Normalising comparative effectiveness trials as clinical practice

Journal article


Briffa, Thomas, Symons, Tanya, Zeps, Nikolajs, Straiton, Nicola, Tarnow-Mordi, William, Simes, John, Harris, Ian A., Cruz, Melinda, Webb, Steven A., Litton, Edward, Nichol, Alistair and Williams, Christopher M.. (2021). Normalising comparative effectiveness trials as clinical practice. Trials. 22(1), pp. 1-4. https://doi.org/10.1186/s13063-021-05566-1
AuthorsBriffa, Thomas, Symons, Tanya, Zeps, Nikolajs, Straiton, Nicola, Tarnow-Mordi, William, Simes, John, Harris, Ian A., Cruz, Melinda, Webb, Steven A., Litton, Edward, Nichol, Alistair and Williams, Christopher M.
Abstract

There is a lack of high-quality evidence underpinning many contemporary clinical practice guidelines embedded in the healthcare systems, leading to treatment uncertainty and practice variation in most medical disciplines. Comparative effectiveness trials (CETs) represent a diverse range of research that focuses on optimising health outcomes by comparing currently approved interventions to generate high-quality evidence to inform decision makers. Yet, despite their ability to produce real-world evidence that addresses the key priorities of patients and health systems, many implementation challenges exist within the healthcare environment.

This manuscript aims to highlight common barriers to conducting CETs and describes potential solutions to normalise their conduct as part of a learning healthcare system.

KeywordsComparative effectiveness; Pragmatic; Trials; High-quality evidence; Clinical care; Embed
Year01 Jan 2021
JournalTrials
Journal citation22 (1), pp. 1-4
PublisherBMC (BioMed Central) Springer
ISSN1745-6215
Digital Object Identifier (DOI)https://doi.org/10.1186/s13063-021-05566-1
Web address (URL)https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-021-05566-1
Open accessOpen access
Research or scholarlyResearch
Page range1-4
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online15 Sep 2021
Publication process dates
Accepted24 Aug 2021
Deposited23 Oct 2024
Additional information

© The Author(s). 2021

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Place of publicationUnited Kingdom
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