Determinants of carbon load in airway macrophages in pregnant women
Journal article
Miri, Mohammad, Rezaei, Hossein, Momtaz, Seyed Mojtaba, Najafi, Moslem Lari, Adli, Abolfazl, Pajohanfar, Nasim sadat, Abroudi, Mina, Bazghandi, Malihe Sadat, Razavi, Zahra, Alonso, Lucia, Tonne, Cathryn, Basagaña, Xavier, Nieuwenhuijsen, Mark J., Sunyer, Jordi, Nawrot, Tim S. and Dadvand, Payam. (2022). Determinants of carbon load in airway macrophages in pregnant women. Environmental Pollution. 297, p. Article 118765. https://doi.org/10.1016/j.envpol.2021.118765
Authors | Miri, Mohammad, Rezaei, Hossein, Momtaz, Seyed Mojtaba, Najafi, Moslem Lari, Adli, Abolfazl, Pajohanfar, Nasim sadat, Abroudi, Mina, Bazghandi, Malihe Sadat, Razavi, Zahra, Alonso, Lucia, Tonne, Cathryn, Basagaña, Xavier, Nieuwenhuijsen, Mark J., Sunyer, Jordi, Nawrot, Tim S. and Dadvand, Payam |
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Abstract | The airway macrophages carbon loading (AMCL) has been suggested to be a biomarker of the long-term exposure to air pollution; however, to date no study has characterized AMCL for the pregnancy period. Therefore, this study aimed to assess the determinants of AMCL during pregnancy in Iran, a middle-income country. This study was based on a sample of 234 pregnant women with term and normal vaginal delivery who were residing in Sabzevar, Iran (2019). We characterized 35 potential determinants of personal exposure to air pollution for each participant, including six personal, nine indoor, and 20 home-outdoor factors. We applied Deletion/Substitution/Addition algorithm to identify the most relevant determinants that could predict AMCL levels. The median (IQR) of AMCL level was 0.12 (0.30) μm2 with a successful sputum induction in 82.9% (194) of participants. Ambient residential PM2.5 levels were positively associated with higher AMCL levels. On the other hand, increased residential distance to the traffic lights, squares and ring-roads, the duration of opening window per day, and opening window during cooking were inversely associated with AMCL levels. Our findings provide novel insights on the different personal, indoor, and outdoor determinants of personal exposure to air pollution during pregnancy in a middle-income country. |
Keywords | air pollution; pregnancy; biomarker; phagocytosis; lung |
Year | 2022 |
Journal | Environmental Pollution |
Journal citation | 297, p. Article 118765 |
Publisher | Elsevier Ltd |
ISSN | 0269-7491 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.envpol.2021.118765 |
PubMed ID | 34973383 |
Scopus EID | 2-s2.0-85122218019 |
Open access | Published as ‘gold’ (paid) open access |
Page range | 1-9 |
Funder | Sabzevar University of Medical Sciences |
Spanish Ministry of Science and Innovation (MICINN) | |
Agency for the Research Centres of Catalonia (CERCA) Programme, Generalitat de Catalunya | |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 29 Dec 2021 |
Publication process dates | |
Accepted | 27 Dec 2021 |
Deposited | 20 Oct 2023 |
Grant ID | 95075 |
https://acuresearchbank.acu.edu.au/item/8zwz5/determinants-of-carbon-load-in-airway-macrophages-in-pregnant-women
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Publisher's version
OA_Miri_2022_Determinants_of_carbon_load_in_airway.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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