Amino acid composition of breast milk from urban Chinese mothers

Journal article

Garcia-Rodenas, Clara L., Affolter, Michael, Vinyes-Parès, Gerard, De Castro, Carlos A., Karagounis, Leonidas G., Zhang, Yumei, Wang, Peiyu and Thakkar, Sagar K.. (2016). Amino acid composition of breast milk from urban Chinese mothers. Nutrients. 8(10), p. Article 606. https://doi.org/10.3390/nu8100606
AuthorsGarcia-Rodenas, Clara L., Affolter, Michael, Vinyes-Parès, Gerard, De Castro, Carlos A., Karagounis, Leonidas G., Zhang, Yumei, Wang, Peiyu and Thakkar, Sagar K.
Abstract

Human breast milk (BM) amino acid (AA) composition may be impacted by lactation stage or factors related to geographical location. The present cross-sectional study is aimed at assessing the temporal changes of BMAA over lactation stages in a large cohort of urban mothers in China. Four hundred fifty BM samples, collected in three Chinese cities covering eight months of lactation were analyzed for free (FAA) and total (TAA) AA by o-phthalaldehyde/ fluorenylmethylchloroformate (OPA/FMOC) derivatization. Concentrations and changes over lactation were aligned with previous reports. Both the sum and the individual TAA values significantly decreased during the first periods of lactation and then generally leveled off. Leucine and methionine were respectively the most and the least abundant indispensable amino acids across all the lactation stages, whereas glutamic acid + glutamine (Glx) was the most and cystine the least abundant dispensable AA. The contribution of FAA to TAA levels was less than 2%, except for free Glx, which was the most abundant FAA. In conclusion, the AA composition of the milk from our cohort of urban Chinese mothers was comparable to previous studies conducted in other parts of the world, suggesting that this is an evolutionary conserved trait largely independent of geographical, ethnic, or dietary factors.

Keywordsbreast milk; amino acids; lactation period; cross-sectional study
Year2016
JournalNutrients
Journal citation8 (10), p. Article 606
PublisherMultidisciplinary Digital Publishing Institute (MDPI AG)
ISSN2072-6643
Digital Object Identifier (DOI)https://doi.org/10.3390/nu8100606
PubMed ID27690094
Scopus EID2-s2.0-84989326321
PubMed Central IDPMC5083994
Open accessPublished as ‘gold’ (paid) open access
Page range1-10
FunderNESTEC
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online28 Sep 2016
Publication process dates
Accepted23 Sep 2016
Deposited28 Nov 2023
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