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Resistance exercise training increases muscle mass and strength in prostate cancer patients on androgen deprivation therapy
Houben, Lisanne H. P. Overkamp, Maarten van Kraaij, Puck Trommelen, Jorn van Roermund, Joep G. H. de Vries, Peter de Laet, Kevin van der Meer, Saskia Mikkelsen, Ulla R. Verdijk, Lex B.
Houben, Lisanne H. P.
Overkamp, Maarten
van Kraaij, Puck
Trommelen, Jorn
van Roermund, Joep G. H.
de Vries, Peter
de Laet, Kevin
van der Meer, Saskia
Mikkelsen, Ulla R.
Verdijk, Lex B.
Abstract
Purpose
This study aimed to assess the effects of 20 wk resistance exercise training with or without protein supplementation on body composition, muscle mass, muscle strength, physical performance, and aerobic capacity in prostate cancer patients receiving androgen deprivation therapy (ADT).
Methods
Sixty prostate cancer patients receiving ADT were randomly assigned to perform 20 wk of resistance exercise training with supplementation of 31 g whey protein (EX + PRO, n = 30) or placebo (EX + PLA, n = 30), consumed immediately after exercise and every night before sleep. A separate control group (CON, n = 36) only received usual care. At baseline and after 20 wk, body composition (dual-energy x-ray absorptiometry), muscle mass (computed tomography scan), muscle strength (1-repetition maximum strength tests), physical performance (Timed Up and Go Test, 30-Second Chair Stand Test, and Stair Climb Test), aerobic capacity (cardiopulmonary exercise test), and habitual dietary intake (food diary) were assessed. Data were analyzed using a two-factor repeated-measures ANOVA.
Results
Over time, muscle mass and strength increased in EX + PRO and EX + PLA and decreased in CON. Total fat mass and fat percentage increased in EX + PRO and CON, but not in EX + PLA. Physical performance did not significantly change over time in either group. Aerobic capacity was maintained in EX + PLA, but it decreased in EX + PRO and CON. Habitual protein intake (without supplements) averaged >1.0 g·kg body weight−1·d−1, with no differences over time or between groups.
Conclusions
In prostate cancer patients, resistance exercise training counteracts the adverse effects of ADT on body composition, muscle mass, muscle strength, and aerobic capacity, with no additional benefits of protein supplementation.
Keywords
hormone therapy, protein supplementation, body composition, physical performance, aerobic capacity
Date
2022
Type
Journal article
Journal
Medicine and Science in Sports and Exercise
Book
Volume
55
Issue
4
Page Range
614-624
Article Number
ACU Department
Centre for Exercise and Nutrition
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY-NC-ND 4.0
File Access
Open