Effects of epicatechin on cardiovascular function in middle-Aged diet-induced obese rat models of metabolic syndrome

Journal article


Connolly, Kylie, Batacan, Romeo, Jackson, Douglas and Fenning, Andrew. (2023). Effects of epicatechin on cardiovascular function in middle-Aged diet-induced obese rat models of metabolic syndrome. British Journal of Nutrition. 131(4), pp. 593-605. https://doi.org/10.1017/S000711452300209X
AuthorsConnolly, Kylie, Batacan, Romeo, Jackson, Douglas and Fenning, Andrew
Abstract

The current study aimed to investigate the cardiovascular effects of epicatechin, a flavonoid found in green tea and cocoa, in attenuating complications associated with metabolic syndrome in diet-induced obese rats. Male Wistar-Kyoto (WKY) rats aged 16 weeks were fed either standard rat chow or given a high-fat-high-carbohydrate (HFHC) diet for 20 weeks. Epicatechin treatment (5 mg/kg/d) was administered to a subset of WKY rats commencing at week 8 of the 20 week HFHC feeding period. Body weights, food, water and energy intakes, blood pressure, heart rate and glucose tolerance were measured throughout the treatment period. Oxidative stress and inflammatory markers, lipid levels, cardiac collagen deposition, cardiac electrical function, aortic and mesenteric vessel reactivity were examined after the treatment. Twenty weeks of HFHC feeding in WKY rats resulted in the development of metabolic syndrome indicated by the presence of abdominal obesity, dyslipidaemia, glucose intolerance and increased blood pressure. Epicatechin treatment was found to enhance the oxidative stress status in HFHC groups through an increase in serum nitric oxide levels and a decrease in 8-isoprostane concentrations. Furthermore, WKY-HFHC rats displayed a decrease in IL-6 levels. The lipid profiles in HFHC groups showed improvement, with a decrease in LDL-cholesterol and TAG and an increase in HDL-cholesterol levels observed in WKY-HFHC rats. However, epicatechin was not effective in preventing weight gain, glucose intolerance or hypertension in HFHC fed rats. Overall, the results of this study suggest that epicatechin has the potential to improve the underlying mechanisms associated with metabolic syndrome in obese rats.

KeywordsEpicatechin; Metabolic syndrome; Diet-induced obesity; CVD; High-fat high-carbohydrate diet
Year01 Jan 2023
JournalBritish Journal of Nutrition
Journal citation131 (4), pp. 593-605
PublisherCambridge University Press
ISSN0007-1145
Digital Object Identifier (DOI)https://doi.org/10.1017/S000711452300209X
Web address (URL)https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effects-of-epicatechin-on-cardiovascular-function-in-middleaged-dietinduced-obese-rat-models-of-metabolic-syndrome/FF3F8BD26365AD86A70C14220252C106
Open accessPublished as ‘gold’ (paid) open access
Research or scholarlyResearch
Page range593-605
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License
File Access Level
Open
Output statusPublished
Publication dates
Print28 Feb 2024
Publication process dates
Accepted14 Sep 2023
Deposited12 Mar 2024
Additional information

© The Author(s), 2023. Published by Cambridge University Press on behalf of The Nutrition Society.

This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence ( http://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.

Place of publicationUnited Kingdom
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