Genetic and epigenetic regulation in Lingo-1 : Effects on cognitive function and white matter microstructure in a case-control study for schizophrenia

Journal article

Andrews, Jessica L., Zalesky, Andrew, Nair, Shalima, Sullivan, Ryan P., Green, Melissa J., Pantelis, Christos, Newell, Kelly A. and Fernandez, Francesca. (2023). Genetic and epigenetic regulation in Lingo-1 : Effects on cognitive function and white matter microstructure in a case-control study for schizophrenia. International Journal of Molecular Sciences. 24(21), p. Article 15624. https://doi.org/10.3390/ijms242115624
AuthorsAndrews, Jessica L., Zalesky, Andrew, Nair, Shalima, Sullivan, Ryan P., Green, Melissa J., Pantelis, Christos, Newell, Kelly A. and Fernandez, Francesca
Abstract

Leucine-rich repeat and immunoglobulin domain-containing protein (Lingo-1) plays a vital role in a large number of neuronal processes underlying learning and memory, which are known to be disrupted in schizophrenia. However, Lingo-1 has never been examined in the context of schizophrenia. The genetic association of a single-nucleotide polymorphism (SNP, rs3144) and methylation (CpG sites) in the Lingo-1 3′-UTR region was examined, with the testing of cognitive dysfunction and white matter (WM) integrity in a schizophrenia case-control cohort (n = 268/group). A large subset of subjects (97 control and 161 schizophrenia subjects) underwent structural magnetic resonance imaging (MRI) brain scans to assess WM integrity. Frequency of the rs3144 minor allele was overrepresented in the schizophrenia population (p = 0.03), with an odds ratio of 1.39 (95% CI 1.016–1.901). CpG sites surrounding rs3144 were hypermethylated in the control population (p = 0.032) compared to the schizophrenia group. rs3144 genotype was predictive of membership to a subclass of schizophrenia subjects with generalized cognitive deficits (p < 0.05), in addition to having associations with WM integrity (p = 0.018). This is the first study reporting a potential implication of genetic and epigenetic risk factors in Lingo-1 in schizophrenia. Both of these genetic and epigenetic alterations may also have associations with cognitive dysfunction and WM integrity in the context of the schizophrenia pathophysiology.

KeywordsLingo-1 gene; schizophrenia; single nucleotide polymorphism; methylation; white mater integrity; cognition
Year2023
JournalInternational Journal of Molecular Sciences
Journal citation24 (21), p. Article 15624
PublisherMultidisciplinary Digital Publishing Institute (MDPI AG)
ISSN1422-0067
Digital Object Identifier (DOI)https://doi.org/10.3390/ijms242115624
Open accessPublished as ‘gold’ (paid) open access
Page range1-16
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online26 Oct 2023
Publication process dates
Accepted22 Oct 2023
Deposited08 Nov 2023
Permalink -

https://acuresearchbank.acu.edu.au/item/8zy76/genetic-and-epigenetic-regulation-in-lingo-1-effects-on-cognitive-function-and-white-matter-microstructure-in-a-case-control-study-for-schizophrenia

Log in to edit

Download files

Publisher's version
OA_Andrews_2023_Genetic_and_epigenetic_regulation_in_Lingo.pdf
License: CC BY 4.0
File access level: Open

  • 56
    total views
  • 24
    total downloads
  • 1
    views this month
  • 1
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Can genetic markers predict the sporadic form of Alzheimer’s disease? An updated review on genetic peripheral markers
Theron, Danelda, Hopkins, Lloyd N., Sutherland, Heidi G., Griffiths, Lyn and Fernandez, Francesca Elizabeth. (2023). Can genetic markers predict the sporadic form of Alzheimer’s disease? An updated review on genetic peripheral markers. International Journal of Molecular Sciences. 24(17), p. Article 24. https://doi.org/10.3390/ijms241713480
Associations between Omega-3 Index, dopaminergic genetic variants and aggressive and metacognitive traits : A study in adult male prisoners
Fernandez, Francesca Elizabeth, Byrne, Mitchell K., Batterham, Marijka, Grant, Luke and Meyer, Barbara J.. (2022). Associations between Omega-3 Index, dopaminergic genetic variants and aggressive and metacognitive traits : A study in adult male prisoners. Nutrients. 14(7), p. Article 1379. https://doi.org/10.3390/nu14071379
Sulfation pathways during neurodevelopment
Clarke, Taylor, Fernandez, Francesca E. and Dawson, Paul A.. (2022). Sulfation pathways during neurodevelopment. Frontiers in Molecular Biosciences. 9, p. Article 866196. https://doi.org/10.3389/fmolb.2022.866196
Antroquinonol administration in animal preclinical studies for Alzheimer's disease (AD) : A new avenue for modifying progression of AD pathophysiology
Fernandez, Francesca, Aust, Caitlin, Lye, Sarah and Griffiths, Lyn. (2022). Antroquinonol administration in animal preclinical studies for Alzheimer's disease (AD) : A new avenue for modifying progression of AD pathophysiology. Brain, Behavior, and Immunity. 21, p. Article 100435. https://doi.org/10.1016/j.bbih.2022.100435
Not all stress is created equal : Acute, not ambient stress, impairs learning in high schizotypes
Walter, Emma E., Fernandez, Francesca and Barkus, Emma. (2022). Not all stress is created equal : Acute, not ambient stress, impairs learning in high schizotypes. PsyCh Journal. 11(2), pp. 179-193. https://doi.org/10.1002/pchj.452
ECHO360 Active Learning Platform in health sciences education : How, when and why to use it?
Cobbold, Christian, Fernandez, Francesca and Lys, Isabelle. (2021). ECHO360 Active Learning Platform in health sciences education : How, when and why to use it? International Journal for Innovation Education and Research. 9(2), pp. 387-395. https://doi.org/10.31686/IJIER.VOL9.ISS2.2958
The effect of omega-3 long chain polyunsaturated fatty acids on aggressive behaviour in adult male prisoners : A structured study protocol for a multicentre, double-blind, randomised placebocontrolled trial and translation into policy and practice
Meyer, Barbara J., Byrne, Mitchell K., Cortie, Colin H., Parletta, Natalie, Jones, Alison, Eckermann, Simon, Butler, Tony, Greenberg, David, Batterham, Marijka, Fernandez, Francesca, Schofield, Peter W., Winberg, Pia C., Bowles, Kate, Dally, Jean, Martin, Anne-Maria and Grant, Luke. (2021). The effect of omega-3 long chain polyunsaturated fatty acids on aggressive behaviour in adult male prisoners : A structured study protocol for a multicentre, double-blind, randomised placebocontrolled trial and translation into policy and practice. Trials. 22(1), p. Article 318. https://doi.org/10.1186/s13063-021-05252-2
The effects of perinatal fluoxetine exposure on emotionality behaviours and cortical and hippocampal glutamatergic receptors in female Sprague-Dawley and Wistar-Kyoto rats
Millard, Samuel J., Lum, Jeremy S., Fernandez, Francesca, Weston-Green, Katrina and Newell, Kelly A.. (2021). The effects of perinatal fluoxetine exposure on emotionality behaviours and cortical and hippocampal glutamatergic receptors in female Sprague-Dawley and Wistar-Kyoto rats. Progress in Neuropsychopharmacology and Biological Psychiatry. 108, p. 110174. https://doi.org/10.1016/j.pnpbp.2020.110174
Exploring new avenues for modifying course of progression of Alzheimer’s diseas e: The rise of natural medicine
Lye, Sarah, Aust, Caitlin E., Griffiths, Lyn R. and Fernandez, Francesca. (2021). Exploring new avenues for modifying course of progression of Alzheimer’s diseas e: The rise of natural medicine. Journal of the Neurological Sciences. 422, p. 117332. https://doi.org/10.1016/j.jns.2021.117332
Salivary biomarkers in Alzheimer's disease
Andrews, Jessica L. and Fernandez, Francesca. (2020). Salivary biomarkers in Alzheimer's disease. In In Martin, Colin R. and Preedy, Victor R. (Ed.). Diagnosis and management in dementia pp. 239-254 Academic Press. https://doi.org/10.1016/B978-0-12-815854-8.00015-X
Genetics of dementia : A focus on Alzheimer's disease
Fernandez, Francesca and Andrews, Jessica L.. (2020). Genetics of dementia : A focus on Alzheimer's disease. In In Martin, Colin R. and Preedy, Victor R. (Ed.). The neuroscience of dementia ; volume 1 pp. 127-146 Academic Press. https://doi.org/10.1016/B978-0-12-815854-8.00009-4
Electrophysiological correlates of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism
Roy, Nikita, Barry, Robert J., Fernandez, Francesca E., Lim, Chai K., Al-Dabbas, Mahmoud A., Karamacoska, Diana, Broyd, Samantha J., Solowij, Nadia, Chiu, Christine L. and Steiner, Genevieve Z.. (2020). Electrophysiological correlates of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism. Scientific Reports. 10(1), p. 17915. https://doi.org/10.1038/s41598-020-74780-9
Oxidative stress in alzheimer’s disease: A review on emergent natural polyphenolic therapeutics
Luke Cassidy, Francesca Fernandez, Joel Johnson, Mani Naiker, Akeem Owoola and Daniel Broszczak. (2020). Oxidative stress in alzheimer’s disease: A review on emergent natural polyphenolic therapeutics. Complementary Therapies in Medicine. 49, pp. 1-11. https://doi.org/10.1016/j.ctim.2019.102294
Perinatal exposure to fluoxetine increases anxiety- and depressive-like behaviours and alters glutamatergic markers in the prefrontal cortex and hippocampus of male adolescent rats: A comparison between Sprague-Dawley rats and the Wistar-Kyoto rat model of depression
Millard, Samuel J., Lum, Jeremy Stephen, Fernandez, Francesca, Weston-Green, Katrina and Newell, Kelly A.. (2019). Perinatal exposure to fluoxetine increases anxiety- and depressive-like behaviours and alters glutamatergic markers in the prefrontal cortex and hippocampus of male adolescent rats: A comparison between Sprague-Dawley rats and the Wistar-Kyoto rat model of depression. Journal of Psychopharmacology. 33(2), pp. 230 - 243. https://doi.org/10.1177/0269881118822141
Perinatal administration of phencyclidine alters expression of Lingo-1 signaling pathway proteins in the prefrontal cortex of juvenile and adult rats
Andrews, Jessica L., Newell, Kelly A., Matosin, Natalie, Huang, Xu-Feng and Fernandez, Francesca. (2018). Perinatal administration of phencyclidine alters expression of Lingo-1 signaling pathway proteins in the prefrontal cortex of juvenile and adult rats. Neuronal Signaling. 2(3), p. Article NS20180059. https://doi.org/10.1042/NS20180059
Effects of common GRM5 genetic variants on cognition, hippocampal volume and mGluR5 protein levels in schizophrenia
Matosin, Natalie, Newell, Kelly A., Quidé, Yann, Andrews, Jessica L., Teroganova, Nina, Green, Melissa and Fernandez, Francesca. (2018). Effects of common GRM5 genetic variants on cognition, hippocampal volume and mGluR5 protein levels in schizophrenia. Brain Imaging and Behavior: an international journal. 12(2), pp. 509 - 517. https://doi.org/10.1007/s11682-017-9712-0
Stress induced cortisol release and schizotypy
Walter, Emma E., Fernandez, Francesca, Snelling, Mollie and Barkus, Emma. (2018). Stress induced cortisol release and schizotypy. Psychoneuroendocrinology. 89, pp. 209 - 215. https://doi.org/10.1016/j.psyneuen.2018.01.012
Effects of GRASP variation on memory in psychiatrically healthy individuals and cognitive dysfunction in schizophrenics
Matosin, Natalie, Green, Melissa, Newell, Kelly A. and Fernandez, Francesca. (2017). Effects of GRASP variation on memory in psychiatrically healthy individuals and cognitive dysfunction in schizophrenics. Gene Reports. 6, pp. 121 - 127. https://doi.org/10.1016/j.genrep.2016.12.010
Alterations of ubiquitin related proteins in the pathology and development of schizophrenia: evidence from human and animal studies
Andrews, Jessica L., Goodfellow, Frederic J., Matosin, Natalie, Snelling, Mollie K., Newell, Kelly A., Huang, Xu F. and Fernandez, Francesca. (2017). Alterations of ubiquitin related proteins in the pathology and development of schizophrenia: evidence from human and animal studies. Journal of Psychiatric Research. 90, pp. 31 - 39. https://doi.org/10.1016/j.jpsychires.2017.01.009
Possibility of a sex-specific role for a genetic variant in FRMPD4 in schizophrenia, but not cognitive function
Matosin, Natalie, Green, Melissa J., Andrews, Jessica L., Newell, Kelly A. and Fernandez-Enright, Francesca. (2016). Possibility of a sex-specific role for a genetic variant in FRMPD4 in schizophrenia, but not cognitive function. NeuroReport. 27(1), pp. 33-38. https://doi.org/10.1097/WNR.0000000000000491
Neurodevelopmental expression profile of dimeric and monomeric group 1 mGluRs: Relevance to Schizophrenia pathogenesis and treatment
Lum, Jeremy S., Fernandez, Francesca, Matosin, Natalie, Andrews, Jessica L., Huang, Xu-Feng, Ooi, Lezanne and Newell, Kelly A.. (2016). Neurodevelopmental expression profile of dimeric and monomeric group 1 mGluRs: Relevance to Schizophrenia pathogenesis and treatment. Scientific Reports. 6, pp. 1 - 10. https://doi.org/10.1038/srep34391
Genetic consideration of schizotypal traits: A review
Walter, Emma E., Fernandez, Francesca, Snelling, Mollie and Barkus, Emma. (2016). Genetic consideration of schizotypal traits: A review. Frontiers in Psychology. 7(1769), pp. 1 - 19. https://doi.org/10.3389/fpsyg.2016.01769
Lingo-1: A novel target in therapy for Alzheimer's disease?
Fernandez, Francesca Elizabeth and Andrews, Jessica. (2016). Lingo-1: A novel target in therapy for Alzheimer's disease? Neural Regeneration Research. 11(1), pp. 88 - 89. https://doi.org/10.4103/1673-5374.175048
Genetic consideration of schizotypal traits: A review
Walter, Emma E., Fernandez, Francesca Elizabeth, Snelling, Mollie and Barkus, Emma. (2016). Genetic consideration of schizotypal traits: A review. Frontiers in Psychology. 7(Nov), pp. 1 - 19. https://doi.org/10.3389/fpsyg.2016.01769
A decade from discovery to therapy: Lingo-1, the dark horse in neurological and psychiatric disorders
Andrews, Jessica L. and Fernandez, Francesca Elizabeth. (2015). A decade from discovery to therapy: Lingo-1, the dark horse in neurological and psychiatric disorders. Neuroscience and Biobehavioral Reviews. 56, pp. 97 - 114. https://doi.org/10.1016/j.neubiorev.2015.06.009
Bardoxolone methyl prevents high-fat diet-induced alterations in prefrontal cortex signalling molecules involved in recognition memory
Camer, Danielle, Yu, Yinghua, Szabo, Alexander, Fernandez, Francesca Elizabeth, Dinh, Chi H. L. and Huang, Xu-Feng. (2015). Bardoxolone methyl prevents high-fat diet-induced alterations in prefrontal cortex signalling molecules involved in recognition memory. Progress in Neuropsychopharmacology and Biological Psychiatry. 59, pp. 68 - 75. https://doi.org/10.1016/j.pnpbp.2015.01.004
Association of a GRIA3 gene polymorphism with migraine in an Australian case-control cohort
Maher, Bridget H., Lea, Rod A., Follett, Jordan, Cox, Hannah C., Fernandez, Francesca, Esposito, Teresa, Gianfrancesco, Fernando, Haupt, Larisa M. and Griffiths, Lyn R.. (2013). Association of a GRIA3 gene polymorphism with migraine in an Australian case-control cohort. Headache. 53(8), pp. 1245 - 1249. https://doi.org/10.1111/head.12151
Short-term effects of fish and fish oil consumption on total and high molecular weight adiponectin levels in overweight and obese adults
Neale, Elizabeth P., Muhlhausler, Beverly, Probst, Yasmine C., Batterham, Marijka J., Fernandez, Francesca and Tapsell, Linda C.. (2013). Short-term effects of fish and fish oil consumption on total and high molecular weight adiponectin levels in overweight and obese adults. Metabolism. 62(5), pp. 651 - 660. https://doi.org/10.1016/j.metabol.2012.10.014
The dopamine b-hydroxylase 19 bp insertion/deletion polymorphism was associated with first-episode but not medicated chronic schizophrenia
Hui, Li, Zhang, Xuan, Huang, Xu Feng, Han, Mei, Fernandez, Francesca, Yu, Yaqin, Sun, ShiLong, Li, Wenjun, Chen, Da Chun, Xiu, Mei Hong, Kosten, Thomas R. and Zhang, Xiang Yang. (2012). The dopamine b-hydroxylase 19 bp insertion/deletion polymorphism was associated with first-episode but not medicated chronic schizophrenia. Journal of Psychiatric Research. 46(6), pp. 733 - 737. https://doi.org/10.1016/j.jpsychires.2012.02.016
Wip1 phosphatase positively modulates dendritic spine morphology and memory processes through the p38MAPK signaling pathway
Fernandez, Francesca, Soon, Irene, Li, Zeng, Kuan, Tan Chee, Min, Deng Hong, Wong, Esther Sook-Miin, Demidov, Oleg N., Paterson, Malcom C., Dawe, Gavin, Bulavin, Dmitry V. and Xiao, Zhi-Cheng. (2012). Wip1 phosphatase positively modulates dendritic spine morphology and memory processes through the p38MAPK signaling pathway. Cell Adhesion and Migration. 6(4), pp. 333 - 343. https://doi.org/10.4161/cam.20892
Significant differences in gene expression of GABA receptors in peripheral blood leukocytes of migraineurs
Plummer, Prue N., Colson, Natalie J., Lewohl, Joanne M., MacKay, Rachel K., Fernandez, Francesca, Haupt, Larisa M. and Griffiths, Lyn R.. (2011). Significant differences in gene expression of GABA receptors in peripheral blood leukocytes of migraineurs. Gene. 490(1-2), pp. 32 - 36. https://doi.org/10.1016/j.gene.2011.08.031
Use of end-tidal carbon dioxide detection to determine correct placement of nasogastric tube: A meta-analysis
Chau, J., Lo, S., Thompson, David R., Fernandez, R. and Griffiths, R.. (2011). Use of end-tidal carbon dioxide detection to determine correct placement of nasogastric tube: A meta-analysis. International Journal of Nursing Studies (print version). 48(4), pp. 513 - 521. https://doi.org/10.1016/j.ijnurstu.2010.12.004