Spatiotemporal Gait Parameters in Adults With Premanifest and Manifest Huntington's Disease : A Systematic Review

Journal article

Browning, Sasha, Holland, Stephanie, Wellwood, Ian and Bilney, Belinda Elizabeth. (2023). Spatiotemporal Gait Parameters in Adults With Premanifest and Manifest Huntington's Disease : A Systematic Review. Journal of Movement Disorders. 16(3), pp. 307-320. https://doi.org/10.14802/jmd.23111
AuthorsBrowning, Sasha, Holland, Stephanie, Wellwood, Ian and Bilney, Belinda Elizabeth
Abstract

Objective
To systematically review and critically evaluate literature on spatiotemporal gait deviations in individuals with premanifest and manifest Huntington’s Disease (HD) in comparison with healthy cohorts.

Methods
We conducted a systematic review, guided by the Joanna Briggs Institute’s Manual for Evidence Synthesis and pre-registered with the International Prospective Register of Systematic Reviews. Eight electronic databases were searched. Studies comparing spatiotemporal footstep parameters in adults with premanifest and manifest HD to healthy controls were screened, included and critically appraised by independent reviewers. Data on spatiotemporal gait changes and variability were extracted and synthesised. Meta-analysis was performed on gait speed, cadence, stride length and stride length variability measures.

Results
We screened 2,721 studies, identified 1,245 studies and included 25 studies (total 1,088 participants). Sample sizes ranged from 14 to 96. Overall, the quality of the studies was assessed as good, but reporting of confounding factors was often unclear. Meta-analysis found spatiotemporal gait deviations in participants with HD compared to healthy controls, commencing in the premanifest stage. Individuals with premanifest HD walk significantly slower (-0.17 m/s; 95% confidence interval [CI] [-0.22, -0.13]), with reduced cadence (-6.63 steps/min; 95% CI [-10.62, -2.65]) and stride length (-0.09 m; 95% CI [-0.13, -0.05]). Stride length variability was also increased in premanifest cohorts by 2.18% (95% CI [0.69, 3.68]), with these changes exacerbated in participants with manifest disease.

Conclusion
Findings suggest individuals with premanifest and manifest HD display significant spatiotemporal footstep deviations. Clinicians could monitor individuals in the premanifest stage of disease for gait changes to identify the onset of Huntington’s symptoms.

KeywordsHuntington’s disease; Gait analysis; Spatiotemporal paramteters; Disease manifest
Year01 Jan 2023
JournalJournal of Movement Disorders
Journal citation16 (3), pp. 307-320
PublisherKorean Movement Disorder Society (KMDS)
ISSN2093-4939
Digital Object Identifier (DOI)https://doi.org/10.14802/jmd.23111
Web address (URL)https://e-jmd.org/journal/view.php?doi=10.14802/jmd.23111
Open accessPublished as ‘gold’ (paid) open access
Research or scholarlyResearch
Page range307-320
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File Access Level
Open
Output statusPublished
Publication dates
Online10 Aug 2023
Publication process dates
Accepted09 Aug 2023
Deposited03 Jun 2023
Supplemental file
License
File Access Level
Open
Supplemental file
License
File Access Level
Open
Additional information

Copyright © 2023 The Korean Movement Disorder Society

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Place of publicationKorea, Republic of (South)
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