.328
Skeletal muscle adaptive responses to different types of short-term exercise training and detraining in middle-age men
Callahan, Marcus J., Parr, Evelyn B., Snijders, Tim, Conceição, Miguel S., Radford, Bridget E., Timmins, Ryan G., Devlin, Brooke L., Hawley, John A. and Camera, Donny M.. (2021). Skeletal muscle adaptive responses to different types of short-term exercise training and detraining in middle-age men. Medicine and Science in Sports and Exercise. 53(10), pp. 2023-2036. https://doi.org/10.1249/MSS.0000000000002684
No differences in muscle protein synthesis rates following ingestion of wheat protein, milk protein, and their protein blend in healthy, young males
Pinckaers, Philippe J. M., Kouw, Imre W. K., Hendriks, Floris K., van Kranenburg, Janneau M. X., de Groot, Lisette C. P. G. M., Verdijk, Lex B., Snijders, Tim and van Loon, Luc J. C.. (2021). No differences in muscle protein synthesis rates following ingestion of wheat protein, milk protein, and their protein blend in healthy, young males. British Journal of Nutrition. 126(12), pp. 1832-1842. https://doi.org/10.1017/S0007114521000635
Frequency of interruptions to sitting time : Benefits for postprandial metabolism in type 2 diabetes
Homer, Ashleigh R., Taylor, Frances C., Dempsey, Paddy C., Wheeler, Michael J., Sethi, Parneet, Townsend, Melanie K., Grace, Megan S., Green, Daniel J., Cohen, Neale D., Larsen, Robyn N., Kingwell, Bronwyn A., Owen, Neville and Dunstan, David W.. (2021). Frequency of interruptions to sitting time : Benefits for postprandial metabolism in type 2 diabetes. Diabetes Care. 44(6), pp. 1-10. https://doi.org/10.2337/dc20-1410
Does supplementation with leucine-enriched protein alone and in combination with fish-oil-derived n-3 PUFA affect muscle mass, strength, physical performance, and muscle protein synthesis in well-nourished older adults? A randomized, double-blind, placebo-controlled trial
Murphy, Caoileann H., Flanagan, Ellen M., De Vito, Giuseppe, Susta, Davide, Mitchelson, Kathleen A. J., de Marco Castro, Elena, Senden, Joan M. G., Goessens, Joy P. B., Mikłosz, Agnieszka, Chabowski, Adrian, Segurado, Ricardo, Corish, Clare A., McCarthy, Sinead N., Egan, Brendan, van Loon, Luc J. C. and Roche, Helen M.. (2021). Does supplementation with leucine-enriched protein alone and in combination with fish-oil-derived n-3 PUFA affect muscle mass, strength, physical performance, and muscle protein synthesis in well-nourished older adults? A randomized, double-blind, placebo-controlled trial. American Journal of Clinical Nutrition. 113(6), pp. 1411-1427. https://doi.org/10.1093/ajcn/nqaa449
Daily myofibrillar protein synthesis rates in response to low- And high-frequency resistance exercise training in healthy, young men
Shad, Brandon J., Thompson, Janice L., McKendry, James, Holwerda, Andrew M., Elhassan, Yasir S., Breen, Leigh, van Loon, Luc J. C. and Wallis, Gareth A.. (2021). Daily myofibrillar protein synthesis rates in response to low- And high-frequency resistance exercise training in healthy, young men. International Journal of Sport Nutrition and Exercise Metabolism. 31(3), pp. 209-216. https://doi.org/10.1123/IJSNEM.2020-0274
Basal protein synthesis rates differ between vastus lateralis and rectus abdominis muscle
Smeets, Joey S. J., Horstman, Astrid M. H., van Dijk, David P. J., van Boxtel, Astrid G. M., ter Woorst, Joost F., Damink, Steven W. M. Olde, Schijns, Olaf E. M. G. and van Loon, Luc J. C.. (2021). Basal protein synthesis rates differ between vastus lateralis and rectus abdominis muscle. Journal of Cachexia, Sarcopenia and Muscle. 12(3), pp. 769-778. https://doi.org/10.1002/jcsm.12701
Myonuclear content and domain size in small versus larger muscle fibres in response to 12 weeks of resistance exercise training in older adults
Snijders, Tim, Holwerda, Andy M., van Loon, Luc J. C. and Verdijk, Lex B.. (2021). Myonuclear content and domain size in small versus larger muscle fibres in response to 12 weeks of resistance exercise training in older adults. Acta Physiologica. 231(4), p. e13599. https://doi.org/10.1111/apha.13599
The impact of beetroot juice supplementation on muscular endurance, maximal strength and countermovement jump performance
Jonvik, Kristin L., Hoogervorst, Daan, Peelen, Harmen B., de Niet, Mark, Verdijk, Lex B., van Loon, Luc J. C. and van Dijk, Jan-Willem. (2021). The impact of beetroot juice supplementation on muscular endurance, maximal strength and countermovement jump performance. European Journal of Sport Science. 21(6), pp. 871-878. https://doi.org/10.1080/17461391.2020.1788649
Assessing the whole-body protein synthetic response to feeding in vivo in human subjects
Trommelen, Jorn and Van Loon, Luc J. C.. (2021). Assessing the whole-body protein synthetic response to feeding in vivo in human subjects. Proceedings of the Nutrition Society. 80, pp. 139-147. https://doi.org/10.1017/S0029665120008009
Exercise plus presleep protein ingestion increases overnight muscle connective tissue protein synthesis rates in healthy older men
Holwerda, Andrew M., Trommelen, Jorn, Kouw, Imre W. K., Senden, Joan M., Goessens, Joy P. B., van Kranenburg, Janneau, Gijsen, Annemie P., Verdijk, Lex B. and van Loon, Luc J. C.. (2021). Exercise plus presleep protein ingestion increases overnight muscle connective tissue protein synthesis rates in healthy older men. International Journal of Sport Nutrition and Exercise Metabolism. 31(3), pp. 317-226. https://doi.org/10.1123/ijsnem.2020-0222
Lower nocturnal blood glucose response to a potato-based mixed evening meal compared to rice in individuals with type 2 diabetes
Devlin, Brooke L., Parr, Evelyn B., Radford, Bridget E. and Hawley, John A.. (2021). Lower nocturnal blood glucose response to a potato-based mixed evening meal compared to rice in individuals with type 2 diabetes. Clinical Nutrition. 40(4), pp. 2200-2209. https://doi.org/10.1016/j.clnu.2020.09.049
Whey protein supplementation does not accelerate recovery from a single bout of eccentric exercise
Hilkens, Luuk, De Bock, Jolien, Kretzers, Joris, Kardinaal, Alwine F. M., Floris-Vollenbroek, Esther G., Scholtens, Petra A. M. J., Horstman, Astrid M. H., van Loon, Luc J. C. and van Dijk, Jan-Willem. (2021). Whey protein supplementation does not accelerate recovery from a single bout of eccentric exercise. Applied Physiology, Nutrition and Metabolism. 39(3), pp. 322-331. https://doi.org/10.1080/02640414.2020.1820184
Muscle fiber capillarization is associated with various indices of skeletal muscle mass in healthy, older men
Betz, M. W., Aussieker, T., Kruger, C. Q., Gorissen, S. H. M., van Loon, L. J. C. and Snijders, T.. (2021). Muscle fiber capillarization is associated with various indices of skeletal muscle mass in healthy, older men. Experimental Gerontology. 143, p. 111161. https://doi.org/10.1016/j.exger.2020.111161
Higher levels of physical activity are associated with greater fruit and vegetable intake in older adults
Van Loon, L.. (2021). Higher levels of physical activity are associated with greater fruit and vegetable intake in older adults. Journal of Nutrition, Health and Aging. 25(2), pp. 230-241. https://doi.org/10.1007/s12603-020-1520-3
Acute ketogenic diet and ketone ester supplementation impairs race walk performance
Whitfield, Jamie, Burke, Louise M., McKay, Alannah K. A., Heikura, Ida A., Hall, Rebecca, Fensham, Nikita and Sharma, Avish P.. (2021). Acute ketogenic diet and ketone ester supplementation impairs race walk performance. Medicine and Science in Sports and Exercise. 53(4), pp. 776-784. https://doi.org/10.1249/MSS.0000000000002517
Dietary protein intake does not modulate daily myofibrillar protein synthesis rates of loss of muscle mass and function during short-term immobilization in young men : a randomized controlled trial
Kilroe, Sean Paul, Fulford, Jonathan, Jackman, Sarah, Holwerda, Andrew, Gijsen, Annemie, van Loon, Luc and Wall, Benjamin Toby. (2021). Dietary protein intake does not modulate daily myofibrillar protein synthesis rates of loss of muscle mass and function during short-term immobilization in young men : a randomized controlled trial. The American Journal of Clinical Nutrition. 113(3), pp. 548-561. https://doi.org/10.1093/ajcn/nqaa136
Can high-intensity interval training promote skeletal muscle anabolism?
Callahan, Marcus J., Parr, Evelyn B., Hawley, John A. and Camera, Donny M.. (2021). Can high-intensity interval training promote skeletal muscle anabolism? Sports Medicine. 51, pp. 405-421. https://doi.org/10.1007/s40279-020-01397-3
Acute effects of interrupting prolonged sitting on vascular function in type 2 diabetes
Dunstan, D., Homer, A., Wheeler, M. and Maniar, N.. (2021). Acute effects of interrupting prolonged sitting on vascular function in type 2 diabetes. American Journal of Physiology: Heart and Circulatory Physiology. 320(1), pp. H393-H403. https://doi.org/10.1152/ajpheart.00422.2020
Adaptation to Low Carbohydrate High Fat diet is rapid but impairs endurance exercise metabolism and performance despite enhanced glycogen availability
Burke, Louise M., Whitfield, Jamie, Heikura, Ida A., Ross, Megan L. R., Tee, Nicolin, Forbes, Sara F., Hall, Rebecca, McKay, Alannah K. A., Wallett, Alice M. and Sharma, Avish P.. (2021). Adaptation to Low Carbohydrate High Fat diet is rapid but impairs endurance exercise metabolism and performance despite enhanced glycogen availability. Journal of Physiology. 599(3), pp. 771-790. https://doi.org/10.1113/JP280221
Effect of acute and short-term dietary fat ingestion on postprandial skeletal muscle protein synthesis rates in middle-aged, overweight and obese men
Tsintzas, Kostas, Jones, Robert, Pabla, Pardeep, Mallinson, Joanne, Barrett, David A., Kim, Dong-Hyun, Cooper, Scott, Davies, Amanda, Taylor, Tariq, Chee, Carolyn, Gaffney, Christopher, van Loon, Luc J. C. and Stephens, Francis B.. (2020). Effect of acute and short-term dietary fat ingestion on postprandial skeletal muscle protein synthesis rates in middle-aged, overweight and obese men. American Journal of Physiology - Endocrinology and Metabolism. 318(3), pp. E417-E429. https://doi.org/10.1152/ajpendo.00344.2019
Chrono-nutrition for the prevention and treatment of obesity and type 2 diabetes : From mice to men
Hawley, John A., Sassone-Corsi, Paolo and Zierath, Juleen R.. (2020). Chrono-nutrition for the prevention and treatment of obesity and type 2 diabetes : From mice to men. Diabetologia. 63(11), pp. 2253-2259. https://doi.org/10.1007/s00125-020-05238-w
Maternal lifestyle interventions : Targeting preconception health
Moholdt, Trine and Hawley, John A.. (2020). Maternal lifestyle interventions : Targeting preconception health. Trends in Endocrinology and Metabolism. 31(8), pp. 561-569. https://doi.org/10.1016/j.tem.2020.03.002
Time-restricted eating as a nutrition strategy for individuals with type 3 diabetes : A feasibility study
Parr, Evelyn B., Devlin, Brooke L., Lim, Karen H. C., Moresi, Laura N. Z., Geils, Claudia, Brennan, Leah and Hawley, John A.. (2020). Time-restricted eating as a nutrition strategy for individuals with type 3 diabetes : A feasibility study. Nutrients. 12(11), p. 3228. https://doi.org/10.3390/nu12113228
In vitro ketone-supported mitochondrial respiration is minimal when other substrates are readily available in cardiac and skeletal muscle
Petrick, Heather L., Brunetta, Henver S., Pignanelli, Chris, Nunes, Everson A., van Loon, Luc J. C., Burr, Jamie F. and Holloway, Graham P.. (2020). In vitro ketone-supported mitochondrial respiration is minimal when other substrates are readily available in cardiac and skeletal muscle. The Journal of Physiology. 598(21), pp. 4869-4885. https://doi.org/10.1113/JP280032
Circulating and adipose tissue miRNAs in women with polycystic ovary syndrome and responses to high-intensity interval training
Lionett,Sofie, Kiel,Ida A., Camera,Donny M., Vanky,Eszter, Parr, E., Lydersen,Stian, Hawley, J. and Moholdt,Trine. (2020). Circulating and adipose tissue miRNAs in women with polycystic ovary syndrome and responses to high-intensity interval training. Frontiers in Physiology. 11, p. 904. https://doi.org/10.3389/fphys.2020.00904
Casein ingestion does not increase muscle connective tissue protein synthesis rates
Trommelen, Jorn, Holwerda, Andrew M., Senden, Joan M., Goessens, Joy P. B., Van Kranenburg, Janneau, Gijsen, Annemie P., Verdijk, Lex B. and van Loon, Luc J. C.. (2020). Casein ingestion does not increase muscle connective tissue protein synthesis rates. Medicine & Science in Sports & Exercise. 52(9), pp. 1983-1991. https://doi.org/10.1249/MSS.0000000000002337
Combined effects of continuous exercise and intermittent active interruptions to prolonged sitting on postprandial glucose, insulin, and triglycerides in adults with obesity : A randomized crossover trial
Wheeler, Michael J., Green, Daniel J., Cerin, Ester, Ellis, Kathryn A., Heinonen, Ilkka, Lewis, Jaye, Naylor, Louise H., Cohen, Neale, Larsen, Robyn, Dempsey, Paddy C., Kingwell, Bronwyn A., Owen, Neville and Dunstan, David W.. (2020). Combined effects of continuous exercise and intermittent active interruptions to prolonged sitting on postprandial glucose, insulin, and triglycerides in adults with obesity : A randomized crossover trial. International Journal of Behavioral Nutrition and Physical Activity. 17(1), p. 152. https://doi.org/10.1186/s12966-020-01057-9
The glycation level of milk protein strongly modulates post-prandial lysine availability in humans
Nyakayiru, Jean, van Lieshout, Glenn A. A., Trommelen, Jorn, van Kranenburg, Janneau, Verdijk, Lex B., Bragt, Marjolijn C. E. and van Loon, Luc J. C.. (2020). The glycation level of milk protein strongly modulates post-prandial lysine availability in humans. British Journal of Nutrition. 123(5), pp. 545-552. https://doi.org/10.1017/S0007114519002927
The concept of skeletal muscle memory : Evidence from animal and human studies
Snijders, Tim, Aussieker, Thorben, Holwerda, Andy, Parise, Gianni, van Loon, Luc J. C. and Verdijk, Lex B.. (2020). The concept of skeletal muscle memory : Evidence from animal and human studies. Acta Physiologica. 229(3), pp. 1-20. https://doi.org/10.1111/apha.13465
Temporal muscle-specific disuse atrophy during one week of leg immobilization
Kilroe, Sean P., Fulford, Jonathan, Jackman, Sarah R., van Loon, Luc J. C. and Wall, Benjamin T.. (2020). Temporal muscle-specific disuse atrophy during one week of leg immobilization. Medicine & Science in Sports & Exercise. 52(4), pp. 944-954. https://doi.org/10.1249/MSS.0000000000002200
Short-term bed rest-induced insulin resistance cannot be explained by increased mitochondrial H2O2 emission
Dirks, Marlou L., Miotto, Paula M., Goossens, Gijs H., Senden, Joan M., Petrick, Heather L., van Kranenburg, Janneau, van Loon, Luc J. C. and Holloway, Graham P.. (2020). Short-term bed rest-induced insulin resistance cannot be explained by increased mitochondrial H2O2 emission. The Journal of Physiology. 598(1), pp. 123-137. https://doi.org/10.1113/JP278920
Protein type, protein dose, and age modulate dietary protein digestion and phenylalanine absorption kinetics and plasma phenylalanine availability in humans
Gorissen, Stefan H. M., Trommelen, Jorn, Kouw, Imre W. K., Holwerda, Andrew M., Pennings, Bart, Groen, Bart B. L., Wall, Benjamin T., Churchward-Venne, Tyler A., Horstman, Astrid M. H., Koopman, René, Burd, Nicholas A., Fuchs, Cas J., Dirks, Marlou L., Res, Peter T., Senden, Joan M. G., Steijns, Jan M. J. M., de Groot, Lisette C. P. G. M., Verdijk, Lex B. and van Loon, Luc J. C.. (2020). Protein type, protein dose, and age modulate dietary protein digestion and phenylalanine absorption kinetics and plasma phenylalanine availability in humans. The Journal of Nutrition. 150(8), pp. 2041-2050. https://doi.org/10.1093/jn/nxaa024
Postexercise cooling impairs muscle protein synthesis rates in recreational athletes
Fuchs, Cas J., Kouw, Imre W. K., Churchward-Venne, Tyler A., Smeets, Joey S. J., Senden, Joan M., Lichtenbelt, Wouter D. van Marken, Verdijk, Lex B. and van Loon, Luc J. C.. (2020). Postexercise cooling impairs muscle protein synthesis rates in recreational athletes. The Journal of Physiology. 598(4), pp. 755-772. https://doi.org/10.1113/JP278996
Omega-3 polyunsaturated fatty acids mitigate palmitate-induced impairments in skeletal muscle cell viability and differentiation
Tachtsis, Bill, Whitfield, Jamie, Hawley, John A. and Hoffman, Nolan J.. (2020). Omega-3 polyunsaturated fatty acids mitigate palmitate-induced impairments in skeletal muscle cell viability and differentiation. Frontiers in Physiology. 11, pp. 1-13. https://doi.org/10.3389/fphys.2020.00563
The Challenge of Maintaining Metabolic Health During a Global Pandemic
Andy J. King, Louise M. Burke, Shona L. Halson and John A. Hawley. (2020). The Challenge of Maintaining Metabolic Health During a Global Pandemic. Sports Medicine. 50(7), pp. 1233-1241. https://doi.org/10.1007/s40279-020-01295-8
Primary, Secondary, and Tertiary Effects of Carbohydrate Ingestion During Exercise
Ian Rollo, Javier T. Gonzalez, Cas J. Fuchs, Lucas Van Loon and Clyde Williams. (2020). Primary, Secondary, and Tertiary Effects of Carbohydrate Ingestion During Exercise. Sports Medicine. 50(11), pp. 1863-1871. https://doi.org/10.1007/s40279-020-01343-3
PRESENT 2020: Text Expanding on the Checklist for Proper Reporting of Evidence in Sport and Exercise Nutrition Trials
James A. Betts, Javier T. Gonzalez, Louise Burke, Graeme L. Close, Ina Garthe, Lewis J James, Asker E Jeukendrup, James P. Morton, David C Nieman, Peter Peeling, Stuart M Phillips, Trent Stellingwerff, Lucas Van Loon, Clyde Williams, Kathleen Woolf, Ronald J. Maughan and Greg Atkinson. (2020). PRESENT 2020: Text Expanding on the Checklist for Proper Reporting of Evidence in Sport and Exercise Nutrition Trials. International Journal of Sport Nutrition and Exercise Metabolism. 30(1), pp. 2-13. https://doi.org/10.1123/ijsnem.2019-0326
Mitochondrial ROS and Aging: Understanding Exercise as a Preventive Tool
Henver S Brunetta, Andrew M Holwerda, Luc Van Loon and Graham P Holloway. (2020). Mitochondrial ROS and Aging: Understanding Exercise as a Preventive Tool. Journal of Science in Sport and Exercise. 2, pp. 15-24. https://doi.org/10.1007/s42978-019-00037-1
Microbiota and muscle highway - two way traffic
John Hawley. (2020). Microbiota and muscle highway - two way traffic. Nature Reviews Endocrinology. 16(2), pp. 71-72. https://doi.org/10.1038/s41574-019-0291-6
Improving reproductive function in women with polycystic ovary syndrome with high-intensity interval training (IMPROV-IT): study protocol for a two-centre, three-armed randomised controlled trial
Ida Almenning Kiel, Sofie Lionett, Evelyn Parr, Helen Jones, Maria Aurora Hernandez Roset, Oyvind Salvesen, Eszter Vanky and Trine Moholdt. (2020). Improving reproductive function in women with polycystic ovary syndrome with high-intensity interval training (IMPROV-IT): study protocol for a two-centre, three-armed randomised controlled trial. BMJ Open. 10(2), pp. 1-9. https://doi.org/10.1136/bmjopen-2019-034733
Impact of whole dairy matrix on musculoskeletal health and aging–current knowledge and research gaps
N.R.W. Geiker, C. Mølgaard, S. Iuliano, R. Rizzoli, Y. Manios, L.J.C. van Loon, J.-M. Lecerf, G. Moschonis, J.-Y. Reginster, I. Givens and A. Astrup. (2020). Impact of whole dairy matrix on musculoskeletal health and aging–current knowledge and research gaps. Osteoporosis International. 31(4), pp. 601-615. https://doi.org/10.1007/s00198-019-05229-7
Intermittent versus continuous enteral nutrition attenuates increases in insulin and leptin during short-term bed rest
Gonzalez, Javier T., Dirks, Marlou L., Holwerda, Andrew M., Kouw, Imre W. K. and van Loon, Luc J. C.. (2020). Intermittent versus continuous enteral nutrition attenuates increases in insulin and leptin during short-term bed rest. European Journal of Applied Physiology. 120, pp. 2083-2094. https://doi.org/10.1007/s00421-020-04431-4
Does high cardiorespiratory fitness confer some protection against pro-inflammatory responses after infection by SARS-CoV-2?
Zbinden-Foncea, Hermann, Francaux, Marc, Deldicque, Louise and Hawley, John A.. (2020). Does high cardiorespiratory fitness confer some protection against pro-inflammatory responses after infection by SARS-CoV-2? Obesity. 28(8), pp. 1378-1381. https://doi.org/10.1002/oby.22849
Impact of exercise-nutritional state interactions in patients with type 2 diabetes
Verboven, Kenneth, Wens, Inez, Vandenabeele, Frank, Stevens, An, Celie, Bert, Lapauw, Bruno, Dendale, Paul, van Loon, Luc J. C., Calders, Patrick and Hansen, Dominique. (2020). Impact of exercise-nutritional state interactions in patients with type 2 diabetes. Medicine and Science in Sports and Exercise. 52(3), pp. 720-728. https://doi.org/10.1249/MSS.0000000000002165
Could intramuscular storage of dietary nitrate contribute to its ergogenic effect? A mini-review
Jean Nyakayiru, Luc Van Loon and Lex B. Verdijk. (2020). Could intramuscular storage of dietary nitrate contribute to its ergogenic effect? A mini-review. Free Radical Biology & Medicine. 152, pp. 295-300. https://doi.org/10.1016/j.freeradbiomed.2020.03.025
Hot-water immersion does not increase postprandial muscle protein synthesis rates during recovery from resistance-type exercise in healthy, young males
Fuchs, Cas J., Smeets, Joey S. J., Senden, Joan M., Zorenc, Antoine H., Goessens, Joy P. B., van Marken Lichtenbelt, Wouter D., Verdijk, Lex B. and van Loon, Luc J. C.. (2020). Hot-water immersion does not increase postprandial muscle protein synthesis rates during recovery from resistance-type exercise in healthy, young males. Journal of Applied Physiology. 128(4), pp. 1012-1022. https://doi.org/10.1152/japplphysiol.00836.2019
A time to eat and a time to exercise
Parr, Evelyn B., Heilbronn, Leonie K. and Hawley, John A.. (2020). A time to eat and a time to exercise. Exercise and Sport Sciences Reviews. 48(1), pp. 4-10. https://doi.org/10.1249/JES.0000000000000207
Genetic loss of AMPK-glycogen binding destabilizes AMPK and disrupts metabolism
Hoffman, Nolan J., Whitfield, Jamie, Janzen, Natalie R., Belhaj, Mehdi R., Galic, Sandra, Murray-Segal, Lisa, Smiles, William J., Ling, Naomi X. Y., Dite, Toby A., Scott, John W., Oakhill, Jonathan S., Brink, Robert, Kemp, Bruce E. and Hawley, John A.. (2020). Genetic loss of AMPK-glycogen binding destabilizes AMPK and disrupts metabolism. Molecular Metabolism. 41, pp. 1-13. https://doi.org/10.1016/j.molmet.2020.101048
Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression
Leonidas S Lundell, Evelyn Parr, Brooke Devlin, Lars R Ingerslev, Ali Altintas, Shogo Sato, Paolo Sassone-Corsi, Romain Barres, Juleen R Zierath and John Hawley. (2020). Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression. Nature Communications. 11(1), pp. 1-11. https://doi.org/10.1038/s41467-020-18412-w
Endurance-type exercise increases bulk and individual mitochondrial protein synthesis rates in rats
Holwerda, Andrew M., Bouwman, Freek G., Nabben, Miranda, Wang, Ping, van Kranenburg, Janneau, Gijsen, Annemie P., Burniston, Jatin G., Mariman, Edwin C. M. and van Loon, Luc J. C.. (2020). Endurance-type exercise increases bulk and individual mitochondrial protein synthesis rates in rats. International Journal of Sport Nutrition and Exercise Metabolism. 30(2), pp. 153-164. https://doi.org/10.1123/ijsnem.2019-0281
End-stage renal disease patients lose a substantial amount of amino acids during hemodialysis
Hendriks, Floris K., Smeets, Joey S. J., Broers, Natascha J. H., van Kranenburg, Janneau M. X., van der Sande, Frank M., Kooman, Jeroen P. and van Loon, Luc J. C.. (2020). End-stage renal disease patients lose a substantial amount of amino acids during hemodialysis. The Journal of Nutrition. 150(5), pp. 1160-1166. https://doi.org/10.1093/jn/nxaa010
During hospitalization, older patients at risk for malnutrition consume <0.65 grams of protein per kilogram body weight per day
Weijzen, Michelle E. G., Kouw, Imre W. K., Geerlings, Phil, Verdijk, Lex B. and van Loon, Luc J. C.. (2020). During hospitalization, older patients at risk for malnutrition consume <0.65 grams of protein per kilogram body weight per day. Nutrition in Clinical Practice. 35(4), pp. 655-663. https://doi.org/10.1002/ncp.10542
Dose-response effects of dietary protein on muscle protein synthesis during recovery from endurance exercise in young men : A double-blind randomized trial
Churchward-Venne, Tyler A., Pinckaers, Philippe J. M., Smeets, Joey S. J., Betz, Milan W., Senden, Joan M., Goessens, Joy P. B., Gijsen, Annemie P., Rollo, Ian, Verdijk, Lex B. and van Loon, Luc J. C.. (2020). Dose-response effects of dietary protein on muscle protein synthesis during recovery from endurance exercise in young men : A double-blind randomized trial. American Journal of Clinical Nutrition. 112(2), pp. 303-317. https://doi.org/10.1093/ajcn/nqaa073
Divergent regulation of myotube formation and gene expression by E2 and EPA during in-vitro differentiation of C2C12 myoblasts
Lacham-Kaplan, Orly, Camera, Donny and Hawley, John. (2020). Divergent regulation of myotube formation and gene expression by E2 and EPA during in-vitro differentiation of C2C12 myoblasts. International Journal of Molecular Sciences. 21(3), pp. 1-18. https://doi.org/10.3390/ijms21030745
Casein protein processing strongly modulates post-prandial plasma amino acid responses in vivo in humans
Trommelen, Jorn, Weijzen, Michelle E. G., van Kranenburg, Janneau, Ganzevles, Renate A., Beelen, Milou, Verdijk, Lex B. and van Loon, Luc J. C.. (2020). Casein protein processing strongly modulates post-prandial plasma amino acid responses in vivo in humans. Nutrients. 12(8), pp. 1-12. https://doi.org/10.3390/nu12082299
A nitrate-rich vegetable intervention elevates plasma nitrate and nitrite concentrations and reduces blood pressure in healthy young adults
van der Avoort, Cindy M. T., Jonvik, Kristin L., Nyakayiru, Jean, van Loon, Luc J. C., Hopman, Maria T. E. and Verdijk, Lex B.. (2020). A nitrate-rich vegetable intervention elevates plasma nitrate and nitrite concentrations and reduces blood pressure in healthy young adults. Journal of the Academy of Nutrition and Dietetics. 120(8), pp. 1305-1317. https://doi.org/10.1016/j.jand.2020.02.014
Voeding bij intensieve sportbeoefening
van Loon, L. J. C., Trommelen, J., van Erp-Baart, A. M. J. and Saris, W. H. M.. (2019). Voeding bij intensieve sportbeoefening. In In Former, Majorie, van Asseldonk, Gerdie, Drenth, Jacqueline and Schuurman, Caroelien (Ed.). Informatorium voor Voeding en Dietetiek - Supplement 100 - December 2018 pp. 65-88 Bohn Stafleu van Loghum. https://doi.org/10.1007/978-90-368-2223-7_5
Single versus split dose of iron optimizes hemoglobin mass gains at 2106 m altitude
Hall, Rebecca, Peeling, Peter, Nemeth, Elizabeta, Bergland, Dan, McCluskey, Walter T. P. and Stellingwerff, Trent. (2019). Single versus split dose of iron optimizes hemoglobin mass gains at 2106 m altitude. Medicine and Science in Sports and Exercise. 51(4), pp. 751-759. https://doi.org/10.1249/MSS.0000000000001847
Short-term muscle disuse induces a rapid and sustained decline in daily myofibrillar protein synthesis rates
Kilroe, Sean P., Fulford, Jonathan, Holwerda, Andrew M., Jackman, Sarah R., Lee, Benjamin P., Gijsen, Annemie P., van Loon, Luc J. C. and Wall, Benjamin T.. (2019). Short-term muscle disuse induces a rapid and sustained decline in daily myofibrillar protein synthesis rates. American Journal of Physiology - Endocrinology and Metabolism. 318(2), pp. E117-E130. https://doi.org/10.1152/ajpendo.00360.2019
The intrinsically labeled protein approach is the preferred method to quantify the release of dietary protein-derived amino acids into the circulation
Jorn Trommelen, Andrew M. Holwerda, Jean Nyakayiru, Stefan H M Gorissen, Olav Rooyackers, Nicholas A Burd, Yves Boirie and Luc J. C. Van Loon. (2019). The intrinsically labeled protein approach is the preferred method to quantify the release of dietary protein-derived amino acids into the circulation. American Journal of Physiology - Endocrinology and Metabolism. 317(3), pp. 433-434. https://doi.org/10.1152/ajpendo.00155.2019
Nutrition and Altitude: Strategies to Enhance Adaptation, Improve Performance and Maintain Health: A Narrative Review
Trent Stellingwerff, Peter Peeling, Laura Lewis, Rebecca Hall, Anu Koivisto, Ida A Heikura and Louise Burke. (2019). Nutrition and Altitude: Strategies to Enhance Adaptation, Improve Performance and Maintain Health: A Narrative Review. Sports Medicine. 49, pp. 169-184. https://doi.org/10.1007/s40279-019-01159-w
Fructose co-ingestion to increase carbohydrate availability in athletes
Cas J. Fuchs, Javier T. Gonzalez and Luc J. C. Van Loon. (2019). Fructose co-ingestion to increase carbohydrate availability in athletes. The Journal of Physiology. 597(14), pp. 3549-3560. https://doi.org/10.1113/JP277116
Dietary Protein and Physical Activity Interventions to Support Muscle Maintenance in End-Stage Renal Disease Patients on Hemodialysis
Floris K. Hendriks, Joey S J Smeets, Frank M van der Sande, Jeroen P Kooman and Lucas Van Loon. (2019). Dietary Protein and Physical Activity Interventions to Support Muscle Maintenance in End-Stage Renal Disease Patients on Hemodialysis. Nutrients. 11(12), pp. 1-13. https://doi.org/10.3390/nu11122972
The Muscle Protein Synthetic Response to Meal Ingestion Following Resistance-Type Exercise
Jorn Trommelen, Milan W Betz and Luc Van Loon. (2019). The Muscle Protein Synthetic Response to Meal Ingestion Following Resistance-Type Exercise. Sports Medicine. 49(2), pp. 185-197. https://doi.org/10.1007/s40279-019-01053-5
Editorial: Cross Adaptation and Cross Tolerance in Human Health and Disease
Ben James Lee, Oliver R Gibson, Charles Douglas Thake, Mike Tipton, John Hawley and James D Cotter. (2019). Editorial: Cross Adaptation and Cross Tolerance in Human Health and Disease. Frontiers in Physiology. 9, pp. 1-3. https://doi.org/10.3389/fphys.2018.01827
Exercising to offset muscle mass loss in hemodialysis patients: The disconnect between intention and intervention
Colleen F. McKenna, Amadeo F. Salvador, Floris K. Hendriks, Alana P. Y. Harris, Luc J. C. Van Loon and Nicholas A. Burd. (2019). Exercising to offset muscle mass loss in hemodialysis patients: The disconnect between intention and intervention. Seminars in Dialysis. 32(4), pp. 379-385. https://doi.org/10.1111/sdi.12805
Perioperative nutritional supplementation and skeletal muscle mass in older hip-fracture patients
Irene Fleur Kramer, Taco J. Blokhuis, Lex B. Verdijk, Luc Van Loon and Martijn Poeze. (2019). Perioperative nutritional supplementation and skeletal muscle mass in older hip-fracture patients. Nutrition Reviews. 77(4), pp. 254-266. https://doi.org/10.1093/nutrit/nuy055
Between-meal sucrose-sweetened beverage consumption impairs glycaemia and lipid metabolism during prolonged sitting : A randomized controlled trial
Varsamis, Pia, Formosa, Melissa F., Larsen, Robyn N., Reddy-Luthmoodoo, Medini, Jennings, Garry L., Cohen, Neale D., Grace, Megan S., Hawley, John A., Devlin, Brooke L., Owen, Neville, Dunstan, David W., Dempsey, Paddy C. and Kingwell, Bronwyn A.. (2019). Between-meal sucrose-sweetened beverage consumption impairs glycaemia and lipid metabolism during prolonged sitting : A randomized controlled trial. Clinical Nutrition. 38(4), pp. 1536-1543. https://doi.org/10.1016/j.clnu.2018.08.021
A single bout of strenuous exercise overcomes lipid-induced anabolic resistance to protein ingestion in overweight, middle-aged men
Smiles, William J., Churchward-Venne, Tyler A., van Loon, Luc J. C., Hawley, John A. and Camera, Donny M.. (2019). A single bout of strenuous exercise overcomes lipid-induced anabolic resistance to protein ingestion in overweight, middle-aged men. The FASEB Journal. 33(6), pp. 7009 - 7017. https://doi.org/10.1096/fj.201801917R
Nutrition and altitude: Strategies to enhance adaptation, improve performance and maintain health: A narrative review
Stellingwerff, Trent, Peeling, Peter, Garvican‑Lewis, Laura A., Hall, Rebecca, Koivisto, Anu E., Heikura, Ida A. and Burke, Louise M.. (2019). Nutrition and altitude: Strategies to enhance adaptation, improve performance and maintain health: A narrative review. Sports Medicine. 49(Supplement 2), pp. 169 - 184. https://doi.org/10.1007/s40279-019-01159-w
One week of step reduction lowers myofibrillar protein synthesis rates in young men
Shad, Brandon J., Thompson, Janice L., Holwerda, Andrew M., Stocks, Ben, Elhassan, Yasir S., Philp, Andrew, Van Loon, Luc J. C. and Wallis, Gareth A.. (2019). One week of step reduction lowers myofibrillar protein synthesis rates in young men. Medicine and Science in Sports and Exercise. 51(10), pp. 2125 - 2134. https://doi.org/10.1249/MSS.0000000000002034
Winter peaks in heart failure: An inevitable or preventable consequence of seasonal vulnerability?
Stewart, Simon, Moholdt, Trine T., Burrell, Louise M., Sliwa, Karen, Mocumbi, Ana O., McMurray, John J. V., Keates, Ashley K. and Hawley, John A.. (2019). Winter peaks in heart failure: An inevitable or preventable consequence of seasonal vulnerability? Cardiac Failure Review. 5(2), pp. 83 - 85. https://doi.org/10.15420/cfr.2018.40.2
Leucine co-ingestion augments the muscle protein synthetic response to the ingestion of 15 g protein following resistance exercise in older men
Holwerda, Andrew M., Paulussen, Kevin J. M., Overkamp, Maarten, Goessens, Joy P. B., Kramer, Irene-Fleur, Wodzig, Will K. W. H., Verdijk, Lex B., de Groot, Lisette C.P.G.M. and van Loon, Luc J. C.. (2019). Leucine co-ingestion augments the muscle protein synthetic response to the ingestion of 15 g protein following resistance exercise in older men. American Journal of Physiology - Endocrinology and Metabolism. 317(3), pp. 473 - 482. https://doi.org/10.1152/ajpendo.00073.2019
Dietary feeding pattern does not modulate the loss of muscle mass or the decline in metabolic health during short-term bed rest
Dirks, Marlou L., Smeets, Joey S. J., Holwerda, Andrew M., Kouw, Imre W. K., Marzuca-Nassr, Gabriel N., Gijsen, Annemie P., Holloway, Graham P., Verdijk, Lex B. and van Loon, Luc J. C.. (2019). Dietary feeding pattern does not modulate the loss of muscle mass or the decline in metabolic health during short-term bed rest. American Journal of Physiology - Endocrinology and Metabolism. 316(3), pp. 536 - 545. https://doi.org/10.1152/ajpendo.00378.2018
Prevalence and profile of "seasonal frequent flyers" with chronic heart disease: Analysis of 1598 patients and 4588 patient-years follow-up
Loader, Jordan, Chan, Yih-Kai, Hawley, John A., Moholdt, Trine, McDonald, Christine F., Jhund, Pardeep, Petrie, Mark C., McMurray, John J., Scuffham, Paul A., Ramchand, Jay, Burrell, Louise M. and Stewart, Simon. (2019). Prevalence and profile of "seasonal frequent flyers" with chronic heart disease: Analysis of 1598 patients and 4588 patient-years follow-up. International Journal of Cardiology. 279, pp. 126 - 132. https://doi.org/10.1016/j.ijcard.2018.12.060
Coordinated regulation of skeletal muscle mass and metabolic plasticity during recovery from disuse
Kneppers, Anita, Leermakers, Pieter, Pansters, Nicholas, Backx, Evelien, Gosker, Harry, van Loon, Luc, Schols, Annemie, Langen, Ramon and Verdijk, Lex. (2019). Coordinated regulation of skeletal muscle mass and metabolic plasticity during recovery from disuse. The FASEB Journal. 33(1), pp. 1288 - 1298. https://doi.org/10.1096/fj.201701403RRR
Time-dependent regulation of postprandial muscle protein synthesis rates after milk protein ingestion in young men
Vliet, Stephan Van, Beals, Joseph W., Holwerda, Andrew M., Emmons, Russell S., Goessens, Joy P., Paluska, Scott A., Lisio, Michael De, van Loon, Luc J. C. and Burd, Nicholas A.. (2019). Time-dependent regulation of postprandial muscle protein synthesis rates after milk protein ingestion in young men. Journal of Applied Physiology. 127(6), pp. 1792 - 1801. https://doi.org/10.1152/japplphysiol.00608.2019
Ascorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: Findings of a randomized cross-over trial
Mason, Shaun A., Rasmussen, Bodil, van Loon, Luc J. C., Salmon, Jo and Wadley, Glenn D.. (2019). Ascorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: Findings of a randomized cross-over trial. Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics. 21(3), pp. 674 - 682. https://doi.org/10.1111/dom.13571
Blood flow restricted resistance exercise and reductions in oxygen tension attenuate mitochondrial H2O2 emission rates in human skeletal muscle
Petrick, Heather L., Pignanelli, Christopher, Barbeau, Pierre-Andre, Churchward-Venne, Tyler A., Dennis, Kaitlyn M. J. H., van Loon, Luc J. C., Burr, Jamie F., Goossens, Gijs H. and Holloway, Graham P.. (2019). Blood flow restricted resistance exercise and reductions in oxygen tension attenuate mitochondrial H2O2 emission rates in human skeletal muscle. The Journal of Physiology. 597(15), pp. 3985 - 3997. https://doi.org/10.1113/JP277765
The effect of minimally invasive surgical aortic valve replacement on postoperative pulmonary and skeletal muscle function
Boujemaa, Hajar, Yilmaz, Alaaddin, Robic, Boris, Koppo, Katrien, Claessen, Guido, Frederix, Ines, Dendale, Paul, Völler, Heinz, van Loon, Luc J. C. and Hansen, Dominique. (2019). The effect of minimally invasive surgical aortic valve replacement on postoperative pulmonary and skeletal muscle function. Experimental Physiology. 104(6), pp. 855 - 865. https://doi.org/10.1113/EP087407
Phenotypic responses to a lifestyle intervention do not account for inter-individual variability in glucose tolerance for individuals at high risk of type 2 diabetes
O'Donoghue, Grainne, Kennedy, Aileen, Andersen, Gregers S., Carr, Bernadette, Cleary, Stephen, Durkan, Eoin, Davis, Heidi, Faerch, Kristine, Fitzpatrick, Paula, Kenny, Helena, McCaffrey, Noel, Monedero, Javier, Murphy, Enda, Noone, John, Suvitaival, Tommi, Thybo, Tanja, Wheeler, Michael, Vistissen, Dorte, Nolan, John J. and O'Gorman, Donal J.. (2019). Phenotypic responses to a lifestyle intervention do not account for inter-individual variability in glucose tolerance for individuals at high risk of type 2 diabetes. Frontiers in Physiology. 10(317), pp. 1 - 12. https://doi.org/10.3389/fphys.2019.00317
Leucine co-ingestion augments the muscle protein synthetic response to the ingestion of 15 g protein following resistance exercise in older men
Holwerda, Andrew M., Paulussen, Kevin J. M., Overkamp, Maarten, Goessens, Joy P. B., Kramer, Irene-Fleur, Wodzig, Will K. W. H., Verdijk, Lex B., de Groot, Lisette C. P. G. M. and Van Loon, Luc. (2019). Leucine co-ingestion augments the muscle protein synthetic response to the ingestion of 15 g protein following resistance exercise in older men. In In A. M. Holwerda (Ed.). Dietary protein to support active aging pp. 53 - 73 Maastricht University. https://doi.org/10.26481/dis.20190321ah
Study design and methods for the ACTIVity And TEchnology (ACTIVATE) trial
Brigid M Lynch, Nga Nguyen, Marina M. Reeves, Melissa Moore, Dori E Rosenberg, Michael Wheeler, Terry Boyle, Jeff K. Vallance, Christine M Friedenreich and Dallas English. (2018). Study design and methods for the ACTIVity And TEchnology (ACTIVATE) trial. Contemporary Clinical Trials. 64, pp. 112-117. https://doi.org/10.1016/j.cct.2017.10.015
The effect of beetroot juice supplementation on dynamic apnea and intermittent sprint performance in elite female water polo playres
Jonvik, Kristin L., van Dijk, Jan Willem, Senden, Joan M. G., van Loon, Luc J. C. and Verdijk, Lex B.. (2018). The effect of beetroot juice supplementation on dynamic apnea and intermittent sprint performance in elite female water polo playres. International Journal of Sport Nutrition and Exercise Metabolism. 28(5), pp. 468-473. https://doi.org/10.1123/ijsnem.2017-0293
Age-Associated Impairments in Mitochondrial ADP Sensitivity Contribute to Redox Stress in Senescent Human Skeletal Muscle
Holloway, Graham P., Holwerda, Andrew M., Miotto, Paula M., Dirks, Marlou L., Verdijk, Lex B. and Van Loon, Luc. (2018). Age-Associated Impairments in Mitochondrial ADP Sensitivity Contribute to Redox Stress in Senescent Human Skeletal Muscle. Cell Reports. 22(11), pp. 2837 - 2848. https://doi.org/10.1016/j.celrep.2018.02.069
Daily resistance-type exercise stimulates muscle protein synthesis in vivo in young men
Holwerda, Andrew M., Paulussen, Kevin J. M., Overkamp, Maarten, Smeets, Joey S. J., Gijsen, Annemie P., Goessens, Joy P. B., Verdijk, Lex B. and Van Loon, Luc. (2018). Daily resistance-type exercise stimulates muscle protein synthesis in vivo in young men. Journal of Applied Physiology. 124(1), pp. 66 - 75. https://doi.org/10.1152/japplphysiol.00610.2017
Effects of providing high-fat versus high-carbohydrate meals on daily and postprandial physical activity and glucose patterns: a randomised controlled trial
Parr, Evelyn, Devlin, Brooke, Callahan, Marcus J., Radford, Bridget, Blankenship, Jennifer M., Dunstan, David and Hawley, John. (2018). Effects of providing high-fat versus high-carbohydrate meals on daily and postprandial physical activity and glucose patterns: a randomised controlled trial. Nutrients. 10(5), pp. 1 - 16. https://doi.org/10.3390/nu10050557
Temporal response of angiogenesis and hypertrophy to resistance training in young men
Holloway, Tanya M., Snijders, Tim, van Kranenburg, Janneau, Van Loon, Luc and Verdijk, Lex B.. (2018). Temporal response of angiogenesis and hypertrophy to resistance training in young men. Medicine and Science in Sports and Exercise. 50(1), pp. 36 - 45. https://doi.org/10.1249/MSS.0000000000001409
Muscle atrophy due to nerve damage is accompanied by elevated myofibrillar protein synthesis rates
Langer, Henning, Senden, Joan M., Gijsen, Annemie P., Kempa, Stefan, van Loon, Luc and Spuler, Simone. (2018). Muscle atrophy due to nerve damage is accompanied by elevated myofibrillar protein synthesis rates. Frontiers in Physiology. 9(1220), pp. 1 - 10. https://doi.org/10.3389/fphys.2018.01220
Reply: measurement of regional rates of protein synthesis in human brain in vivo with l-[1-11c]-leucine PET
Smeets, Joey S.J and Van Loon, Luc. (2018). Reply: measurement of regional rates of protein synthesis in human brain in vivo with l-[1-11c]-leucine PET. Brain: a journal of neurology. 141(7), pp. 52 - 52. https://doi.org/10.1093/brain/awy119
Impact of first meal size during prolonged sitting on postprandial glycaemia in individuals with prediabetes: a randomised, crossover study
Parr, Evelyn, Devlin, Brooke, Pinto, Samuel, Dunstan, David and Hawley, John. (2018). Impact of first meal size during prolonged sitting on postprandial glycaemia in individuals with prediabetes: a randomised, crossover study. Nutrients. 10(6), pp. 1 - 15. https://doi.org/10.3390/nu10060733
Interacting effects of exercise with breaks in sitting time on cognitive and metabolic function in older adults: rationale and design of a randomised crossover trial
Dunstan, David, Wheeler, Michael, Ellis, Kathryn A.H., Cerin, Ester and Green, Daniel. (2018). Interacting effects of exercise with breaks in sitting time on cognitive and metabolic function in older adults: rationale and design of a randomised crossover trial. Mental Health and Physical Activity. 15, pp. 11 - 16. https://doi.org/10.1016/j.mhpa.2018.05.003
Skeletal muscle fiber characteristics in patients with chronic heart failure: Impact of disease severity and relation with muscle oxygenation during exercise
Niemeijer, Victor M., Snijders, Tim, Verdijk, Lex B., Van Kranenburg, Janneau, Groen, Bart B.L., Holwerda, Andrew M., Spee, Ruud F., Wijn, Pieter F. F., van Loon, Luc and Kemps, Hareld M.C.. (2018). Skeletal muscle fiber characteristics in patients with chronic heart failure: Impact of disease severity and relation with muscle oxygenation during exercise. Journal of Applied Physiology. 125(4), pp. 1266 - 1276. https://doi.org/10.1152/japplphysiol.00057.2018
Dose-response effects of supplementation with calcifediol on serum 25-hydroxyvitamin D status and its metabolites: a randomized controlled trial in older adults
Vaes, Anouk M.M., Tieland, Michael, de Regt, Margot F., Wittwer, Jonas, van Loon, Luc and de Groot, Lisette C.P.G.M.. (2018). Dose-response effects of supplementation with calcifediol on serum 25-hydroxyvitamin D status and its metabolites: a randomized controlled trial in older adults. Clinical Nutrition. 37(3), pp. 808 - 814. https://doi.org/10.1016/j.clnu.2017.03.029
Reply: measurement of regional rates of protein synthesis in human brain in vivo with l-[1-11c]-leucine PET
Smeets, Joey S.J and Van Loon, Luc. (2018). Reply: measurement of regional rates of protein synthesis in human brain in vivo with l-[1-11c]-leucine PET. Brain: a journal of neurology. 141(7), pp. 52 - 52. https://doi.org/10.1093/brain/awy119
Increasing vegetable intake to obtain the health promoting and ergogenic effects of dietary nitrate
Van der Avoort, Cindy M. T., van Loon, Luc, Hopman, Maria T. and Verdijk, Lex B.. (2018). Increasing vegetable intake to obtain the health promoting and ergogenic effects of dietary nitrate. European Journal of Clinical Nutrition. 72, pp. 1485 - 1489. https://doi.org/10.1038/s41430-018-0140-z
Effects of creatine and carbohydrate loading on cycling time trial performance
Tomcik, Kristyen A., Camera, Donny, Bone, Julia L. L., Ross, Meg, Jeacocke, N. A., Tachtsis, Bill, Senden, Joan M., Van Loon, Luc, Hawley, John and Burke, Louise. (2018). Effects of creatine and carbohydrate loading on cycling time trial performance. Medicine and Science in Sports and Exercise. 50(1), pp. 141 - 150. https://doi.org/10.1249/MSS.0000000000001401
Sending the signal: Muscle glycogen availability as a regulator of training adaptation
Hawley, John A.. (2018). Sending the signal: Muscle glycogen availability as a regulator of training adaptation. In In B. Spiegelman (Ed.). Hormones, metabolism and the benefits of exercise pp. 43 - 55 Springer Nature. https://doi.org/10.1007/978-3-319-72790-5_4
IOC consensus statement: dietary supplements and the high-performance athlete0306
Maughan, Ronald J., Burke, Louise, Dvorak, Jiri, Larson-Meyer, D. E., Peeling, Peter, Phillips, Stuart M., Rawson, Eric S., Walsh, Neil P., Garthe, Ina, Geyer, Hans, Meeusen, Romain, Van Loon, Luc, Shirreffs, Susan M., Spriet, Lawrence L., Stuart, Mark, Vernec, Alan, Currell, Kevin, Ali, Vidya M., Budgett, Richard, ... Engebretsen, Lars. (2018). IOC consensus statement: dietary supplements and the high-performance athlete0306. British Journal of Sports Medicine. 52(7), pp. 439 - 455. https://doi.org/10.1136/bjsports-2018-099027
Organization of dietary control for nutrition-training intervention involving periodized carbohydrate availability and ketogenic low-carbohydrate high-fat diet
Mirtschin, Joanne G., Forbes, Sara F., Cato, Louise E., Heikura, Ida A., Strobel, Nicki, Hall, Rebecca and Burke, Louise M.. (2018). Organization of dietary control for nutrition-training intervention involving periodized carbohydrate availability and ketogenic low-carbohydrate high-fat diet. International Journal of Sport Nutrition and Exercise Metabolism. 28(5), pp. 480 - 489. https://doi.org/10.1123/ijsnem.2017-0249
Swifter, higher, stronger: what's on the menu?
Burke, Louise M. and Hawley, John A.. (2018). Swifter, higher, stronger: what's on the menu? Science. 362(6416), pp. 781 - 787. https://doi.org/10.1126/science.aau2093
The 2017 dutch physical activity guidelines
Weggemans, Rianne M., Backx, Frank J.G., Borghouts, Lars, Chinapaw, Mai J.M., Hopman, Maria T., Koster, Annemarie, Kremers, Stef, Van Loon, Luc, May, Anne M., Mosterd, Arend, van der Ploeg, Hidde, Takken, Tim, Visser, Marjolein, Wendel-Vos, Wanda and de Geus, Eco J.C.. (2018). The 2017 dutch physical activity guidelines. International Journal of Behavioral Nutrition and Physical Activity. 15(58), pp. 1 - 12. https://doi.org/10.1186/s12966-018-0661-9
Interventional strategies to combat muscle disuse atrophy in humans: Focus on neuromuscular electrical stimulation and dietary protein
Dirks, Marlou L., Wall, Benjamin T. and van Loon, Luc. (2018). Interventional strategies to combat muscle disuse atrophy in humans: Focus on neuromuscular electrical stimulation and dietary protein. Journal of Applied Physiology. 125(3), pp. 850 - 861. https://doi.org/10.1152/japplphysiol.00985.2016
IOC Consensus Statement: Dietary Supplements and the High-Performance Athlete
Maughan, Ronald J., Burke, Louise, Dvorak, Jiri, Larson-Meyer, D. E., Peeling, Peter, Phillips, Stuart M., Rawson, Eric S., Walsh, Neil P., Garthe, Ina, Geyer, Hans, Meeusen, Romain, Van Loon, Luc, Shirreffs, Susan M., Spriet, Lawrence L., Stuart, Mark, Vernec, Alan, Currell, Kevin, Ali, Vidya M., Budgett, Richard, ... Engebretsen, Lars. (2018). IOC Consensus Statement: Dietary Supplements and the High-Performance Athlete. International Journal of Sport Nutrition and Exercise Metabolism. 28(2), pp. 104 - 125. https://doi.org/10.1123/ijsnem.2018-0020
Effect of resistance training and protein intake pattern on myofibrillar protein synthesis and proteome kinetics in older men in energy restriction
Murphy, Caoileann, Shankaran, Mahalakshmi, Churchward-Venne, T. A., Mitchell, Cameron J., Kolar, Nathan M., Burke, Louise, Hawley, John, Kassis, Amira, Karagounis, Leonidas G., Li, Kelvin, King, Chelsea, Hellerstein, Marc and Phillips, S. M.. (2018). Effect of resistance training and protein intake pattern on myofibrillar protein synthesis and proteome kinetics in older men in energy restriction. The Journal of Physiology. 596(11), pp. 2091 - 2120. https://doi.org/10.1113/JP275246
A novel in vitro model for the assessment of postnatal myonuclear accretion
Kneppers, Anita, Verdijk, Lex B., de Theije, Chiel, Corten, Mark, Gielen, Ellis, van Loon, Luc, Schols, Annemie and Langen, Ramon. (2018). A novel in vitro model for the assessment of postnatal myonuclear accretion. Skeletal Muscle. 8(4), pp. 1 - 13. https://doi.org/10.1186/s13395-018-0151-4
Protein supplementation after exercise and before sleep does not further augment muscle mass and strength gains during resistance exercise training in active older men
Holwerda, Andrew M., Overkamp, Maarten, Paulussen, Kevin J. M., Smeets, Joey S. J., Van Kranenburg, Janneau, Backx, E. M. P., Gijsen, Annemie P., Goessens, Joy P. B., Verdijk, Lex B. and van Loon, Luc. (2018). Protein supplementation after exercise and before sleep does not further augment muscle mass and strength gains during resistance exercise training in active older men. The Journal of Nutrition. 148(11), pp. 1723 - 1732. https://doi.org/10.1093/jn/nxy169
Protein content and amino acid composition of commercially available plant-based protein isolates
Gorissen, Stefan H. M., Crombag, Julie J. R., Senden, Joan M., Huub Waterval, W. A., Bierau, Jörgen, Verdijk, Lex B. and van Loon, Luc. (2018). Protein content and amino acid composition of commercially available plant-based protein isolates. Amino Acids. 50(12), pp. 1685 - 1695. https://doi.org/10.1007/s00726-018-2640-5
Leucine supplementation does not attenuate skeletal muscle loss during leg immobilization in healthy, young men
Backx, E. M. P., Horstman, Astrid M. H., Marzuca-Nassr, Gabriel N., Van Kranenburg, Janneau, Smeets, Joey S. J., Fuchs, Cas J., Janssen, Anniek A. W., de Groot, Lisette C. P. G. M., Snijders, Tim, Verdijk, Lex B. and van Loon, Luc. (2018). Leucine supplementation does not attenuate skeletal muscle loss during leg immobilization in healthy, young men. Nutrients. 10(635), pp. 1 - 12. https://doi.org/10.3390/nu10050635
Protein availability and satellite cell dynamics in skeletal muscle
Shamim, Baubak, Hawley, John and Camera, Donny. (2018). Protein availability and satellite cell dynamics in skeletal muscle. Sports Medicine. 48(6), pp. 1329 - 1343. https://doi.org/10.1007/s40279-018-0883-7
Brain tissue plasticity: protein synthesis rates of the human brain0006
Smeets, Joey S. J., Horstman, Astrid M. H., Schijns, Olaf E. M. G., Dings, Jim T. A., Hoogland, Govert, Gijsen, Annemie P., Goessens, Joy P. K., Bouwman, Freek G., Wodzig, Will K. W. H., Mariman, Edwin C. and Van Loon, Luc. (2018). Brain tissue plasticity: protein synthesis rates of the human brain0006. Brain: a journal of neurology. 141(4), pp. 1122 - 1129. https://doi.org/10.1093/brain/awy015
Adipose tissue lipolytic inhibition enhances the glucoregulatory properties of exercise in type 2 diabetes patients
Hansen, Dominique, Verboven, Kenneth, van Dijk, Jan Willem, Zorenc, Antoine H., Minten, Lennert, Smeets, Kevin, Verdijk, Lex B. and Van Loon, Luc. (2018). Adipose tissue lipolytic inhibition enhances the glucoregulatory properties of exercise in type 2 diabetes patients. European Journal of Sport Science. 18(9), pp. 1245 - 1254. https://doi.org/10.1080/17461391.2018.1483428
Sodium nitrate supplementation alters mitochondrial H2O2 emission but does not improve mitochondrial oxidative metabolism in the heart of healthy rats
Monaco, Cynthia, Miotto, Paula M., Huber, Jason S., Van Loon, Luc, Simpson, Jeremy A. and Holloway, Graham P.. (2018). Sodium nitrate supplementation alters mitochondrial H2O2 emission but does not improve mitochondrial oxidative metabolism in the heart of healthy rats. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 315(2), pp. 191 - 204. https://doi.org/10.1152/ajpregu.00275.2017
Human metabolomics reveal daily variations under nutritional challenges specific to serum and skeletal muscle
Sato, Shogo, Evelyn, Parr B., Devlin, Brooke L., Hawley, John A. and Sassone-Corsi, Paolo. (2018). Human metabolomics reveal daily variations under nutritional challenges specific to serum and skeletal muscle. Molecular Metabolism. 16, pp. 1-11. https://doi.org/10.1016/j.molmet.2018.06.008
Toward a common understanding of diet-exercise strategies to manipulate fuel availability for training and competition preparation in endurance sport
Burke, Louise, Hawley, John, Jeukendrup, A. E., Morton, James P., Stellingwerff, T. and Maughan, Ronald J.. (2018). Toward a common understanding of diet-exercise strategies to manipulate fuel availability for training and competition preparation in endurance sport. International Journal of Sport Nutrition and Exercise Metabolism. 28(5), pp. 451 - 463. https://doi.org/10.1123/ijsnem.2018-0289
The effect of acute and 7-days dietary nitrate on mechanical efficiency, exercise performance and cardiac biomarkers in patients with chronic obstructive pulmonary disease
Beijers, Rosanne J. H. C. G., Huysmans, Stephanie M. D., van de Bool, Coby, Kingma, Boris R. M., Verdijk, Lex B., Van Loon, Luc, Meex, Steven J. R., Gosker, Harry R. and Schols, Annemie M. W. J.. (2018). The effect of acute and 7-days dietary nitrate on mechanical efficiency, exercise performance and cardiac biomarkers in patients with chronic obstructive pulmonary disease. Clinical Nutrition. 37(6), pp. 1852 - 1861. https://doi.org/10.1016/j.clnu.2017.10.011
Repeated-sprint performance and plasma responses following beetroot juice supplementation do not differ between recreational, competitive and elite sprint athletes
Jonvik, Kristin L., Nyakayiru, Jean, van Dijk, Jan Willem, Maase, K., Ballak, S. B., Senden, Joan M., van Loon, Luc and Verdijk, Lex B.. (2018). Repeated-sprint performance and plasma responses following beetroot juice supplementation do not differ between recreational, competitive and elite sprint athletes. European Journal of Sport Science. 18(4), pp. 524 - 533. https://doi.org/10.1080/17461391.2018.1433722
Molecular basis of exercise-induced skeletal muscle mitochondrial biogenesis: Historical advances, current knowledge, and future challenges
Perry, Christopher G. R. and Hawley, John. (2018). Molecular basis of exercise-induced skeletal muscle mitochondrial biogenesis: Historical advances, current knowledge, and future challenges. Cold Spring Harbor Perspectives in Medicine. 8(9), pp. 1 - 15. https://doi.org/10.1101/cshperspect.a029686
Adaptations to concurrent training in combination with high protein availability: A comparative trial in healthy, recreationally active men
Shamim, Baubak, Devlin, Brooke L., Timmins, Ryan G., Tofari, Paul, Dow, Connor Lee, Coffey, Vernon G., Hawley, John A. and Camera, Donny M.. (2018). Adaptations to concurrent training in combination with high protein availability: A comparative trial in healthy, recreationally active men. Sports Medicine. 48(12), pp. 2869 - 2883. https://doi.org/10.1007/s40279-018-0999-9
High dietary fat intake increases fat oxidation and reduces skeletal muscle mitochondrial respiration in trained humans
Leckey, Jill J., Hoffman, Nolan J., Parr, Evelyn B., Devlin, Brooke L., Trewin, Adam J., Stepto, Nigel K., Morton, James P., Burke, Louise M. and Hawley, John A.. (2018). High dietary fat intake increases fat oxidation and reduces skeletal muscle mitochondrial respiration in trained humans. FASEB Journal. 32(6), pp. 2979-2991. https://doi.org/10.1096/fj.201700993R
Maximizing cellular adaptation to endurance exercise in skeletal muscle
Hawley, John, Lundby, Carsten, Cotter, James D. and Burke, Louise. (2018). Maximizing cellular adaptation to endurance exercise in skeletal muscle. Cell Metabolism. 27(5), pp. 962 - 976. https://doi.org/10.1016/j.cmet.2018.04.014
Reply: measurement of regional rates of protein synthesis in human brain in vivo with l-[1-11c]-leucine PET
Smeets, Joey S.J. and Van Loon, Luc. (2018). Reply: measurement of regional rates of protein synthesis in human brain in vivo with l-[1-11c]-leucine PET. Brain: a journal of neurology. 141(7), pp. 52 - 52. https://doi.org/10.1093/brain/awy119
Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in patients with mitochondrial myopathy
Nabben, Miranda, Schmitz, Joep P. J., Ciapaite, Jolita, le Clercq, Carlijn M. P., van Riel, Natal A., Haak, Harm R., Nicolay, Klaas, de Coo, Irenaeus F. M., Smeets, Hubert, Praet, Stephan F., van Loon, Lucas J. and Prompers, Jeanine J.. (2017). Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in patients with mitochondrial myopathy. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 312(5), pp. R689-R701. https://doi.org/10.1152/ajpregu.00264.2016
Detection of localized hepatocellular amino acid kinetics by using mass spectrometry imaging of stable isotopes
Arts, Martijn, Soons, Zita, Ellis, Shane R., Pierzchalski, Keely A., Balluff, Benjamin, Eijkel, Gert B., Dubois, Ludwig J., Lieuwes, Natasja G., Agten, Stijn M., Hackeng, Tilman M., Van Loon, Luc, Heeren, Ron M.A. and Damink, Steven W.O.. (2017). Detection of localized hepatocellular amino acid kinetics by using mass spectrometry imaging of stable isotopes. Angewandte Chemie. 56(25), pp. 7146 - 7150. https://doi.org/10.1002/anie.201702669
Post-exercise muscle glycogen resynthesis in humans
Burke, Louise M., van Loon, Luc J. C. and Hawley, John A.. (2017). Post-exercise muscle glycogen resynthesis in humans. Journal of Applied Physiology. 122(5), pp. 1055-1067. https://doi.org/0.1152/japplphysiol.00860.2016
The impact of dietary protein or amino acid supplementation on muscle mass and strength in elderly people: individual participant data and meta-analysis of rct's
Tieland, Michael, Franssen, Rinske, Dullemeijer, C., van Dronkelaar, C., Kim, H. K., Ispoglou, T., Zhu, Kun, Prince, R. L., Van Loon, Luc and de Groot, Lisette C.P.G.M.. (2017). The impact of dietary protein or amino acid supplementation on muscle mass and strength in elderly people: individual participant data and meta-analysis of rct's. Journal of Nutrition, Health and Aging. 21(9), pp. 994 - 1001. https://doi.org/10.1007/s12603-017-0896-1
Ketone diester ingestion impairs time-trial performance in professional cyclists
Leckey, Jill J., Ross, Megan L., Quod, Marc, Hawley, John A. and Burke, Louise M.. (2017). Ketone diester ingestion impairs time-trial performance in professional cyclists. Frontiers in Physiology. 8(OCT), pp. 1 - 10. https://doi.org/10.3389/fphys.2017.00806
Fenugreek increases insulin-stimulated creatine content in l6C11 muscle myotubes
Tomcik, Kristyen, Smiles, William, Camera, Donny, Hugel, Helmut M., Hawley, John and Watts, Rani. (2017). Fenugreek increases insulin-stimulated creatine content in l6C11 muscle myotubes. European Journal of Nutrition. 56(3), pp. 973 - 979. https://doi.org/10.1007/s00394-015-1145-1
Acute low-intensity cycling with blood-flow restriction has no effect on metabolic signaling in human skeletal muscle compared to traditional exercise
Smiles, William J., Conceição, Miguel S., Telles, Guilherme D., Chacon-Mikahil, Mara P. T., Cavaglieri, Cláudia R., Vechin, Felipe C., Libardi, Cleiton A., Hawley, John A. and Camera, Donny M.. (2017). Acute low-intensity cycling with blood-flow restriction has no effect on metabolic signaling in human skeletal muscle compared to traditional exercise. European Journal of Applied Physiology. 117(2), pp. 345-358. https://doi.org/10.1007/s00421-016-3530-8
Single and combined effects of beetroot crystals and sodium bicarbonate on 4-km cycling time trial performance
Callahan, Marcus J., Parr, Evelyn B., Hawley, John A. and Burke, Louise M.. (2017). Single and combined effects of beetroot crystals and sodium bicarbonate on 4-km cycling time trial performance. International Journal of Sport Nutrition and Exercise Metabolism. 27(3), pp. 271-278. https://doi.org/10.1123/ijsnem.2016-0228
Neuromuscular electrical stimulation prior to presleep protein feeding stimulates the use of protein-derived amino acids for overnight muscle protein synthesis
Dirks, Marlou L., Groen, Bart B.L., Franssen, Rinske, van Kranenburg, Janneau and Van Loon, Luc. (2017). Neuromuscular electrical stimulation prior to presleep protein feeding stimulates the use of protein-derived amino acids for overnight muscle protein synthesis. Journal of Applied Physiology. 122(1), pp. 20 - 27. https://doi.org/10.1152/japplphysiol.00331.2016
Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health
Wheeler, Michael, Dempsey, Paddy C., Grace, Megan S., Ellis, Kathryn A., Gardiner, Paul A., Green, Daniel and Dunstan, David. (2017). Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health. Alzheimer's and Dementia: Translational Research and Clinical Interventions. 3(3), pp. 291 - 300. https://doi.org/10.1016/j.trci.2017.04.001
Muscle fiber capillarization as determining factor on indices of insulin sensitivity in humans
Snijders, Tim, Nederveen, Joshua P., Verdijk, Lex B., Houben, Alfons J.H.M., Goossens, Gijs H., Parise, Gianna and Van Loon, Luc. (2017). Muscle fiber capillarization as determining factor on indices of insulin sensitivity in humans. Physiological Reports. 5(10), pp. 1 - 5. https://doi.org/10.14814/phy2.13278
Similar metabolic response to lower- versus upper-body interval exercise or endurance exercise
Francois, Monique E., Graham, Matthew J., Parr, Evelyn, Rehrer, Nancy J., Lucas, Samuel J. E., Stavrianeas, Stasinos and Cotter, James D.. (2017). Similar metabolic response to lower- versus upper-body interval exercise or endurance exercise. Metabolism: Clinical and experimental. 68, pp. 1 - 10. https://doi.org/10.1016/j.metabol.2016.11.009
Postexercise muscle glycogen resynthesis in humans
Burke, Louise, Van Loon, Luc and Hawley, John. (2017). Postexercise muscle glycogen resynthesis in humans. Journal of Applied Physiology. 122(5), pp. 1055 - 1067. https://doi.org/10.1152/japplphysiol.00860.2016
Molecular basis of exercise-induced skeletal muscle mitochondrial biogenesis: Historical advances, current knowledge, and future challenges
Perry, Christopher G. R. and Hawley, John. (2017). Molecular basis of exercise-induced skeletal muscle mitochondrial biogenesis: Historical advances, current knowledge, and future challenges. In In J. R. Zierath, M. J. Joyner and J. A. Hawley (Ed.). The biology of exercise: A subject collection from Cold Spring Harbor Persepectives in Medicine pp. 73 - 87 Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/cshperspect.a029686
Consideration of insects as a source of dietary protein for human consumption
Churchward-Venne, T. A., Pinckaers, Philippe J. M., van Loon, Joop J. A. and Van Loon, Luc. (2017). Consideration of insects as a source of dietary protein for human consumption. Nutrition Reviews. 75(12), pp. 1035 - 1045. https://doi.org/10.1093/nutrit/nux057
Protein supplementation augments muscle fiber hypertrophy but does not modulate satellite cell content during prolonged resistance-type exercise training in frail elderly
Dirks, Marlou L., Tieland, Michael, Verdijk, Lex B., Losen, Mario, Nilwik, Rachel, Mensink, Marco, de Groot, Lisette C.P.G.M. and Van Loon, Luc. (2017). Protein supplementation augments muscle fiber hypertrophy but does not modulate satellite cell content during prolonged resistance-type exercise training in frail elderly. Journal of the American Medical Directors Association (JAMDA): long-term care: management, applied research and clinical issues. 18(7), pp. 608 - 615. https://doi.org/10.1016/j.jamda.2017.02.006
Glucose plus fructose ingestion for post exercise recovery greater than the sum of its parts?
Gonzalez, Javier T., Fuchs, Cas J., Betts, James A. and Van Loon, Luc. (2017). Glucose plus fructose ingestion for post exercise recovery greater than the sum of its parts? Nutrients. 9(4), pp. 1 - 15. https://doi.org/10.3390/nu9040344
Twenty-four-hour biological variation profiles of cardiac troponin I in individuals with or without chronic kidney disease
Van Der Linden, Noreen, Hilderink, Judith M., Cornelis, Tom, Kimenai, Dorien M., Klinkenberg, Lieke J.J., Van Doorn, William P., Litjens, Elisabeth J.R., Van Suijlen, Jeroen D.E., Van Loon, Luc, Bekers, Otto, Kooman, Jeroen P. and Meex, Steven J.R.. (2017). Twenty-four-hour biological variation profiles of cardiac troponin I in individuals with or without chronic kidney disease. Clinical Chemistry (Washington, DC): international journal of molecular diagnostics and laboratory medicine. 63(10), pp. 1655 - 1656. https://doi.org/10.1373/clinchem.2017.275107
Dietary protein intake and distribution patterns of well-trained Dutch athletes
Gillen, Jenna B., Trommelen, Jorn, Wardenaar, Floris C., Brinkmans, Naomi Y.J., Versteegen, Joline J., Jonvik, Kristin L., Kapp, Christoph, de Vries, Jeanne, van den Borne, Joost J.G.C., Gibala, M. J. and Van Loon, Luc. (2017). Dietary protein intake and distribution patterns of well-trained Dutch athletes. International Journal of Sport Nutrition and Exercise Metabolism. 27(2), pp. 105 - 114. https://doi.org/10.1123/ijsnem.2016-0154
Concurrent exercise training: Do opposites distract?
Coffey, Vernon and Hawley, John. (2017). Concurrent exercise training: Do opposites distract? The Journal of Physiology. 595(9), pp. 2883 - 2896. https://doi.org/10.1113/JP272270
Differential effects of leucine and leucine-enriched whey protein on skeletal muscle protein synthesis in aged mice
Dijk, Francina J., van Dijk, Miriam, Walrand, Stéphane, Van Loon, Luc, van Norren, Klaske and Luiking, Yvette C.. (2017). Differential effects of leucine and leucine-enriched whey protein on skeletal muscle protein synthesis in aged mice. Clinical Nutrition ESPEN. 24, pp. 127 - 133. https://doi.org/10.1016/j.clnesp.2017.12.013
Low carbohydrate, high fat diet impairs exercise economy and negates the performance benefit from intensified training in elite race walkers
Burke, Louise, Ross, Megan L.L., Garvican, Laura A., Welvaert, Marijke, Heikura, Ida A., Forbes, Sara G., Mirtschin, Jo, Cato, Louise E., Strobel, Nicki, Sharma, Avish P. and Hawley, John. (2017). Low carbohydrate, high fat diet impairs exercise economy and negates the performance benefit from intensified training in elite race walkers. The Journal of Physiology. 595(9), pp. 2785 - 2807. https://doi.org/10.1113/JP273230
Extensive type ii muscle fiber atrophy in elderly female hip fracture patients
Kramer, Irene F., Snijders, Tim, Smeets, Joey S.J., Leenders, Marika, van Kranenburg, Janneau, den Hoed, Marcel, Verdijk, Lex B., Poeze, Martijn and Van Loon, Luc. (2017). Extensive type ii muscle fiber atrophy in elderly female hip fracture patients. The Journals of Gerontology: Series A. 72(10), pp. 1369 - 1375. https://doi.org/10.1093/gerona/glw253
Dynamic proteome profiling of individual proteins in human skeletal muscle after a high-fat diet and resistance exercise
Camera, Donny M., Burniston, Jatin G., Pogson, Mark A., Smiles, William J. and Hawley, John A.. (2017). Dynamic proteome profiling of individual proteins in human skeletal muscle after a high-fat diet and resistance exercise. The FASEB Journal. 31(12), pp. 5478-5494. https://doi.org/10.1096/fj.201700531R
Fructose and sucrose intake increase exogenous carbohydrate oxidation during exercise
Trommelen, Jorn, Fuchs, Cas J., Beelen, M, Lenaerts, Kaatje, Jeukendrup, A. E., Cermak, N. and Van Loon, Luc. (2017). Fructose and sucrose intake increase exogenous carbohydrate oxidation during exercise. Nutrients. 9(2), pp. 1 - 12. https://doi.org/10.3390/nu9020167
Transcriptomic and epigenetic responses to short-term nutrient-exercise stress in humans
Laker, R. C., Garde, C., Camera, Donny, Smiles, William, Zierath, J. R., Hawley, John and Barrès, R.. (2017). Transcriptomic and epigenetic responses to short-term nutrient-exercise stress in humans. Scientific Reports. 7(1), pp. 1 - 12. https://doi.org/10.1038/s41598-017-15420-7
Protein ingestion before sleep increases overnight muscle protein synthesis rates in healthy older men: A randomized controlled trial
Kouw, Imre W.K., Holwerda, Andrew M., Trommelen, Jorn, Kramer, Irene Fleur, Bastiaanse, Jacqueline, Halson, Shona, Wodzig, Will K.W.H., Verdijk, Lex B. and Van Loon, Luc. (2017). Protein ingestion before sleep increases overnight muscle protein synthesis rates in healthy older men: A randomized controlled trial. The Journal of Nutrition. 147(12), pp. 2252 - 2261. https://doi.org/10.3945/jn.117.254532
Sodium nitrate ingestion increases skeletal muscle nitrate content in humans
Nyakayiru, Jean, Kouw, Imre W.K., Cermak, N, Senden, Joan M., Van Loon, Luc and Verdijk, Lex B.. (2017). Sodium nitrate ingestion increases skeletal muscle nitrate content in humans. Journal of Applied Physiology. 123(3), pp. 637 - 644. https://doi.org/10.1152/japplphysiol.01036.2016
Intramyocellular lipid content and lipogenic gene expression responses following a single bout of resistance type exercise differ between young and older men
Tsintzas, Kostas, Stephens, F. B., Snijders, Tim, Wall, Benjamin T., Cooper, Scott, Mallinson, Joanne, Verdijk, Lex B. and Van Loon, Luc. (2017). Intramyocellular lipid content and lipogenic gene expression responses following a single bout of resistance type exercise differ between young and older men. Experimental Gerontology. 93, pp. 36 - 45. https://doi.org/10.1016/j.exger.2017.03.018
Commentaries on Viewpoint: A time for exercise: the exercise window
Boule, Normand G., Terada, Tasuku, Francois, Monique E., Hawley, John, Cotter, James D., Kruse, Nicholas T., McDonald, Matthew W., Olver, T D., Paoli, Antonio, Sacchetti, Massimo, Di Luigi, Luigi, van Dijk, Jan W., Van Loon, Luc, Yardley, Jane E., DiPietro, Loretta, Gribok, Andrei and Rumpler, William. (2017). Commentaries on Viewpoint: A time for exercise: the exercise window. Journal of Applied Physiology. 122(1), pp. 210 - 213. https://doi.org/10.1152/japplphysiol.00938.2016
No effect of acute and 6-day nitrate supplementation on VO2 and time-trial performance in highly trained cyclists
Nyakayiru, Jean, Jonvik, Kristin L., Pinckaers, Philippe J.M., Senden, Joan M., Van Loon, Luc and Verdijk, Lex B.. (2017). No effect of acute and 6-day nitrate supplementation on VO2 and time-trial performance in highly trained cyclists. International Journal of Sport Nutrition and Exercise Metabolism. 27(1), pp. 11 - 17. https://doi.org/10.1123/ijsnem.2016-0034
Food ingestion in an upright sitting position increases postprandial amino acid availability when compared with food ingestion in a lying down position
Holwerda, Andrew M., Lenaerts, Kaatje, Bierau, Jörgen, Wodzig, Will K.W.H. and Van Loon, Luc. (2017). Food ingestion in an upright sitting position increases postprandial amino acid availability when compared with food ingestion in a lying down position. Applied Physiology, Nutrition and Metabolism. 42(7), pp. 738 - 743. https://doi.org/10.1139/apnm-2016-0522
Beetroot juice supplementation improves high-intensity intermittent type exercise performance in trained soccer players
Nyakayiru, Jean, Jonvik, Kristin L., Trommelen, Jorn, Pinckaers, Philippe J.M., Senden, Joan M., Van Loon, Luc and Verdijk, Lex B.. (2017). Beetroot juice supplementation improves high-intensity intermittent type exercise performance in trained soccer players. Nutrients. 9(3), pp. 1 - 10. https://doi.org/10.3390/nu9030314
Sprinting toward fitness
Gibala, M. J. and Hawley, John. (2017). Sprinting toward fitness. Cell Metabolism. 25(5), pp. 988 - 990. https://doi.org/10.1016/j.cmet.2017.04.030
Seasonal variation in vitamin d status in elite athletes: a longitudinal study
Backx, E. M.P., van der Avoort, Cindy van, Tieland, Michael, Maase, K., Kies, A. K., Van Loon, Luc, de Groot, Lisette C.P.G.M. and Mensink, M.. (2017). Seasonal variation in vitamin d status in elite athletes: a longitudinal study. International Journal of Sport Nutrition and Exercise Metabolism. 27(1), pp. 6 - 10. https://doi.org/10.1123/ijsnem.2016-0177
Expression of microRNAs and target proteins in skeletal muscle of rats selectively bred for high and low running capacity
Pinto, Samuel K., Lamon, Séverine, Stephenson, Erin J., Kalanon, M., Mikovic, Jasmine, Koch, L G., Britton, S. L., Hawley, John and Camera, Donny. (2017). Expression of microRNAs and target proteins in skeletal muscle of rats selectively bred for high and low running capacity. American Journal of Physiology - Endocrinology and Metabolism. 313(3), pp. 335 - 343. https://doi.org/10.1152/ajpendo.00043.2017
Postexercise high-fat feeding suppresses p70S6K1 activity in human skeletal muscle
Hammond, Kelly M., Impey, Samuel G., Currell, Kevin, Mitchell, Nigel, Shepherd, Sam O., Jeromson, Stewart, Hawley, John A., Close, Graeme L., Hamilton, Lee D., Sharples, Adam P. and Morton, James P.. (2016). Postexercise high-fat feeding suppresses p70S6K1 activity in human skeletal muscle. Medicine and Science in Sports and Exercise. 48(11), pp. 2108-2117. https://doi.org/10.1249/MSS.0000000000001009
Controversies in omega-3 efficacy and novel concepts for application
Radcliffe, J. E., Thomas, J., Bramley, A. L., Kouris-Blazos, A., Radford, B. E., Scholey, A. B., Pipingas, A., Thomas, C. J. and Itsiopoulos, C.. (2016). Controversies in omega-3 efficacy and novel concepts for application. Journal of Nutrition & Intermediary Metabolism. 5, pp. 11-22. https://doi.org/10.1016/j.jnim.2016.05.002
Adaptations to prolonged, intense endurance training in human skeletal muscle
Hawley, J. A. (2016). Adaptations to prolonged, intense endurance training in human skeletal muscle. In In I Mujika and Y Le Meur (Ed.). Endurance Training pp. 119-126 Inigo Mujika.
Glycemic control during consecutive days with prolongedwalking exercise in individuals with type 1 diabetes mellitus
van Dijk, Jan Willem, Eijsvogels, Thijs M., Nyakayiru, Jean, Schreuder, Tim H. A., Hopman, Maria T., Thijssen, Dick H. and Van Loon, Lucas. (2016). Glycemic control during consecutive days with prolongedwalking exercise in individuals with type 1 diabetes mellitus. Diabetes Research and Clinical Practice. 117, pp. 74 - 81. https://doi.org/10.1016/j.diabres.2016.04.053
May bed rest cause greater muscle loss than limb immobilization?
Dirks, M. L., Backx, E. M. P., Wall, B. T., Verdijk, L. B. and van Loon, L.. (2016). May bed rest cause greater muscle loss than limb immobilization? Acta Physiologica. 218(1), pp. 10-12. https://doi.org/10.1111/apha.12699
Update on the effects of physical activity on insulin sensitivity in humans
Bird, Stephen R. and Hawley, John. (2016). Update on the effects of physical activity on insulin sensitivity in humans. 2(1), pp. 1 - 26. https://doi.org/10.1136/bmjsem-2016-000143
Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: A feasibility study
Rozenberg, Robert, Mankowski, Robert T., van Loon, Luc, Langendonk, Janneke G., Sijbrands, Eric J. G., van den Meiracker, Anton H., Stam, Henk J. and Praet, Stephan F. E.. (2016). Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: A feasibility study. European Journal of Medical Research. 21(1), pp. 1 - 8. https://doi.org/10.1186/s40001-015-0194-5
Revisiting the three component synthesis of isoxazolo[5,4-b]pyridines, 4-aryl-3,7,7-trimethyl-isoxazolo[5,4-b]quinolin-5(6H)-ones and related heterocycles
Lingham, Anthony R., Hawley, John A., Greaves, Tamar, Jackson, Neale, Antolasic, Frank and Hugel, Helmut M.. (2016). Revisiting the three component synthesis of isoxazolo[5,4-b]pyridines, 4-aryl-3,7,7-trimethyl-isoxazolo[5,4-b]quinolin-5(6H)-ones and related heterocycles. Polyhedron. 120, pp. 175 - 179. https://doi.org/10.1016/j.poly.2016.09.011
Carbohydrate dependence during prolonged simulated cycling time trials
Torrens, Samuel L., Areta, José L., Parr, Evelyn B. and Hawley, John A.. (2016). Carbohydrate dependence during prolonged simulated cycling time trials. European Journal of Applied Physiology. 116(4), pp. 781-790. https://doi.org/10.1007/s00421-016-3333-y
Cardiac Troponin T and i Release after a 30-km Run
Klinkenberg, Lieke J. J., Luyten, Peter, Van Der Linden, Noreen, Urgel, Kim, Snijders, Daniëlle P. C., Knackstedt, Christian, Dennert, Robert, Kietselaer, Bastiaan L. J. H., Mingels, Alma M. A., Cardinaels, Eline P. M., Peeters, Frederique E. C. M., Van Suijlen, Jeroen D. E., Kate, Joop Ten, Marsch, Elke, Theelen, Thomas L., Sluimer, Judith C., Wouters, Kristiaan, Bekers, Otto, Bekkers, Sebastiaan C. A. M., ... Meex, Steven J. R.. (2016). Cardiac Troponin T and i Release after a 30-km Run. American Journal of Cardiology. 118(2), pp. 281 - 287. https://doi.org/10.1016/j.amjcard.2016.04.030
Low-volume intense exercise elicits post-exercise hypotension and subsequent hypervolemia, irrespective of which limbs are exercised
Graham, Matthew J., Lucas, Samuel J. E., Francois, Monique E., Stavrianeas, Stasinos, Parr, Evelyn B., Thomas, Kate N. and Cotter, James D.. (2016). Low-volume intense exercise elicits post-exercise hypotension and subsequent hypervolemia, irrespective of which limbs are exercised. Frontiers in Physiology. 7(May), pp. 1 - 11. https://doi.org/10.3389/Fphys.2016.00199
Prognostic value of basal high-sensitive cardiac troponin levels on mortality in the general population
van der Linden, Noreen, Klinkenberg, Lieke J. J., Bekers, Otto, van Loon, Luc, Van Dieijen-Visser, Marja P., Zeegers, Maurice P. and Meex, Steven J. R.. (2016). Prognostic value of basal high-sensitive cardiac troponin levels on mortality in the general population. Medicine. https://doi.org/10.1097/MD.0000000000005703
Short-term muscle disuse lowers myofibrillar protein synthesis rates and induces anabolic resistance to protein ingestion
Wall, Benjamin T., Dirks, Marlou L., Snijders, Tim, Willem van Dijk, Jan, Fritsch, Mario, Verdijk, Lex B. and Van Loon, Luc. (2016). Short-term muscle disuse lowers myofibrillar protein synthesis rates and induces anabolic resistance to protein ingestion. American Journal of Physiology - Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00227.2015
Acute endurance exercise induces nuclear p53 abundance in human skeletal muscle
Tachtsis, Bill, Smiles, William, Lane, Steven C., Hawley, John Alan and Camera, Donny Michael. (2016). Acute endurance exercise induces nuclear p53 abundance in human skeletal muscle. Frontiers in Physiology. 7(144), pp. 1 - 10. https://doi.org/10.3389/fphys.2016.00144
Circulating microRNA responses between 'high' and 'low' responders to a 16-wk diet and exercise weight loss intervention
Parr, Evelyn B., Camera, Donny M., Burke, Louise M., Phillips, Stuart M., Coffey, Vernon G. and Hawley, John Alan. (2016). Circulating microRNA responses between 'high' and 'low' responders to a 16-wk diet and exercise weight loss intervention. PLoS ONE. 11(4), pp. 1 - 14. https://doi.org/10.1371/journal.pone.0152545
Altering fatty acid availability does not impair prolonged, continuous running to fatigue: Evidence for carbohydrate dependence
Leckey, Jill, Burke, Louise Mary, Morton, James P. and Hawley, John Alan. (2016). Altering fatty acid availability does not impair prolonged, continuous running to fatigue: Evidence for carbohydrate dependence. Journal of Applied Physiology. 120(2), pp. 107 - 113. https://doi.org/10.1152/japplphysiol.00855.2015
Impact of diet composition on blood glucose regulation
Russell, Wendy R., Baka, Athanasia, Bjorck, Inger, Delzenne, Nathalie, Gao, Dan, Griffiths, Helen R., Hadjilucas, Ellie, Juvonen, Kristiina, Lahtinen, Sampo, Lansink, Mirian, van Loon, Luc, Mykkanen, Hannu, Ostman, Elin, Riccardi, Gabrielle, Vinoy, Sophie and Weickert, Martin O.. (2016). Impact of diet composition on blood glucose regulation. Critical Reviews in Food Science and Nutrition. 56(4), pp. 541 - 590. https://doi.org/10.1080/10408398.2013.792772
The Martin Vigorimeter Represents a Reliable and More Practical Tool Than the Jamar Dynamometer to Assess Handgrip Strength in the Geriatric Patient
Sipers, Walther M. W. H., Verdijk, Lex B., Sipers, Simone J. E., Schols, Jos M. G. A. and Van Loon, Luc. (2016). The Martin Vigorimeter Represents a Reliable and More Practical Tool Than the Jamar Dynamometer to Assess Handgrip Strength in the Geriatric Patient. Journal of the American Medical Directors Association. 17(5), pp. 1 - 7. https://doi.org/10.1016/j.jamda.2016.02.026
Resistance training increases skeletal muscle capillarization in healthy older men
Verdijk, Lex B., Snijders, Tim, Holloway, Tanya M., Van Kranenburg, Janneau and van Loon, Luc. (2016). Resistance training increases skeletal muscle capillarization in healthy older men. Medicine and Science in Sports and Exercise. 48(11), pp. 2157 - 2164. https://doi.org/10.1249/MSS.0000000000001019
Habitual Dietary Nitrate Intake in Highly Trained Athletes
Jonvik, Kristin L., Nyakayiru, Jean, Willem van Dijk, Jan, Wardenaar, Floris C., Van Loon, Lucas and Verdijk, Lex B.. (2016). Habitual Dietary Nitrate Intake in Highly Trained Athletes. International Journal of Sport Nutrition and Exercise Metabolism. https://doi.org/10.1123/ijsnem.2016-0239
Protein intake and lean body mass preservation during energy intake restriction in overweight older adults
Backx, E. M. P., Tieland, Michael, Borgonjen-Van Den Berg, Karin J., Claessen, P. R., Van Loon, Lucas and de Groot, Lisette C.P.G.M.. (2016). Protein intake and lean body mass preservation during energy intake restriction in overweight older adults. International Journal of Obesity. https://doi.org/10.1038/ijo.2015.182
Changes in myonuclear domain size do not precede muscle hypertrophy during prolonged resistance-type exercise training
Snijders, Tim, Smeets, Joey S. J., Van Kranenburg, Janneau, Kies, A. K., Van Loon, Lucas and Verdijk, Lex B.. (2016). Changes in myonuclear domain size do not precede muscle hypertrophy during prolonged resistance-type exercise training. Acta Physiologica. https://doi.org/10.1111/apha.12609
Resistance exercise augments postprandial overnight muscle protein synthesis rates
Trommelen, Jorn, Holwerda, Andrew M., Kouw, Imre W. K., Langer, Henning, Halson, Shona L., Verdijk, Lex B. and van Loon, Luc J. C.. (2016). Resistance exercise augments postprandial overnight muscle protein synthesis rates. Medicine and Science in Sports and Exercise. 48(12), pp. 2517-2525. https://doi.org/10.1249/MSS.0000000000001045
Commentaries on Viewpoint: The rigorous study of exercise adaptations: Why mRNA might not be enough
Camera, Donny and Hawley, John. (2016). Commentaries on Viewpoint: The rigorous study of exercise adaptations: Why mRNA might not be enough. Journal of Applied Physiology. 121(2), pp. 598 - 598. https://doi.org/10.1152/japplphysiol.00509.2016
Exercise-induced skeletal muscle signaling pathways and human athletic performance
Camera, Donny Michael, Smiles, William J. and Hawley, John Alan. (2016). Exercise-induced skeletal muscle signaling pathways and human athletic performance. Free Radical Biology & Medicine. 98, pp. 131 - 143. https://doi.org/10.1016/j.freeradbiomed.2016.02.007
Presleep protein ingestion does not compromise the muscle protein synthetic response to protein ingested the following morning
Wall, Benjamin T., Burd, Nicholas A., Franssen, Rinske, Gorissen, Stefan H. M., Snijders, Tim, Senden, Joan M., Gijsen, Annemie P. and van Loon, Luc. (2016). Presleep protein ingestion does not compromise the muscle protein synthetic response to protein ingested the following morning. American Journal of Physiology - Endocrinology and Metabolism. 311(6), pp. E964-E973. https://doi.org/10.1152/ajpendo.00325.2016
Effects of skeletal muscle energy availability on protein turnover responses to exercise
Smiles, William J., Hawley, John Alan and Camera, Donny Michael. (2016). Effects of skeletal muscle energy availability on protein turnover responses to exercise. Journal of Experimental Biology. 219(Pt 2), pp. 214 - 225. https://doi.org/10.1242/jeb.125104
Periodization of carbohydrate intake: Short-term effect on performance
Marquet, Laurie-Anne, Hausswirth, Christophe, Molle, Odeline, Hawley, John A., Burke, Louise M., Tiollier, Eve and Brisswalter, Jeanick. (2016). Periodization of carbohydrate intake: Short-term effect on performance. Nutrients. 8(12), pp. 1 - 13. https://doi.org/10.3390/nu8120755
A randomized trial of high-dairy-protein, variable-carbohydrate diets and exercise on body composition in adults with obesity
Parr, Evelyn B., Coffey, Vernon Glenn, Cato, Louise E., Phillips, Stuart M., Burke, Louise Mary and Hawley, John Alan. (2016). A randomized trial of high-dairy-protein, variable-carbohydrate diets and exercise on body composition in adults with obesity. Obesity. 24(5), pp. 1035 - 1045. https://doi.org/10.1002/oby.21451
Diurnal rhythm of cardiac troponin: Consequences for the diagnosis of acute myocardial infarction
Klinkenberg, Lieke J. J., Wildi, Karin, Van Der Linden, Noreen, Kouw, Imre W. K., Niens, Marijke, Twerenbold, Raphael, Gimenez, Maria Rubini, Puelacher, Christian, Neuhaus, Jean Daniel, Hillinger, Petra, Nestelberger, Thomas, Boeddinghaus, Jasper, Grimm, Karin, Sabti, Zaid, Bons, Judith A. P., Van Suijlen, Jeroen D. E., Tan, Frans E. S., Kate, Joop Ten, Bekers, Otto, ... Meex, Steven J. R.. (2016). Diurnal rhythm of cardiac troponin: Consequences for the diagnosis of acute myocardial infarction. Clinical Chemistry. 62(12), pp. 1602 - 1611. https://doi.org/10.1373/clinchem.2016.257485
Metabolism: One step forward for exercise
Hawley, John Alan and Krook, Anna. (2016). Metabolism: One step forward for exercise. Nature Reviews Endocrinology. 12(1), pp. 7 - 8. https://doi.org/10.1038/nrendo.2015.201
Expression of protocadherin gamma in skeletal muscle tissue is associated with age and muscle weakness
Hangelbroek, Roland W. J., Fazelzadeh, Parastoo, Tieland, Michael, Boekschoten, Mark V., Hooiveld, Guido J. E. J., van Duynhoven, John P. M., Timmons, James A., Verdijk, Lex B., de Groot, Lisette C. P. G. M., Van Loon, Luc and Müller, Michael. (2016). Expression of protocadherin gamma in skeletal muscle tissue is associated with age and muscle weakness. Journal Cachexia Sarcopenia Muscle. 7(5), pp. 604 - 614. https://doi.org/10.1002/jcsm.12099
The impact of 1-year vitamin D supplementation on vitamin D status in athletes: A dose-response study
Backx, E. M. P., Tieland, Michael, Maase, K., Kies, A. K., Mensink, M., Van Loon, Luc and de Groot, Lisette C. P. G. M.. (2016). The impact of 1-year vitamin D supplementation on vitamin D status in athletes: A dose-response study. European Journal of Clinical Nutrition. 70(9), pp. 1009 - 1014. https://doi.org/10.1038/ejcn.2016.133
Protein coingestion with alcohol following strenuous exercise attenuates alcohol-induced intramyocellular apoptosis and inhibition of autophagy
Smiles, William J., Parr, Evelyn B., Coffey, Vernon G., Lacham-Kaplan, Orly, Hawley, John Alan and Camera, Donny Michael. (2016). Protein coingestion with alcohol following strenuous exercise attenuates alcohol-induced intramyocellular apoptosis and inhibition of autophagy. American Journal of Physiology - Endocrinology and Metabolism. 311(5), pp. E836 - E849. https://doi.org/10.1152/ajpendo.00303.2016
Attenuated PGC-1α isoforms following endurance exercise with blood flow restriction
Conceição, Miguel Soares, Chacon-Mikahil, Mara Patricia Traina, Telles, Guilherme Defante, Libardi, Cleiton Augusto, Júnior, Edson Manoel Mendes, Vechin, Felipe Cassaro, Lugani de Andrade, André Luis, Gáspari, Arthur Fernandes, Brum, Patrícia Chakur, Cavaglieri, Cláudia Regina, Serag, Sara, Spiegelman, Bruce M., Hawley, John A. and Camera, Donny M.. (2016). Attenuated PGC-1α isoforms following endurance exercise with blood flow restriction. Medicine and Science in Sports and Exercise. 16(4809), pp. 1699-1707. https://doi.org/10.1249/MSS.0000000000000970
Recommendations for the conduct of clinical trials for drugs to treat or prevent sarcopenia
Reginster, Jean Yves, Cooper, Cyrus, Rizzoli, Rene, Kanis, John A., Appelboom, Geoff, Bautmans, Ivan, Bischoff-Ferrari, Heike A., Boers, Maarten, Brandi, Maria Luisa, Bruyère, Olivier, Cherubini, Antonio, Flamion, Bruno, Fielding, Roger A., Gasparik, Andrea Ildiko, Van Loon, Lucas, McCloskey, Eugene, Mitlak, Bruce, Pilotto, Alberto, Reiter-Niesert, Suzanne, ... Cruz-Jentoft, Alfonso J.. (2016). Recommendations for the conduct of clinical trials for drugs to treat or prevent sarcopenia. Aging Clinical and Experimental Research. https://doi.org/10.1007/s40520-015-0517-y
SnapShot: Exercise metabolism
Egan, Brendan, Hawley, John Alan and Zierath, Juleen R.. (2016). SnapShot: Exercise metabolism. Cell Metabolism. 24(2), pp. 342 - 342. https://doi.org/10.1016/j.cmet.2016.07.013
Selective modulation of microRNA expression with protein ingestion following concurrent resistance and endurance exercise in human skeletal muscle
Camera, Donny Michael, Ong, Jun N., Coffey, Vernon Glenn and Hawley, John Alan. (2016). Selective modulation of microRNA expression with protein ingestion following concurrent resistance and endurance exercise in human skeletal muscle. Frontiers in Physiology. 7(Mar), pp. 1 - 8. https://doi.org/10.3389/fphys.2016.00087
Enhanced endurance performance by periodization of CHO intake: "Sleep Low" strategy
Marquet, Laurie-Anne, Brisswalter, Jeanick, Louis, Julien, Tiollier, Eve, Burke, Louise Mary, Hawley, John Alan and Hausswirth, Christophe. (2016). Enhanced endurance performance by periodization of CHO intake: "Sleep Low" strategy. Medicine and Science in Sports and Exercise. 48(4), pp. 663 - 672. https://doi.org/10.1249/MSS.0000000000000823
Modulation of autophagy signaling with resistance exercise and protein ingestion following short-term energy deficit
Smiles, William J., Areta, José L., Coffey, Vernon G., Phillips, Stuart M., Moore, Daniel R., Stellingwerff, Trent, Burke, Louise M., Hawley, John A. and Camera, Donny M.. (2015). Modulation of autophagy signaling with resistance exercise and protein ingestion following short-term energy deficit. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 309(5), pp. R603-R612. https://doi.org/10.1152/ajpregu.00413.2014
Exercise and nutrient interactions: Effects on skeletal muscle and body fat mass
Parr, Evelyn Bridget. (2015). Exercise and nutrient interactions: Effects on skeletal muscle and body fat mass [Thesis]. https://doi.org/10.4226/66/5a9cbd34b0b99
Carbohydrate dependence during prolonged, intense endurance exercise
Hawley, John and Leckey, Jill. (2015). Carbohydrate dependence during prolonged, intense endurance exercise. Sports Medicine: reviews of applied medicine and science in sport and exercise. 45, pp. 5 - 12. https://doi.org/10.1007/s40279-015-0400-1
Hypoxia induces a prothrombotic state independently of the physical activity
Ninivaggi, Marisa, De Laat, Marieke, Lancé, Marcus M. D., Kicken, Cécile H., Pelkmans, Leonie, Bloemen, Saartje, Dirks, Marlou L., Van Loon, Luc, Govers-Riemslag, José W. P., Lindhout, Theo, Konings, Joke and De Laat, Bas. (2015). Hypoxia induces a prothrombotic state independently of the physical activity. PLoS ONE. 10(10), pp. 1 - 14. https://doi.org/10.1371/journal.pone.0141797
Carbohydrate availability and exercise training adaptation : Too much of a good thing?
Bartlett, Jonathan, Hawley, John and Morton, James. (2015). Carbohydrate availability and exercise training adaptation : Too much of a good thing? European Journal of Sport Science. 15(1), pp. 3 - 12. https://doi.org/10.1080/17461391.2014.920926
Nutritional strategies to enhance fat oxidation during aerobic exercise
Burke, Louise and Hawley, John. (2015). Nutritional strategies to enhance fat oxidation during aerobic exercise. In In L. Burke and V. Deakin (Ed.). Clinical sports nutrition pp. 463 - 492 McGraw-Hill Education (Australia) Pty Ltd.
Prolonged adaptation to a low or high protein diet does not modulate basal muscle protein synthesis rates: A substudy
Hursel, Rick, Martens, Eveline A. P., Gonnissen, Hanne K. J., Hamer, Henrike M., Senden, Joan M., Van Loon, Luc and Westerterp-Plantenga, Margriet S.. (2015). Prolonged adaptation to a low or high protein diet does not modulate basal muscle protein synthesis rates: A substudy. PLoS ONE. 10(9), pp. 1 - 15. https://doi.org/10.1371/journal.pone.0137183
Can elite athletes benefit from dietary nitrate supplementation?
Jonvik, Kristin L., Nyakayiru, Jean, Van Loon, Luc and Verdijk, Lex B.. (2015). Can elite athletes benefit from dietary nitrate supplementation? Journal of Applied Physiology. 119(6), pp. 759 - 761. https://doi.org/10.1152/japplphysiol.00232.2015
Exercise strategies to optimize glycemic control in type 2 diabetes: A continuing glucose monitoring perspective
van Dijk, Jan Willem and Van Loon, Luc. (2015). Exercise strategies to optimize glycemic control in type 2 diabetes: A continuing glucose monitoring perspective. Diabetes Spectrum. 28(1), pp. 24 - 31. https://doi.org/10.2337/diaspect.28.1.24
Aging is accompanied by a blunted muscle protein synthetic response to protein ingestion
Wall, Benjamin T., Gorissen, Stefan H. M., Pennings, Bart, Koopman, René, Groen, Bart B. L., Verdijk, Lex B. and Van Loon, Luc. (2015). Aging is accompanied by a blunted muscle protein synthetic response to protein ingestion. PLoS ONE. 10(11), pp. 1 - 13. https://doi.org/10.1371/journal.pone.0140903
Need for measures of satellite cell activation along with muscle protein synthesis?
Camera, Donny and Hawley, John. (2015). Need for measures of satellite cell activation along with muscle protein synthesis? Journal of Applied Physiology. 118(4), pp. 500 - 500. https://doi.org/10.1152/japplphysiol.00609.2014.
Post-prandial protein handling: You are what you just ate
Groen, Bart B. L., Horstman, Astrid M. H., Hamer, Henrike M., De Haan, Michiel, Van Kranenburg, Janneau, Bierau, Jörgen, Poeze, Martijn, Wodzig, Will K. W. H., Rasmussen, Blake B. and van Loon, Luc. (2015). Post-prandial protein handling: You are what you just ate. PLoS ONE. 10(11), pp. 1 - 22. https://doi.org/10.1371/journal.pone.0141582
Alcohol ingestion impairs maximal post-exercise rates of myofibrillar protein synthesis following a single bout of concurrent training
Parr, Evelyn, Camera, Donny, Areta, José, Burke, Louise, Phillips, Stuart, Hawley, John A. and Coffey, Vernon. (2014). Alcohol ingestion impairs maximal post-exercise rates of myofibrillar protein synthesis following a single bout of concurrent training. PLoS ONE. 9(2), pp. 1 - 9. https://doi.org/10.1371/journal.pone.0088384
Ramping up the signal : Promoting endurance training adaptation in skeletal muscle by nutritional manipulation
Hawley, John and Morton, James. (2014). Ramping up the signal : Promoting endurance training adaptation in skeletal muscle by nutritional manipulation. Clinical and Experimental Pharmacology & Physiology. 41(8), pp. 608 - 613. https://doi.org/10.1111/1440-1681.12246
Single and combined effects of beetroot juice and caffeine supplementation on cycling time trial performance
Lane, Stephen C., Hawley, John, Desbrow, Ben, Jones, Andrew M., Blackwell, James R., Ross, Megan L. L., Zemski, Adam J. and Burke, Louise. (2014). Single and combined effects of beetroot juice and caffeine supplementation on cycling time trial performance. 39(9), pp. 1050 - 1057. https://doi.org/10.1139/apnm-2013-0336
'Exercise snacks' before meals: A novel strategy to improve glycaemic control in individuals with insulin resistance
Francois, Monique, Baldi, James, Manning, Patrick, Lucas, Samuel, Hawley, John Alan, Williams, Michael and Cotter, James. (2014). 'Exercise snacks' before meals: A novel strategy to improve glycaemic control in individuals with insulin resistance. Diabetologia. 57(7), pp. 1437 - 1445. https://doi.org/10.1007/s00125-014-3244-6
Mitochondrial function in metabolic health: A genetic and environmental tug of war
Stephenson, Erin and Hawley, John Alan. (2014). Mitochondrial function in metabolic health: A genetic and environmental tug of war. Biochimica et Biophysica Acta. 1840(4), pp. 1285 - 1294. https://doi.org/10.1016/j.bbagen.2013.12.004
Dietary Protein as a Trigger for Metabolic Adaptation
Van Loon, Luc. (2014). Dietary Protein as a Trigger for Metabolic Adaptation. In In R. J. Maughan (Ed.). The Encyclopaedia of Sports Medicine: An IOC Medical Commission Publication pp. 147-155 Wiley-Blackwell.
Single and combined effects of betroot juice and caffeine supplementation on cycling time trial performance
Lane, Stephen, Hawley, John, Desbrow, Ben, Jones, Andrew, Blackwell, James, Ross, Megan, Zemski, Adam and Burke, Louise. (2014). Single and combined effects of betroot juice and caffeine supplementation on cycling time trial performance. Applied Physiology, Nutrition and Metabolism. 39(9), pp. 1050 - 1057. https://doi.org/10.1139/apnm-2013-0336
The use of doubly labeled milk protein to measure postprandial muscle protein synthesis rates in vivo in humans
Burd, N., Cermak, N., Kouw, Imre W. K., Gorissen, Stefan H. M., Gijsen, Annemie P. and Van Loon, Luc. (2014). The use of doubly labeled milk protein to measure postprandial muscle protein synthesis rates in vivo in humans. Journal of Applied Physiology. 117(11), pp. 1363 - 1370. https://doi.org/10.1152/japplphysiol.00411.2014
Beyond muscle hypertrophy: Why dietary protein is important for endurance athletes
Moore, Daniel, Camera, Donny, Areta, José and Hawley, John A.. (2014). Beyond muscle hypertrophy: Why dietary protein is important for endurance athletes. Applied Physiology, Nutrition and Metabolism. 39(9), pp. 987 - 997. https://doi.org/10.1139/apnm-2013-0591
Integrative Biology of Exercise
Hawley, John A., Hargreaves, Mark, Joyner, Michael J. and Zierath, Juleen R.. (2014). Integrative Biology of Exercise. Cell. 159(4), pp. 738 - 749. https://doi.org/10.1016/j.cell.2014.10.029
The relationship between exercise, nutrition and type 2 diabetes
Stephenson, Erin J., Smiles, William and Hawley, John Alan. (2014). The relationship between exercise, nutrition and type 2 diabetes. Medicine and Sport Science. 60, pp. 1 - 10. https://doi.org/10.1159/000357331
Increasing leucine concentration stimulates mechanistic target of rapamycin signaling an cell growth in C2C12 skeletal muscle cells
Areta, José, Hawley, John A., Ye, Ji-Ming, Chan, M. H. Stanley and Coffey, Vernon. (2014). Increasing leucine concentration stimulates mechanistic target of rapamycin signaling an cell growth in C2C12 skeletal muscle cells. Nutrition Research. 34(11), pp. 1000 - 1007. https://doi.org/10.1016/j.nutres.2014.09.011
Reduced resting skeletal muscle protein synthesis is reduced by resistance exercise and protein ingestion following short-term energy deficit
Areta, José, Burke, Louise, Camera, Donny, West, Daniel, Crawshay, Siobhan, Moore, Daniel, Stellingwerff, Trent, Phillips, Stuart, Hawley, John A. and Coffey, Vernon. (2014). Reduced resting skeletal muscle protein synthesis is reduced by resistance exercise and protein ingestion following short-term energy deficit. American Journal of Physiology - Endocrinology and Metabolism. 306(8), pp. E989 - E997. https://doi.org/10.1152/ajpendo.00590.2013
Ramping up the signal: Promoting endurance training adaptation in skeletal muscle by nutritional manipulation
Hawley, John Alan and Morton, James. (2014). Ramping up the signal: Promoting endurance training adaptation in skeletal muscle by nutritional manipulation. Clinical and Experimental Pharmacology & Physiology. 41(8), pp. 608 - 613. https://doi.org/10.1111/1440-1681.12246
The effect of a six-month resistance-type exercise training program on the course of high sensitive cardiac troponin T levels in (pre)frail elderly
Van Der Linden, Noreen, Tieland, Michael, Klinkenberg, Lieke J. J., Verdijk, Lex B., de Groot, Lisette C. P. G. M., Van Loon, Lucas, Van Dieijen-Visser, Marja P. and Meex, Steven J. R.. (2014). The effect of a six-month resistance-type exercise training program on the course of high sensitive cardiac troponin T levels in (pre)frail elderly. International Journal of Cardiology. 175(2), pp. 374 - 375. https://doi.org/10.1016/j.ijcard.2014.05.017
Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis
Rao, Rajesh, Long, Jonathan, White, James, Svensson, Katrin, Lou, Jesse, Lokurkar, Isha, Jedrychowski, Mark, Ruas, Jorge, Wrann, Christiane, Lo, James, Camera, Donny, Lachey, Jenn, Gygi, Steven, Seehra, Jasbir, Hawley, John and Spiegelman, Bruce. (2014). Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell. 157(6), pp. 1279 - 1291. https://doi.org/10.1016/j.cell.2014.03.065
Integrative biology of exercise
Hawley, John A., Hargreaves, Mark, Joyner, Michael J. and Zierath, Juleen R.. (2014). Integrative biology of exercise. Cell. 159(6), pp. 738 - 749. https://doi.org/10.1016/j.cell.2014.10.029
Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis
Rao, Rajesh, Long, Jonathan Z., White, James P., Svensson, Katrin J., Lou, Jesse, Lokurkar, Isha, Jedrychowski, Mark P., Ruas, Jorge L., Wrann, Christine D., Camera, Donny, Lachey, Jenn, Gygi, Steven, Seehra, Jasbir, Hawley, John and Spiegelman, Bruce M.. (2014). Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis. Cell. 157(6), pp. 1279 - 1291. https://doi.org/10.1016/j.cell.2014.03.065
Acute changes to biomarkers as a consequence of prolonged strenuous running
Bird, Stephen R., Linden, Matthew and Hawley, John Alan. (2014). Acute changes to biomarkers as a consequence of prolonged strenuous running. Annals of Clinical Biochemistry. 51(2), pp. 137 - 150. https://doi.org/10.1177/0004563213492147
Kracht- en duurinspanning verbeteren 24-uurs bloedglucosehomeostase bij personen met een verminderde glucosetolerantie bij patiënten met type 2 diabetes
Jan Willem van Dijk, Ralph J F Manders, Kyra Tummers, A G Bonomi, Coen D A Stehouwer, Fred Hartgens and Luc Van Loon. (2013). Kracht- en duurinspanning verbeteren 24-uurs bloedglucosehomeostase bij personen met een verminderde glucosetolerantie bij patiënten met type 2 diabetes. Nederlands Tijdschrift voor Diabetologie. 11(2), pp. 52-53. https://doi.org/10.1007/s12467-013-0019-5
Voeding bij intensieve sportbeoefening
Van Loon, L., van Erp-Baart, A. M. J. and Saris, Wim H. M. (2013). Voeding bij intensieve sportbeoefening. In In Majorie Former (Ed.). Informatorium Voeding en Dietetiek - Voedingsleer pp. 547-568 Springer.
Two weeks of reduced-volume sprint interval or traditional exercise training does not improve metabolic functioning in sedentary obese men
Skleryk, J, Karagounis, Leonidas, Hawley, John, Sharman, Matthew, Laursen, Paul and Watson, Greg. (2013). Two weeks of reduced-volume sprint interval or traditional exercise training does not improve metabolic functioning in sedentary obese men. Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics. https://doi.org/10.1111/dom.12150
Nutritional strategies to modulate the adaptive response to endurance training
Hawley, John Alan. (2013). Nutritional strategies to modulate the adaptive response to endurance training. Nestle Nutrition Institute Workshop Series. 75, pp. 1 - 14. https://doi.org/10.1159/000345813
Exercise training enhances white adipose tissue metabolism in rats selectively bred for low- or high-endurance running capacity
Stephenson, Erin, Lessard, Sarah, Rivas, Donato, Watt, Matthew, Yaspelkis III, Ben, Koch, Lauren, Britton, Steven and Hawley, John. (2013). Exercise training enhances white adipose tissue metabolism in rats selectively bred for low- or high-endurance running capacity. American Journal of Physiology - Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00544.2012
The role of amino acids in skeletal muscle adaptation to exercise
Aguirre, Nick, Van Loon, Lucas and Baar, Keith. (2013). The role of amino acids in skeletal muscle adaptation to exercise. In In E. Isolauri, P.M. Sherman and W. A. Walker (Ed.). Nestle Nutrition Institute workshop series pp. 85 - 102 S. Karger AG. https://doi.org/10.1159/000350261
Caffeine ingestion and cycling power output in a low or normal muscle glycogen state
Lane, Suzanne, Areta, José, Bird, S, Coffey, Vernon, Burke, Louise, Desbrow, B, Karagounis, L and Hawley, John A.. (2013). Caffeine ingestion and cycling power output in a low or normal muscle glycogen state. Medicine and Science in Sports and Exercise. https://doi.org/10.1249/MSS.0b013e31828af183
Disturbed energy metabolism and muscular dystrophy caused by pure creatine deficiency are reversible by creatine intake
Nabuurs, C. I., Choe, C. U., Veltien, A., Kan, H. E., Van Loon, Luc, Rodenburg, R. J. T., Matschke, J., Wieringa, B., Kemp, G. J., Isbrandt, D. and Heerschap, A.. (2013). Disturbed energy metabolism and muscular dystrophy caused by pure creatine deficiency are reversible by creatine intake. Journal of Physiology. 591(2), pp. 571 - 592. https://doi.org/10.1113/jphysiol.2012.241760
Effect of a carbohydrate mouth rinse on simulated cycling time-trial performance commenced in a fed or fasted state
Lane, Stephen, Bird, S, Burke, Louise and Hawley, John. (2013). Effect of a carbohydrate mouth rinse on simulated cycling time-trial performance commenced in a fed or fasted state. Applied Physiology, Nutrition and Metabolism. https://doi.org/10.1139/apnm-2012-0300
Elderly men and women benefit equally from prolonged resistance-type exercise training
Leenders, Marika, Verdijk, Lex B., van der Hoeven, Letty, Van Kranenburg, Janneau, Nilwik, Rachel and Van Loon, Luc. (2013). Elderly men and women benefit equally from prolonged resistance-type exercise training. Journals of Gerontology: Series A Biological Sciences and Medical Sciences. 68(7), pp. 769 - 779. https://doi.org/10.1093/gerona/gls241
Validity and Reliability of Tools to Measure Muscle Mass, Strength, and Physical Performance in Community-Dwelling Older People: A Systematic Review
Mijnarends, Donja M., Meijers, Judith M. M., Halfens, Ruud J. G., Borg, Sovianne Ter, Luiking, Yvette C., Verlaan, Sjors, Schoberer, Daniela, Cruz-Jentoft, Alfonso J., Van Loon, Luc and Schols, Jos M. G. A.. (2013). Validity and Reliability of Tools to Measure Muscle Mass, Strength, and Physical Performance in Community-Dwelling Older People: A Systematic Review. Journal of the American Medical Directors Association. 14(3), pp. 170 - 178. https://doi.org/10.1016/j.jamda.2012.10.009
Substantial differences between organ and muscle specific tracer incorporation rates in a lactating dairy cow
Burd, N, Hamer, Henrike M., Pennings, Bart, Pellikaan, Wilbert F., Senden, Joan M., Gijsen, Annemie P. and Van Loon, Luc. (2013). Substantial differences between organ and muscle specific tracer incorporation rates in a lactating dairy cow. PLoS ONE. 8(6), pp. 1 - 10. https://doi.org/10.1371/journal.pone.0068109
Effect of antioxidant supplementation on exercise-induced cardiac troponin release in cyclists: A randomized trial
Klinkenberg, Lieke J. J., Res, Peter T., Haenen, Guido R., Bast, Aalt, Van Loon, Luc, Van Dieijen-Visser, Marja P. and Meex, Steven J. R.. (2013). Effect of antioxidant supplementation on exercise-induced cardiac troponin release in cyclists: A randomized trial. PLoS ONE. 8(11), pp. 1 - 6. https://doi.org/10.1371/journal.pone.0079280
ERK1/2 in the brain mediates the effects of central resistin on reducing thermogenesis in brown adipose tissue
Kosari, Samin, Camera, Donny Michael, Hawley, John Alan, Stebbing, Martin and Badoer, Emilio. (2013). ERK1/2 in the brain mediates the effects of central resistin on reducing thermogenesis in brown adipose tissue. International Journal of Physiology, Pathophysiology and Pharmacology. 5(3), pp. 184 - 189.
Limits of Human Endurance
Van Loon, Luc and Meeusen, Romain. (2012). Limits of Human Endurance S. Karger AG.
Nutritional approaches to treating sarcopenia
Paddon-Jones, Douglas and van Loon, Luc. (2012). Nutritional approaches to treating sarcopenia. In In Cruz-Jentoft, Alfonso J. and Morley, John E. (Ed.). Sarcopenia pp. 275-295 Wiley-Blackwell.
Preexercise aminoacidemia and muscle protein synthesis after resistance exercise
Burke, Louise, Hawley, John, Ross, M, Moore, Daniel, Phillips, S, Slater, G, Stellingwerff, T, Tipton, K, Garnham, A and Coffey, Vernon. (2012). Preexercise aminoacidemia and muscle protein synthesis after resistance exercise. Medicine and Science in Sports and Exercise. 44(10), pp. 1968 - 1977. https://doi.org/10.1249/MSS.0b013e31825d28fa
Strong link between basal and exercise-induced cardiac troponin T levels: Do both reflect risk?
Klinkenberg, Lieke J. J., Res, Peter T., Van Loon, Lucas, Van Dieijen-Visser, Marja P. and Meex, Steven J. R.. (2012). Strong link between basal and exercise-induced cardiac troponin T levels: Do both reflect risk? International Journal of Cardiology. 158(1), pp. 129 - 131. https://doi.org/10.1016/j.ijcard.2012.04.050
Skeletal muscle respiratory capacity is enhanced in rats consuming an obesogenic Western diet
Stephenson, E, Camera, Donny, Jenkins, T, Kosari, S, Lee, Joohyung, Hawley, John and Stepto, N. (2012). Skeletal muscle respiratory capacity is enhanced in rats consuming an obesogenic Western diet. American Journal of Physiology - Endocrinology and Metabolism. 302(12), pp. E1541 - E1549. https://doi.org/10.1152/ajpendo.00590.2011
What's new since Hippocrates? : Preventing type 2 diabetes by physical exercise and diet
Hawley, John and Gibala, M. (2012). What's new since Hippocrates? : Preventing type 2 diabetes by physical exercise and diet. Diabetologia. 55(3), pp. 535 - 539. https://doi.org/10.1007/s00125-012-2460-1
Daytime pattern of post-exercise protein intake affects whole-body protein turnover in resistance-trained males
Moore, Daniel, Areta, José, Coffey, Vernon, Stellingwerff, Trent, Phillips, Stuart, Burke, Louise, Cleroux, Marilyn, Godin, Jean-Philippe and Hawley, John Alan. (2012). Daytime pattern of post-exercise protein intake affects whole-body protein turnover in resistance-trained males. Nutrition and Metabolism. 9(91), pp. 1 - 5. https://doi.org/10.1186/1743-7075-9-91
Divergent skeletal muscle respiratory capacities in rats artificially selected for high and low running ability : A role for Nor1?
Stephenson, E, Stepto, N, Koch, L, Britton, S and Hawley, John. (2012). Divergent skeletal muscle respiratory capacities in rats artificially selected for high and low running ability : A role for Nor1? Journal of Applied Physiology. 113(9), pp. 1403 - 1412. https://doi.org/10.1152/japplphysiol.00788.2012
The single biopsy approach is reliable for the measurement of muscle protein synthesis rates in vivo in older men
Burd, N., Pennings, Bart, Groen, Bart B. L., Gijsen, Annemie P., Senden, Joan M. and Van Loon, Luc. (2012). The single biopsy approach is reliable for the measurement of muscle protein synthesis rates in vivo in older men. Journal of Applied Physiology. 113(6), pp. 896 - 902. https://doi.org/10.1152/japplphysiol.00513.2012
Inspanningstherapie bij type 2 diabetes: is dagelijkse inspanning noodzakelijk om glycemische controle te optimaliseren?
van Dijk, Jan W., Tummers, Kyra, Stehouwer, Coen D.A., Hartgens, Fred and van Loon, Luc. (2012). Inspanningstherapie bij type 2 diabetes: is dagelijkse inspanning noodzakelijk om glycemische controle te optimaliseren? Nederlands Tijdschrift voor Diabetologie. 10(2), pp. 60 - 61. https://doi.org/10.1007/s12467-012-0021-3
Reply from M. J. Gibala, J. P. Little, M. J. MadDonald and J. A. Hawley
Gibala, M. J., Little, John, Macdonald, M. J. and Hawley, John. (2012). Reply from M. J. Gibala, J. P. Little, M. J. MadDonald and J. A. Hawley. The Journal of Physiology. 590(14), pp. 3391 - 3391. https://doi.org/10.1113/jphysiol.2012.235127
Preexercise nutrient timing in endurance activity
Broad, E., Karagounis, L. and Hawley, John Alan. (2012). Preexercise nutrient timing in endurance activity. In In C. M. Kerksick (Ed.). Nutrient Timing: Metabolic Optimization for Health, Performance, and Recovery pp. 118 - 118 Taylor & Francis.
Sex-based comparisons of myofibrillar protein synthesis after resistance exercise in the fed state
West, D, Burd, N, Churchward-Venne, T, Camera, Donny, Mitchell, Cameron, Baker, S, Hawley, John, Coffey, Vernon and Phillips, S. (2012). Sex-based comparisons of myofibrillar protein synthesis after resistance exercise in the fed state. Journal of Applied Physiology. 112(11), pp. 1805 - 1813. https://doi.org/10.1152/japplphysiol.00170.2012
Protein Supplementation Improves Physical Performance in Frail Elderly People: A Randomized, Double-Blind, Placebo-Controlled Trial
Tieland, Michael, De Rest, Ondine Van, Dirks, Marlou L., Van Der Zwalu, Nikita L., Mensink, Marco, Van Loon, Luc and de Groot, Lisette C. P. G. M.. (2012). Protein Supplementation Improves Physical Performance in Frail Elderly People: A Randomized, Double-Blind, Placebo-Controlled Trial. Journal of the American Medical Directors Association. 13(8), pp. 720 - 726. https://doi.org/10.1016/j.jamda.2012.07.005
Low muscle glycogen concentration does not suppress the anabolic response to resistance exercise
Camera, Donny, West, D, Burd, N, Phillips, S, Garnham, A, Hawley, John and Coffey, Vernon. (2012). Low muscle glycogen concentration does not suppress the anabolic response to resistance exercise. Journal of Applied Physiology. 113(2), pp. 206 - 214. https://doi.org/10.1152/japplphysiol.00395.2012
Physiological adaptations to low-volume, high-intensity interval training in health and disease
Gibala, M, Little, John, Macdonald, M and Hawley, John. (2012). Physiological adaptations to low-volume, high-intensity interval training in health and disease. The Journal of Physiology. 590(5), pp. 1077 - 1084. https://doi.org/10.1113/jphysiol.2011.224725
Nutrient provision increases signalling and protein synthesis in human skeletal muscle after repeated sprints
Coffey, Vernon, Moore, Daniel, Burd, N, Rerecich, T, Stellingwerff, T, Garnham, A, Phillips, S and Hawley, John. (2011). Nutrient provision increases signalling and protein synthesis in human skeletal muscle after repeated sprints. European Journal of Applied Physiology. 111(7), pp. 1473 - 1483. https://doi.org/10.1007/s00421-010-1768-0
Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exercise
West, D, Burd, N, Coffey, Vernon, Baker, S, Burke, Louise, Hawley, John, Moore, Daniel, Stellingwerff, T and Phillips, S. (2011). Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exercise. American Journal of Clinical Nutrition: A journal reporting the practical application of our world-wide knowledge of nutrition. 94(3), pp. 795 - 803. https://doi.org/10.3945/ajcn.111.013722
Nutritional modulation of training-induced skeletal muscle adaptations
Hawley, John, Burke, Louise, Phillips, S and Spriet, L. (2011). Nutritional modulation of training-induced skeletal muscle adaptations. Journal of Applied Physiology. 110(3), pp. 834 - 845. https://doi.org/10.1152/japplphysiol.00949.2010
Single-leg cycle training is superior to double-leg cycling in improving the oxidative potential and metabolic profile of trained skeletal muscle
Abbiss, Chris, Karagounis, L, Laursen, P, Peiffer, J, Martin, D, Hawley, John, Fatehee, N and Martin, J.. (2011). Single-leg cycle training is superior to double-leg cycling in improving the oxidative potential and metabolic profile of trained skeletal muscle. Journal of Applied Physiology. 110(5), pp. 1248 - 1255. https://doi.org/10.1152/japplphysiol.01247.2010
Carbohydrates for training and competition
Burke, Louise, Hawley, John, Wong, S and Jeukendrup, A. (2011). Carbohydrates for training and competition. Journal of Sports Sciences. 29(Suppl 1), pp. S17 - S27. https://doi.org/10.1080/02640414.2011.585473
Exercise-Induced splanchnic hypoperfusion results in gut dysfunction in healthy men
Wijck, Kim V., Lenaerts, Kaatje, Van Loon, Luc, Peters, Wilbert H. M., Buurman, Wim A. and Dejong, Cornelis H. C.. (2011). Exercise-Induced splanchnic hypoperfusion results in gut dysfunction in healthy men. PLoS ONE. 6(7), pp. 1 - 10. https://doi.org/10.1371/journal.pone.0022366
A randomised controlled trial of caseload midwifery care: M@NGO (Midwives @ New Group practice Options)
Tracy, S., Hartz, D., Hall, B., Allen, Jyai D., Forti, A., Lainchbury, A., White, J., Walsh, A., Tracy, M. and Kildea, Sue. (2011). A randomised controlled trial of caseload midwifery care: M@NGO (Midwives @ New Group practice Options). BMC Pregnancy and Childbirth. 11(82), pp. 1 - 8. https://doi.org/10.1186/1471-2393-11-82
Exercise training reverses impaired skeletal muscle metabolism induced by artificial selection for low aerobic capacity
Lessard, S, Rivas, D, Stephenson, E, Yaspelkis, Koch, L, Britton, S, Hawley, John and III, B Yaspelkis. (2011). Exercise training reverses impaired skeletal muscle metabolism induced by artificial selection for low aerobic capacity. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 300(1), pp. R175 - R182. https://doi.org/10.1152/ajpregu.00338.2010
Low intrinsic running capacity is associated with reduced skeletal muscle substrate oxidation and lower mitochondrial content in white skeletal muscle
Rivas, D, Lessard, S, Saito, M, Friedhuber, A, Koch, L, Britton, S, Yaspelkis III, B and Hawley, John. (2011). Low intrinsic running capacity is associated with reduced skeletal muscle substrate oxidation and lower mitochondrial content in white skeletal muscle. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 300(4), pp. 835 - 843. https://doi.org/10.1152/ajpregu.00659.2010
Substrate oxidation
Hawley, John A.. (2010). Substrate oxidation. In In Connes, Philippe, Hue, Olivier and Perrey, Stéphane (Ed.). Exercise physiology : From a cellular to an integrative approach pp. 340-347 IOS Press.
The effect of exercise on the skeletal muscle phospholipidome of rats fed a high-fat diet
Mitchell, Todd, Turner, Nigel, Else, Paul, Hulbert, Anthony and Hawley, John. (2010). The effect of exercise on the skeletal muscle phospholipidome of rats fed a high-fat diet. International Journal of Molecular Sciences. 11(10), pp. 3954 - 3964. https://doi.org/10.3390/ijms11103954
Acute signalling responses to intense endurance training commenced with low or normal muscle glycogen : Experimental Physiology-Research Paper
Yeo, W, McGee, S, Carey, A, Paton, C, Garnham, A, Hargreaves, M and Hawley, John. (2010). Acute signalling responses to intense endurance training commenced with low or normal muscle glycogen : Experimental Physiology-Research Paper. Experimental Physiology. 95(2), pp. 351 - 358. https://doi.org/10.1113/expphysiol.2009.049353
Reply
Hawley, John and Martin, David. (2010). Reply. International Journal of Sports Physiology and Performance. 5(4), pp. 434 - 436.
Early time course of akt phosphorylation after endurance and resistance exercise
Camera, Donny, Edge, J, Short, M, Hawley, John and Coffey, Vernon. (2010). Early time course of akt phosphorylation after endurance and resistance exercise. Medicine and Science in Sports and Exercise. 42(10), pp. 1843 - 1852. https://doi.org/10.1249/MSS.0b013e3181d964e4
Short-term endurance training does not alter the oxidative capacity of human subcutaneous adipose tissue
Camera, Donny, Anderson, Malcolm, Hawley, John and Carey, A. (2010). Short-term endurance training does not alter the oxidative capacity of human subcutaneous adipose tissue. European Journal of Applied Physiology. 109(2), pp. 307 - 316. https://doi.org/10.1007/s00421-010-1356-3
Contraction-induced changes in TNFalpha and Akt-mediated signalling are associated with increased myofibrillar protein in rat skeletal muscle
Karagounis, L, Yaspelkis III, B, Reeder, D, Lancaster, G, Hawley, John and Coffey, Vernon. (2010). Contraction-induced changes in TNFalpha and Akt-mediated signalling are associated with increased myofibrillar protein in rat skeletal muscle. European Journal of Applied Physiology. 109(5), pp. 839 - 848. https://doi.org/10.1007/s00421-010-1427-5
Gamma tocopherol supplementation prevents exercise induced coagulation and platelet aggregation
Vucinic, L, Singh, I, Spargo, F, Hawley, John and Linden, M. (2010). Gamma tocopherol supplementation prevents exercise induced coagulation and platelet aggregation. Thrombosis Research: vascular obstruction, hemorrhage and hemostasis. 125(2), pp. 196 - 199. https://doi.org/10.1016/j.thromres.2009.11.015
Carbohydrate availability and training adaptation: Effects on cell metabolism
Hawley, John and Burke, Louise. (2010). Carbohydrate availability and training adaptation: Effects on cell metabolism. Exercise and Sport Sciences Reviews. 38(4), pp. 152 - 160. https://doi.org/10.1097/JES.0b013e3181f44dd9
Nutritional strategies to promote postexercise recovery
Beelen, M, Burke, Louise, Gibala, M and van Loon, Luc. (2010). Nutritional strategies to promote postexercise recovery. International Journal of Sport Nutrition and Exercise Metabolism. 20(6), pp. 515 - 532. https://doi.org/10.1123/ijsnem.20.6.515
Daily training with high carbohydrate availability increases exogenous carbohydrate oxidation during endurance cycling
Cox, Geoffrey, Clark, Sally, Cox, A, Halson, Shona, Hargreaves, M, Hawley, John, Jeacocke, N, Snow, Rod, Yeo, W and Burke, Louise. (2010). Daily training with high carbohydrate availability increases exogenous carbohydrate oxidation during endurance cycling. Journal of Applied Physiology. 109(1), pp. 126 - 134. https://doi.org/10.1152/japplphysiol.00950.2009
Aerobic training reverses high-fat diet-induced pro-inflammatory signalling in rat skeletal muscle
Yaspelkis III, B, Kvasha, I, Lessard, S, Rivas, D and Hawley, John. (2010). Aerobic training reverses high-fat diet-induced pro-inflammatory signalling in rat skeletal muscle. European Journal of Applied Physiology. 110(4), pp. 779 - 788. https://doi.org/10.1007/s00421-010-1559-7
Cytokine responses to carbohydrate ingestion during recovery from exercise-induced muscle injury
Ross, M, Halson, Shona, Suzuki, K, Garnham, A, Hawley, John, Cameron-Smith, David and Peake, J. (2010). Cytokine responses to carbohydrate ingestion during recovery from exercise-induced muscle injury. Journal of Interferon and Cytokine Research. 30(5), pp. 329 - 337. https://doi.org/10.1089/jir.2009.0079
Skeletal muscle : increasing the size of the locomotor cell
Karagounis, L and Hawley, John. (2010). Skeletal muscle : increasing the size of the locomotor cell. The International Journal of Biochemistry and Cell Biology. 42(9), pp. 1376 - 1379. https://doi.org/10.1016/j.biocel.2010.05.013
Global gene expression in skeletal muscle from well-trained strength and endurance athletes
Stepto, Nigel K., Coffey, Vernon Glenn, Carey, Andrew L., Ponnampalam, Anna P., Canny, Benedict J., Powell, David and Hawley, John Alan. (2009). Global gene expression in skeletal muscle from well-trained strength and endurance athletes. Medicine and Science in Sports and Exercise. 41(3), pp. 546 - 565. https://doi.org/10.1249/MSS.0b013e31818c6be9
Effect of consecutive repeated sprint and resistance exercise bouts on acute adaptive responses in human skeletal muscle
Coffey, Vernon Glenn, Jemiolo, Bozena, Edge, Johann, Garnham, Andrew P., Trappe, Scott W. and Hawley, John Alan. (2009). Effect of consecutive repeated sprint and resistance exercise bouts on acute adaptive responses in human skeletal muscle. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 297(5), pp. 1441 - 1451. https://doi.org/10.1152/ajpregu.00351.2009
Exercise intensity and insulin sensitivity: How low can you go?
Hawley, John Alan and Gibala, M. J.. (2009). Exercise intensity and insulin sensitivity: How low can you go? Diabetologia. 52(9), pp. 1709 - 1713. https://doi.org/10.1007/s00125-009-1425-5
Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside
Rivas, Donato A., Yaspelkis, Ben B., Hawley, John Alan and Lessard, Sarah J.. (2009). Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside. Journal of Endocrinology. 202(3), pp. 441 - 451. https://doi.org/10.1677/JOE-09-0202
Molecular responses to strength and endurance training: Are they incompatible?
Hawley, John Alan. (2009). Molecular responses to strength and endurance training: Are they incompatible? Applied Physiology, Nutrition and Metabolism. 34(3), pp. 355 - 361. https://doi.org/10.1139/H09-023
The 5' adenosine monophosphate-activated protein kinase: Regulating the ebb and flow of cellular energetics
Karagounis, Leonidas G. and Hawley, John Alan. (2009). The 5' adenosine monophosphate-activated protein kinase: Regulating the ebb and flow of cellular energetics. The International Journal of Biochemistry and Cell Biology. 41(12), pp. 2360 - 2363. https://doi.org/10.1016/j.biocel.2009.07.004
Exercise: It's the real thing!
Hawley, John Alan and Holloszy, J O.. (2009). Exercise: It's the real thing! Nutrition Reviews. 67(3), pp. 172 - 178. https://doi.org/10.1111/j.1753-4887.2009.00185.x
Impaired skeletal muscle beta-adrenergic activation and lipolysis are associated with whole-body insulin resistance in rats bred for low intrinsic exercise capacity
Lessard, Sarah J., Rivas, Donato A., Chen, Zhu-Ping, van Denderen, Bryce J., Watt, Matthew J., Koch, Lauren G., Britton, Steven L., Kemp, Bruce Ernest and Hawley, John Alan. (2009). Impaired skeletal muscle beta-adrenergic activation and lipolysis are associated with whole-body insulin resistance in rats bred for low intrinsic exercise capacity. Endocrinology. 150(11), pp. 4883 - 4891. https://doi.org/10.1210/en.2009-0158
Spectroscopic correlation analysis of NMR-based metabonomics in exercise science
Kirwan, Gemma M., Coffey, Vernon Glenn, Niere, Julie O., Hawley, John Alan and Adams, Michael J.. (2009). Spectroscopic correlation analysis of NMR-based metabonomics in exercise science. Analytica Chimica Acta. 652(1-2), pp. 173 - 179. https://doi.org/10.1016/j.aca.2009.07.011
Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle
Coffey, Vernon Glenn, Pilegaard, Henriette, Garnham, Andrew P., O'Brien, Brendan J. and Hawley, John Alan. (2009). Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle. Journal of Applied Physiology. 106(4), pp. 1187 - 1197. https://doi.org/10.1152/japplphysiol.91221.2008
In search of the big fish: Investigating the coexistence of the big-fish-little-pond effect with the positive effects of upward comparisons
Seaton, Marjorie, Marsh, Herb, Dumas, F., Huguet, P., Monteil, J. M., Regner, I., Blanton, H., Buunk, A. P., Gibbons, F. X., Kuyper, H., Suls, J. and Wheeler, L.. (2008). In search of the big fish: Investigating the coexistence of the big-fish-little-pond effect with the positive effects of upward comparisons. British Journal of Social Psychology. 47(1), pp. 73 - 103. https://doi.org/10.1348/014466607X202309
Specificity of training adaptation: Time for a rethink?
Hawley, John Alan. (2008). Specificity of training adaptation: Time for a rethink? The Journal of Physiology. 586(1), pp. 1 - 2. https://doi.org/10.1113/jphysiol.2007.147397
Evidence for presribing exercise as a therapy for treating patients with type 2 diabetes
Lessard, Sarah J. and Hawley, John Alan. (2008). Evidence for presribing exercise as a therapy for treating patients with type 2 diabetes. In In J.A. Hawley and J. R. Zierath (Ed.). Physical activity and type 2 diabetes: Therapeutic effects and mechanisms of action pp. 203 - 214 Human Kinetics Publishers Inc..
The effects of polyphenols in olive leaves on platelet function
Singh, Indu, Mok, Michelle, Christensen, Anne-Marie, Turner, Alan H. and Hawley, John Alan. (2008). The effects of polyphenols in olive leaves on platelet function. Nutrition Metabolism and Cardiovascular Diseases. 18(2), pp. 127 - 132. https://doi.org/10.1016/j.numecd.2006.09.001
Skeletal muscle adaptation and performance responses to once a day versus twice every second day endurance training regimens
Yeo, Wee Kian, Paton, Carl D., Garnham, Andrew P., Burke, Louise M., Carey, Andrew L. and Hawley, John Alan. (2008). Skeletal muscle adaptation and performance responses to once a day versus twice every second day endurance training regimens. Journal of Applied Physiology. 105(5), pp. 1462 - 1470. https://doi.org/10.1152/japplphysiol.90882.2008
Commentary on viewpoint: Exercise and cardiovascular risk reduction: Time to update the rationale for exercise?
Reid, Julianne J. and Hawley, John Alan. (2008). Commentary on viewpoint: Exercise and cardiovascular risk reduction: Time to update the rationale for exercise? Journal of Applied Physiology. 105(2), pp. 772 - 772. https://doi.org/10.1152/japplphysiol.90362.2008
Metabolic adaptations to training
Hawley, John Alan and Nader, Gustavo A.. (2008). Metabolic adaptations to training. In In M.P. Schwellnus (Ed.). Olympic textbook of medicine in sport pp. 78 - 87 Wiley-Blackwell.
Exercise training-induced improvements in insulin action
Hawley, John Alan and Lessard, S. J.. (2008). Exercise training-induced improvements in insulin action. Acta Physiologica. 192(1), pp. 127 - 135. https://doi.org/10.1111/j.1748-1716.2007.01783.x
Exercise-induced phospho-proteins in skeletal muscle
Deshmukh, A. S., Hawley, John Alan and Zierath, J. R.. (2008). Exercise-induced phospho-proteins in skeletal muscle. International Journal of Obesity. 32(SUPPL.4), pp. S18 - S23. https://doi.org/10.1038/ijo.2008.118
Activation of atypical protein kinase Czeta toward TC10 is regulated by high-fat diet and aerobic exercise in skeletal muscle
Saito, Misato, Lessard, S. J., Rivas, Donato A., Reeder, Donald W., Hawley, John Alan and Yaspelkis, Ben B.. (2008). Activation of atypical protein kinase Czeta toward TC10 is regulated by high-fat diet and aerobic exercise in skeletal muscle. Metabolism: Clinical and experimental. 57(9), pp. 1173 - 1180. https://doi.org/10.1016/j.metabol.2008.03.023
Commentary on viewpoint: Perspective on the future use of genomics in exercise prescription
Hawley, John Alan. (2008). Commentary on viewpoint: Perspective on the future use of genomics in exercise prescription. Journal of Applied Physiology. 104(4), pp. 1249 - 1249. https://doi.org/10.1152/japplphysiol.00047.2008
Oxidative stress-induced insulin resistance in skeletal muscle cells is ameliorated by gamma-tocopherol treatment
Singh, Indu, Carey, Andrew L., Watson, Nadine, Febbraio, Mark A. and Hawley, John Alan. (2008). Oxidative stress-induced insulin resistance in skeletal muscle cells is ameliorated by gamma-tocopherol treatment. European Journal of Nutrition. 47(7), pp. 387 - 392. https://doi.org/10.1007/s00394-008-0739-2
High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine
Pedersen, David J., Lessard, Sarah J., Coffey, Vernon Glenn, Churchley, Emmanuel G., Wootton, Andrew M., Ng, They, Watt, Matthew J. and Hawley, John Alan. (2008). High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine. Journal of Applied Physiology. 105(1), pp. 7 - 13. https://doi.org/10.1152/japplphysiol.01121.2007
Overweight and obesity in Australia
Hawley, John Alan and Dunstan, David Wayne. (2008). Overweight and obesity in Australia. Medical Journal of Australia. 188(11), pp. 678 - 679.
Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans
Yeo, Wee Kian, Lessard, Sarah J., Chen, Zhi-Ping, Garnham, Andrew P., Burke, Louise, Rivas, Donato A., Kemp, Bruce Ernest and Hawley, John Alan. (2008). Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans. Journal of Applied Physiology. 105(5), pp. 1519 - 1526. https://doi.org/10.1152/japplphysiol.90540.2008
The battle against obesity - Attacking physical inactivity as a primary means of defense
Hawley, John and Dunstan, David. (2008). The battle against obesity - Attacking physical inactivity as a primary means of defense. Nature Reviews Endocrinology. 4(10), pp. 548 - 549. https://doi.org/10.1038/ncpendmet0918