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The effect of resistance training on markers of immune function and inflammation in previously sedentary women recovering from breast cancer: A randomized controlled
Hagstrom, Amanda D. Marshall, Paul W. M. Lonsdale, Chris Papalia, Shona Cheema, Birinder S. Toben, Catherine Baune, Bernhard T. Fiatarone Singh, Maria A. Green, Simon
Hagstrom, Amanda D.
Marshall, Paul W. M.
Lonsdale, Chris
Papalia, Shona
Cheema, Birinder S.
Toben, Catherine
Baune, Bernhard T.
Fiatarone Singh, Maria A.
Green, Simon
Abstract
The purpose of this randomized controlled trial was to determine the effects of resistance training (RT) on markers of inflammation and immune function in breast cancer survivors. Thirty-nine breast cancer survivors were randomly assigned to a RT (n = 20) or control (n = 19) group. RT performed supervized exercise three times per week. Natural killer cell (NK) and natural killer T-cell (NKT) function, and markers of inflammation (serum TNF-α, IL-6, IL-10, and CRP) were measured before and after training. Changes in NK and NKT cell function were analyzed using ANCOVA, with the change score the dependent variable, and the baseline value of the same variable the covariate. Effect sizes (ES) were calculated via partial eta-squared. We found a significant reduction, and large associated ESs, in the RT group compared to the control group for change in NK cell expression of TNF-α (p = 0.005, ES = 0.21) and NKT cell expression of TNF-α (p = 0.04, ES = 0.12). No differences were observed in any serum marker. Significant improvements in all measurements of strength were found in RT compared to control (p < 0.001; large ESs ranging from 0.32 to 0.51). These data demonstrate that RT has a beneficial effect on the NK and NKT cell expression of TNF-α indicating that RT may be beneficial in improving the inflammatory profile in breast cancer survivors.
Keywords
resistance training, immune function, inflammation, breast cancer survivors
Date
2016
Type
Journal article
Journal
Breast Cancer Research and Treatment
Book
Volume
155
Issue
3
Page Range
471-482
Article Number
ACU Department
Non-faculty
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled