Association between single-nucleotide polymorphisms in growth factor genes and quality of life in men with prostate cancer and the general population
Journal article
Alexander, Kimberly E., Chambers, Suzanne, Spurdle, Amanda B., Batra, Jyotsna, Lose, Felicity, O’Mara, Tracy A., Gardiner, Robert, Aitken, Joanne, Clements, Judith A., Kedda, Mary-Anne and Janda, Monika. (2015). Association between single-nucleotide polymorphisms in growth factor genes and quality of life in men with prostate cancer and the general population. Quality of Life Research. 24(9), pp. 2183-2193. https://doi.org/10.1007/s11136-015-0950-6
Authors | Alexander, Kimberly E., Chambers, Suzanne, Spurdle, Amanda B., Batra, Jyotsna, Lose, Felicity, O’Mara, Tracy A., Gardiner, Robert, Aitken, Joanne, Clements, Judith A., Kedda, Mary-Anne and Janda, Monika |
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Abstract | Purpose improved survival for men with prostate cancer has led to increased attention to factors influencing quality of life (qol). As protein levels of vascular endothelial growth factor (vegf) and insulin-like growth factor 1 (igf-1) have been reported to be associated with qol in people with cancer, we sought to identify whether single-nucleotide polymorphisms (snps) of these genes were associated with qol in men with prostate cancer. Methods multiple linear regression of two data sets (including approximately 750 men newly diagnosed with prostate cancer and 550 men from the general population) was used to investigate snps of vegf and igf-1 (10 snps in total) for associations with qol (measured by the sf-36v2 health survey). Results men with prostate cancer who carried the minor ‘t’ allele for igf-1 snp rs35767 had higher mean role-physical scale scores (≥0.3 sd) compared to non-carriers (p < 0.05). While this association was not identified in men from the general population, one igf-1 snp rs7965399 was associated with higher mean bodily pain scale scores in men from the general population that was not found in men with prostate cancer. Men from the general population who carried the rare ‘c’ allele had higher mean bodily pain scale scores (≥0.3 sd) than non-carriers (p < 0.05). Conclusions through identifying snps that are associated with qol in men with prostate cancer and men from the general population, this study adds to the mapping of complex interrelationships that influence qol and suggests a role for igf-i in physical qol outcomes. Future research may identify biomarkers associated with increased risk of poor qol that could assist in the provision of pre-emptive support for those identified at risk. |
Keywords | Quality of life; Cancer ; Oncology ; Polymorphisms ; Vascular endothelial growth factor ; Insulin-like growth factor 1 |
Year | 01 Jan 2015 |
Journal | Quality of Life Research |
Journal citation | 24 (9), pp. 2183-2193 |
Publisher | Springer-Verlag Dordrecht |
ISSN | 0962-9343 |
Digital Object Identifier (DOI) | https://doi.org/10.1007/s11136-015-0950-6 |
Web address (URL) | https://link.springer.com/article/10.1007/s11136-015-0950-6#Sec12 |
Open access | Published as non-open access |
Research or scholarly | Research |
Page range | 2183-2193 |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 28 Feb 2015 |
Publication process dates | |
Accepted | 18 Feb 2015 |
Deposited | 22 May 2024 |
Supplemental file | License All rights reserved File Access Level Controlled |
Additional information | © Springer International Publishing Switzerland 2015 |
Place of publication | Netherlands |
https://acuresearchbank.acu.edu.au/item/9081q/association-between-single-nucleotide-polymorphisms-in-growth-factor-genes-and-quality-of-life-in-men-with-prostate-cancer-and-the-general-population
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