Examining the association of life course neurocognitive ability with real-world functioning in schizophrenia-spectrum disorders
Journal article
Romanowska, Sylvia, Best, Michael W., Bowie, Christopher R., Depp, Colin A., Patterson, Thomas L., Penn, David L., Pinkham, Amy E. and Harvey, Philip D.. (2022). Examining the association of life course neurocognitive ability with real-world functioning in schizophrenia-spectrum disorders. Schizophrenia Research: Cognition. 29, p. Article 100254. https://doi.org/10.1016/j.scog.2022.100254
Authors | Romanowska, Sylvia, Best, Michael W., Bowie, Christopher R., Depp, Colin A., Patterson, Thomas L., Penn, David L., Pinkham, Amy E. and Harvey, Philip D. |
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Abstract | There is considerable variability in neurocognitive functioning within schizophrenia-spectrum disorders, and neurocognitive performance ranges from severe global impairment to normative performance. Few investigations of neurocognitive clusters have considered the degree to which deterioration relative to premorbid neurocognitive abilities is related to key illness characteristics. Moreover, while neurocognition and community functioning are strongly related, understanding of the sources of variability in the association between these two domains is also limited; it is unknown what proportion of participants would over-perform or under-perform the level of functioning expected based on current neurocognitive performance vs. lifelong attainment. This study examined data from 954 outpatients with schizophrenia-spectrum disorders across three previous studies. Neurocognition, community functioning, and symptoms were assessed. Neurocognitive subgroups were created based on current neurocognition, estimated premorbid IQ, and degree of deterioration from premorbid using z-score cut-offs; functional subgroups were created with cluster analysis based on the Specific Level of Functioning Scale and current neurocognition. The sample was neurocognitively heterogeneous; 65% displayed current neurocognitive impairment and 84% experienced some level of deterioration. Thirty percent of our sample was relatively higher functioning despite significant neurocognitive impairment. Individuals with better community functioning, regardless of neurocognitive performance, had lower symptom severity compared to those with worse functioning. These results highlight the variability in neurocognition and its role in functioning. Understanding individual differences in neurocognitive and functional profiles and the interaction between prior and current cognitive functioning can guide individualized treatment and selection of participants for clinical treatment studies. |
Keywords | psychosis; schizophrenia; neurocognition; functioning; cluster analysis |
Year | 2022 |
Journal | Schizophrenia Research: Cognition |
Journal citation | 29, p. Article 100254 |
Publisher | Elsevier Inc. |
ISSN | 2215-0013 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.scog.2022.100254 |
PubMed ID | 35521291 |
Scopus EID | 2-s2.0-85129128132 |
PubMed Central ID | PMC9062312 |
Open access | Published as ‘gold’ (paid) open access |
Page range | 1-8 |
Funder | National Institute of Mental Health (NIMH), United States of America |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 26 Apr 2022 |
Publication process dates | |
Accepted | 13 Apr 2022 |
Deposited | 01 Nov 2023 |
Grant ID | R01MH093432 |
MH078775 | |
MH078737 | |
R01MH079784 |
https://acuresearchbank.acu.edu.au/item/8zy08/examining-the-association-of-life-course-neurocognitive-ability-with-real-world-functioning-in-schizophrenia-spectrum-disorders
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Publisher's version
OA_Romanowska_2022_Examining_the_association_of_life_course.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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