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Psychological distress in men with prostate cancer undertaking androgen deprivation therapy : Modifying effects of exercise from a year-long randomized controlled trial
Galvão, Daniel Newton, Robert U. Chambers, Suzanne K. Spry, Nigel Joseph, David Gardiner, Robert A. Fairman, Ciaran M. Taaffe, Dennis R.
Galvão, Daniel
Newton, Robert U.
Chambers, Suzanne K.
Spry, Nigel
Joseph, David
Gardiner, Robert A.
Fairman, Ciaran M.
Taaffe, Dennis R.
Citations
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Author
Galvão, Daniel
Newton, Robert U.
Chambers, Suzanne K.
Spry, Nigel
Joseph, David
Gardiner, Robert A.
Fairman, Ciaran M.
Taaffe, Dennis R.
Newton, Robert U.
Chambers, Suzanne K.
Spry, Nigel
Joseph, David
Gardiner, Robert A.
Fairman, Ciaran M.
Taaffe, Dennis R.
Abstract
Objectives
To assess the long-term effects of various exercise modes on psychological distress in men with prostate cancer on androgen deprivation therapy (ADT).
Patients and methods
135 prostate cancer patients aged 43–90 years on ADT were randomized to twice weekly supervised impact loading and resistance exercise (ImpRes), supervised aerobic and resistance exercise (AerRes), and usual care/delayed supervised aerobic exercise (DelAer) for 12 months, and completed measures of psychological distress using the Brief Symptom Inventory-18 (BSI-18). BSI-18 provides three subscales for anxiety, depression, and somatisation, as well as the global severity index (GSI) where higher scores indicate higher distress.
Results
Following the intervention, somatization was not different to baseline, however, there were significant interactions (p < 0.01) for depression, anxiety, and the GSI. In ImpRes, depression was reduced at 12 months compared to baseline and 6 months (0.78 ± 1.39 vs. 1.88 ± 3.24 and 1.48 ± 2.65, p < 0.001), as was the GSI (3.67 ± 4.34 vs. 5.94 ± 7.46 and 4.64 ± 4.73, p < 0.001) with anxiety reduced compared to baseline (1.08 ± 1.54 vs. 1.98 ± 2.56). Depression and the GSI decreased (p < 0.05) in AerRes at 6 months but increased by 12 months, while in DelAer the GSI was reduced at 12 months compared to 6 months (3.78 ± 3.94 vs. 5.25 ± 4.22, p = 0.031). Men with the highest level of anxiety, depression, somatization, and the GSI improved the most with exercise (ptrend < 0.001).
Conclusion
Various supervised exercise modes (aerobic, resistance and impact loading) are effective in reducing psychological distress in men with prostate cancer on ADT. Those with the highest level of psychological distress improved the most. Supervised exercise should be prescribed to improve psychological health in prostate cancer patients on ADT.
Keywords
Date
2021
Type
Journal article
Journal
Prostate Cancer and Prostatic Diseases
Book
Volume
24
Issue
3
Page Range
758-766
Article Number
ACU Department
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY 4.0
File Access
Open
Notes
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