Can genetic markers predict the sporadic form of Alzheimer’s disease? An updated review on genetic peripheral markers
Journal article
Theron, Danelda, Hopkins, Lloyd N., Sutherland, Heidi G., Griffiths, Lyn and Fernandez, Francesca Elizabeth. (2023). Can genetic markers predict the sporadic form of Alzheimer’s disease? An updated review on genetic peripheral markers. International Journal of Molecular Sciences. 24(17), p. Article 24. https://doi.org/10.3390/ijms241713480
Authors | Theron, Danelda, Hopkins, Lloyd N., Sutherland, Heidi G., Griffiths, Lyn and Fernandez, Francesca Elizabeth |
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Abstract | Alzheimer’s disease (AD) is the most common form of dementia that affects millions of individuals worldwide. Although the research over the last decades has provided new insight into AD pathophysiology, there is currently no cure for the disease. AD is often only diagnosed once the symptoms have become prominent, particularly in the late-onset (sporadic) form of AD. Consequently, it is essential to further new avenues for early diagnosis. With recent advances in genomic analysis and a lower cost of use, the exploration of genetic markers alongside RNA molecules can offer a key avenue for early diagnosis. We have here provided a brief overview of potential genetic markers differentially expressed in peripheral tissues in AD cases compared to controls, as well as considering the changes to the dynamics of RNA molecules. By integrating both genotype and RNA changes reported in AD, biomarker profiling can be key for developing reliable AD diagnostic tools. |
Keywords | Alzheimer’s disease; genes; micro-RNA; circular-RNA; long-coding RNA; biomarkers; peripheral tissues |
Year | 2023 |
Journal | International Journal of Molecular Sciences |
Journal citation | 24 (17), p. Article 24 |
Publisher | Multidisciplinary Digital Publishing Institute (MDPI AG) |
ISSN | 1661-6596 |
Digital Object Identifier (DOI) | https://doi.org/10.3390/ijms241713480 |
PubMed ID | 37686283 |
Scopus EID | 2-s2.0-85170352091 |
PubMed Central ID | PMC10488021 |
Open access | Published as ‘gold’ (paid) open access |
Page range | 1-18 |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 30 Aug 2023 |
Publication process dates | |
Accepted | 25 Aug 2023 |
Deposited | 31 Oct 2023 |
https://acuresearchbank.acu.edu.au/item/8zxx4/can-genetic-markers-predict-the-sporadic-form-of-alzheimer-s-disease-an-updated-review-on-genetic-peripheral-markers
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Publisher's version
OA_Theron_2023_Can_genetic_markers_predict_the_sporadic.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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