A randomized feasibility trial of time-restricted eating during pregnancy in people with increased risk of gestational diabetes
Journal article
Skarstad, Hanna M. S., Haganes, Kamilla L., Sujan, Md Abu Jafar, Gellein, Trine M., Johansen, Mariell K., Salvesen, Kjell Å., Hawley, John A. and Moholdt, Trine. (2024). A randomized feasibility trial of time-restricted eating during pregnancy in people with increased risk of gestational diabetes. Scientific Reports. 14(1), p. Article 22476. https://doi.org/10.1038/s41598-024-72913-y
Authors | Skarstad, Hanna M. S., Haganes, Kamilla L., Sujan, Md Abu Jafar, Gellein, Trine M., Johansen, Mariell K., Salvesen, Kjell Å., Hawley, John A. and Moholdt, Trine |
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Abstract | Time-restricted eating (TRE) is a nutritional intervention that confines the daily time-window for energy intake. TRE reduces fasting glucose concentrations in non-pregnant individuals, but whether this eating protocol is feasible and effective for glycemic control in pregnancy is unknown. The aim of this randomized controlled trial was to investigate the adherence to and effect of a 5-week TRE intervention (maximum 10 h daily eating window) among pregnant individuals at risk of gestational diabetes mellitus (GDM), compared with a usual-care control group. Participants underwent 2-h oral glucose tolerance tests and estimation of body composition, before and after the intervention. Interstitial glucose levels were continuously measured, and adherence rates and ratings of hunger were recorded daily. Thirty of 32 participants completed the trial. Participants allocated to TRE reduced their daily eating window from 12.3 (SD 1.3) to 9.9 (SD 1.0) h, but TRE did not affect glycemic measures, blood pressure, or body composition, compared with the control group. TRE increased hunger levels in the evening, but not in the morning, and induced only small changes in dietary intake. Adhering to a 5-week TRE intervention was feasible for pregnant individuals with increased risk of GDM but had no effect on cardiometabolic outcomes. |
Keywords | diet; continuous glucose monitoring; insulin; obesity; female; prevention |
Year | 2024 |
Journal | Scientific Reports |
Journal citation | 14 (1), p. Article 22476 |
Publisher | Nature Publishing Group |
ISSN | 2045-2322 |
Digital Object Identifier (DOI) | https://doi.org/10.1038/s41598-024-72913-y |
PubMed ID | 39341847 |
Scopus EID | 2-s2.0-85205335748 |
PubMed Central ID | PMC11439041 |
Open access | Published as ‘gold’ (paid) open access |
Page range | 1-11 |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 28 Sep 2024 |
Publication process dates | |
Accepted | 11 Sep 2024 |
Deposited | 07 May 2025 |
Additional information | © The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
https://acuresearchbank.acu.edu.au/item/91vv9/a-randomized-feasibility-trial-of-time-restricted-eating-during-pregnancy-in-people-with-increased-risk-of-gestational-diabetes
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Publisher's version
OA_Skarstad_2024_A_randomized_feasibility_trial_of_time.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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