Effect of interrupting prolonged sitting with frequent activity breaks on postprandial glycemia and insulin sensitivity in adults with type 1 diabetes on continuous subcutaneous insulin infusion therapy : A randomized crossover pilot trial
Journal article
Larsen, Robyn, Taylor, Frances, Dempsey, Paddy C., McNarry, Melitta, Rickards, Kym, Sethi, Parneet, Homer, Ashleigh, Cohen, Neale, Owen, Neville, Kumareswaran, Kavita, MacIsaac, Richard, McAuley, Sybil A., O'Neal, David and Dunstan, David W.. (2025). Effect of interrupting prolonged sitting with frequent activity breaks on postprandial glycemia and insulin sensitivity in adults with type 1 diabetes on continuous subcutaneous insulin infusion therapy : A randomized crossover pilot trial. Diabetes Technology and Therapeutics. 27(2), pp. 101-112. https://doi.org/10.1089/dia.2024.0146
Authors | Larsen, Robyn, Taylor, Frances, Dempsey, Paddy C., McNarry, Melitta, Rickards, Kym, Sethi, Parneet, Homer, Ashleigh, Cohen, Neale, Owen, Neville, Kumareswaran, Kavita, MacIsaac, Richard, McAuley, Sybil A., O'Neal, David and Dunstan, David W. |
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Abstract | Objective: This study examined acute effects of interrupting prolonged sitting with short activity breaks on postprandial glucose/insulin responses and estimations of insulin sensitivity in adults with type 1 diabetes (T1D). Method: In a randomized crossover trial, eight adults (age = 46 ± 14 years [mean ± SD], body mass index [BMI] = 27.2 ± 3.8 kg/m2) receiving continuous subcutaneous insulin infusion (CSII) therapy completed two 6-h conditions as follows: uninterrupted sitting (SIT) and sitting interrupted with 3-min bouts of simple resistance activities (SRAs) every 30 min. Basal and bolus insulin were standardized across conditions except in cases of hypoglycemia. Postprandial responses were assessed using incremental area-under-the-curve (iAUC) and total AUC (tAUC) from half-hourly venous sampling. Meal-based insulin sensitivity determined from glucose sensor and insulin pump (SiSP) was assessed from flash continuous glucose monitor and insulin pump data. Outcomes were analyzed using mixed models adjusted for sex, BMI, treatment order, and preprandial values. Results: Glucose iAUC did not differ by condition (SIT: 19.8 ± 3.0 [estimated marginal means ± standard error] vs. SRA: 14.4 ± 3.0 mmol.6 h.L−1; P = 0.086). Despite CSII being standardized between conditions, insulin iAUC was higher in SRA compared to SIT (137.1 ± 22.7 vs. 170.9 ± 22.7 mU.6 h.L−1; P < 0.001). This resulted in a lower glucose response relative to the change in plasma insulin in SRA (tAUCglu/tAUCins: 0.32 ± 0.02 vs. 0.40 ± 0.02 mmol.mU−1; P = 0.03). SiSP was also higher at dinner following the SRA condition, with no between-condition differences at breakfast or lunch. Conclusion: Regularly interrupting prolonged sitting in T1D may increase plasma insulin and improve insulin sensitivity when meals and CSII are standardized. Future studies should explore underlying mechanistic determinants and the applicability of findings to those on multiple daily injections. Trial Registration: Australian and New Zealand Clinical Trial Registry Identifier-ACTRN12618000126213 (www.anzctr.org.au). |
Keywords | type 1 diabetes; sedentary behavior; glucose control; insulin therapy |
Year | 2025 |
Journal | Diabetes Technology and Therapeutics |
Journal citation | 27 (2), pp. 101-112 |
Publisher | Mary Ann Liebert, Inc. |
ISSN | 1557-8593 |
Digital Object Identifier (DOI) | https://doi.org/10.1089/dia.2024.0146 |
PubMed ID | 39506625 |
Scopus EID | 2-s2.0-85209646035 |
Page range | 101-112 |
Funder | Diabetes Australia |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 03 Feb 2025 |
Publication process dates | |
Deposited | 10 Jun 2025 |
Grant ID | Y18G-DUND |
https://acuresearchbank.acu.edu.au/item/91yxz/effect-of-interrupting-prolonged-sitting-with-frequent-activity-breaks-on-postprandial-glycemia-and-insulin-sensitivity-in-adults-with-type-1-diabetes-on-continuous-subcutaneous-insulin-infusion
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