A pocket guide on how to structure SARS-CoV-2 drugs and therapies

Journal article

Littler, Dene R., MacLachlan, Bruce J., Watson, Gabrielle M., Vivian, Julian Philip and Gully, Benjamin S.. (2020). A pocket guide on how to structure SARS-CoV-2 drugs and therapies. Biochemical Society Transactions. 48(6), pp. 2625-2641. https://doi.org/10.1042/BST20200396
AuthorsLittler, Dene R., MacLachlan, Bruce J., Watson, Gabrielle M., Vivian, Julian Philip and Gully, Benjamin S.
Abstract

The race to identify a successful treatment for COVID19 will be defined by fundamental research into the replication cycle of the SARS-CoV-2 virus. This has identified five distinct stages from which numerous vaccination and clinical trials have emerged alongside an innumerable number of drug discovery studies currently in development for disease intervention. Informing every step of the viral replication cycle has been an unprecedented ‘call-to-arms' by the global structural biology community. Of the 20 main SARS-CoV-2 proteins, 13 have been resolved structurally for SARS-CoV-2 with most having a related SARS-CoV and MERS-CoV structural homologue totalling some 300 structures currently available in public repositories. Herein, we review the contribution of structural studies to our understanding of the virus and their role in structure-based development of therapeutics.

KeywordsCOVID-19; SARS-CoV-2; structural biology
Year01 Jan 2020
JournalBiochemical Society Transactions
Journal citation48 (6), pp. 2625-2641
PublisherPortland Press Ltd.
ISSN0300-5127
Digital Object Identifier (DOI)https://doi.org/10.1042/BST20200396
Web address (URL)https://portlandpress.com/biochemsoctrans/article/48/6/2625/227086/A-pocket-guide-on-how-to-structure-SARS-CoV-2
Open accessPublished as ‘gold’ (paid) open access
Research or scholarlyResearch
Page range2625-2641
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License
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Open
Output statusPublished
Publication dates
Online01 Dec 2020
Publication process dates
Accepted29 Oct 2020
Deposited23 Feb 2025
Additional information

© 2020 The Author(s).

This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NCND). https://creativecommons.org/licenses/by-nc-nd/4.0/

Place of publicationUnited Kingdom
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