Genetic studies of body mass index yield new insights for obesity biology
Journal article
Locke, A, Bratati, K, Berndt, S, Justice, A, Pers, T, Day, F, Powell, C, Vedantam, Buchkovich, M, Vandenput, Liesbeth and et al. (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature. 518(7538), pp. 197-206. https://doi.org/10.1038/nature14177
Authors | Locke, A, Bratati, K, Berndt, S, Justice, A, Pers, T, Day, F, Powell, C, Vedantam, Buchkovich, M, Vandenput, Liesbeth and et al |
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Abstract | Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10−8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis. |
Keywords | association study; genome-wide; meta analysis; obesity; body mass index ; BMI |
Year | 01 Jan 2015 |
Journal | Nature |
Journal citation | 518 (7538), pp. 197-206 |
Publisher | Nature Publishing Group |
ISSN | 0028-0836 |
Digital Object Identifier (DOI) | https://doi.org/10.1038/nature14177 |
Web address (URL) | https://www.nature.com/articles/nature14177#Abs1 |
Open access | Published as non-open access |
Research or scholarly | Research |
Page range | 197-206 |
Author's accepted manuscript | License All rights reserved File Access Level Open |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 11 Feb 2015 |
Publication process dates | |
Accepted | 23 Dec 2014 |
Deposited | 31 May 2024 |
Supplemental file | License All rights reserved File Access Level Controlled |
Additional information | © 2015 Macmillan Publishers Limited. All rights reserved |
Place of publication | United Kingdom |
https://acuresearchbank.acu.edu.au/item/90842/genetic-studies-of-body-mass-index-yield-new-insights-for-obesity-biology
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AM_Vandenput_2015_Genetic_studies_of_body_mass_index.pdf | |
License: All rights reserved | |
File access level: Open |
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