Assessment of gene-by-sex interaction effect on bone mineral density
Journal article
Liu, Ching-Ti, Estrada, Karol, Yerges-Armstrong, Laura, Amin, Najaf, Evangelou, Evangelos, Li, Guo, Minster, Ryan L., Carless, Melanie, Kammerer, Candace M., Oei, Ling, Zhou, Yanhua, Alonso, Nerea, Vandenput, Liesbeth, Lorentzon, Karl Mattias, Dailiana, Zoe, Eriksson, Joel, Garcia-Giralt, Natalia, Giroux, Sylvie, Husted, Lise Bjerre, ... al, et. (2012). Assessment of gene-by-sex interaction effect on bone mineral density. Journal of Bone and Mineral Research. 27(10), pp. 2051-2064. https://doi.org/10.1002/jbmr.1679
Authors | Liu, Ching-Ti, Estrada, Karol, Yerges-Armstrong, Laura, Amin, Najaf, Evangelou, Evangelos, Li, Guo, Minster, Ryan L., Carless, Melanie, Kammerer, Candace M., Oei, Ling, Zhou, Yanhua, Alonso, Nerea, Vandenput, Liesbeth, Lorentzon, Karl Mattias, Dailiana, Zoe, Eriksson, Joel, Garcia-Giralt, Natalia, Giroux, Sylvie, Husted, Lise Bjerre, Khusainova, Rita, Koromila, Theodora, Kung, Annie, Lewis, Joshua R., Masi, Laura, Mencej-Bedrac, Simona, Nogues, Xavier, Patel, Millan S., Prezelj, Janez, Richards, J. Brent, Sham, Pak Chung, Sector, Timothy, Xiao, Su-Mei, Zheng, Hou-Feng, Zhu, Kun, Balcells, Susana, Brandi, Maria, Frost, Morten, Goltzman, David, Gonzalez-Macias, J, Karlsson, Magnus, Khusnutdinova, Elza, Kollia, Panagoula, Langdahl, Bente, Ljunggren, Osten and al, et |
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Abstract | Sexual dimorphism in various bone phenotypes, including bone mineral density (BMD), is widely observed; however, the extent to which genes explain these sex differences is unclear. To identify variants with different effects by sex, we examined gene‐by‐sex autosomal interactions genome‐wide, and performed expression quantitative trait loci (eQTL) analysis and bioinformatics network analysis. We conducted an autosomal genome‐wide meta‐analysis of gene‐by‐sex interaction on lumbar spine (LS) and femoral neck (FN) BMD in 25,353 individuals from 8 cohorts. In a second stage, we followed up the 12 top single‐nucleotide polymorphisms (SNPs; p < 1 × 10−5) in an additional set of 24,763 individuals. Gene‐by‐sex interaction and sex‐specific effects were examined in these 12 SNPs. We detected one novel genome‐wide significant interaction associated with LS‐BMD at the Chr3p26.1‐p25.1 locus, near the GRM7 gene (male effect = 0.02 and p = 3.0 × 10−5; female effect = −0.007 and p = 3.3 × 10−2), and 11 suggestive loci |
Keywords | gene-by-sex interaction; BMD; association; aging |
Year | 01 Jan 2012 |
Journal | Journal of Bone and Mineral Research |
Journal citation | 27 (10), pp. 2051-2064 |
Publisher | Wiley-Blackwell Publishing, Inc. (US) |
ISSN | 0884-0431 |
Digital Object Identifier (DOI) | https://doi.org/10.1002/jbmr.1679 |
Web address (URL) | https://academic.oup.com/jbmr/article/27/10/2051/7598388#438704797 |
Open access | Published as non-open access |
Research or scholarly | Research |
Page range | 2051-2064 |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 18 Sep 2012 |
Publication process dates | |
Accepted | 29 May 2012 |
Deposited | 27 May 2024 |
Supplemental file | License All rights reserved File Access Level Controlled |
Additional information | © 2012 American Society for Bone and Mineral Research. |
Funding : multiple funding sources for this article see acknowledgements at https://academic.oup.com/jbmr/article/27/10/2051/7598388#438704851 | |
Place of publication | United States |
https://acuresearchbank.acu.edu.au/item/90837/assessment-of-gene-by-sex-interaction-effect-on-bone-mineral-density
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