Gynostemma Pentaphyllum Increases Exercise Performance and Alters Mitochondrial Respiration and AMPK in Healthy Males
Journal article
Nayyar, Deepti, Yan, Xu, Xu, Guoqin, Shi, Min, Garnham, Andrew Peter, Mathai, Michael and McAinch, Andrew. (2023). Gynostemma Pentaphyllum Increases Exercise Performance and Alters Mitochondrial Respiration and AMPK in Healthy Males. Nutrients. 15(22), pp. 1-18. https://doi.org/10.3390/nu15224721
Authors | Nayyar, Deepti, Yan, Xu, Xu, Guoqin, Shi, Min, Garnham, Andrew Peter, Mathai, Michael and McAinch, Andrew |
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Abstract | This research aimed to determine the effects of Gynostemma pentaphyllum (G. pentaphyllum) on exercise performance, AMP-activated protein kinase (AMPK), and mitochondrial signaling in human muscle. This randomized double-blind placebo control crossover study provided placebo or 450 mg of G. pentaphyllum dried leaf extract equivalent to 2.25 g of dry leaf per day for four weeks to 16 healthy untrained young males, separated by four weeks wash-out. Following 4-week supplementation with G. pentaphyllum, participants had significantly lower leptin and blood glucose levels and improved time trial performance over 20 km, which corresponded with a higher muscle oxygen flux compared to placebo. Muscle AMPK Thr172 phosphorylation significantly increased after 60 min exercise following G. pentaphyllum supplementation. AMPK Thr172 phosphorylation levels relative to total AMPK increased earlier following exercise with G. pentaphyllum compared to placebo. Total ACC-α was lower following G. pentaphyllum supplementation compared to placebo. While further research is warranted, G. pentaphyllum supplementation improved exercise performance in healthy untrained males, which corresponded with improved mitochondrial respiration, altered AMPK and ACC, and decreased plasma leptin and glucose levels. |
Keywords | adiponectin; blood glucose; leptin; oxygen flux |
Year | 01 Jan 2023 |
Journal | Nutrients |
Journal citation | 15 (22), pp. 1-18 |
Publisher | MDPI AG |
ISSN | 2072-6643 |
Digital Object Identifier (DOI) | https://doi.org/10.3390/nu15224721 |
Web address (URL) | https://www.mdpi.com/2072-6643/15/22/4721 |
Open access | Published as ‘gold’ (paid) open access |
Research or scholarly | Research |
Page range | 1-18 |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 08 Nov 2023 |
Publication process dates | |
Accepted | 06 Nov 2023 |
Deposited | 02 Apr 2024 |
Additional information | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | |
Place of publication | Switzerland |
https://acuresearchbank.acu.edu.au/item/904x8/gynostemma-pentaphyllum-increases-exercise-performance-and-alters-mitochondrial-respiration-and-ampk-in-healthy-males
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Publisher's version
OA_Garnham_2023_Gynostemma_Pentaphyllum_Increases_Exercise_Performance_and.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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