Bone Remodeling and Modeling : Cellular Targets for Antiresorptive and Anabolic Treatments, Including Approaches Through the Parathyroid Hormone (PTH)/PTH-Related Protein Pathway
Journal article
Martin, T. John and Seeman, Ego. (2023). Bone Remodeling and Modeling : Cellular Targets for Antiresorptive and Anabolic Treatments, Including Approaches Through the Parathyroid Hormone (PTH)/PTH-Related Protein Pathway. Neurospine. 20(4), pp. 1097-1109. https://doi.org/10.14245/ns.2346966.483
Authors | Martin, T. John and Seeman, Ego |
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Abstract | Bone is continuously in a state of building and renewal, though the process of remodeling that takes place at many sites asynchronously throughout the skeleton, with bone formation and resorption equal at these sites (bone multicellular units). Remodeling takes place on bone surfaces, both on trabeculae and in the cortex, and serves the purposes of replacing old bone or that damaged by microfractures throughout the skeleton. The bone loss and consequent osteoporotic fractures that result from excess resorption over formation have mainly been prevented or treated by antiresorptive drugs that inhibit osteoclast formation and/or activity. Virtually all of the evidence leading to acceptance of antiresorptive drugs as treatment has depended upon their prevention of vertebral fractures. In recent decades, new prospects came of anabolic treatments that partly restore bone volume and microstructure restore bone that has been lost. The first of these was parathyroid hormone (PTH), shown by daily injection to increase markers of bone formation and prevent fractures. This field of interest enlarged with the discovery of PTH-related protein (PTHrP), so closely related in structure and action to PTH. The structural relationship between PTH and PTHrP is important in assessing their physiological and pharmacological roles, with the N-terminal domains of the 2 having virtually equal actions on target cells. Abaloparatide, a peptide analogue based on the structures of PTHrP and PTH, has been approved in some countries as a therapy for osteoporosis. Treatment through the PTH receptor activation pathway, and probably with any anabolic therapy, needs to be followed by antiresorptive treatment in order to maintain bone that has been restored. No matter how effective anabolic therapies for the skeleton become, it seems highly likely that there will be a continuing need for antiresorptive drugs. |
Keywords | Bone remodeling; Parathyroid hormone; Wnt signaling; Parathyroid hormonerelated protein; Osteoporosis |
Year | 01 Jan 2023 |
Journal | Neurospine |
Journal citation | 20 (4), pp. 1097-1109 |
Publisher | The Korean Spinal Neurosurgery Society |
ISSN | 2586-6583 |
Digital Object Identifier (DOI) | https://doi.org/10.14245/ns.2346966.483 |
Web address (URL) | https://www.e-neurospine.org/journal/view.php?doi=10.14245/ns.2346966.483 |
Open access | Open access |
Research or scholarly | Research |
Page range | 1097-1109 |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 31 Dec 2023 |
Publication process dates | |
Accepted | 14 Dec 2023 |
Deposited | 19 Nov 2024 |
Additional information | Copyright © 2023 by the Korean Spinal Neurosurgery Society |
This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. | |
Place of publication | Korea, Republic of (South) |
https://acuresearchbank.acu.edu.au/item/9112w/bone-remodeling-and-modeling-cellular-targets-for-antiresorptive-and-anabolic-treatments-including-approaches-through-the-parathyroid-hormone-pth-pth-related-protein-pathway
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Publisher's version
OA_2023_Seeman_Bone_Remodeling_and_Modeling_Cellular_Targets.pdf | |
License: CC BY-NC 4.0 | |
File access level: Open |
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