Cannabis dependence is associated with reduced hippocampal subregion volumes independently of sex : Findings from an ENIGMA addiction working group multi-country study
Journal article
Lorenzetti, Valentina, Gaillard, Alexandra, McTavish, Eugene, Sally, Grace, Rossetti, Maria Gloria, Batalla, Albert, Bellani, Marcella, Brambilla, Paolo, Chye, Yann, Conrod, Patricia, Cousijn, Janna, Labuschagne, Izelle, Clemente, Adam, Mackey, Scott, Rendell, Peter, Solowij, Nadia, Suo, Chao, Li, Chiang-Shan R., Terrett, Gillian, ... Roberts, Carl A.. (2024). Cannabis dependence is associated with reduced hippocampal subregion volumes independently of sex : Findings from an ENIGMA addiction working group multi-country study. Cannabis and Cannabinoid Research. X(X), pp. 1-14. https://doi.org/10.1089/can.2023.0204
Authors | Lorenzetti, Valentina, Gaillard, Alexandra, McTavish, Eugene, Sally, Grace, Rossetti, Maria Gloria, Batalla, Albert, Bellani, Marcella, Brambilla, Paolo, Chye, Yann, Conrod, Patricia, Cousijn, Janna, Labuschagne, Izelle, Clemente, Adam, Mackey, Scott, Rendell, Peter, Solowij, Nadia, Suo, Chao, Li, Chiang-Shan R., Terrett, Gillian, Thompson, Paul, Yucel, Murat, Garavan, Hugh and Roberts, Carl A. |
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Abstract | Background: Males and females who consume cannabis can experience different mental health and cognitive problems. Neuroscientific theories of addiction postulate that dependence is underscored by neuroadaptations, but do not account for the contribution of distinct sexes. Further, there is little evidence for sex differences in the neurobiology of cannabis dependence as most neuroimaging studies have been conducted in largely male samples in which cannabis dependence, as opposed to use, is often not ascertained. Methods: We examined subregional hippocampus and amygdala volumetry in a sample of 206 people recruited from the ENIGMA Addiction Working Group. They included 59 people with cannabis dependence (17 females), 49 cannabis users without cannabis dependence (20 females), and 98 controls (33 females). Results: We found no group-by-sex effect on subregional volumetry. The left hippocampal cornu ammonis subfield 1 (CA1) volumes were lower in dependent cannabis users compared with non-dependent cannabis users ( p < 0.001, d = 0.32) and with controls ( p = 0.022, d = 0.18). Further, the left cornu ammonis subfield 3 (CA3) and left dentate gyrus volumes were lower in dependent versus non-dependent cannabis users but not versus controls ( p = 0.002, d = 0.37, and p = 0.002, d = 0.31, respectively). All models controlled for age, intelligence quotient (IQ), alcohol and tobacco use, and intracranial volume. Amygdala volumetry was not affected by group or groupby-sex, but was smaller in females than males. Conclusions: Our findings suggest that the relationship between cannabis dependence and subregional volumetry was not moderated by sex. Specifically, dependent (rather than non-dependent) cannabis use may be associated with alterations in selected hippocampus subfields high in cannabinoid type 1 (CB1) receptors and implicated in addictive behavior. As these data are cross-sectional, it is plausible that differences predate cannabis dependence onset and contribute to the initiation of cannabis dependence. Longitudinal neuroimaging work is required to examine the time-course of the onset of subregional hippocampal alterations in cannabis dependence, and their progression as cannabis dependence exacerbates or recovers over time. |
Keywords | addiction; hippocampus; CB1; THC; cannabis; MRI; neuroimaging; dependence; sex differences |
Year | 01 Jan 2024 |
Journal | Cannabis and Cannabinoid Research |
Journal citation | X (X), pp. 1-14 |
Publisher | Mary Ann Liebert Inc |
ISSN | 2378-8763 |
Digital Object Identifier (DOI) | https://doi.org/10.1089/can.2023.0204 |
Web address (URL) | https://www.liebertpub.com/doi/10.1089/can.2023.0204 |
Open access | Published as non-open access |
Research or scholarly | Research |
Page range | 1-14 |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 18 Mar 2024 |
Publication process dates | |
Accepted | 2024 |
Deposited | 07 Jun 2024 |
Additional information | © Mary Ann Liebert, Inc |
Place of publication | United States |
https://acuresearchbank.acu.edu.au/item/9099v/cannabis-dependence-is-associated-with-reduced-hippocampal-subregion-volumes-independently-of-sex-findings-from-an-enigma-addiction-working-group-multi-country-study
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