Dose response effects of theacrine on cognitive performance and subsequent sleep
Journal article
Gardiner, Carissa L., Weakley, Jonathon, Leota, Josh, Burke, Louise M., Karagounis, Leonidas G., Russell, Suzanna, Johnston, Rich D., Townshend, Andrew and Halson, Shona L.. (2024). Dose response effects of theacrine on cognitive performance and subsequent sleep. Scientific Reports. 14(1), p. Article 28614. https://doi.org/10.1038/s41598-024-79046-2
Authors | Gardiner, Carissa L., Weakley, Jonathon, Leota, Josh, Burke, Louise M., Karagounis, Leonidas G., Russell, Suzanna, Johnston, Rich D., Townshend, Andrew and Halson, Shona L. |
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Abstract | Psychostimulants can be employed as a countermeasure to cognitive declines resulting from insufficient sleep. Although caffeine is the most consumed psychostimulant, consumption can cause adverse side-effects, including sleep disturbance. Therefore, there is interest in identifying alternative supplements that improve cognitive performance without compromising subsequent sleep. Here we investigate the influence of the dose and timing of theacrine consumption on cognitive performance and subsequent sleep using conditions that replicate a low (100 mg) and high (400 mg) dose consumed in the morning (12 h prior to bedtime), afternoon (eight hours prior to bedtime), and evening (four hours prior to bedtime). We found no significant effect of the low or high theacrine dose on subsequent sleep although the high dose showed small non-significant effects on sleep efficiency and wake after sleep onset at each timepoint of consumption. However, consuming theacrine within eight hours of bedtime improved next-morning cognitive performance, with the 400 mg dose reducing the number of lapses on the Psychomotor Vigilance Task, although there were no significant effects on reaction time. Our findings provide initial scientific evidence suggesting that theacrine consumption may improve some aspects of next-morning cognitive performance but not others, with small non-significant effects on nighttime sleep. |
Keywords | caffeine; adenosine; sleepiness; sleep disruption; vigilance; alertness |
Year | 2024 |
Journal | Scientific Reports |
Journal citation | 14 (1), p. Article 28614 |
Publisher | Nature Publishing Group |
ISSN | 2045-2322 |
Digital Object Identifier (DOI) | https://doi.org/10.1038/s41598-024-79046-2 |
PubMed ID | 39562624 |
Scopus EID | 2-s2.0-85209371436 |
PubMed Central ID | PMC11576848 |
Open access | Published as ‘gold’ (paid) open access |
Page range | 1-11 |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 19 Nov 2024 |
Publication process dates | |
Accepted | 06 Nov 2024 |
Deposited | 09 May 2025 |
Additional information | © The Author(s) 2024. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/. |
https://acuresearchbank.acu.edu.au/item/91w01/dose-response-effects-of-theacrine-on-cognitive-performance-and-subsequent-sleep
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OA_Gardiner_2024_Dose_response_effects_of_theacrine_on.pdf | |
License: CC BY-NC-ND 4.0 | |
File access level: Open |
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