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Highly porous and mechanically robust polyester poly(ethylene glycol) sponges as implantable scaffolds
Ozcelik, Berkay Blencowe, Anton Palmer, Jason Ladewig, Katharina Stevens, Geoffrey Abberton, Keren Morrison, Wayne Qiao, Greg
Ozcelik, Berkay
Blencowe, Anton
Palmer, Jason
Ladewig, Katharina
Stevens, Geoffrey
Abberton, Keren
Morrison, Wayne
Qiao, Greg
Abstract
The development of suitable scaffolds plays a significant role in tissue engineering research. Although scaffolds with promising features have been produced via a variety of innovative methods, there are no fully synthetic tissue engineering scaffolds that possess all the desired properties in one three-dimensional construct. Herein, we report the development of novel polyester poly(ethylene glycol) (PEG) sponges that display many of the desirable scaffold characteristics. Our novel synthetic approach utilizes acid chloride/alcohol chemistry, whereby the reaction between a hydroxyl end-functionalized 4-arm PEG and sebacoyl chloride resulted in cross-linking and simultaneous hydrogen chloride gas production, which was exploited for the in situ formation of highly interconnected pores. Variation of the fabrication conditions, including the precursor volume and concentration, allowed the pore size and structure as well as the compressive properties to be tailored. The sponges were found to possess excellent elastic properties, preserving their shape even after 80% compressive strain without failure. The benign properties of the sponges were demonstrated in an in vivo subcutaneous rat model, which also revealed uniform infiltration of vascularized tissue by 8 weeks and complete degradation of the sponges by 16 weeks, with only a minimal inflammatory response being observed over the course of the experiments.
Keywords
Polyethylene glycol, Scaffold, Biocompatibility, Biodegradation
Date
2014
Type
Journal article
Journal
Acta Biomaterialia
Book
Volume
10
Issue
6
Page Range
2769-2780
Article Number
ACU Department
School of Nursing, Midwifery and Paramedicine
Faculty of Health Sciences
School of Behavioural and Health Sciences
Faculty of Health Sciences
School of Behavioural and Health Sciences
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled