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The translocator protein (TSPO): A novel target for cancer chemotherapy
Austin, Christopher J. D. Kahlert, Jan Kassiou, Michael Rendina, Louis M.
Austin, Christopher J. D.
Kahlert, Jan
Kassiou, Michael
Rendina, Louis M.
Abstract
The translocator protein (TSPO) is an 18 kDa transmembrane protein primarily found in the outer mitochondrial membrane where it forms a key part of the mitochondrial permeability transition pore (MPTP). Omnipresent in almost all tissues, TSPO up-regulation has been connected to neuronal damage and inflammation, making the protein an important bio-imaging marker for disease progression. More recently, TSPO has attracted attention as a possible molecular target for tumour imaging and chemotherapy. In this review we summarize TSPO's molecular characteristics and highlight research progress in recent years in the field of TSPO-targeted cancer diagnostics and treatments.
Keywords
translocator protein, TSPO, cancer, apoptosis, cell homoeostasis
Date
2013
Type
Journal article
Journal
The International Journal of Biochemistry and Cell Biology
Book
Volume
45
Issue
7
Page Range
1212-1216
Article Number
ACU Department
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled