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Aerobic exercise-induced changes in cardiorespiratory fitness in breast cancer patients receiving chemotherapy : A systematic review and meta-analysis
Maginador, Guilherme Lixandrão, Manoel E. Bortolozo, Henrique I. Vechin, Felipe C. Sarian, Luís O. Derchain, Sophie Telles, Guilherme D. Zopf, Eva Ugrinowitsch, Carlos Conceição, Miguel S.
Maginador, Guilherme
Lixandrão, Manoel E.
Bortolozo, Henrique I.
Vechin, Felipe C.
Sarian, Luís O.
Derchain, Sophie
Telles, Guilherme D.
Zopf, Eva
Ugrinowitsch, Carlos
Conceição, Miguel S.
Abstract
While performing aerobic exercise during chemotherapy has been proven feasible and safe, the efficacy of aerobic training on cardiorespiratory fitness (CRF) in women with breast cancer undergoing chemotherapy has not yet been systematically assessed. Therefore, the objective of this work was to determine (a) the efficacy of aerobic training to improve CRF; (b) the role of aerobic training intensity (moderate or vigorous) on CRF response; (c) the effect of the aerobic training mode (continuous or interval) on changes in CRF in women with breast cancer (BC) receiving chemotherapy. A systematic review and meta-analysis were conducted as per PRISMA guidelines, and randomized controlled trials comparing usual care (UC) and aerobic training in women with BC undergoing chemotherapy were eligible. The results suggest that increases in CRF are favored by (a) aerobic training when compared to usual care; (b) vigorous-intensity aerobic exercise (64–90% of maximal oxygen uptake, VO2max) when compared to moderate-intensity aerobic exercise (46–63% of VO2max); and (c) both continuous and interval aerobic training are effective at increasing the VO2max. Aerobic training improves CRF in women with BC undergoing chemotherapy. Notably, training intensity significantly impacts the VO2max response. Where appropriate, vigorous intensity aerobic training should be considered for women with BC receiving chemotherapy.
Keywords
aerobic fitness, breast cancer, exercise rehabilitation, VO2max
Date
2020
Type
Journal article
Journal
Cancers
Book
Volume
12
Issue
8
Page Range
1-14
Article Number
Article 2240
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY 4.0
File Access
Open