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Efficacy of two doses of external counterpulsation (ECP) on glycemic control in people with type 2 diabetes mellitus : A randomized SHAM-controlled trial
Coombes, Jeff S. Dias, Katrin A. Lal, Ravin Fassett, Robert G. Wallen, Matthew P. Ramos, Joyce S. Russell, Suzanna Vear, Natalie K. Gajanand, Trishan Bailey, Tom G.
Coombes, Jeff S.
Dias, Katrin A.
Lal, Ravin
Fassett, Robert G.
Wallen, Matthew P.
Ramos, Joyce S.
Russell, Suzanna
Vear, Natalie K.
Gajanand, Trishan
Bailey, Tom G.
Abstract
Aims
To determine the efficacy of two doses of external counterpulsation (ECP) on glycemic control in people with type 2 diabetes mellitus (T2D), and any persistent benefits 7 weeks following treatment.
Methods
50 participants with T2D were randomly assigned to either 1) 20x45-minute ECP sessions over 7 weeks (ECP45), 2) 20x30-minute ECP sessions over 7 weeks (ECP30) or 3) SHAM control. Outcomes were assessed at baseline, after 7 weeks of the intervention and 7 weeks after the interventions finished. Efficacy was determined from changes in HbA1c.
Results
After 7 weeks, there were significant between-group differences, with ECP45 lowering HbA1c compared to SHAM (mean [95% CI] −0.7 [-0.1 to −1.3] %; −7 [-1 to −15] mmol/mol). Within group changes were; ECP45 (mean ± SD −0.8 ± 0.8%; −8 ± 8 mmol/mol), ECP30 (-0.2 ± 0.5%; −2 ± 6 mmol/mol) and SHAM (-0.1 ± 0.9%; −1 ± 10 mmol/mol). HbA1c in the ECP45 group remained lower 7 weeks after completing the intervention; ECP45 (7.0 ± 1.1%; 53 ± 26 mmol/mol), ECP30 (7.7 ± 1.4%; 60 ± 16 mmol/mol) and SHAM (7.7 ± 1.0%; 60 ± 10 mmol/mol).
Conclusions
In people with T2D, ECP45 for 7 weeks improved glycemic control when compared to ECP30 and a SHAM control group.
Keywords
HbA1c, insulin resistance, insulin sensitivity, beta cell function, basal disposition index
Date
2023
Type
Journal article
Journal
Diabetes Research and Clinical Practice
Book
Volume
200
Issue
Page Range
1-9
Article Number
Article 110701
ACU Department
School of Behavioural and Health Sciences
Faculty of Health Sciences
Faculty of Health Sciences
Relation URI
Source URL
Event URL
Open Access Status
License
All rights reserved
File Access
Controlled