SGC-CAMKK2-1 : A chemical probe for CAMKK2
Journal article
Wells, Carrow, Liang, Yi, Pulliam, Thomas L., Lin, Chenchu, Awad, Dominik, Eduful, Benjamin, O’Byrne, Sean, Hossain, Mohammad Anwar, Catta-Preta, Carolina Moura Costa, Ramos, Priscila Zonzini, Gileadi, Opher, Gileadi, Carina, Couñago, Rafael M., Stork, Brittany, Langendorf, Christopher G., Nay, Kevin, Oakhill, Jonathan S., Mukherjee, Debarati, Racioppi, Luigi, ... Drewry, David H.. (2023). SGC-CAMKK2-1 : A chemical probe for CAMKK2. Cells. 12(2), p. Article 287. https://doi.org/10.3390/cells12020287
Authors | Wells, Carrow, Liang, Yi, Pulliam, Thomas L., Lin, Chenchu, Awad, Dominik, Eduful, Benjamin, O’Byrne, Sean, Hossain, Mohammad Anwar, Catta-Preta, Carolina Moura Costa, Ramos, Priscila Zonzini, Gileadi, Opher, Gileadi, Carina, Couñago, Rafael M., Stork, Brittany, Langendorf, Christopher G., Nay, Kevin, Oakhill, Jonathan S., Mukherjee, Debarati, Racioppi, Luigi, Means, Anthony R., York, Brian, McDonnell, Donald P., Scott, John W., Frigo, Daniel E. and Drewry, David H. |
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Abstract | The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed. Having a selective small molecule tool to interrogate this kinase will help demonstrate that CAMKK2 inhibition can be therapeutically beneficial. Herein, we disclose SGC-CAMKK2-1, a selective chemical probe that targets CAMKK2. |
Keywords | CAMKK2; kinase; chemical probe; NanoBRET; kinase selectivity |
Year | 2023 |
Journal | Cells |
Journal citation | 12 (2), p. Article 287 |
Publisher | Multidisciplinary Digital Publishing Institute (MDPI AG) |
ISSN | 2073-4409 |
Digital Object Identifier (DOI) | https://doi.org/10.3390/cells12020287 |
PubMed ID | 36672221 |
Scopus EID | 2-s2.0-85146743607 |
PubMed Central ID | PMC9856672 |
Open access | Published as ‘gold’ (paid) open access |
Page range | 1-17 |
Funder | National Cancer Institute (NCI), National Institutes of Health |
Illuminating the Druggable Genome (IDG) Program, National Institutes of Health | |
National Institutes of Health (NIH), United States of America | |
Mike Slive Foundation for Prostate Cancer Research | |
The São Paulo Research Foundation (FAPESP) | |
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
AbbVie | |
Bayer | |
Boehringer Ingelheim | |
Canada Foundation for Innovation | |
Eshelman Institute for Innovation | |
Genome Canada | |
Innovative Medicines Initiative (IMI), European Union | |
Janssen-Cilag | |
Merck KGaA Darmstadt Germany | |
Merck Sharp & Dohme (MSD) | |
Novartis Pharmaceuticals | |
Ontario Ministry of Economic Development and Innovation | |
Pfizer | |
Takeda Pharmaceuticals | |
Wellcome Trust | |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 11 Jan 2023 |
Publication process dates | |
Accepted | 05 Jan 2023 |
Deposited | 29 Nov 2023 |
Grant ID | R01CA218442 |
1U24DK116204-01 | |
R01CA184208 | |
2013/50724-5 | |
2014/50897-0 | |
465651/2014-3 | |
115766 | |
106169/ZZ14/Z |
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Publisher's version
OA_Wells_2023_SGC_CAMKK2_1_A_chemical_probe.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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