Resting state functional connectivity in adolescent synthetic cannabinoid users with and without attention-deficit/hyperactivity disorder

Journal article

Yüncü, Zeki, Cakmak Celik, Zehra, Colak, Ciğdem, Thapa, Tribikram, Fornito, Alex, Bora, Emre, Kitis, Omer and Zorlu, Nabi. (2021). Resting state functional connectivity in adolescent synthetic cannabinoid users with and without attention-deficit/hyperactivity disorder. Human Psychopharmacology. 36(5), p. Article e2781. https://doi.org/10.1002/hup.2781
AuthorsYüncü, Zeki, Cakmak Celik, Zehra, Colak, Ciğdem, Thapa, Tribikram, Fornito, Alex, Bora, Emre, Kitis, Omer and Zorlu, Nabi
Abstract

Objective
Synthetic cannabinoids (SCs) have become increasingly popular in recent years, especially among adolescents. The first aim of the current study was to examine resting-state functional connectivity (rsFC) in SC users compared to controls. Our second aim was to examine the influence of comorbid attention-deficit/hyperactivity disorder (ADHD) symptomatology on rsFC changes in SC users compared to controls.

Methods
Resting-state functional magnetic resonance imaging (fMRI) analysis included 25 SC users (14 without ADHD and 11 with ADHD combined type) and 12 control subjects.

Results
We found (i) higher rsFC between the default mode network (DMN) and salience network, dorsal attention network and cingulo-opercular network, and (ii) lower rsFC within the DMN and between the DMN and visual network in SC users compared to controls. There were no significant differences between SC users with ADHD and controls, nor were there any significant differences between SC users with and without ADHD.

Conclusions
We found the first evidence of abnormalities within and between resting state networks in adolescent SC users without ADHD. In contrast, SC users with ADHD showed no differences compared to controls. These results suggest that comorbidity of ADHD and substance dependence may show different rsFC alterations than substance use alone.

KeywordsADHD; connectomics; functional connectivity; synthetic cannabinoids
Year2021
JournalHuman Psychopharmacology
Journal citation36 (5), p. Article e2781
PublisherJohn Wiley & Sons Ltd
ISSN0885-6222
Digital Object Identifier (DOI)https://doi.org/10.1002/hup.2781
PubMed ID33675677
Scopus EID2-s2.0-85102076822
Page range1-8
FunderEge University
TÜBİTAK-BİDEB 2219
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online06 Mar 2021
Publication process dates
Accepted11 Feb 2021
Deposited31 Oct 2023
Grant ID2015 EGEBAM 001
53325897‐115.02‐39691
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