Can genetic markers predict the sporadic form of Alzheimer’s disease? An updated review on genetic peripheral markers

Journal article


Theron, Danelda, Hopkins, Lloyd N., Sutherland, Heidi G., Griffiths, Lyn and Fernandez, Francesca Elizabeth. (2023). Can genetic markers predict the sporadic form of Alzheimer’s disease? An updated review on genetic peripheral markers. International Journal of Molecular Sciences. 24(17), p. Article 24. https://doi.org/10.3390/ijms241713480
AuthorsTheron, Danelda, Hopkins, Lloyd N., Sutherland, Heidi G., Griffiths, Lyn and Fernandez, Francesca Elizabeth
Abstract

Alzheimer’s disease (AD) is the most common form of dementia that affects millions of individuals worldwide. Although the research over the last decades has provided new insight into AD pathophysiology, there is currently no cure for the disease. AD is often only diagnosed once the symptoms have become prominent, particularly in the late-onset (sporadic) form of AD. Consequently, it is essential to further new avenues for early diagnosis. With recent advances in genomic analysis and a lower cost of use, the exploration of genetic markers alongside RNA molecules can offer a key avenue for early diagnosis. We have here provided a brief overview of potential genetic markers differentially expressed in peripheral tissues in AD cases compared to controls, as well as considering the changes to the dynamics of RNA molecules. By integrating both genotype and RNA changes reported in AD, biomarker profiling can be key for developing reliable AD diagnostic tools.

KeywordsAlzheimer’s disease; genes; micro-RNA; circular-RNA; long-coding RNA; biomarkers; peripheral tissues
Year2023
JournalInternational Journal of Molecular Sciences
Journal citation24 (17), p. Article 24
PublisherMultidisciplinary Digital Publishing Institute (MDPI AG)
ISSN1661-6596
Digital Object Identifier (DOI)https://doi.org/10.3390/ijms241713480
PubMed ID37686283
Scopus EID2-s2.0-85170352091
PubMed Central IDPMC10488021
Open accessPublished as ‘gold’ (paid) open access
Page range1-18
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online30 Aug 2023
Publication process dates
Accepted25 Aug 2023
Deposited31 Oct 2023
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