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Cognitive-behavioural therapy with post-session D-cycloserine augmentation for paediatric obsessive-compulsive disorder: Pilot randomised controlled trial
Mataix-Cols, David Turner, Cynthia Michelle Monzani, Benedetta Isomura, Kayoko Murphy, Caroline Krebs, Georgina Heyman, Isobel
Mataix-Cols, David
Turner, Cynthia Michelle
Monzani, Benedetta
Isomura, Kayoko
Murphy, Caroline
Krebs, Georgina
Heyman, Isobel
Abstract
A partial N-methyl-d-aspartate agonist, d-cycloserine, enhances fear extinction when given before or shortly after exposure to feared stimuli in animals. In this pilot double-blind placebo-controlled trial (trial number: ISRCTN70977225), 27 youth with obsessive-compulsive disorder were randomised to either 50 mg d-cycloserine or placebo administered immediately after each of ten cognitive-behavioural therapy (CBT) sessions, primarily consisting of exposure and ritual prevention. Both groups improved significantly and maintained their gains at 1-year follow-up, with no significant advantage of d-cycloserine over placebo at any time point. The effects of CBT may not be augmented or accelerated when d-cycloserine is administered after sessions.
Keywords
Date
2014
Type
Journal article
Journal
British Journal of Psychiatry
Book
Volume
204
Issue
1
Page Range
77-78
Article Number
ACU Department
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled